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The map label for this gene is alr

Identifier: 221229582

GI number: 221229582

Start: 468141

End: 469307

Strand: Direct

Name: alr

Synonym: MLBr_00375

Alternate gene names: 221229582

Gene position: 468141-469307 (Clockwise)

Preceding gene: 221229581

Following gene: 221229583

Centisome position: 14.32

GC content: 61.27

Gene sequence:

>1167_bases
TTGGCTGTTACACCGATATCCTTGAGGCCAGGTGTCTTGGCCGAAGCTGTTGTGGATCTGGGAGCTATTGACTACAACGT
GCGCGTGTTGCGTGAGCACGCTGGCATGGCGCAACTGATGGTTGTCCTCAAAGCCGACGCCTACGGTCACGGTGCCACCC
AGGTTGCCCTCGCCGCATTGGCAGCCGGTGCGGCCGAGCTGGGTGTGGCCACCGTCGACGAAGCGCTCGCATTGCGCGCG
GACGGTATCAGTGCACCGGTGCTGGCCTGGCTGCATCCACCCGGAATCGACTTCGGGCCCGCGCTGCTGGCCGACGTGCA
GATAGCGGTGTCCTCGGTGCGTCAGCTTGACGAGCTGCTGGATGCGGTGCGTCGGACCGGTCGTACGGCGACGGTGACCG
TCAAAGCCGACACCGGGCTGAACCGCAACGGGGTCGTCACCGATCAATACCCGGCGATGCTGACCGCGTTGCAGCGGGCT
GTCGTAGAAGACGCCGTAAGGCTGCGCGGGTTGATGTCGCACTTGGTTTACGCTGACCAGCCCGATAATCCCAGCAATGA
CGTTCAGGGCAAGCGGTTTGCTGCTCTGCTCGCTCAGGCGCACGAACAGGGATTGCGGTTCGAGGTGGCGCATCTGTCGA
ATTCATCAGCTACGATGTCTCGTCCTGACCTGGCTTACGACCTGGTCAGGCCCGGCATCGCGGTGTACGGTCTTAGTCCT
GTGCCTTCCCGCGGTGATATGGGACTAATACCCGCAATGACGGTGAAATGCGCTGTTGCGATGGTGAAGTCTATTCGTGC
TGGTGAAGGTGTTTCGTACGGACACGACTGGATTGCGCAGCATGACACCAATTTGGCGCTGTTGCCGGTTGGATATGCGG
ACGGTGTGTTCCGGTCGCTGGGCGGCCGGCTGGATGTGCTGATCAATGGCAAGCGCCGGCCTGGCGTCGGACGGATCTGT
ATGGACCAGTTTGTCGTCGACTTGGGTCCGGGGCCAATCGATGTAGCCGAAGGCGACGAAGCCATCTTGTTCGGTCCCGG
CGCCAGAGGCGAACCCACTGCGCAAGATTGGGCTGATCTGCTTGGAACTATCCACTATGAAGTGGTCACCAGTCTACGCG
GGCGGATCACCAGAACGTACCGCGAGGCCCAAACCGTTGACAGATGA

Upstream 100 bases:

>100_bases
TTGTGCTCCGTAATCGACACGCGTGGATCGGCATGCCCCATTGGTTCTGGGAAAATGTCGGCAGCGAGTTGACACACATC
TAAATAGGAGCACGTTTATT

Downstream 100 bases:

>100_bases
TGAAATCCGCAGGCGTCGGAACGGCCGGCCTTGGCTTGCGGGAGGCACCGGGCTGGTCCCGGTCGCCACCATCGTCGGAG
CCTTGTCGCTCCGATCGATA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MAVTPISLRPGVLAEAVVDLGAIDYNVRVLREHAGMAQLMVVLKADAYGHGATQVALAALAAGAAELGVATVDEALALRA
DGISAPVLAWLHPPGIDFGPALLADVQIAVSSVRQLDELLDAVRRTGRTATVTVKADTGLNRNGVVTDQYPAMLTALQRA
VVEDAVRLRGLMSHLVYADQPDNPSNDVQGKRFAALLAQAHEQGLRFEVAHLSNSSATMSRPDLAYDLVRPGIAVYGLSP
VPSRGDMGLIPAMTVKCAVAMVKSIRAGEGVSYGHDWIAQHDTNLALLPVGYADGVFRSLGGRLDVLINGKRRPGVGRIC
MDQFVVDLGPGPIDVAEGDEAILFGPGARGEPTAQDWADLLGTIHYEVVTSLRGRITRTYREAQTVDR

Sequences:

>Translated_388_residues
MAVTPISLRPGVLAEAVVDLGAIDYNVRVLREHAGMAQLMVVLKADAYGHGATQVALAALAAGAAELGVATVDEALALRA
DGISAPVLAWLHPPGIDFGPALLADVQIAVSSVRQLDELLDAVRRTGRTATVTVKADTGLNRNGVVTDQYPAMLTALQRA
VVEDAVRLRGLMSHLVYADQPDNPSNDVQGKRFAALLAQAHEQGLRFEVAHLSNSSATMSRPDLAYDLVRPGIAVYGLSP
VPSRGDMGLIPAMTVKCAVAMVKSIRAGEGVSYGHDWIAQHDTNLALLPVGYADGVFRSLGGRLDVLINGKRRPGVGRIC
MDQFVVDLGPGPIDVAEGDEAILFGPGARGEPTAQDWADLLGTIHYEVVTSLRGRITRTYREAQTVDR
>Mature_387_residues
AVTPISLRPGVLAEAVVDLGAIDYNVRVLREHAGMAQLMVVLKADAYGHGATQVALAALAAGAAELGVATVDEALALRAD
GISAPVLAWLHPPGIDFGPALLADVQIAVSSVRQLDELLDAVRRTGRTATVTVKADTGLNRNGVVTDQYPAMLTALQRAV
VEDAVRLRGLMSHLVYADQPDNPSNDVQGKRFAALLAQAHEQGLRFEVAHLSNSSATMSRPDLAYDLVRPGIAVYGLSPV
PSRGDMGLIPAMTVKCAVAMVKSIRAGEGVSYGHDWIAQHDTNLALLPVGYADGVFRSLGGRLDVLINGKRRPGVGRICM
DQFVVDLGPGPIDVAEGDEAILFGPGARGEPTAQDWADLLGTIHYEVVTSLRGRITRTYREAQTVDR

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=371, Percent_Identity=33.4231805929919, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1787439, Length=369, Percent_Identity=32.520325203252, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_MYCLE (P38056)

Other databases:

- EMBL:   U00020
- EMBL:   AL583918
- PIR:   S72995
- RefSeq:   NP_301367.1
- ProteinModelPortal:   P38056
- SMR:   P38056
- EnsemblBacteria:   EBMYCT00000029360
- GeneID:   909060
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0375
- NMPDR:   fig|272631.1.peg.239
- Leproma:   ML0375
- GeneTree:   EBGT00050000016627
- HOGENOM:   HBG712172
- OMA:   EGTPVWV
- ProtClustDB:   PRK00053
- BioCyc:   MLEP272631:ML0375-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 41084; Mature: 40952

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 44-44 ACT_SITE 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTPISLRPGVLAEAVVDLGAIDYNVRVLREHAGMAQLMVVLKADAYGHGATQVALAAL
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHH
AAGAAELGVATVDEALALRADGISAPVLAWLHPPGIDFGPALLADVQIAVSSVRQLDELL
HHCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DAVRRTGRTATVTVKADTGLNRNGVVTDQYPAMLTALQRAVVEDAVRLRGLMSHLVYADQ
HHHHHCCCEEEEEEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PDNPSNDVQGKRFAALLAQAHEQGLRFEVAHLSNSSATMSRPDLAYDLVRPGIAVYGLSP
CCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHCCCEEEEECCC
VPSRGDMGLIPAMTVKCAVAMVKSIRAGEGVSYGHDWIAQHDTNLALLPVGYADGVFRSL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHC
GGRLDVLINGKRRPGVGRICMDQFVVDLGPGPIDVAEGDEAILFGPGARGEPTAQDWADL
CCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEECCCCCCEEEECCCCCCCCCHHHHHHH
LGTIHYEVVTSLRGRITRTYREAQTVDR
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVTPISLRPGVLAEAVVDLGAIDYNVRVLREHAGMAQLMVVLKADAYGHGATQVALAAL
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHH
AAGAAELGVATVDEALALRADGISAPVLAWLHPPGIDFGPALLADVQIAVSSVRQLDELL
HHCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DAVRRTGRTATVTVKADTGLNRNGVVTDQYPAMLTALQRAVVEDAVRLRGLMSHLVYADQ
HHHHHCCCEEEEEEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PDNPSNDVQGKRFAALLAQAHEQGLRFEVAHLSNSSATMSRPDLAYDLVRPGIAVYGLSP
CCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHCCCEEEEECCC
VPSRGDMGLIPAMTVKCAVAMVKSIRAGEGVSYGHDWIAQHDTNLALLPVGYADGVFRSL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHC
GGRLDVLINGKRRPGVGRICMDQFVVDLGPGPIDVAEGDEAILFGPGARGEPTAQDWADL
CCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEECCCCCCEEEECCCCCCCCCHHHHHHH
LGTIHYEVVTSLRGRITRTYREAQTVDR
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002