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The map label for this gene is folB

Identifier: 221229500

GI number: 221229500

Start: 297558

End: 297956

Strand: Direct

Name: folB

Synonym: MLBr_00225

Alternate gene names: 221229500

Gene position: 297558-297956 (Clockwise)

Preceding gene: 221229499

Following gene: 221229501

Centisome position: 9.11

GC content: 62.16

Gene sequence:

>399_bases
ATGGCTGACCGAATGGAGTTGCGCGGTTTGATAGTTCGTGGACGACACGGTGTCTACGAGGTCGAGCGCGCCAACGGACA
AGACTTCATCGTGGATGTCATCTTATGGATCGATCTGGCCGATGCGGCCGCGAACGACAACCTAGCTGACACCTATGACT
ACGTGGTTCTGGCCGAGCGGACTGCCGCGATCATCGCCGGCCCACCACGGAACCTGATCGAGACAGTCGGCAGCGAGATT
GCCGACTTCGTGATGGACGACGAACGCGTGCACGCCGTCGAGGTGGTGGTGCACAAGCCGCAGGCGCCGATCCCGCAGCA
GTTCTCTGATGTGGCGGTGGTGGTTCGGCGATCGCGACGCGGCGGTCGCGGTTCGATGATTCCTGCGAGCGGGGTGTGA

Upstream 100 bases:

>100_bases
TGGGGTGTTCGGGTGCACGATGTGCGTGCCTCGGTCGACGCACTCAAGGTCGTCGGGGCTTGGCTGCATGCTGGGCCGCA
GATTGAAAAGGTTAGATGTG

Downstream 100 bases:

>100_bases
TGACTCGCGTCGTACTGTCTATAGGATCCAATCTGGGTGACCGGCTGGCGTGGCTGCAGTCAGCCGTCGATGGGCTGGGT
GATGCGGTTGTCGCGGTCTC

Product: putative dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA

Number of amino acids: Translated: 132; Mature: 131

Protein sequence:

>132_residues
MADRMELRGLIVRGRHGVYEVERANGQDFIVDVILWIDLADAAANDNLADTYDYVVLAERTAAIIAGPPRNLIETVGSEI
ADFVMDDERVHAVEVVVHKPQAPIPQQFSDVAVVVRRSRRGGRGSMIPASGV

Sequences:

>Translated_132_residues
MADRMELRGLIVRGRHGVYEVERANGQDFIVDVILWIDLADAAANDNLADTYDYVVLAERTAAIIAGPPRNLIETVGSEI
ADFVMDDERVHAVEVVVHKPQAPIPQQFSDVAVVVRRSRRGGRGSMIPASGV
>Mature_131_residues
ADRMELRGLIVRGRHGVYEVERANGQDFIVDVILWIDLADAAANDNLADTYDYVVLAERTAAIIAGPPRNLIETVGSEIA
DFVMDDERVHAVEVVVHKPQAPIPQQFSDVAVVVRRSRRGGRGSMIPASGV

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLB_MYCLE (O69529)

Other databases:

- EMBL:   AL023093
- EMBL:   AL583917
- PIR:   A86937
- RefSeq:   NP_301285.1
- ProteinModelPortal:   O69529
- SMR:   O69529
- EnsemblBacteria:   EBMYCT00000029405
- GeneID:   908411
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0225
- NMPDR:   fig|272631.1.peg.157
- Leproma:   ML0225
- GeneTree:   EBGT00050000017251
- HOGENOM:   HBG635896
- OMA:   APIPDFG
- ProtClustDB:   CLSK799351
- BioCyc:   MLEP272631:ML0225-MONOMER
- BRENDA:   4.1.2.25
- InterPro:   IPR006156
- InterPro:   IPR006157
- PANTHER:   PTHR20941:SF3
- SMART:   SM00905
- TIGRFAMs:   TIGR00525
- TIGRFAMs:   TIGR00526

Pfam domain/function: PF02152 FolB

EC number: =4.1.2.25

Molecular weight: Translated: 14450; Mature: 14318

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRMELRGLIVRGRHGVYEVERANGQDFIVDVILWIDLADAAANDNLADTYDYVVLAER
CCCCHHHCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEECC
TAAIIAGPPRNLIETVGSEIADFVMDDERVHAVEVVVHKPQAPIPQQFSDVAVVVRRSRR
CEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCC
GGRGSMIPASGV
CCCCCCCCCCCC
>Mature Secondary Structure 
ADRMELRGLIVRGRHGVYEVERANGQDFIVDVILWIDLADAAANDNLADTYDYVVLAER
CCCHHHCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEECC
TAAIIAGPPRNLIETVGSEIADFVMDDERVHAVEVVVHKPQAPIPQQFSDVAVVVRRSRR
CEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCC
GGRGSMIPASGV
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002