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The map label for this gene is folP

Identifier: 221229499

GI number: 221229499

Start: 296711

End: 297565

Strand: Direct

Name: folP

Synonym: MLBr_00224

Alternate gene names: 221229499

Gene position: 296711-297565 (Clockwise)

Preceding gene: 221229498

Following gene: 221229500

Centisome position: 9.08

GC content: 60.0

Gene sequence:

>855_bases
GTGAGTTTGGCGCCAGTGCAGGTTATTGGGGTTTTGAACGTCACTGACAATTCGTTCTCAGATGGCGGACGTTACCTTGA
TCCTGACGATGCTGTCCAGCACGGCCTGGCAATGGTCGCGGAAGGCGCGGCGATTGTCGACGTCGGTGGCGAATCGACCC
GGCCCGGTGCCATTAGGACCGATCCTCGAGTTGAACTCTCTCGTATCGTTCCTGTCGTAAAAGAACTTGCAGCACAGGGG
ATTACAGTAAGTATCGATACTACGCGCGCTGATGTTGCACGGGCGGCGCTGCAAAGCGGCGCACGGATCGTCAACGATGT
GTCTGGTGGGCGAGCAGATCCCGCGATGGCTCCTCTGGTGGCTGAAGCCGGTGTTGCGTGGGTGTTGATGCACTGGCGAC
TGATGTCGGCTGAACGGCCGTATGAGGCTCCGAATTACCGCGACGTGGTGGCTGAAGTGCGTGCCGACCTACTGGCTGGT
GTCGATCAGGCTGTGGCCGCAGGTGTTGATCCTGGGAGTCTAGTGATCGATCCCGGGCTTGGATTCGCCAAGACGGGACA
GCACAATTGGGCGCTGCTGAATGCGTTACCGGAGTTGGTGGCTACTGGGGTCCCGATTCTACTTGGCGCCTCGCGTAAAC
GGTTCCTGGGTAGGTTATTAGCTGGGGCTGATGGCGCGGTACGACCGCCGGACGGACGTGAGACGGCGACCGCGGTGATT
TCCGCACTTGCTGCCCTACACGGGGCTTGGGGTGTTCGGGTGCACGATGTGCGTGCCTCGGTCGACGCACTCAAGGTCGT
CGGGGCTTGGCTGCATGCTGGGCCGCAGATTGAAAAGGTTAGATGTGATGGCTGA

Upstream 100 bases:

>100_bases
TCCGCAAGCCTGGCGCGATCACGACGACGTCGGCGGTGCGCGGTCAGTTCAAAACTGATGCTGCTTCTCGTGCCGAAGCG
CTCGGCCTCATCCTGCGTAA

Downstream 100 bases:

>100_bases
CCGAATGGAGTTGCGCGGTTTGATAGTTCGTGGACGACACGGTGTCTACGAGGTCGAGCGCGCCAACGGACAAGACTTCA
TCGTGGATGTCATCTTATGG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MSLAPVQVIGVLNVTDNSFSDGGRYLDPDDAVQHGLAMVAEGAAIVDVGGESTRPGAIRTDPRVELSRIVPVVKELAAQG
ITVSIDTTRADVARAALQSGARIVNDVSGGRADPAMAPLVAEAGVAWVLMHWRLMSAERPYEAPNYRDVVAEVRADLLAG
VDQAVAAGVDPGSLVIDPGLGFAKTGQHNWALLNALPELVATGVPILLGASRKRFLGRLLAGADGAVRPPDGRETATAVI
SALAALHGAWGVRVHDVRASVDALKVVGAWLHAGPQIEKVRCDG

Sequences:

>Translated_284_residues
MSLAPVQVIGVLNVTDNSFSDGGRYLDPDDAVQHGLAMVAEGAAIVDVGGESTRPGAIRTDPRVELSRIVPVVKELAAQG
ITVSIDTTRADVARAALQSGARIVNDVSGGRADPAMAPLVAEAGVAWVLMHWRLMSAERPYEAPNYRDVVAEVRADLLAG
VDQAVAAGVDPGSLVIDPGLGFAKTGQHNWALLNALPELVATGVPILLGASRKRFLGRLLAGADGAVRPPDGRETATAVI
SALAALHGAWGVRVHDVRASVDALKVVGAWLHAGPQIEKVRCDG
>Mature_283_residues
SLAPVQVIGVLNVTDNSFSDGGRYLDPDDAVQHGLAMVAEGAAIVDVGGESTRPGAIRTDPRVELSRIVPVVKELAAQGI
TVSIDTTRADVARAALQSGARIVNDVSGGRADPAMAPLVAEAGVAWVLMHWRLMSAERPYEAPNYRDVVAEVRADLLAGV
DQAVAAGVDPGSLVIDPGLGFAKTGQHNWALLNALPELVATGVPILLGASRKRFLGRLLAGADGAVRPPDGRETATAVIS
ALAALHGAWGVRVHDVRASVDALKVVGAWLHAGPQIEKVRCDG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain

Homologues:

Organism=Escherichia coli, GI87082224, Length=274, Percent_Identity=39.051094890511, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324073, Length=325, Percent_Identity=28.9230769230769, Blast_Score=126, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHPS1_MYCLE (P0C0X1)

Other databases:

- EMBL:   AB028658
- EMBL:   AB028659
- EMBL:   AB028660
- EMBL:   AB028661
- EMBL:   AB028662
- EMBL:   AB028663
- EMBL:   AB028656
- EMBL:   AB028657
- EMBL:   AF117618
- EMBL:   AL023093
- EMBL:   AL583917
- PIR:   H86936
- RefSeq:   NP_301284.1
- ProteinModelPortal:   P0C0X1
- SMR:   P0C0X1
- EnsemblBacteria:   EBMYCT00000028197
- GeneID:   908646
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0224
- NMPDR:   fig|272631.1.peg.156
- Leproma:   ML0224
- GeneTree:   EBGT00050000015914
- HOGENOM:   HBG754410
- OMA:   FNPVMAR
- ProtClustDB:   CLSK799350
- BioCyc:   MLEP272631:ML0224-MONOMER
- BRENDA:   2.5.1.15
- DrugBank:   DB00250
- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489
- Gene3D:   G3DSA:3.20.20.20
- PANTHER:   PTHR20941:SF1
- TIGRFAMs:   TIGR01496

Pfam domain/function: PF00809 Pterin_bind; SSF51717 DHP_synth_like

EC number: =2.5.1.15

Molecular weight: Translated: 29448; Mature: 29317

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00792 DHPS_1; PS00793 DHPS_2; PS50972 PTERIN_BINDING

Important sites: BINDING 21-21 BINDING 86-86 BINDING 105-105 BINDING 177-177 BINDING 213-213 BINDING 253-253 BINDING 255-255

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAPVQVIGVLNVTDNSFSDGGRYLDPDDAVQHGLAMVAEGAAIVDVGGESTRPGAIRT
CCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
DPRVELSRIVPVVKELAAQGITVSIDTTRADVARAALQSGARIVNDVSGGRADPAMAPLV
CCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHH
AEAGVAWVLMHWRLMSAERPYEAPNYRDVVAEVRADLLAGVDQAVAAGVDPGSLVIDPGL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
GFAKTGQHNWALLNALPELVATGVPILLGASRKRFLGRLLAGADGAVRPPDGRETATAVI
CCCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
SALAALHGAWGVRVHDVRASVDALKVVGAWLHAGPQIEKVRCDG
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCC
>Mature Secondary Structure 
SLAPVQVIGVLNVTDNSFSDGGRYLDPDDAVQHGLAMVAEGAAIVDVGGESTRPGAIRT
CCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
DPRVELSRIVPVVKELAAQGITVSIDTTRADVARAALQSGARIVNDVSGGRADPAMAPLV
CCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHH
AEAGVAWVLMHWRLMSAERPYEAPNYRDVVAEVRADLLAGVDQAVAAGVDPGSLVIDPGL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
GFAKTGQHNWALLNALPELVATGVPILLGASRKRFLGRLLAGADGAVRPPDGRETATAVI
CCCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
SALAALHGAWGVRVHDVRASVDALKVVGAWLHAGPQIEKVRCDG
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10474189; 10542185; 11234002