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The map label for this gene is pgi

Identifier: 221229451

GI number: 221229451

Start: 211177

End: 212841

Strand: Reverse

Name: pgi

Synonym: MLBr_00150

Alternate gene names: 221229451

Gene position: 212841-211177 (Counterclockwise)

Preceding gene: 221229452

Following gene: 221229449

Centisome position: 6.51

GC content: 57.18

Gene sequence:

>1665_bases
ATGACCTCCATGCAAGCAATCCCCGACATCACTGCCACCCCGGCGTGGGACGCTCTGCGCAGGCATCACGATGAGATCGG
GGCAACCCATTTACGCCAGTTCTTCGCCGATAATCCCAATCGCGGCCGCGAGCTCGTGATCACAGTCGGAGATCTTTACA
TCGACTACAGCAAACATCGCATCACCCACGATACGGTGCAGCTGCTGGTAGATCTGGCCCGAGCTGCCAACCTTGAACAA
CGCCGCGACCAGATGCTCGCCGGCGTACACGTCAACACCTCGGAGAATCGGTCGGTGCTACACACCGCGCTGCGGCTACC
CCGAGACACCGAACTGATCGTCGACGGCCAAAACGTGGTCCAGGACGTACACGCGGTACTGGACGTCATGGGTGACTTCA
CCGACCGGCTACGCAGCGGCGAATGGACCGGAGCCACCGGGAAACGTATCAACACTGTCGTCAACATCGGCATTGGTGGT
TCAGACCTGGGTCCAGTTATGGTTTACCAGGCACTGCGCCACTATGCCGACGCGGGGATCTCGGCGCGTTTCGTGTCCAA
CATCGATCCCGCCGATCTGACTGCTAAATTGTCAGATTTAGAGCCTGGCACAACGCTTTTCATCGTAGCATCGAAGACGT
TCTCTACGCTGGAAACATTGACCAACGCCACCGCTGCGCGGCGCTGGCTGACCGACGCACTTGGCGAAGCCGCCGTTTCC
AAGCATTTCGTCGCTGTCTCTACCAACAAACGCCTGGTTAAGGACTTCGGTATCAACACGGCTAATATGTTCGGCTTCTG
GGAATGGGTTGGTGGCCGTTATTCGGTCGATTCGGCGATCGGGCTGTCGCTGATGGCGGTCGTCGGGCGAGAGTCTTTCG
CTGATTTCCTGTCCGGCTTCCACATCGTTGACCAACATTTCCAGAACGCGCCATTGGAGTCCAACGCTCCTGTGCTGCTC
GGCCTGATCGGACTGTGGTACTCTGATTTCTTGGGTGCACAATCACGAGCCGTGCTGCCGTATTCCAACGACTTGGCGCG
TTTCGCGGCCTATCTGCAACAGCTAACTATGGAATCCAACGGTAAGTCGACGCGCGCTGACGGCACGCCAGTCACTACCA
ATACCGGTGAAATCTATTGGGGCGAAACGGGAACCAATGGTCAACACGCTTTTTACCAGTTGCTGCATCAGGGCACCCGG
CTGGTTCCGGCCGATTTCATCGGATTCAGCCAACCTATCGACGATTTGCCAACTGTCGATGGCATCGGCAGCATGCACGA
TCTGTTAATGAGCAATTTCTTCGCTCAGACCCAAGTGCTGGCATTCGGCAAAACTGCGGAAGAAATCGCAGCAGAAGGTA
CACCCGCCGAAGTTGTTCCACACAAGGTAATGCCTGGAAATCGTCCGACAACATCGATCCTGGCCAACCGACTCACCCCG
TCGGTGTTGGGCCAACTGATAGCACTCTACGAGCATCAGGTGTTCACCGAGGGCGTGATTTGGGGCATCGACTCGTTCGA
CCAGTGGGGTGTGGAGCTGGGCAAGAAACAAGCCGAAGCACTGCTTCCGGTAATTACTGGCAACGCCTCGCCCGCGCAAC
AGTTGGACAGCTCCACTGATACGCTGGTTCGTCGCTACCGGACAGAACGAGGGCGTACGAGCTGA

Upstream 100 bases:

>100_bases
GTCAGATTTGCAGCGTGTAAAGCGTGTAATGGGCGCCGGTTAAACGCGCTAAACTTGGTCTAACTGCACCGTAGCGTCAA
AGCGAACTAGGGTCAAAACC

Downstream 100 bases:

>100_bases
CGTGCTTACGCAGCGAGTGTCCGCAAAATGCTCCCCCAATGCAGCGTGTCGTTGTACAGACCCCTTACGATCTCAGCCAG
GAGAAGCGCTGCAGCGATAC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTSMQAIPDITATPAWDALRRHHDEIGATHLRQFFADNPNRGRELVITVGDLYIDYSKHRITHDTVQLLVDLARAANLEQ
RRDQMLAGVHVNTSENRSVLHTALRLPRDTELIVDGQNVVQDVHAVLDVMGDFTDRLRSGEWTGATGKRINTVVNIGIGG
SDLGPVMVYQALRHYADAGISARFVSNIDPADLTAKLSDLEPGTTLFIVASKTFSTLETLTNATAARRWLTDALGEAAVS
KHFVAVSTNKRLVKDFGINTANMFGFWEWVGGRYSVDSAIGLSLMAVVGRESFADFLSGFHIVDQHFQNAPLESNAPVLL
GLIGLWYSDFLGAQSRAVLPYSNDLARFAAYLQQLTMESNGKSTRADGTPVTTNTGEIYWGETGTNGQHAFYQLLHQGTR
LVPADFIGFSQPIDDLPTVDGIGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEGTPAEVVPHKVMPGNRPTTSILANRLTP
SVLGQLIALYEHQVFTEGVIWGIDSFDQWGVELGKKQAEALLPVITGNASPAQQLDSSTDTLVRRYRTERGRTS

Sequences:

>Translated_554_residues
MTSMQAIPDITATPAWDALRRHHDEIGATHLRQFFADNPNRGRELVITVGDLYIDYSKHRITHDTVQLLVDLARAANLEQ
RRDQMLAGVHVNTSENRSVLHTALRLPRDTELIVDGQNVVQDVHAVLDVMGDFTDRLRSGEWTGATGKRINTVVNIGIGG
SDLGPVMVYQALRHYADAGISARFVSNIDPADLTAKLSDLEPGTTLFIVASKTFSTLETLTNATAARRWLTDALGEAAVS
KHFVAVSTNKRLVKDFGINTANMFGFWEWVGGRYSVDSAIGLSLMAVVGRESFADFLSGFHIVDQHFQNAPLESNAPVLL
GLIGLWYSDFLGAQSRAVLPYSNDLARFAAYLQQLTMESNGKSTRADGTPVTTNTGEIYWGETGTNGQHAFYQLLHQGTR
LVPADFIGFSQPIDDLPTVDGIGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEGTPAEVVPHKVMPGNRPTTSILANRLTP
SVLGQLIALYEHQVFTEGVIWGIDSFDQWGVELGKKQAEALLPVITGNASPAQQLDSSTDTLVRRYRTERGRTS
>Mature_553_residues
TSMQAIPDITATPAWDALRRHHDEIGATHLRQFFADNPNRGRELVITVGDLYIDYSKHRITHDTVQLLVDLARAANLEQR
RDQMLAGVHVNTSENRSVLHTALRLPRDTELIVDGQNVVQDVHAVLDVMGDFTDRLRSGEWTGATGKRINTVVNIGIGGS
DLGPVMVYQALRHYADAGISARFVSNIDPADLTAKLSDLEPGTTLFIVASKTFSTLETLTNATAARRWLTDALGEAAVSK
HFVAVSTNKRLVKDFGINTANMFGFWEWVGGRYSVDSAIGLSLMAVVGRESFADFLSGFHIVDQHFQNAPLESNAPVLLG
LIGLWYSDFLGAQSRAVLPYSNDLARFAAYLQQLTMESNGKSTRADGTPVTTNTGEIYWGETGTNGQHAFYQLLHQGTRL
VPADFIGFSQPIDDLPTVDGIGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEGTPAEVVPHKVMPGNRPTTSILANRLTPS
VLGQLIALYEHQVFTEGVIWGIDSFDQWGVELGKKQAEALLPVITGNASPAQQLDSSTDTLVRRYRTERGRTS

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=566, Percent_Identity=47.3498233215548, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI296080693, Length=566, Percent_Identity=43.8162544169611, Blast_Score=463, Evalue=1e-130,
Organism=Escherichia coli, GI1790457, Length=551, Percent_Identity=50.8166969147005, Blast_Score=534, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI71996703, Length=540, Percent_Identity=47.962962962963, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI71996708, Length=540, Percent_Identity=47.962962962963, Blast_Score=484, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=47.7231329690346, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24651916, Length=552, Percent_Identity=48.3695652173913, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24651914, Length=552, Percent_Identity=48.3695652173913, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI17737445, Length=552, Percent_Identity=48.3695652173913, Blast_Score=516, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_MYCLB (B8ZTZ5)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002502867.1
- ProteinModelPortal:   B8ZTZ5
- SMR:   B8ZTZ5
- EnsemblBacteria:   EBMYCT00000085362
- GeneID:   7325866
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016991
- HOGENOM:   HBG352954
- OMA:   LGKGVYQ
- ProtClustDB:   PRK00179
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 60635; Mature: 60504

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 389-389 ACT_SITE 515-515

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSMQAIPDITATPAWDALRRHHDEIGATHLRQFFADNPNRGRELVITVGDLYIDYSKHR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECEEEECCHHH
ITHDTVQLLVDLARAANLEQRRDQMLAGVHVNTSENRSVLHTALRLPRDTELIVDGQNVV
CHHHHHHHHHHHHHHCCHHHHHHHHHHCEEECCCCCHHHHHHHHHCCCCCEEEECCHHHH
QDVHAVLDVMGDFTDRLRSGEWTGATGKRINTVVNIGIGGSDLGPVMVYQALRHYADAGI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
SARFVSNIDPADLTAKLSDLEPGTTLFIVASKTFSTLETLTNATAARRWLTDALGEAAVS
CCHHHCCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHFVAVSTNKRLVKDFGINTANMFGFWEWVGGRYSVDSAIGLSLMAVVGRESFADFLSGF
HCEEEEECCCHHHHHHCCCCHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHH
HIVDQHFQNAPLESNAPVLLGLIGLWYSDFLGAQSRAVLPYSNDLARFAAYLQQLTMESN
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHCCC
GKSTRADGTPVTTNTGEIYWGETGTNGQHAFYQLLHQGTRLVPADFIGFSQPIDDLPTVD
CCCCCCCCCCEECCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCC
GIGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEGTPAEVVPHKVMPGNRPTTSILANRLTP
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHCCCCCCCCCCCHHHHHHHHCCH
SVLGQLIALYEHQVFTEGVIWGIDSFDQWGVELGKKQAEALLPVITGNASPAQQLDSSTD
HHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHCCHHH
TLVRRYRTERGRTS
HHHHHHHHHCCCCC
>Mature Secondary Structure 
TSMQAIPDITATPAWDALRRHHDEIGATHLRQFFADNPNRGRELVITVGDLYIDYSKHR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECEEEECCHHH
ITHDTVQLLVDLARAANLEQRRDQMLAGVHVNTSENRSVLHTALRLPRDTELIVDGQNVV
CHHHHHHHHHHHHHHCCHHHHHHHHHHCEEECCCCCHHHHHHHHHCCCCCEEEECCHHHH
QDVHAVLDVMGDFTDRLRSGEWTGATGKRINTVVNIGIGGSDLGPVMVYQALRHYADAGI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
SARFVSNIDPADLTAKLSDLEPGTTLFIVASKTFSTLETLTNATAARRWLTDALGEAAVS
CCHHHCCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHFVAVSTNKRLVKDFGINTANMFGFWEWVGGRYSVDSAIGLSLMAVVGRESFADFLSGF
HCEEEEECCCHHHHHHCCCCHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHH
HIVDQHFQNAPLESNAPVLLGLIGLWYSDFLGAQSRAVLPYSNDLARFAAYLQQLTMESN
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHCCC
GKSTRADGTPVTTNTGEIYWGETGTNGQHAFYQLLHQGTRLVPADFIGFSQPIDDLPTVD
CCCCCCCCCCEECCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCC
GIGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEGTPAEVVPHKVMPGNRPTTSILANRLTP
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHCCCCCCCCCCCHHHHHHHHCCH
SVLGQLIALYEHQVFTEGVIWGIDSFDQWGVELGKKQAEALLPVITGNASPAQQLDSSTD
HHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHCCHHH
TLVRRYRTERGRTS
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA