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The map label for this gene is mas [H]

Identifier: 221229429

GI number: 221229429

Start: 159276

End: 160286

Strand: Reverse

Name: mas [H]

Synonym: MLBr_00118

Alternate gene names: 221229429

Gene position: 160286-159276 (Counterclockwise)

Preceding gene: 221229430

Following gene: 221229427

Centisome position: 4.9

GC content: 61.82

Gene sequence:

>1011_bases
ATGCACGCCATCGTCGCTGAATCAGCCAACCAAATGGTATGGCGGGAAGTACCCGATGTCACAGCAGGCCCCGGCGAGGT
ACTGATCGAGGTTGCAGCGTCCGGAGTAAACCGCGCCGACGTGCTGCAGGTAGCCGGAAAATATCCGCACCCGCCAGGGG
CCAGTGCGATCATCGGCATGGAGGTAGCCGGTGTCGTCGCAGCAGTCAGCTCAGGGGTCACCGAATGGTCTGTTGGACAA
GAAGTTTGCGCTTTGCTTGCCGGCGGCGGCTACGCGGAATATGTCGCCGTTCCCGCCAGCCAAGTGATGCCGATCCCCAA
GGGGGTCAACGTGGTCGACTCCGCGGGAATACCGGAAGTGGCCTGCACGGTGTGGTCGAACCTGGTGATGGCCGCTCATC
TGAGCGCAGGCCAGCTGCTGCTGTTGCATGGCGGTACCAGTGGCATAGGAAGCCACGGGATCCAGGTGGCACGAGCGTTG
GGCGCCAAGGTCGCGGTCACCGCTGGATCGGAAGAAAAGCTGGAATTTTGTCGCGCCCTGGGCGCCCAAATTACCATCAA
CTACCGCGACGAGGACTTCGTCGCACGGCTGCAGCAGCAGAATGGCGGCGCTGACGTAATCCTCGATATCATGGGCGCGG
CGTATCTGGACCGCAATATCGACGCCCTTGCCATCGACGGGCAACTTATCGTCATAGGCTTGCAGGGCGGGGTAAAAGGC
GAGCTCAACCTCGGCAAGGTGCTGAGCAAACGGGCCCGGATTATCGGCAGTACACTGCGGGCCCGGCCCGTAAACGGCCC
GAACAGTAAAAGCGAAATCGTGGCCGCAGTCACGGCCTCGATCTGGCCGATGATCGCCGACGGTTCTGTGCGGCCCATCA
TCGGAGCACGCATGGCTGTCCAACAGGCGGCTGACGCGCACCAACTGTTGTTGTCAGGGAAGGTTTCCGGGAAGATCGTG
CTGACCGTCGCAGGCTCGGGAACCGAGACTTTACTCTCGCGGCACCACTAG

Upstream 100 bases:

>100_bases
GTCTCTCGCTTTCAAGACGAGCGCATTAGGCCGCTCTGCCACGCCACCGTTGACAACAATATCAACAATATAAGGAATAA
GAGGGTAGTACCGTAACAAC

Downstream 100 bases:

>100_bases
CCAAGCGACGCCAGCGTGCGCACTAACTGGTCGACTTCGACCGTCGTCGAATAATGCGCTAGCCCGACAGTAACCGCGCC
GCCGATGTCATTTACGCCGA

Product: putative oxidireductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MHAIVAESANQMVWREVPDVTAGPGEVLIEVAASGVNRADVLQVAGKYPHPPGASAIIGMEVAGVVAAVSSGVTEWSVGQ
EVCALLAGGGYAEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQLLLLHGGTSGIGSHGIQVARAL
GAKVAVTAGSEEKLEFCRALGAQITINYRDEDFVARLQQQNGGADVILDIMGAAYLDRNIDALAIDGQLIVIGLQGGVKG
ELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASIWPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSGKIV
LTVAGSGTETLLSRHH

Sequences:

>Translated_336_residues
MHAIVAESANQMVWREVPDVTAGPGEVLIEVAASGVNRADVLQVAGKYPHPPGASAIIGMEVAGVVAAVSSGVTEWSVGQ
EVCALLAGGGYAEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQLLLLHGGTSGIGSHGIQVARAL
GAKVAVTAGSEEKLEFCRALGAQITINYRDEDFVARLQQQNGGADVILDIMGAAYLDRNIDALAIDGQLIVIGLQGGVKG
ELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASIWPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSGKIV
LTVAGSGTETLLSRHH
>Mature_336_residues
MHAIVAESANQMVWREVPDVTAGPGEVLIEVAASGVNRADVLQVAGKYPHPPGASAIIGMEVAGVVAAVSSGVTEWSVGQ
EVCALLAGGGYAEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQLLLLHGGTSGIGSHGIQVARAL
GAKVAVTAGSEEKLEFCRALGAQITINYRDEDFVARLQQQNGGADVILDIMGAAYLDRNIDALAIDGQLIVIGLQGGVKG
ELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASIWPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSGKIV
LTVAGSGTETLLSRHH

Specific function: Catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA (not malonyl-CoA) as the elongating agent to form mycocerosyl lipids [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=318, Percent_Identity=40.5660377358491, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI22538444, Length=318, Percent_Identity=40.5660377358491, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI194239674, Length=300, Percent_Identity=29.3333333333333, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI13236495, Length=300, Percent_Identity=29.3333333333333, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI28557745, Length=262, Percent_Identity=32.0610687022901, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI194239676, Length=298, Percent_Identity=26.8456375838926, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI18379349, Length=308, Percent_Identity=25, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI41872631, Length=322, Percent_Identity=27.3291925465839, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI197927207, Length=198, Percent_Identity=28.7878787878788, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI24308257, Length=322, Percent_Identity=22.6708074534161, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI47519420, Length=350, Percent_Identity=25.1428571428571, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1790485, Length=302, Percent_Identity=29.1390728476821, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17507255, Length=300, Percent_Identity=26.3333333333333, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71987554, Length=197, Percent_Identity=28.9340101522843, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=290, Percent_Identity=27.9310344827586, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=290, Percent_Identity=26.8965517241379, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=290, Percent_Identity=25.8620689655172, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319520, Length=321, Percent_Identity=27.1028037383178, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=229, Percent_Identity=27.5109170305677, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24581345, Length=338, Percent_Identity=25.1479289940828, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19920632, Length=301, Percent_Identity=26.2458471760797, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330659, Length=306, Percent_Identity=26.1437908496732, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR013968
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00107 ADH_zinc_N; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]

EC number: =2.3.1.111 [H]

Molecular weight: Translated: 34441; Mature: 34441

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAIVAESANQMVWREVPDVTAGPGEVLIEVAASGVNRADVLQVAGKYPHPPGASAIIGM
CCEEECCCCCHHHHHHCCCCCCCCHHHHHEEHHCCCCHHHHHHHCCCCCCCCCCCEEEHH
EVAGVVAAVSSGVTEWSVGQEVCALLAGGGYAEYVAVPASQVMPIPKGVNVVDSAGIPEV
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCEECCCCCCHH
ACTVWSNLVMAAHLSAGQLLLLHGGTSGIGSHGIQVARALGAKVAVTAGSEEKLEFCRAL
HHHHHHHHHHHEECCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHC
GAQITINYRDEDFVARLQQQNGGADVILDIMGAAYLDRNIDALAIDGQLIVIGLQGGVKG
CCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCC
ELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASIWPMIADGSVRPIIGARMAV
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCEECCCCCCHHHHHHHHH
QQAADAHQLLLSGKVSGKIVLTVAGSGTETLLSRHH
HHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCC
>Mature Secondary Structure
MHAIVAESANQMVWREVPDVTAGPGEVLIEVAASGVNRADVLQVAGKYPHPPGASAIIGM
CCEEECCCCCHHHHHHCCCCCCCCHHHHHEEHHCCCCHHHHHHHCCCCCCCCCCCEEEHH
EVAGVVAAVSSGVTEWSVGQEVCALLAGGGYAEYVAVPASQVMPIPKGVNVVDSAGIPEV
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCEECCCCCCHH
ACTVWSNLVMAAHLSAGQLLLLHGGTSGIGSHGIQVARALGAKVAVTAGSEEKLEFCRAL
HHHHHHHHHHHEECCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHC
GAQITINYRDEDFVARLQQQNGGADVILDIMGAAYLDRNIDALAIDGQLIVIGLQGGVKG
CCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCC
ELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASIWPMIADGSVRPIIGARMAV
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCEECCCCCCHHHHHHHHH
QQAADAHQLLLSGKVSGKIVLTVAGSGTETLLSRHH
HHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1527058; 12788972 [H]