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The map label for this gene is fbpA

Identifier: 221229410

GI number: 221229410

Start: 121184

End: 122176

Strand: Direct

Name: fbpA

Synonym: MLBr_00097

Alternate gene names: 221229410

Gene position: 121184-122176 (Clockwise)

Preceding gene: 221229409

Following gene: 221229411

Centisome position: 3.71

GC content: 60.52

Gene sequence:

>993_bases
ATGAAGTTTGTTGATAGGTTTCGAGGTGCCGTGGCGGGTATGCTGCGCCGACTCGTCGTTGAGGCCATGGGTGTGGCCTT
GCTGTCGGCTCTGATCGGTGTCGTCGGCTCGGCCCCCGCGGAAGCGTTCTCCCGGCCGGGATTGCCGGTGGAGTACCTTC
AGGTGCCATCACCGTCGATGGGACGTGACATCAAGGTCCAGTTCCAAAACGGCGGCGCCAACTCCCCCGCACTGTACCTG
TTAGACGGGTTGCGCGCGCAGGACGATTTCAGCGGTTGGGACATCAATACCACCGCTTTCGAGTGGTACTATCAGTCCGG
TATTTCGGTAGTCATGCCGGTCGGAGGACAGTCCAGCTTCTACAGCGACTGGTACAGCCCGGCCTGCGGCAAGGCCGGTT
GCCAGACCTACAAATGGGAGACCTTCCTGACTAGCGAGCTGCCGCAGTACCTGCAGAGCAACAAGCAGATAAAGCCCACC
GGCAGCGCGGCGGTCGGTCTTTCGATGGCCGGTTTGTCGGCCCTGACGCTGGCGATCTACCACCCGGACCAGTTCATCTA
TGTTGGCTCGATGTCGGGCTTGCTAGACCCCTCCAACGCAATGGGTCCCTCGCTAATCGGTCTGGCGATGGGTGACGCCG
GCGGCTACAAGGCCGCGGATATGTGGGGCCCGTCCACGGACCCGGCATGGAAGCGCAACGACCCGACGGTGAACGTTGGC
ACCCTGATTGCCAACAACACTCGCATCTGGATGTACTGTGGTAATGGCAAGCCTACGGAATTGGGCGGCAACAACTTGCC
CGCCAAGTTGCTCGAGGGCTTAGTGCGTACCAGCAACATCAAATTCCAGGACGGTTACAACGCAGGCGGCGGTCACAACG
CCGTCTTCAACTTCCCGGACAGCGGGACACACAGCTGGGAGTACTGGGGCGAACAGCTGAACGACATGAAGCCTGACCTT
CAGCAGTATTTAGGGGCTACCCCGGGTGCTTAG

Upstream 100 bases:

>100_bases
GCAGCGTTTAGCGCATGCAGTTCTACCTGATTTAAGAGTTCTACCTGATTTAAGGATGCGCCGACACGTAACAATGCGCG
TAAAGGATGAGGAAGCAAGA

Downstream 100 bases:

>100_bases
CCTATACCGCTAACGGCGGCGACCTGTGGAGGTCGCCGCCGTTAGCTATTTCCGGGTAGCTTCAACCCGTGTGGTGTTAT
TCACTACCCCACGGAGGTGG

Product: antigen 85A, mycolytransferase

Products: NA

Alternate protein names: Antigen 85 complex A; 85A; Ag85A; Fibronectin-binding protein A; Mycolyl transferase 85A

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKFVDRFRGAVAGMLRRLVVEAMGVALLSALIGVVGSAPAEAFSRPGLPVEYLQVPSPSMGRDIKVQFQNGGANSPALYL
LDGLRAQDDFSGWDINTTAFEWYYQSGISVVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQYLQSNKQIKPT
GSAAVGLSMAGLSALTLAIYHPDQFIYVGSMSGLLDPSNAMGPSLIGLAMGDAGGYKAADMWGPSTDPAWKRNDPTVNVG
TLIANNTRIWMYCGNGKPTELGGNNLPAKLLEGLVRTSNIKFQDGYNAGGGHNAVFNFPDSGTHSWEYWGEQLNDMKPDL
QQYLGATPGA

Sequences:

>Translated_330_residues
MKFVDRFRGAVAGMLRRLVVEAMGVALLSALIGVVGSAPAEAFSRPGLPVEYLQVPSPSMGRDIKVQFQNGGANSPALYL
LDGLRAQDDFSGWDINTTAFEWYYQSGISVVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQYLQSNKQIKPT
GSAAVGLSMAGLSALTLAIYHPDQFIYVGSMSGLLDPSNAMGPSLIGLAMGDAGGYKAADMWGPSTDPAWKRNDPTVNVG
TLIANNTRIWMYCGNGKPTELGGNNLPAKLLEGLVRTSNIKFQDGYNAGGGHNAVFNFPDSGTHSWEYWGEQLNDMKPDL
QQYLGATPGA
>Mature_330_residues
MKFVDRFRGAVAGMLRRLVVEAMGVALLSALIGVVGSAPAEAFSRPGLPVEYLQVPSPSMGRDIKVQFQNGGANSPALYL
LDGLRAQDDFSGWDINTTAFEWYYQSGISVVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQYLQSNKQIKPT
GSAAVGLSMAGLSALTLAIYHPDQFIYVGSMSGLLDPSNAMGPSLIGLAMGDAGGYKAADMWGPSTDPAWKRNDPTVNVG
TLIANNTRIWMYCGNGKPTELGGNNLPAKLLEGLVRTSNIKFQDGYNAGGGHNAVFNFPDSGTHSWEYWGEQLNDMKPDL
QQYLGATPGA

Specific function: Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintain

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Secreted

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial A85 antigen family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): A85A_MYCLE (Q05861)

Other databases:

- EMBL:   D43841
- EMBL:   M90648
- EMBL:   AL583917
- EMBL:   Z21950
- PIR:   A86921
- PIR:   S32107
- RefSeq:   NP_301195.1
- ProteinModelPortal:   Q05861
- SMR:   Q05861
- EnsemblBacteria:   EBMYCT00000029221
- GeneID:   908289
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0097
- NMPDR:   fig|272631.1.peg.67
- Leproma:   ML0097
- GeneTree:   EBGT00050000015316
- HOGENOM:   HBG564791
- OMA:   GGHNAVW
- BioCyc:   MLEP272631:ML0097-MONOMER
- InterPro:   IPR000801

Pfam domain/function: PF00756 Esterase

EC number: NA

Molecular weight: Translated: 35411; Mature: 35411

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: ACT_SITE 168-168 ACT_SITE 272-272 ACT_SITE 304-304

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVDRFRGAVAGMLRRLVVEAMGVALLSALIGVVGSAPAEAFSRPGLPVEYLQVPSPSM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEECCCCCC
GRDIKVQFQNGGANSPALYLLDGLRAQDDFSGWDINTTAFEWYYQSGISVVMPVGGQSSF
CCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCH
YSDWYSPACGKAGCQTYKWETFLTSELPQYLQSNKQIKPTGSAAVGLSMAGLSALTLAIY
HHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCEEEEEEE
HPDQFIYVGSMSGLLDPSNAMGPSLIGLAMGDAGGYKAADMWGPSTDPAWKRNDPTVNVG
CCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
TLIANNTRIWMYCGNGKPTELGGNNLPAKLLEGLVRTSNIKFQDGYNAGGGHNAVFNFPD
EEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCEEECCC
SGTHSWEYWGEQLNDMKPDLQQYLGATPGA
CCCCCHHHHHHHHHCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MKFVDRFRGAVAGMLRRLVVEAMGVALLSALIGVVGSAPAEAFSRPGLPVEYLQVPSPSM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEECCCCCC
GRDIKVQFQNGGANSPALYLLDGLRAQDDFSGWDINTTAFEWYYQSGISVVMPVGGQSSF
CCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCH
YSDWYSPACGKAGCQTYKWETFLTSELPQYLQSNKQIKPTGSAAVGLSMAGLSALTLAIY
HHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCEEEEEEE
HPDQFIYVGSMSGLLDPSNAMGPSLIGLAMGDAGGYKAADMWGPSTDPAWKRNDPTVNVG
CCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
TLIANNTRIWMYCGNGKPTELGGNNLPAKLLEGLVRTSNIKFQDGYNAGGGHNAVFNFPD
EEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCEEECCC
SGTHSWEYWGEQLNDMKPDLQQYLGATPGA
CCCCCHHHHHHHHHCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7829901; 11234002; 8359887