Click here to switch to the map view.

The map label for this gene is ppe68 [H]

Identifier: 221229379

GI number: 221229379

Start: 62197

End: 63105

Strand: Reverse

Name: ppe68 [H]

Synonym: MLBr_00051

Alternate gene names: 221229379

Gene position: 63105-62197 (Counterclockwise)

Preceding gene: 221229380

Following gene: 221229378

Centisome position: 1.93

GC content: 58.97

Gene sequence:

>909_bases
ATGACTTGGCCGATGTTGTGGCCCGCATCAGTCCCGAGCGAGTGTCCGCCGAATTATTGGCACACCCCAGCTCCCTCAGC
GAAGTGTGAACCAGAGCAAGCAGCGGTGGCGCCGATTGCGGCTGCCAAGCCCATGATTACCTGGCTGCAATCCGCTGCAG
AGCAGACAACCACGCAGGCCGAAGCGCACAGGCAAGCAATGGCAAGCACGCCGGGAATGGCCGTGATTACCGAAAACCAC
ATCACCCAGGCAATCCTTGCCACCATCAACTTCTTTGGCATCAATATGGCGCCAATCGCCTTTACGGAAGCGGGCGATTT
CATTTGCATGCGAACCCAGACCGCCTTAGCAATGAACTCCTACCAGGCGGAAACCCTGCTGAACACGGCTTTCCAAAAGC
TTGAGCCAATGGCCGCGATCCTTAATCCGTCGAGCTACTCCCCGCCATCAGCCCTAACGTCCCAGGTGAACCAATTCACG
CAGATGATATCCGGATTTTCCGCTGCCCTGCCTTCAACCCAGGTGCTGCAGCAAACGGTTGGGCAGGTCGCGGAGCTTGC
TCGCCCGATGCAGCAGGTGAAGTCACTCTTCACCTCTATAGATAGCACTGGCGTTTACACGAGTGCCCAACGCGGCGACA
CGGAAAGCGCCCATCGCATTGGTCTTTTTGGTGCCAGTACACTATCCAGCCATCCTTTGGTCGGTATAACGGGCACAACC
ACCGACACAAGACTGCTGTGCGCGGAGTCGCTGCCCAGTGCGAGCGGGTCGTTGGCGTGGACACCGCTGATGACCCAGTT
CCAGTTGATCGATAAGTCGATTGCGCCGGAGCCTCGGCAACGGGTGATGCTGCCCCCGTGGGCGGCAGGCTCTCCGGGGC
ACAACGCCCAAGACGGTGGAACGACCTGA

Upstream 100 bases:

>100_bases
ATGTCTATTCGCGAGTCAACAGTCGCGCTGACATGGTTGCGGTGTCGCAGTTTGACCCGACAAAACATCAATACATTGCA
GACAGTAGGGAGCTGACAAC

Downstream 100 bases:

>100_bases
ACAGCTCTGGTAAGCCACCAGCACAACAGTTCGGGATGCCCAACGAGAACGATTGAGAGGACTGGGATGACGACCAGCAC
AACTGGTGAACACCCAAAAT

Product: PPE-family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTWPMLWPASVPSECPPNYWHTPAPSAKCEPEQAAVAPIAAAKPMITWLQSAAEQTTTQAEAHRQAMASTPGMAVITENH
ITQAILATINFFGINMAPIAFTEAGDFICMRTQTALAMNSYQAETLLNTAFQKLEPMAAILNPSSYSPPSALTSQVNQFT
QMISGFSAALPSTQVLQQTVGQVAELARPMQQVKSLFTSIDSTGVYTSAQRGDTESAHRIGLFGASTLSSHPLVGITGTT
TDTRLLCAESLPSASGSLAWTPLMTQFQLIDKSIAPEPRQRVMLPPWAAGSPGHNAQDGGTT

Sequences:

>Translated_302_residues
MTWPMLWPASVPSECPPNYWHTPAPSAKCEPEQAAVAPIAAAKPMITWLQSAAEQTTTQAEAHRQAMASTPGMAVITENH
ITQAILATINFFGINMAPIAFTEAGDFICMRTQTALAMNSYQAETLLNTAFQKLEPMAAILNPSSYSPPSALTSQVNQFT
QMISGFSAALPSTQVLQQTVGQVAELARPMQQVKSLFTSIDSTGVYTSAQRGDTESAHRIGLFGASTLSSHPLVGITGTT
TDTRLLCAESLPSASGSLAWTPLMTQFQLIDKSIAPEPRQRVMLPPWAAGSPGHNAQDGGTT
>Mature_301_residues
TWPMLWPASVPSECPPNYWHTPAPSAKCEPEQAAVAPIAAAKPMITWLQSAAEQTTTQAEAHRQAMASTPGMAVITENHI
TQAILATINFFGINMAPIAFTEAGDFICMRTQTALAMNSYQAETLLNTAFQKLEPMAAILNPSSYSPPSALTSQVNQFTQ
MISGFSAALPSTQVLQQTVGQVAELARPMQQVKSLFTSIDSTGVYTSAQRGDTESAHRIGLFGASTLSSHPLVGITGTTT
DTRLLCAESLPSASGSLAWTPLMTQFQLIDKSIAPEPRQRVMLPPWAAGSPGHNAQDGGTT

Specific function: Stimulates high levels of gamma interferon secretion in peripheral blood mononuclear cells isolated from tuberculosis patients, as well as from healthy tuberculin purified protein derivative-positive donors. Does not interfere with the secretion and prese

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall. Cell membrane. Note=Detected predominantly in the membrane and cell wall fractions [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000030 [H]

Pfam domain/function: PF00823 PPE [H]

EC number: NA

Molecular weight: Translated: 32136; Mature: 32005

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWPMLWPASVPSECPPNYWHTPAPSAKCEPEQAAVAPIAAAKPMITWLQSAAEQTTTQA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAHRQAMASTPGMAVITENHITQAILATINFFGINMAPIAFTEAGDFICMRTQTALAMNS
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEECHHHHHHHH
YQAETLLNTAFQKLEPMAAILNPSSYSPPSALTSQVNQFTQMISGFSAALPSTQVLQQTV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
GQVAELARPMQQVKSLFTSIDSTGVYTSAQRGDTESAHRIGLFGASTLSSHPLVGITGTT
HHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHEEEEEECHHCCCCCEEEEECCC
TDTRLLCAESLPSASGSLAWTPLMTQFQLIDKSIAPEPRQRVMLPPWAAGSPGHNAQDGG
CCHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHCEECCCCCCCCCCCCCCCCC
TT
CC
>Mature Secondary Structure 
TWPMLWPASVPSECPPNYWHTPAPSAKCEPEQAAVAPIAAAKPMITWLQSAAEQTTTQA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAHRQAMASTPGMAVITENHITQAILATINFFGINMAPIAFTEAGDFICMRTQTALAMNS
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEECHHHHHHHH
YQAETLLNTAFQKLEPMAAILNPSSYSPPSALTSQVNQFTQMISGFSAALPSTQVLQQTV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
GQVAELARPMQQVKSLFTSIDSTGVYTSAQRGDTESAHRIGLFGASTLSSHPLVGITGTT
HHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHEEEEEECHHCCCCCEEEEECCC
TDTRLLCAESLPSASGSLAWTPLMTQFQLIDKSIAPEPRQRVMLPPWAAGSPGHNAQDGG
CCHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHCEECCCCCCCCCCCCCCCCC
TT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]