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The map label for this gene is eccD1 [H]

Identifier: 221229375

GI number: 221229375

Start: 58016

End: 59554

Strand: Reverse

Name: eccD1 [H]

Synonym: MLBr_00047

Alternate gene names: 221229375

Gene position: 59554-58016 (Counterclockwise)

Preceding gene: 221229376

Following gene: 221229370

Centisome position: 1.82

GC content: 60.43

Gene sequence:

>1539_bases
TTGAGCGCGCCTGCTGTAACTGCTGGCCCGGCCACTGCCGGGATCACTCCTGCGCGACCTTCCGCGACCCGGGTGACGAT
TCTTACTGGCAAACGTATGACCGACCTGGTGCTGCCCTCGACGGTGTCGATCGAGGCCTACATTGATGAAACCGTAGCGG
TGCTATCCGACCTGCTCGAAGACGCACCGGCGGATGTCCTGGCGGGCTTCGACTTTTCCGCCCAGGGTGTGTGGACATTT
GCCCGGCCCGGATCGCCACCCATGAAACTCGACCAGTCGCTCGATGATGCCGGGGTTGTCGACGGGTCGCTGTTGACCCT
GGTGTCAACGAGTCGCACAGAACGGTATCGGCCGCTGGTCGAAGACGTCATCGACGCGATCGCAGTGCTCAACGAATCGC
CAGAGTTCAATCGCAAGGCGGTGGACCGTTTTATCGGGGTGGCAATCCCCGTCTTGAGCCTGCCGATCACTGCCGTCGCG
GTGTGGGCCTGGTGGGTAACCGGGCGCAGCCCATTCTGGTCGCTGGCGATCGGCATCCTGAGCATCGTTGCGCTGACCGG
CAGCATCGTCGCCGAAAAATTCTACAAAAATCTGGATCTTTCTGAGAGCCTGCTGCTCACTTCGTACCCGCTGATCGCCA
GTGCCGCGGCGTTGGTCACCCCGCTACCAAATGGGGTCGACTCGTTGGGGCCGCCGCAGGTTGCTGCTGCTGCGGCGGCT
GTCCTGTTTTTAACCCTGCTGACCCGGGGAGGCGCCCGACGGCATTCTGGCTACGCCTCGTTCACCGCGATCACCACGAT
CGCGATCGTGGTGATCGCCATTGCGTACGGCTTTGGCTACCAGCACTGGGTGCCGACCGGGGCAGTTGCCTTCGGGCTGT
TCATCGTGACGAACGCAGCCAAGCTGACCGTTGCCGTCGCCCGGATCGCTCTACCACCGATACCCGTTCCCGGCGAGACC
GTAGACAACGAAGAATTGCTTGATCCCGTTGTCACTCCGCACGAGGCTACTCATGAAGAGACGCCAACCTGGCAGGCCAT
CATCGCTTCCGTGCCTGACTCCGCGGTGCGGCTTACCGAACGCAGCTCCTTGGCCAAACGGTTGCTGATCGGTTACGTCA
TATCCGGCACCCTAATTTTGTGTTCCGGTGCTATCGCGGTGATCGTGCGCGGACACTTCTTCGCACATAGCTTAGTGGTG
GCGTTTCTGCTAACGGTGGTGTGCACGTTTCGGTCGCGACTCTACGCCGAGCGTTGGTGCGCATGGGCGCTACTGGCAGC
CGCCGTTGTGATTCCGACCGGGTTGACCGTCAAGCTATGTATCTGGTACACGCAGATTGCCTGGCTATTGCTGACCAGCT
ACCTGGTGGCAGCCATTATTGCACTGATGGTATTTGGAGCAACGGTCAGGGTTCGTCGTGTTTCACCGGTGACGAAGCGG
ATTATGGAATTGATCGACGGCGCGGTGGTCGCATCCATCATTCCGCTGCTGTTGTGGATCGCCGGCGTTTACGATATGGT
CCGCAACCTAAGCTTTTAG

Upstream 100 bases:

>100_bases
GAACCGAAATTCGACTCGACCGGCTCGACCCCCTCTACCGGCGCCGGATCCTCGAACTGGCCGCAGCACTGTCCGACGAT
TTTGAGAGAGCTGGACGTCA

Downstream 100 bases:

>100_bases
CGGTGACCGTAGTATTGCGATATTGGCGAGAGTGCGGCAATTCAGTGGTGCCAAGTCCGGTAAATTTCCTCAAGTGCAAC
CCAGAGCATGCCCGGCGATG

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component D1; Type VII secretion system protein eccD1; T7SS protein eccD1 [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSAPAVTAGPATAGITPARPSATRVTILTGKRMTDLVLPSTVSIEAYIDETVAVLSDLLEDAPADVLAGFDFSAQGVWTF
ARPGSPPMKLDQSLDDAGVVDGSLLTLVSTSRTERYRPLVEDVIDAIAVLNESPEFNRKAVDRFIGVAIPVLSLPITAVA
VWAWWVTGRSPFWSLAIGILSIVALTGSIVAEKFYKNLDLSESLLLTSYPLIASAAALVTPLPNGVDSLGPPQVAAAAAA
VLFLTLLTRGGARRHSGYASFTAITTIAIVVIAIAYGFGYQHWVPTGAVAFGLFIVTNAAKLTVAVARIALPPIPVPGET
VDNEELLDPVVTPHEATHEETPTWQAIIASVPDSAVRLTERSSLAKRLLIGYVISGTLILCSGAIAVIVRGHFFAHSLVV
AFLLTVVCTFRSRLYAERWCAWALLAAAVVIPTGLTVKLCIWYTQIAWLLLTSYLVAAIIALMVFGATVRVRRVSPVTKR
IMELIDGAVVASIIPLLLWIAGVYDMVRNLSF

Sequences:

>Translated_512_residues
MSAPAVTAGPATAGITPARPSATRVTILTGKRMTDLVLPSTVSIEAYIDETVAVLSDLLEDAPADVLAGFDFSAQGVWTF
ARPGSPPMKLDQSLDDAGVVDGSLLTLVSTSRTERYRPLVEDVIDAIAVLNESPEFNRKAVDRFIGVAIPVLSLPITAVA
VWAWWVTGRSPFWSLAIGILSIVALTGSIVAEKFYKNLDLSESLLLTSYPLIASAAALVTPLPNGVDSLGPPQVAAAAAA
VLFLTLLTRGGARRHSGYASFTAITTIAIVVIAIAYGFGYQHWVPTGAVAFGLFIVTNAAKLTVAVARIALPPIPVPGET
VDNEELLDPVVTPHEATHEETPTWQAIIASVPDSAVRLTERSSLAKRLLIGYVISGTLILCSGAIAVIVRGHFFAHSLVV
AFLLTVVCTFRSRLYAERWCAWALLAAAVVIPTGLTVKLCIWYTQIAWLLLTSYLVAAIIALMVFGATVRVRRVSPVTKR
IMELIDGAVVASIIPLLLWIAGVYDMVRNLSF
>Mature_511_residues
SAPAVTAGPATAGITPARPSATRVTILTGKRMTDLVLPSTVSIEAYIDETVAVLSDLLEDAPADVLAGFDFSAQGVWTFA
RPGSPPMKLDQSLDDAGVVDGSLLTLVSTSRTERYRPLVEDVIDAIAVLNESPEFNRKAVDRFIGVAIPVLSLPITAVAV
WAWWVTGRSPFWSLAIGILSIVALTGSIVAEKFYKNLDLSESLLLTSYPLIASAAALVTPLPNGVDSLGPPQVAAAAAAV
LFLTLLTRGGARRHSGYASFTAITTIAIVVIAIAYGFGYQHWVPTGAVAFGLFIVTNAAKLTVAVARIALPPIPVPGETV
DNEELLDPVVTPHEATHEETPTWQAIIASVPDSAVRLTERSSLAKRLLIGYVISGTLILCSGAIAVIVRGHFFAHSLVVA
FLLTVVCTFRSRLYAERWCAWALLAAAVVIPTGLTVKLCIWYTQIAWLLLTSYLVAAIIALMVFGATVRVRRVSPVTKRI
MELIDGAVVASIIPLLLWIAGVYDMVRNLSF

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as esxA (ESAT-6) and esxB (CFP-10). Responsible for multiple suppressive effects on macrophages and required for bacterial replication after phagocytosis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eccD/snm4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006707 [H]

Pfam domain/function: PF04600 DUF571 [H]

EC number: NA

Molecular weight: Translated: 54504; Mature: 54373

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPAVTAGPATAGITPARPSATRVTILTGKRMTDLVLPSTVSIEAYIDETVAVLSDLLE
CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCEEEHHHHHHHHHHHHHHHH
DAPADVLAGFDFSAQGVWTFARPGSPPMKLDQSLDDAGVVDGSLLTLVSTSRTERYRPLV
CCCHHHHCCCCCCCCCEEEECCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EDVIDAIAVLNESPEFNRKAVDRFIGVAIPVLSLPITAVAVWAWWVTGRSPFWSLAIGIL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SIVALTGSIVAEKFYKNLDLSESLLLTSYPLIASAAALVTPLPNGVDSLGPPQVAAAAAA
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
VLFLTLLTRGGARRHSGYASFTAITTIAIVVIAIAYGFGYQHWVPTGAVAFGLFIVTNAA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHCHH
KLTVAVARIALPPIPVPGETVDNEELLDPVVTPHEATHEETPTWQAIIASVPDSAVRLTE
HHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHH
RSSLAKRLLIGYVISGTLILCSGAIAVIVRGHFFAHSLVVAFLLTVVCTFRSRLYAERWC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWALLAAAVVIPTGLTVKLCIWYTQIAWLLLTSYLVAAIIALMVFGATVRVRRVSPVTKR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHH
IMELIDGAVVASIIPLLLWIAGVYDMVRNLSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAPAVTAGPATAGITPARPSATRVTILTGKRMTDLVLPSTVSIEAYIDETVAVLSDLLE
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCEEEHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]