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The map label for this gene is 221229372

Identifier: 221229372

GI number: 221229372

Start: 50652

End: 51992

Strand: Direct

Name: 221229372

Synonym: MLBr_00041

Alternate gene names: NA

Gene position: 50652-51992 (Clockwise)

Preceding gene: 221229371

Following gene: 221229373

Centisome position: 1.55

GC content: 60.85

Gene sequence:

>1341_bases
GTGCACCGTATCTTGCTGATGATGGTGGCGTTGGCGTTGCTGTACGCGCCTCCTGCTCTGGCGATCAACCCACCCTCGAT
TGACCCGGGCGCGGTTCCGCCCGATGTGACGGGGCCTGACCAGCCCACCGAACAGAAGGTGATGTGCTCAGCGCCCACAA
CGCTGCCGGATTCCAGTTTCCACGATCCGCCCTGGAGTAACATCTACATAGGCGTCAGTGAGGCGCACAAGTTCGCTACC
GGGGCTGGGGTGACAGTAGCCGTGATCGACACTGGCGTCGAGGCCTCGCCGCGTGTCCCGGCGGAACCCGGTGGCGACTT
TGTCGATCAAGCTGGCAACGGGCTATCCGATTGCGACGCGCATGGAACGCTTACCGCGTCTATCATAGGCGGTCGGCCTG
CGCCCACAGACGGATTCATCGGCGTAGCGCCAGATGTGCGTCTGCTCTCGTTACGACAAACCTCAGAGGCCTTTCAGCCG
GTCGGCGTGCAACCTAACGCCAATGATCCCAACGCGATACCGGCGGCTGGGTCGATCCGCAGTCTGGCCCGCGCGGTGGT
GCACGCCGCTAATCTTGGTGCGAGCGTGATCAATATCAGCGAAACAGCCTGCTACAAAGCAAATAAGCCGCTCGATGAAT
CGACATTGGGCGCAGCGATCAACTACGCGGTCAACGTCAAGGGTGTGGTGATCATAGTGGCGGCCGGCAACACCGGCGGG
GATTGCACGCAGAATCCGATGCCTGACGTATCAATGCCCAACGACCCACGCGGCTGGAGCAAGGTGCAGACAATCGCTAC
ACCAGCGTGGTATGCACCTTTGGTGCTCACCGTCGGTGGTATTGCACAGAACGGGATGCCGAGCCAATTCTCAGTGCACG
GACCGTGGGTAAGCGTCGCGGCGCCGACGGAAAACATCACCACGCTAGGCTATAACGGTGAACCGGTGAACGCGTTGCCA
GGCGAGGAGGGTCCGGTTGCACTCGCTGGCACTTCGTTTGCCACCGCATATGTCTCAGGTTTGGCCGCCCTGCTGCGACA
AAGATTTCCAGACCTGACGCCAGCTCAGATTATCAACCGGATCATCGCCACCGCGCGCCATCCCGGAGGCGGCGTTGACG
ACATAGTCGGCGCGGGTGTCATCGATGCTGTGGCAGCTCTTACCTGGGATATTACACCGGGGTCCGCGTCGGAACTGTTC
AATGTCAGAAGCGTTCCGCCGCCGGTCATTACGCCGGGCCCTGATCGCAACACGATCATGATTGTGGCTCAAGGGATCTT
GGGCTTGTCGATAGCGCTGGGACTGGGTGTACTGGTTAGGCGGGCGCTACAACGCCAATGA

Upstream 100 bases:

>100_bases
AGGCCCAATGTCCGAGCAGATCGTTCTCGAGCAACCACGCGTGACGAGCCACCACACCAGTGCAGCAGCTTAAAAACATG
AATGGAATGGAGTAGTCTGG

Downstream 100 bases:

>100_bases
GGAATCCAGTATGGCTACGTTTCAGCATGGGACGTGCACTGCTCGTCACAGCGTTGGTTCCGCCATGCATCATATTGTTT
TTTCACACCCAATACTGGTG

Product: putative secreted protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MHRILLMMVALALLYAPPALAINPPSIDPGAVPPDVTGPDQPTEQKVMCSAPTTLPDSSFHDPPWSNIYIGVSEAHKFAT
GAGVTVAVIDTGVEASPRVPAEPGGDFVDQAGNGLSDCDAHGTLTASIIGGRPAPTDGFIGVAPDVRLLSLRQTSEAFQP
VGVQPNANDPNAIPAAGSIRSLARAVVHAANLGASVINISETACYKANKPLDESTLGAAINYAVNVKGVVIIVAAGNTGG
DCTQNPMPDVSMPNDPRGWSKVQTIATPAWYAPLVLTVGGIAQNGMPSQFSVHGPWVSVAAPTENITTLGYNGEPVNALP
GEEGPVALAGTSFATAYVSGLAALLRQRFPDLTPAQIINRIIATARHPGGGVDDIVGAGVIDAVAALTWDITPGSASELF
NVRSVPPPVITPGPDRNTIMIVAQGILGLSIALGLGVLVRRALQRQ

Sequences:

>Translated_446_residues
MHRILLMMVALALLYAPPALAINPPSIDPGAVPPDVTGPDQPTEQKVMCSAPTTLPDSSFHDPPWSNIYIGVSEAHKFAT
GAGVTVAVIDTGVEASPRVPAEPGGDFVDQAGNGLSDCDAHGTLTASIIGGRPAPTDGFIGVAPDVRLLSLRQTSEAFQP
VGVQPNANDPNAIPAAGSIRSLARAVVHAANLGASVINISETACYKANKPLDESTLGAAINYAVNVKGVVIIVAAGNTGG
DCTQNPMPDVSMPNDPRGWSKVQTIATPAWYAPLVLTVGGIAQNGMPSQFSVHGPWVSVAAPTENITTLGYNGEPVNALP
GEEGPVALAGTSFATAYVSGLAALLRQRFPDLTPAQIINRIIATARHPGGGVDDIVGAGVIDAVAALTWDITPGSASELF
NVRSVPPPVITPGPDRNTIMIVAQGILGLSIALGLGVLVRRALQRQ
>Mature_446_residues
MHRILLMMVALALLYAPPALAINPPSIDPGAVPPDVTGPDQPTEQKVMCSAPTTLPDSSFHDPPWSNIYIGVSEAHKFAT
GAGVTVAVIDTGVEASPRVPAEPGGDFVDQAGNGLSDCDAHGTLTASIIGGRPAPTDGFIGVAPDVRLLSLRQTSEAFQP
VGVQPNANDPNAIPAAGSIRSLARAVVHAANLGASVINISETACYKANKPLDESTLGAAINYAVNVKGVVIIVAAGNTGG
DCTQNPMPDVSMPNDPRGWSKVQTIATPAWYAPLVLTVGGIAQNGMPSQFSVHGPWVSVAAPTENITTLGYNGEPVNALP
GEEGPVALAGTSFATAYVSGLAALLRQRFPDLTPAQIINRIIATARHPGGGVDDIVGAGVIDAVAALTWDITPGSASELF
NVRSVPPPVITPGPDRNTIMIVAQGILGLSIALGLGVLVRRALQRQ

Specific function: Shows keratinolytic activity [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020
- InterPro:   IPR010259 [H]

Pfam domain/function: PF05922 Inhibitor_I9; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 45696; Mature: 45696

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRILLMMVALALLYAPPALAINPPSIDPGAVPPDVTGPDQPTEQKVMCSAPTTLPDSSF
CHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
HDPPWSNIYIGVSEAHKFATGAGVTVAVIDTGVEASPRVPAEPGGDFVDQAGNGLSDCDA
CCCCCCCEEEEHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
HGTLTASIIGGRPAPTDGFIGVAPDVRLLSLRQTSEAFQPVGVQPNANDPNAIPAAGSIR
CCCEEEEEECCCCCCCCCEEECCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
SLARAVVHAANLGASVINISETACYKANKPLDESTLGAAINYAVNVKGVVIIVAAGNTGG
HHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCHHHHHHEEEEEEECCEEEEEEECCCCCC
DCTQNPMPDVSMPNDPRGWSKVQTIATPAWYAPLVLTVGGIAQNGMPSQFSVHGPWVSVA
CCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCHHCCCCCCCEEECCCEEEEE
APTENITTLGYNGEPVNALPGEEGPVALAGTSFATAYVSGLAALLRQRFPDLTPAQIINR
CCCCCCEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IIATARHPGGGVDDIVGAGVIDAVAALTWDITPGSASELFNVRSVPPPVITPGPDRNTIM
HHHHCCCCCCCHHHHHHCHHHHHHHHHEEECCCCCHHHHHCCCCCCCCCCCCCCCCCEEE
IVAQGILGLSIALGLGVLVRRALQRQ
EEECHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHRILLMMVALALLYAPPALAINPPSIDPGAVPPDVTGPDQPTEQKVMCSAPTTLPDSSF
CHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
HDPPWSNIYIGVSEAHKFATGAGVTVAVIDTGVEASPRVPAEPGGDFVDQAGNGLSDCDA
CCCCCCCEEEEHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
HGTLTASIIGGRPAPTDGFIGVAPDVRLLSLRQTSEAFQPVGVQPNANDPNAIPAAGSIR
CCCEEEEEECCCCCCCCCEEECCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
SLARAVVHAANLGASVINISETACYKANKPLDESTLGAAINYAVNVKGVVIIVAAGNTGG
HHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCHHHHHHEEEEEEECCEEEEEEECCCCCC
DCTQNPMPDVSMPNDPRGWSKVQTIATPAWYAPLVLTVGGIAQNGMPSQFSVHGPWVSVA
CCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCHHCCCCCCCEEECCCEEEEE
APTENITTLGYNGEPVNALPGEEGPVALAGTSFATAYVSGLAALLRQRFPDLTPAQIINR
CCCCCCEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IIATARHPGGGVDDIVGAGVIDAVAALTWDITPGSASELFNVRSVPPPVITPGPDRNTIM
HHHHCCCCCCCHHHHHHCHHHHHHHHHEEECCCCCHHHHHCCCCCCCCCCCCCCCCCEEE
IVAQGILGLSIALGLGVLVRRALQRQ
EEECHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1369007; 11058132; 1370008 [H]