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The map label for this gene is fadE [H]

Identifier: 220919351

GI number: 220919351

Start: 4755415

End: 4757157

Strand: Direct

Name: fadE [H]

Synonym: A2cp1_4272

Alternate gene names: 220919351

Gene position: 4755415-4757157 (Clockwise)

Preceding gene: 220919350

Following gene: 220919353

Centisome position: 94.55

GC content: 70.8

Gene sequence:

>1743_bases
ATGGTGGACAAGAAGACCGCGAGCTTCATGCGCTCGCTCGCCCTGGGTGACATCGAGGAGGAGATCCTCCTCCCCTACCC
GGAGCCGCGCCGCGCCGAGAAGGAGACCCTGGAGGCGATCCAGCAGACCTTGAAGTCCATGCTGGGCGGGCGCGGCGCCG
ACTTCCGCGCCTGGGACCGCGCCGGCGAGATGCCGCCCGGCTTCGTGCAGGACCTGAAGGACGCCGGGCTGTTCAGCCTG
GTGGTCCCGGAGCACCACGGCGGCATGGGGCTCGGCGCCACCGCCTACGCCCGCGTCATCCAGGAGCTGGGGCGCTACGA
CGCCTCGGTCGCGGTCACCGTCGGCGCGCACAGCTCCATCGGCATGCGCGGCCTGCTCCTGTTCGGCACCGAGGAGCAGA
AGGCGCGCTACCTGCCGCGCCTCGCCACCGGCGAGCTCATCGCCGCCTTCTGCCTCACCGAGCCGGGCGCCGGCTCCGAC
GCCGCCAGCATCAAGACCACCGCGGTCCGCGACGGCGACGACTGGATCCTGAACGGCGAGAAGCTCTGGATCACGAACGG
CGGCATCGCCGACTTCTTCACGGTCTTCGCGAAGACCTCGCTGGAGGGGCGCGGCCACATCACCGCCTTCATCGTCACGC
GCGACATGAAGGGCGTCACCACCGGCCCGCACGAGGACAAGATGGGCATCCGCGCCTCCTCCACCACCACGGTGGTGCTC
GAGGACGTGCGCGTGCCCGCGGCGAACGTGCTCGGCGAGGAGGGCAAGGGCTTCAAGGTCGCGATGAAGATCCTGAACGC
CGGCCGCACCGGCCTGGGCGGCGGCTCGGTGGGCGGGATGAAGCGGCTCATCGAGCTGTCGGTGGCGCAGGCGAAGGAGC
GCAAGCAGTTCGGCCAGCCCATCGCGAGCTTCGGGCTCGTCCAGCAGAAGATCGGCCAGATGGTGATCGACTGCTACGCG
GCCGAGAGCGTCGTGAACATGGTGGCGGGGCTGGTGGACCGGGGGTTCGAGGAGACGCAGGTCGAGGCGGCCATCTCGAA
GGTGCTCGCCTCGGAGAGCGTGTGGCGCACCGCCGACGAGGCCCTGCAGATCGCGGCCGGCTCGGGGTACATGCGCGAGA
TGCCGTACGAGATGGCGCTCCGCGACACCCGCATCAACCGCATCTTCGAGGGCACGAACGAGATCCTCCGGCTGTTCATC
GCGCTCACCGCGGTGAACGACCTGGGCCAGGAGCTGGCCGACGTGGCGGAGTCGATGAAGGGCGTGCTCGCCGATCCCAT
CAAGGGCTTCGGCGTCATGTCCGACTACGCGAAGCGCCGCGCCGCGCTCGCCACCGGGCTGCGCCGCAAGAAGGGCAAGT
GGACCATGCTCCACCCGGCGCTCGCCGAGGACGCGGCGGTGTTCGAGGCCGCCGCCACCGACCTCGCCATCGCCGCGGAC
AAGCTGCTGCGCAGGTACGGCAAGAAGATCGTGGGCGCGCAGCTCCTCACCAAGCGGCTCGCCGACGCGATGATCGACCT
GTTCACGCTCGCCTGCATGCTGGCGCGCGTGTCCACGCGGCTCGAGGACCACGGCGAGGCGGCCGCGGTGGAGGAGCGGC
GCATCCTGACGGTGTTCGCGCGCCAGGCCCGCCGGCGCGTGGAGGCGGGGCTCGCCGGCCTCGAGCAGAACGAGGACGGC
GCGCTCCAGGCCGTCGCGGCGCACGCGCTCGAGACCGGCCGGTACGGCTGGGACAATCTGTAG

Upstream 100 bases:

>100_bases
CACCCCGTCCGGGGGACTGCGCTCCGGTCGTGCTGCGACGCGTTATGATTCTGGAATCAGCGACGGCGCCATCCCCCCCC
GCGCCAGCCCGGAGACCGCC

Downstream 100 bases:

>100_bases
CGCGGACGCGAAGCGCCCGCGCGCTCCCCGGGGACGGTGGAGCGCGCGGGCCGTGGGTTCGCGGGCGAGGGGCACCGCGG
CCGCGCCGGGCTACGCGGCG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MVDKKTASFMRSLALGDIEEEILLPYPEPRRAEKETLEAIQQTLKSMLGGRGADFRAWDRAGEMPPGFVQDLKDAGLFSL
VVPEHHGGMGLGATAYARVIQELGRYDASVAVTVGAHSSIGMRGLLLFGTEEQKARYLPRLATGELIAAFCLTEPGAGSD
AASIKTTAVRDGDDWILNGEKLWITNGGIADFFTVFAKTSLEGRGHITAFIVTRDMKGVTTGPHEDKMGIRASSTTTVVL
EDVRVPAANVLGEEGKGFKVAMKILNAGRTGLGGGSVGGMKRLIELSVAQAKERKQFGQPIASFGLVQQKIGQMVIDCYA
AESVVNMVAGLVDRGFEETQVEAAISKVLASESVWRTADEALQIAAGSGYMREMPYEMALRDTRINRIFEGTNEILRLFI
ALTAVNDLGQELADVAESMKGVLADPIKGFGVMSDYAKRRAALATGLRRKKGKWTMLHPALAEDAAVFEAAATDLAIAAD
KLLRRYGKKIVGAQLLTKRLADAMIDLFTLACMLARVSTRLEDHGEAAAVEERRILTVFARQARRRVEAGLAGLEQNEDG
ALQAVAAHALETGRYGWDNL

Sequences:

>Translated_580_residues
MVDKKTASFMRSLALGDIEEEILLPYPEPRRAEKETLEAIQQTLKSMLGGRGADFRAWDRAGEMPPGFVQDLKDAGLFSL
VVPEHHGGMGLGATAYARVIQELGRYDASVAVTVGAHSSIGMRGLLLFGTEEQKARYLPRLATGELIAAFCLTEPGAGSD
AASIKTTAVRDGDDWILNGEKLWITNGGIADFFTVFAKTSLEGRGHITAFIVTRDMKGVTTGPHEDKMGIRASSTTTVVL
EDVRVPAANVLGEEGKGFKVAMKILNAGRTGLGGGSVGGMKRLIELSVAQAKERKQFGQPIASFGLVQQKIGQMVIDCYA
AESVVNMVAGLVDRGFEETQVEAAISKVLASESVWRTADEALQIAAGSGYMREMPYEMALRDTRINRIFEGTNEILRLFI
ALTAVNDLGQELADVAESMKGVLADPIKGFGVMSDYAKRRAALATGLRRKKGKWTMLHPALAEDAAVFEAAATDLAIAAD
KLLRRYGKKIVGAQLLTKRLADAMIDLFTLACMLARVSTRLEDHGEAAAVEERRILTVFARQARRRVEAGLAGLEQNEDG
ALQAVAAHALETGRYGWDNL
>Mature_580_residues
MVDKKTASFMRSLALGDIEEEILLPYPEPRRAEKETLEAIQQTLKSMLGGRGADFRAWDRAGEMPPGFVQDLKDAGLFSL
VVPEHHGGMGLGATAYARVIQELGRYDASVAVTVGAHSSIGMRGLLLFGTEEQKARYLPRLATGELIAAFCLTEPGAGSD
AASIKTTAVRDGDDWILNGEKLWITNGGIADFFTVFAKTSLEGRGHITAFIVTRDMKGVTTGPHEDKMGIRASSTTTVVL
EDVRVPAANVLGEEGKGFKVAMKILNAGRTGLGGGSVGGMKRLIELSVAQAKERKQFGQPIASFGLVQQKIGQMVIDCYA
AESVVNMVAGLVDRGFEETQVEAAISKVLASESVWRTADEALQIAAGSGYMREMPYEMALRDTRINRIFEGTNEILRLFI
ALTAVNDLGQELADVAESMKGVLADPIKGFGVMSDYAKRRAALATGLRRKKGKWTMLHPALAEDAAVFEAAATDLAIAAD
KLLRRYGKKIVGAQLLTKRLADAMIDLFTLACMLARVSTRLEDHGEAAAVEERRILTVFARQARRRVEAGLAGLEQNEDG
ALQAVAAHALETGRYGWDNL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=593, Percent_Identity=41.6526138279933, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI76496475, Length=568, Percent_Identity=41.9014084507042, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI4557235, Length=567, Percent_Identity=41.9753086419753, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI4557233, Length=345, Percent_Identity=39.7101449275362, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI226958412, Length=385, Percent_Identity=36.3636363636364, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI226958414, Length=337, Percent_Identity=38.2789317507418, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI4557231, Length=348, Percent_Identity=36.2068965517241, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI187960098, Length=348, Percent_Identity=36.2068965517241, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI4501859, Length=338, Percent_Identity=36.6863905325444, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI7656849, Length=346, Percent_Identity=31.5028901734104, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI4501857, Length=353, Percent_Identity=34.5609065155807, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI7669494, Length=235, Percent_Identity=34.8936170212766, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4503943, Length=235, Percent_Identity=34.8936170212766, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI38505218, Length=396, Percent_Identity=27.2727272727273, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI211971008, Length=361, Percent_Identity=29.0858725761773, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI48976061, Length=361, Percent_Identity=29.0858725761773, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI156104866, Length=359, Percent_Identity=25.6267409470752, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI156104864, Length=359, Percent_Identity=25.6267409470752, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786223, Length=344, Percent_Identity=29.9418604651163, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI87081958, Length=350, Percent_Identity=30, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI87081702, Length=392, Percent_Identity=27.8061224489796, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87082384, Length=264, Percent_Identity=25, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71985184, Length=548, Percent_Identity=39.2335766423358, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71985192, Length=351, Percent_Identity=43.019943019943, Blast_Score=279, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17508101, Length=341, Percent_Identity=39.2961876832845, Blast_Score=245, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17506239, Length=342, Percent_Identity=40.0584795321637, Blast_Score=244, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI17534899, Length=358, Percent_Identity=37.1508379888268, Blast_Score=231, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=35.7702349869452, Blast_Score=227, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17538396, Length=344, Percent_Identity=35.4651162790698, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17533517, Length=393, Percent_Identity=31.2977099236641, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17570075, Length=348, Percent_Identity=35.0574712643678, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=39.7959183673469, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=44.7368421052632, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17551932, Length=404, Percent_Identity=29.2079207920792, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=371, Percent_Identity=28.8409703504043, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=287, Percent_Identity=33.4494773519164, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17534353, Length=351, Percent_Identity=28.2051282051282, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17531909, Length=233, Percent_Identity=33.9055793991416, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17562446, Length=297, Percent_Identity=27.9461279461279, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17540912, Length=499, Percent_Identity=22.0440881763527, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=322, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=322, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281363737, Length=582, Percent_Identity=40.3780068728522, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=40.2144772117962, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24646207, Length=380, Percent_Identity=38.4210526315789, Blast_Score=238, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24660351, Length=348, Percent_Identity=38.5057471264368, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24666513, Length=383, Percent_Identity=36.2924281984334, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI21355753, Length=345, Percent_Identity=37.1014492753623, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI19920834, Length=236, Percent_Identity=37.7118644067797, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24652780, Length=526, Percent_Identity=25.6653992395437, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 62548; Mature: 62548

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDKKTASFMRSLALGDIEEEILLPYPEPRRAEKETLEAIQQTLKSMLGGRGADFRAWDR
CCCHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHC
AGEMPPGFVQDLKDAGLFSLVVPEHHGGMGLGATAYARVIQELGRYDASVAVTVGAHSSI
CCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCC
GMRGLLLFGTEEQKARYLPRLATGELIAAFCLTEPGAGSDAASIKTTAVRDGDDWILNGE
CCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEECCC
KLWITNGGIADFFTVFAKTSLEGRGHITAFIVTRDMKGVTTGPHEDKMGIRASSTTTVVL
EEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEECCCEEEEE
EDVRVPAANVLGEEGKGFKVAMKILNAGRTGLGGGSVGGMKRLIELSVAQAKERKQFGQP
ECCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
IASFGLVQQKIGQMVIDCYAAESVVNMVAGLVDRGFEETQVEAAISKVLASESVWRTADE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALQIAAGSGYMREMPYEMALRDTRINRIFEGTNEILRLFIALTAVNDLGQELADVAESMK
HHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLADPIKGFGVMSDYAKRRAALATGLRRKKGKWTMLHPALAEDAAVFEAAATDLAIAAD
HHHHCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
KLLRRYGKKIVGAQLLTKRLADAMIDLFTLACMLARVSTRLEDHGEAAAVEERRILTVFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RQARRRVEAGLAGLEQNEDGALQAVAAHALETGRYGWDNL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVDKKTASFMRSLALGDIEEEILLPYPEPRRAEKETLEAIQQTLKSMLGGRGADFRAWDR
CCCHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHC
AGEMPPGFVQDLKDAGLFSLVVPEHHGGMGLGATAYARVIQELGRYDASVAVTVGAHSSI
CCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCC
GMRGLLLFGTEEQKARYLPRLATGELIAAFCLTEPGAGSDAASIKTTAVRDGDDWILNGE
CCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEECCC
KLWITNGGIADFFTVFAKTSLEGRGHITAFIVTRDMKGVTTGPHEDKMGIRASSTTTVVL
EEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEECCCEEEEE
EDVRVPAANVLGEEGKGFKVAMKILNAGRTGLGGGSVGGMKRLIELSVAQAKERKQFGQP
ECCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
IASFGLVQQKIGQMVIDCYAAESVVNMVAGLVDRGFEETQVEAAISKVLASESVWRTADE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALQIAAGSGYMREMPYEMALRDTRINRIFEGTNEILRLFIALTAVNDLGQELADVAESMK
HHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLADPIKGFGVMSDYAKRRAALATGLRRKKGKWTMLHPALAEDAAVFEAAATDLAIAAD
HHHHCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
KLLRRYGKKIVGAQLLTKRLADAMIDLFTLACMLARVSTRLEDHGEAAAVEERRILTVFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RQARRRVEAGLAGLEQNEDGALQAVAAHALETGRYGWDNL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]