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The map label for this gene is trpF [H]

Identifier: 220919278

GI number: 220919278

Start: 4685276

End: 4685899

Strand: Direct

Name: trpF [H]

Synonym: A2cp1_4199

Alternate gene names: 220919278

Gene position: 4685276-4685899 (Clockwise)

Preceding gene: 220919277

Following gene: 220919279

Centisome position: 93.16

GC content: 76.92

Gene sequence:

>624_bases
ATGGCGCCGCCGCCCAGGGTGAAGATCTGCGGGGTGACCCGGCTCGAGGACGCGCTCGAGGCCGCACGGCTGGGCGCGGA
CGCGGTTGGCTTCAACTTCTGGCCGCGCTCGAAGCGCTACGTCCCGCCGGCCACGGCGCGCGCGTTGGTGGCCGCGCTGC
CGCCGTTCGTGACGGCCGTGGGCGTGTTCGTGGATCCCACGCGCGAGGAGCTGCTCGCCGCGGTGGCGGCCTCCGGGGTG
CAGGTCGCGCAGCTCCACGGGGACGAGCCGCCGGAGCTGCTCGAGGGCCTGCCCTTCCCCGTGGTGAAGGCCATCCGCGT
GGGCGGGCCCGAGGCGCTCGACCAGCTCGCGCGCTACCCGGCCGCGGCCGGCTTCCTGCTCGACTCCGCCTCGCCGGGCT
ACGGCGGCAGCGGGGTCGCGTTCGACTGGGCGCTCGCGGCGCGCGCCGCGGAGCGGACCGCGGTCGTGCTGGCCGGCGGG
CTCACCCCGGCCAACGTGGCGGACGCGATCCGCGCGGTGCGGCCCTGGGCGGTGGACGTGGCGAGCGGCGTCGAGTCGGC
GCCCGGCGTGAAGGATCGGCAGCTCATGGCGCGGTTCGTCCGCGCGGCAAAGGAGACGACGTGA

Upstream 100 bases:

>100_bases
CCCGGCTGCGCCGCGCCGGGGCCGCGAACCTGCTGGTGGGCGAGGCGCTGGTGCGCGCCGAGGACCCGGCCGCGCTGCTG
CGCGCGCTGGGCGAGGCGTG

Downstream 100 bases:

>100_bases
AGACGGCAGCCCTCCCCGACGAGCGGGGGCGCTTCGGCGCCTTCGGCGGGCGCTTCGTGCCCGAGACCCTGGTGCCGGCG
CTGGACGAGCTCGAGCAGGC

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MAPPPRVKICGVTRLEDALEAARLGADAVGFNFWPRSKRYVPPATARALVAALPPFVTAVGVFVDPTREELLAAVAASGV
QVAQLHGDEPPELLEGLPFPVVKAIRVGGPEALDQLARYPAAAGFLLDSASPGYGGSGVAFDWALAARAAERTAVVLAGG
LTPANVADAIRAVRPWAVDVASGVESAPGVKDRQLMARFVRAAKETT

Sequences:

>Translated_207_residues
MAPPPRVKICGVTRLEDALEAARLGADAVGFNFWPRSKRYVPPATARALVAALPPFVTAVGVFVDPTREELLAAVAASGV
QVAQLHGDEPPELLEGLPFPVVKAIRVGGPEALDQLARYPAAAGFLLDSASPGYGGSGVAFDWALAARAAERTAVVLAGG
LTPANVADAIRAVRPWAVDVASGVESAPGVKDRQLMARFVRAAKETT
>Mature_206_residues
APPPRVKICGVTRLEDALEAARLGADAVGFNFWPRSKRYVPPATARALVAALPPFVTAVGVFVDPTREELLAAVAASGVQ
VAQLHGDEPPELLEGLPFPVVKAIRVGGPEALDQLARYPAAAGFLLDSASPGYGGSGVAFDWALAARAAERTAVVLAGGL
TPANVADAIRAVRPWAVDVASGVESAPGVKDRQLMARFVRAAKETT

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=197, Percent_Identity=36.0406091370558, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320210, Length=219, Percent_Identity=35.6164383561644, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 21442; Mature: 21311

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPPPRVKICGVTRLEDALEAARLGADAVGFNFWPRSKRYVPPATARALVAALPPFVTAV
CCCCCCEEEECHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GVFVDPTREELLAAVAASGVQVAQLHGDEPPELLEGLPFPVVKAIRVGGPEALDQLARYP
HHHCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHCCCCHHHHHHHHCCCHHHHHHHHHCC
AAAGFLLDSASPGYGGSGVAFDWALAARAAERTAVVLAGGLTPANVADAIRAVRPWAVDV
HHHHHEECCCCCCCCCCCCHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCHHHHH
ASGVESAPGVKDRQLMARFVRAAKETT
HHCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
APPPRVKICGVTRLEDALEAARLGADAVGFNFWPRSKRYVPPATARALVAALPPFVTAV
CCCCCEEEECHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GVFVDPTREELLAAVAASGVQVAQLHGDEPPELLEGLPFPVVKAIRVGGPEALDQLARYP
HHHCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHCCCCHHHHHHHHCCCHHHHHHHHHCC
AAAGFLLDSASPGYGGSGVAFDWALAARAAERTAVVLAGGLTPANVADAIRAVRPWAVDV
HHHHHEECCCCCCCCCCCCHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCHHHHH
ASGVESAPGVKDRQLMARFVRAAKETT
HHCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA