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The map label for this gene is glmU

Identifier: 220919181

GI number: 220919181

Start: 4585583

End: 4587049

Strand: Direct

Name: glmU

Synonym: A2cp1_4101

Alternate gene names: 220919181

Gene position: 4585583-4587049 (Clockwise)

Preceding gene: 220919179

Following gene: 220919182

Centisome position: 91.18

GC content: 75.19

Gene sequence:

>1467_bases
ATGCCACGCACCCGCACACCGCTCGCCGCCATCGTCCTCGCCGCCGGCAAGGGCACCCGGATGAAGTCGAACAAGGCCAA
GGTCCTGCACGAGGTCGCGGGCCGGCCGCTCGCGTACTATCCGGTGAAGCGCGCCCTGGAGCTGGGCGCGAGCCCGGTGG
TGGTGGTGGTGGGCCACCAGGCCGAGGCGGTGGAGGCGGCCCTCTCCGCCGCGCTCCCCGAGGCGCCGCTGCGCTTCGCG
GTCCAGGAGCAGCAGCTCGGGACGGCGCACGCGGTGCTCGCGGCGAAGCGCGCCCTGCGCGGCTACCGCGGCCCGGTGCT
GATCCTCTCCGGCGACACGCCGCTGCTCCGCGCCGAGACGCTCGAGGCGGTCGTGTCCGCCGGCCGCCGGGCCCGCGCCG
CGGTCTCGCTCGCCACCATGACCCTCGAGGTCCCGCGCGGCTACGGCCGGGTGGTGCGTGACGCGCGCGGCCGGCCGGCG
CGCATCGTGGAGGAGAAGGACGCGACCGAGGCCGAGCGCGCGGTGCGCGAGGTGAACGCCGGGCTGTACTGCGTGGACGC
GGAGCTGCTCTGGAAGAAGCTCGCGAAGGTGGGCACCGCCAACGCGCAGCGCGAGTTCTACCTCACCGACCTGGTGCCCA
TGGCCGCGCAGGCGGGCGGCGTGGCGGGCGTCGAGGTCCCCGCCGAGGAGGCCTCCGGCGTCAACGATCGGGTCGAGCTC
TCGCGGGCGAACCGCGTGATGGTGGGCCGGCTCGCCGAGGCGTTCATGCGCGCGGGCGTGACCATCGAGGACCCGGCCCG
CTTCGACTGCGACGAGGGCGTGGAGATCGGCGCGGACGCGGTGATCGAGCCGAACGTGCGGCTGCGCGGTCGCACCCGCG
TCGGCGCGCGCACGCGGGTGGGCGTCGGCGCGGTCATCACCGACGGCGTCCTCGCCGACGGCGTGACGGTGAACCCGTAC
ACCGTGATCTCGGAGGCGCAGGTCGCCGAGGGCGCCATCCTGGGCCCGTTCTCGCGCCTCCGCCCGGGCGCCGACATCGG
CCCCGAGGCGCACGTGGGCAACTTCGTCGAGGTGAAGAAGAGCCGGCTCGGGAAGGGTGCGAAGGCGAACCACCTCGCCT
ACCTCGGCGACGCGGAGATCGGCGCGGGCGCGAACATCGGCGCCGGCACGATCACCTGCAACTACGACGGGGAGCGCAAG
AACCCGACGCGGATCGGCGAGGGGGCGTTCATCGGCTCCGACTCCATCCTGGTCGCGCCCATCGAGATCGGCGCCGGCGC
CTACGTCGCGGCAGGCTCCACGCTCACCGACCCGGTGCCGGCAGGCGCCCTGGCGCTCGGCCGGGCACGCCAGGTGACGA
AGGAGGGGTGGGTGGCCCAGCGGCAGGCGGAGAAGCAGATGAAGGGGACGGCCACCGGCCCGGCGTCCGCCCGCAAGGGC
CGCCCGGCCGCCCGGCGGGCGAGTTAG

Upstream 100 bases:

>100_bases
ACCTCCGGGCCCCCCGCCGGCGCCGCCCGGAGGCCCGCGCTCCGGGTCACACGTGCGCAGGCTTGATCGCAGCCCCCACC
CGCGCCTAGCCTCCGCGACC

Downstream 100 bases:

>100_bases
CAGCGCGCGCGCCCCGCGTGGTATTGAGGCGACCCTATGTGCGGAATCGTTGGTTACGTCGGCCCCCGGCAGTGCGTGGA
TCTCATCGTGGGTGGTCTCC

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MPRTRTPLAAIVLAAGKGTRMKSNKAKVLHEVAGRPLAYYPVKRALELGASPVVVVVGHQAEAVEAALSAALPEAPLRFA
VQEQQLGTAHAVLAAKRALRGYRGPVLILSGDTPLLRAETLEAVVSAGRRARAAVSLATMTLEVPRGYGRVVRDARGRPA
RIVEEKDATEAERAVREVNAGLYCVDAELLWKKLAKVGTANAQREFYLTDLVPMAAQAGGVAGVEVPAEEASGVNDRVEL
SRANRVMVGRLAEAFMRAGVTIEDPARFDCDEGVEIGADAVIEPNVRLRGRTRVGARTRVGVGAVITDGVLADGVTVNPY
TVISEAQVAEGAILGPFSRLRPGADIGPEAHVGNFVEVKKSRLGKGAKANHLAYLGDAEIGAGANIGAGTITCNYDGERK
NPTRIGEGAFIGSDSILVAPIEIGAGAYVAAGSTLTDPVPAGALALGRARQVTKEGWVAQRQAEKQMKGTATGPASARKG
RPAARRAS

Sequences:

>Translated_488_residues
MPRTRTPLAAIVLAAGKGTRMKSNKAKVLHEVAGRPLAYYPVKRALELGASPVVVVVGHQAEAVEAALSAALPEAPLRFA
VQEQQLGTAHAVLAAKRALRGYRGPVLILSGDTPLLRAETLEAVVSAGRRARAAVSLATMTLEVPRGYGRVVRDARGRPA
RIVEEKDATEAERAVREVNAGLYCVDAELLWKKLAKVGTANAQREFYLTDLVPMAAQAGGVAGVEVPAEEASGVNDRVEL
SRANRVMVGRLAEAFMRAGVTIEDPARFDCDEGVEIGADAVIEPNVRLRGRTRVGARTRVGVGAVITDGVLADGVTVNPY
TVISEAQVAEGAILGPFSRLRPGADIGPEAHVGNFVEVKKSRLGKGAKANHLAYLGDAEIGAGANIGAGTITCNYDGERK
NPTRIGEGAFIGSDSILVAPIEIGAGAYVAAGSTLTDPVPAGALALGRARQVTKEGWVAQRQAEKQMKGTATGPASARKG
RPAARRAS
>Mature_487_residues
PRTRTPLAAIVLAAGKGTRMKSNKAKVLHEVAGRPLAYYPVKRALELGASPVVVVVGHQAEAVEAALSAALPEAPLRFAV
QEQQLGTAHAVLAAKRALRGYRGPVLILSGDTPLLRAETLEAVVSAGRRARAAVSLATMTLEVPRGYGRVVRDARGRPAR
IVEEKDATEAERAVREVNAGLYCVDAELLWKKLAKVGTANAQREFYLTDLVPMAAQAGGVAGVEVPAEEASGVNDRVELS
RANRVMVGRLAEAFMRAGVTIEDPARFDCDEGVEIGADAVIEPNVRLRGRTRVGARTRVGVGAVITDGVLADGVTVNPYT
VISEAQVAEGAILGPFSRLRPGADIGPEAHVGNFVEVKKSRLGKGAKANHLAYLGDAEIGAGANIGAGTITCNYDGERKN
PTRIGEGAFIGSDSILVAPIEIGAGAYVAAGSTLTDPVPAGALALGRARQVTKEGWVAQRQAEKQMKGTATGPASARKGR
PAARRAS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=452, Percent_Identity=44.9115044247788, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_ANAD2 (B8J9N1)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002494485.1
- ProteinModelPortal:   B8J9N1
- SMR:   B8J9N1
- GeneID:   7297526
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_4101
- HOGENOM:   HBG688195
- ProtClustDB:   CLSK2516865
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 50903; Mature: 50772

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 371-371 BINDING 82-82 BINDING 149-149 BINDING 164-164 BINDING 179-179 BINDING 395-395 BINDING 413-413 BINDING 431-431 BINDING 448-448

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRTRTPLAAIVLAAGKGTRMKSNKAKVLHEVAGRPLAYYPVKRALELGASPVVVVVGHQ
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHCCCCCEEEEECCC
AEAVEAALSAALPEAPLRFAVQEQQLGTAHAVLAAKRALRGYRGPVLILSGDTPLLRAET
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHH
LEAVVSAGRRARAAVSLATMTLEVPRGYGRVVRDARGRPARIVEEKDATEAERAVREVNA
HHHHHHCCCHHHHEEEEEEEEEECCCCHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHCC
GLYCVDAELLWKKLAKVGTANAQREFYLTDLVPMAAQAGGVAGVEVPAEEASGVNDRVEL
CEEEECHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCCEEECCHHHHCCCCCHHHH
SRANRVMVGRLAEAFMRAGVTIEDPARFDCDEGVEIGADAVIEPNVRLRGRTRVGARTRV
HHCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEECCCCEEECCCCCCCCCCC
GVGAVITDGVLADGVTVNPYTVISEAQVAEGAILGPFSRLRPGADIGPEAHVGNFVEVKK
CCCEEEECCCCCCCEEECCEEEECCCHHHCCCEECCHHHCCCCCCCCCCCCCCCHHHHHH
SRLGKGAKANHLAYLGDAEIGAGANIGAGTITCNYDGERKNPTRIGEGAFIGSDSILVAP
HHCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCEEEEE
IEIGAGAYVAAGSTLTDPVPAGALALGRARQVTKEGWVAQRQAEKQMKGTATGPASARKG
EEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
RPAARRAS
CCCCCCCC
>Mature Secondary Structure 
PRTRTPLAAIVLAAGKGTRMKSNKAKVLHEVAGRPLAYYPVKRALELGASPVVVVVGHQ
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHCCCCCEEEEECCC
AEAVEAALSAALPEAPLRFAVQEQQLGTAHAVLAAKRALRGYRGPVLILSGDTPLLRAET
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHH
LEAVVSAGRRARAAVSLATMTLEVPRGYGRVVRDARGRPARIVEEKDATEAERAVREVNA
HHHHHHCCCHHHHEEEEEEEEEECCCCHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHCC
GLYCVDAELLWKKLAKVGTANAQREFYLTDLVPMAAQAGGVAGVEVPAEEASGVNDRVEL
CEEEECHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCCEEECCHHHHCCCCCHHHH
SRANRVMVGRLAEAFMRAGVTIEDPARFDCDEGVEIGADAVIEPNVRLRGRTRVGARTRV
HHCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEECCCCEEECCCCCCCCCCC
GVGAVITDGVLADGVTVNPYTVISEAQVAEGAILGPFSRLRPGADIGPEAHVGNFVEVKK
CCCEEEECCCCCCCEEECCEEEECCCHHHCCCEECCHHHCCCCCCCCCCCCCCCHHHHHH
SRLGKGAKANHLAYLGDAEIGAGANIGAGTITCNYDGERKNPTRIGEGAFIGSDSILVAP
HHCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCEEEEE
IEIGAGAYVAAGSTLTDPVPAGALALGRARQVTKEGWVAQRQAEKQMKGTATGPASARKG
EEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
RPAARRAS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA