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The map label for this gene is hom [H]

Identifier: 220919152

GI number: 220919152

Start: 4551910

End: 4552962

Strand: Direct

Name: hom [H]

Synonym: A2cp1_4072

Alternate gene names: 220919152

Gene position: 4551910-4552962 (Clockwise)

Preceding gene: 220919151

Following gene: 220919155

Centisome position: 90.51

GC content: 79.39

Gene sequence:

>1053_bases
ATGTCCCGCGCCGCCCCCCGCCCGCTCCGCCTCGCGCTCGCCGGCTTCGGCAACGTCGGCCGGACCTTCGCCGAGCTGCT
CCCTGGTCCGTACGGCCGCGCGCTCCGCGCCGAGGGCGCGGCGCCTGTCGTCACCGCCATCTTCACGAACCGTCACGGGG
CCGCGATCGATCCGCGCGGGCTGCCGCTCCGGCGCGCGCTGCGGCTGGTGCGCGCCGGCGGCTCGCTCGACGCGCTCCAC
CGCGGGCCGCCGGTCGCCTCGGCGCTCGACCTCGTCCGCCGCGCGCCGGCCGACGTGCTGGTGGAGCTGACCCCCCTCGC
GCCCACCACCGGCGAGCCGGCCATCTCGCTGGCCCGCGCCGCGCTGGGGCGCGGGCTGCACGTGGTGACCGCGAACAAGG
GGCCGGTGGCGCACGCCCGCGCGCGGCTGGCGCGCCTCGCGGCACGGAACGGCGTGCGCTTCCTGCACGAGGGCGCCGTG
CTCGACGGGACGCCGGTGTTCAACCTGGTGGAGCGTTGCCTGCCCGGCGCGCGGATCCTCGGCTTCCGCGGCCTGCTCAA
CAGCACCACCACCCGCGTCCTCGCCGGCATGGAGGCCGGGGCGAGCTTCGAGGCGGCGCTCGCCGACGCGCAGCGCGCCG
GCGTGGCGGAGGCCGACCCGCGGCACGACCTCGAGGGCTGGGACGCGGCGGTGAAGGCCTGCGCGCTCGCGAACGCGCTC
ATGGGCGCGGACGTGCGGCCCGCCGCCGTCGAGCGCCGGGGCATCACCGGCCTCGGCCCCGAGGACGTCCGCGCCGCCCG
CGGGCGCGGGGCGGTGCTCCGCCTCGTCGCCCGGGCGCGGCGCGACGGCCGCGCGGTGCGGGTGAGCGTGGGGCCGGAGG
AGGTCGCGGACGGCGACGTGCTCGTCTCGCGGGGCGCCGACGGCGTGCTCGTGCTCGAGACCGACCTCATGCGCGAGATC
GGCATCTGGGAGGGCGCCGGCGGGGTGGACCAGACCGCCTACGCGATCCTGTCCGACCTGGTGGCGATCGCCCGCGGGCG
CCGGCGCCGCTGA

Upstream 100 bases:

>100_bases
CGCCTTGGCGGGCTCGCACGAGGTCCCCGCGGGCGCGGCTTCGCCGCGCGCTCGAGAGCACATTGACAGGCGGGGGAGGG
CCGGACCACCCTCCCCCGCC

Downstream 100 bases:

>100_bases
TCGCGCCGGCTCAGCAGCGCGGCGCAGGACCGCCGGGGCCCTCGCCGTCCTGCGGCTCGCCGTCCTGCGTGCCGGCCCCG
GACCGGGGCCGCTGCGGCAC

Product: Homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSRAAPRPLRLALAGFGNVGRTFAELLPGPYGRALRAEGAAPVVTAIFTNRHGAAIDPRGLPLRRALRLVRAGGSLDALH
RGPPVASALDLVRRAPADVLVELTPLAPTTGEPAISLARAALGRGLHVVTANKGPVAHARARLARLAARNGVRFLHEGAV
LDGTPVFNLVERCLPGARILGFRGLLNSTTTRVLAGMEAGASFEAALADAQRAGVAEADPRHDLEGWDAAVKACALANAL
MGADVRPAAVERRGITGLGPEDVRAARGRGAVLRLVARARRDGRAVRVSVGPEEVADGDVLVSRGADGVLVLETDLMREI
GIWEGAGGVDQTAYAILSDLVAIARGRRRR

Sequences:

>Translated_350_residues
MSRAAPRPLRLALAGFGNVGRTFAELLPGPYGRALRAEGAAPVVTAIFTNRHGAAIDPRGLPLRRALRLVRAGGSLDALH
RGPPVASALDLVRRAPADVLVELTPLAPTTGEPAISLARAALGRGLHVVTANKGPVAHARARLARLAARNGVRFLHEGAV
LDGTPVFNLVERCLPGARILGFRGLLNSTTTRVLAGMEAGASFEAALADAQRAGVAEADPRHDLEGWDAAVKACALANAL
MGADVRPAAVERRGITGLGPEDVRAARGRGAVLRLVARARRDGRAVRVSVGPEEVADGDVLVSRGADGVLVLETDLMREI
GIWEGAGGVDQTAYAILSDLVAIARGRRRR
>Mature_349_residues
SRAAPRPLRLALAGFGNVGRTFAELLPGPYGRALRAEGAAPVVTAIFTNRHGAAIDPRGLPLRRALRLVRAGGSLDALHR
GPPVASALDLVRRAPADVLVELTPLAPTTGEPAISLARAALGRGLHVVTANKGPVAHARARLARLAARNGVRFLHEGAVL
DGTPVFNLVERCLPGARILGFRGLLNSTTTRVLAGMEAGASFEAALADAQRAGVAEADPRHDLEGWDAAVKACALANALM
GADVRPAAVERRGITGLGPEDVRAARGRGAVLRLVARARRDGRAVRVSVGPEEVADGDVLVSRGADGVLVLETDLMREIG
IWEGAGGVDQTAYAILSDLVAIARGRRRR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=247, Percent_Identity=29.1497975708502, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 36477; Mature: 36345

Theoretical pI: Translated: 11.76; Mature: 11.76

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAAPRPLRLALAGFGNVGRTFAELLPGPYGRALRAEGAAPVVTAIFTNRHGAAIDPRG
CCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEECCCCCCCCCCC
LPLRRALRLVRAGGSLDALHRGPPVASALDLVRRAPADVLVELTPLAPTTGEPAISLARA
CCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCHHEEEEECCCCCCCCHHHHHHHH
ALGRGLHVVTANKGPVAHARARLARLAARNGVRFLHEGAVLDGTPVFNLVERCLPGARIL
HHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHCCCEECCCHHHHHHHHHCCCCHHH
GFRGLLNSTTTRVLAGMEAGASFEAALADAQRAGVAEADPRHDLEGWDAAVKACALANAL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MGADVRPAAVERRGITGLGPEDVRAARGRGAVLRLVARARRDGRAVRVSVGPEEVADGDV
HCCCCCHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCHHHHCCCCE
LVSRGADGVLVLETDLMREIGIWEGAGGVDQTAYAILSDLVAIARGRRRR
EEECCCCCEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SRAAPRPLRLALAGFGNVGRTFAELLPGPYGRALRAEGAAPVVTAIFTNRHGAAIDPRG
CCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEECCCCCCCCCCC
LPLRRALRLVRAGGSLDALHRGPPVASALDLVRRAPADVLVELTPLAPTTGEPAISLARA
CCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCHHEEEEECCCCCCCCHHHHHHHH
ALGRGLHVVTANKGPVAHARARLARLAARNGVRFLHEGAVLDGTPVFNLVERCLPGARIL
HHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHCCCEECCCHHHHHHHHHCCCCHHH
GFRGLLNSTTTRVLAGMEAGASFEAALADAQRAGVAEADPRHDLEGWDAAVKACALANAL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MGADVRPAAVERRGITGLGPEDVRAARGRGAVLRLVARARRDGRAVRVSVGPEEVADGDV
HCCCCCHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCHHHHCCCCE
LVSRGADGVLVLETDLMREIGIWEGAGGVDQTAYAILSDLVAIARGRRRR
EEECCCCCEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]