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The map label for this gene is maeB [H]

Identifier: 220919151

GI number: 220919151

Start: 4549436

End: 4551751

Strand: Direct

Name: maeB [H]

Synonym: A2cp1_4071

Alternate gene names: 220919151

Gene position: 4549436-4551751 (Clockwise)

Preceding gene: 220919150

Following gene: 220919152

Centisome position: 90.46

GC content: 69.17

Gene sequence:

>2316_bases
ATGGCCTCCGACTTCACGCCCCCGCAGAACCCGCCCTCGTCGCCCGTTCCCAAGAAGAAGATCCGCCGGGAGGACGCGCT
CGCGTACCACTCGTCCGGCCGCAGGGGGAAGATCGAGGTCGTCCCCACCAAGCCGTGCGCCACCGCGCGCGATCTCGCGC
TCGCCTACAGCCCGGGCGTGGCCGAGCCGTGCCTCGAGATCGAGAAGGATCCCGACGCTTCGTACCTCTACACGGCGCGT
GGAAACCTGGTCGCGGTGGTCTCCAACGGGACCGCGGTGCTCGGCCTCGGCAACATCGGGCCCGCCGCCGGCAAGCCGGT
GATGGAGGGCAAGGGCGTCCTCTTCAAGAAGTTCGCCGACGTGGACGTGTTCGACATCAACGTGGACGCGCTCGAGATCG
ACAAGTTCTGCACGGTGGTGAAGGCGCTCGAGCCCACCTTCGGCGGCATCAACCTCGAGGACATCAAGGCGCCGGAGTGC
TTCGTCATCGAGGCGCGCCTGAAGAAGGAGATGCAGATCCCGGTCTTCCACGACGACCAGCACGGCACCGCCATCATCTC
CGGCGCGGCCCTGCTGAACGCGCTGGAGCTGGCCGGCAAGAAGATCGGCGACGTGCGCGTGGTGGTCTCCGGCGCCGGCG
CGTCCGCCATCGCCTGCACCAAGTTCTACCTGACGCTCGGCGTGCGGCGCGAGAACGTCGTCATGGTGGACACGAAGGGC
GTCATCTACCGCGGGCGCACCGAGGGCATGAACGAGTGGAAGGCGGAGTTCGCGGCCGACACCAAGGCCCGCACGCTCGC
CGACGCGCTGAAGGGCGCGGACGTGCTGCTGGGCTGCTCCACCAAGGGGATGGTCGCGCAGGAGATGGTCCGCTCGATGG
CGAAGGACCCCATCGTCTTCGCGCTCGCCAACCCGGATCCCGAGATCGACTACCCGGAGGCGAAGGCCGCGCGCGAGGAC
GTCATCATGGCGACCGGGCGCTCCGACTTCCCGAACCAGGTCAACAACGTCCTCGGCTTCCCGTACATCTTCCGCGGCGC
GCTCGACGTCCGCGCCAAGGCCATCACCGAGGACATGAAGATGGCGGCGGCGAAGGCGCTCGCCGAGCTGGCCAAGCAGG
ACGTGCCGGACTCGGTGTCGCGCGCCTACGCCGGCGAGAAGTTCCGCTTCGGCCGCGACTACATCATCCCGAAGCCGCTC
GACCCGCGCGTGCTGCTCTGGGTCGCCCCGGCCGTGGCACAGGCCGCCATCGACGGCGGCGTGGCCCGCGTGAAGCTCGA
CATGGACGAGTACCGCGACCGGCTGCGCAAGATGCAGAGCCGCTCGCACCAGGTGATGGGCTCCATCTTCACCAAGGCGA
AGAAGAAGCTCGCCCGGATCGTGTTCCCGGAGGGCCACCACCCGAAGATCCAGCAGGCCGCCGAGATCCTCCGCGAGGAG
GCGATCTGCGAGCCGGTGCTGCTCGGGCCGGTGGAGGCGATCCGCCGCTCCATCGCGGACCAGCGGCTCGACGACCTCGA
CGGCGTGACCATCATCGACCCGATGGACAGCCCCGAGTTCGCGCGCTACGTGGCGCGGTACTGGGAGCTGCGCCAGCGCC
GCGGCATCACGGTGGAGGAGGCGCGCCGCCGCATCCGCACGCGCAACTACTTCGGCGCGGTCATGCTCGAGCTGGGCGAG
GTGGACGGGCTCGTCACCGGCCTCACCAGCGGCTACGCCGACGCGGTCCGCCCCTCGCTCGAGGTGGTGCGCACCCGCGC
CGGCAAGCGCGCGGCCGGCGTGTACATCGTGGTCACGAAGCACGACTTCAAGTTCTTCGCCGACTGCACCGTGAACATCG
ACCCGGACGCCGACGAGCTGGCCGAGATCGCCATCACCACCAGCGACCTGGCCCGCTACTTCGAGGTGACGCCGCGGGTG
GCGATGCTCTCCTACTCGACGTTCGGGTCCGCCGGCGGCGGCAGCCCGCAGAAGATGCGCGACGCCGCGGCGCTGGTCCG
CCAGCGCCGTCCGGACCTGGAGGTCGAGGGCGAGATCCAGGTCGCGATCGCGACCAACGGCGACGTCCGCGTGCCCGAGT
TCCCGTTCTCGACGCTCAAGGAGGACGCGAACGTGTTCGTCTTCCCGAACCTCGACTCGGCCAACATCGCCTACCAGCTG
CTCGAGAACGTGGGCGGCGCCGAGGTCATCGGGCCGGTGCTGCTCGGCATGCACAAGCCGGTGAACTGCCTGCAGATGGG
CTGCTCGGTGCAGTCGATCGTGAACCTGGCCGCGATCACGGCGCTGCGCGCGCAGGGCGATCAGTTCCTGTTCTGA

Upstream 100 bases:

>100_bases
CACCAATTGATCTGCGTCTCATTGACAGCGGATTTATTTTGGGATTTCCTCTTCGCCCCAATTCAAGCTCGTCGACTCCT
ACCGCCGCACCGAGGAGATC

Downstream 100 bases:

>100_bases
TCTGACGGGGCTGCGCGCCGCCCCACCCTGCTGCGCGGGCCCCGTGACCTCGTGCGCCCGCCTTGGCGGGCTCGCACGAG
GTCCCCGCGGGCGCGGCTTC

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MASDFTPPQNPPSSPVPKKKIRREDALAYHSSGRRGKIEVVPTKPCATARDLALAYSPGVAEPCLEIEKDPDASYLYTAR
GNLVAVVSNGTAVLGLGNIGPAAGKPVMEGKGVLFKKFADVDVFDINVDALEIDKFCTVVKALEPTFGGINLEDIKAPEC
FVIEARLKKEMQIPVFHDDQHGTAIISGAALLNALELAGKKIGDVRVVVSGAGASAIACTKFYLTLGVRRENVVMVDTKG
VIYRGRTEGMNEWKAEFAADTKARTLADALKGADVLLGCSTKGMVAQEMVRSMAKDPIVFALANPDPEIDYPEAKAARED
VIMATGRSDFPNQVNNVLGFPYIFRGALDVRAKAITEDMKMAAAKALAELAKQDVPDSVSRAYAGEKFRFGRDYIIPKPL
DPRVLLWVAPAVAQAAIDGGVARVKLDMDEYRDRLRKMQSRSHQVMGSIFTKAKKKLARIVFPEGHHPKIQQAAEILREE
AICEPVLLGPVEAIRRSIADQRLDDLDGVTIIDPMDSPEFARYVARYWELRQRRGITVEEARRRIRTRNYFGAVMLELGE
VDGLVTGLTSGYADAVRPSLEVVRTRAGKRAAGVYIVVTKHDFKFFADCTVNIDPDADELAEIAITTSDLARYFEVTPRV
AMLSYSTFGSAGGGSPQKMRDAAALVRQRRPDLEVEGEIQVAIATNGDVRVPEFPFSTLKEDANVFVFPNLDSANIAYQL
LENVGGAEVIGPVLLGMHKPVNCLQMGCSVQSIVNLAAITALRAQGDQFLF

Sequences:

>Translated_771_residues
MASDFTPPQNPPSSPVPKKKIRREDALAYHSSGRRGKIEVVPTKPCATARDLALAYSPGVAEPCLEIEKDPDASYLYTAR
GNLVAVVSNGTAVLGLGNIGPAAGKPVMEGKGVLFKKFADVDVFDINVDALEIDKFCTVVKALEPTFGGINLEDIKAPEC
FVIEARLKKEMQIPVFHDDQHGTAIISGAALLNALELAGKKIGDVRVVVSGAGASAIACTKFYLTLGVRRENVVMVDTKG
VIYRGRTEGMNEWKAEFAADTKARTLADALKGADVLLGCSTKGMVAQEMVRSMAKDPIVFALANPDPEIDYPEAKAARED
VIMATGRSDFPNQVNNVLGFPYIFRGALDVRAKAITEDMKMAAAKALAELAKQDVPDSVSRAYAGEKFRFGRDYIIPKPL
DPRVLLWVAPAVAQAAIDGGVARVKLDMDEYRDRLRKMQSRSHQVMGSIFTKAKKKLARIVFPEGHHPKIQQAAEILREE
AICEPVLLGPVEAIRRSIADQRLDDLDGVTIIDPMDSPEFARYVARYWELRQRRGITVEEARRRIRTRNYFGAVMLELGE
VDGLVTGLTSGYADAVRPSLEVVRTRAGKRAAGVYIVVTKHDFKFFADCTVNIDPDADELAEIAITTSDLARYFEVTPRV
AMLSYSTFGSAGGGSPQKMRDAAALVRQRRPDLEVEGEIQVAIATNGDVRVPEFPFSTLKEDANVFVFPNLDSANIAYQL
LENVGGAEVIGPVLLGMHKPVNCLQMGCSVQSIVNLAAITALRAQGDQFLF
>Mature_770_residues
ASDFTPPQNPPSSPVPKKKIRREDALAYHSSGRRGKIEVVPTKPCATARDLALAYSPGVAEPCLEIEKDPDASYLYTARG
NLVAVVSNGTAVLGLGNIGPAAGKPVMEGKGVLFKKFADVDVFDINVDALEIDKFCTVVKALEPTFGGINLEDIKAPECF
VIEARLKKEMQIPVFHDDQHGTAIISGAALLNALELAGKKIGDVRVVVSGAGASAIACTKFYLTLGVRRENVVMVDTKGV
IYRGRTEGMNEWKAEFAADTKARTLADALKGADVLLGCSTKGMVAQEMVRSMAKDPIVFALANPDPEIDYPEAKAAREDV
IMATGRSDFPNQVNNVLGFPYIFRGALDVRAKAITEDMKMAAAKALAELAKQDVPDSVSRAYAGEKFRFGRDYIIPKPLD
PRVLLWVAPAVAQAAIDGGVARVKLDMDEYRDRLRKMQSRSHQVMGSIFTKAKKKLARIVFPEGHHPKIQQAAEILREEA
ICEPVLLGPVEAIRRSIADQRLDDLDGVTIIDPMDSPEFARYVARYWELRQRRGITVEEARRRIRTRNYFGAVMLELGEV
DGLVTGLTSGYADAVRPSLEVVRTRAGKRAAGVYIVVTKHDFKFFADCTVNIDPDADELAEIAITTSDLARYFEVTPRVA
MLSYSTFGSAGGGSPQKMRDAAALVRQRRPDLEVEGEIQVAIATNGDVRVPEFPFSTLKEDANVFVFPNLDSANIAYQLL
ENVGGAEVIGPVLLGMHKPVNCLQMGCSVQSIVNLAAITALRAQGDQFLF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=359, Percent_Identity=23.9554317548747, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI62420880, Length=359, Percent_Identity=23.9554317548747, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI239049447, Length=359, Percent_Identity=23.9554317548747, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI4505143, Length=345, Percent_Identity=22.0289855072464, Blast_Score=77, Evalue=8e-14,
Organism=Escherichia coli, GI1788806, Length=751, Percent_Identity=50.9986684420772, Blast_Score=717, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=319, Percent_Identity=39.1849529780564, Blast_Score=212, Evalue=9e-56,
Organism=Escherichia coli, GI1788800, Length=315, Percent_Identity=32.0634920634921, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI87081919, Length=408, Percent_Identity=23.7745098039216, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537199, Length=419, Percent_Identity=26.491646778043, Blast_Score=90, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322823, Length=419, Percent_Identity=27.6849642004773, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646388, Length=348, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24646386, Length=348, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281362672, Length=407, Percent_Identity=24.8157248157248, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356279, Length=407, Percent_Identity=24.8157248157248, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281362674, Length=407, Percent_Identity=24.8157248157248, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI78707242, Length=410, Percent_Identity=23.1707317073171, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI78707238, Length=410, Percent_Identity=23.1707317073171, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83945; Mature: 83813

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDFTPPQNPPSSPVPKKKIRREDALAYHSSGRRGKIEVVPTKPCATARDLALAYSPGV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHEEEEECCCC
AEPCLEIEKDPDASYLYTARGNLVAVVSNGTAVLGLGNIGPAAGKPVMEGKGVLFKKFAD
CCHHHHCCCCCCCCEEEEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEEECC
VDVFDINVDALEIDKFCTVVKALEPTFGGINLEDIKAPECFVIEARLKKEMQIPVFHDDQ
CEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEEHHHCCCCCCEEECCC
HGTAIISGAALLNALELAGKKIGDVRVVVSGAGASAIACTKFYLTLGVRRENVVMVDTKG
CCCEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHEEEEEECCCCCCEEEEECCC
VIYRGRTEGMNEWKAEFAADTKARTLADALKGADVLLGCSTKGMVAQEMVRSMAKDPIVF
EEEECCCCCCHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEE
ALANPDPEIDYPEAKAAREDVIMATGRSDFPNQVNNVLGFPYIFRGALDVRAKAITEDMK
EECCCCCCCCCCCHHHHHCCEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
MAAAKALAELAKQDVPDSVSRAYAGEKFRFGRDYIIPKPLDPRVLLWVAPAVAQAAIDGG
HHHHHHHHHHHHHCCCHHHHHHHCCCCEECCCCCCCCCCCCCCEEEEECHHHHHHHHCCC
VARVKLDMDEYRDRLRKMQSRSHQVMGSIFTKAKKKLARIVFPEGHHPKIQQAAEILREE
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
AICEPVLLGPVEAIRRSIADQRLDDLDGVTIIDPMDSPEFARYVARYWELRQRRGITVEE
HHCCCHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHH
ARRRIRTRNYFGAVMLELGEVDGLVTGLTSGYADAVRPSLEVVRTRAGKRAAGVYIVVTK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHCCCCCCCEEEEEEE
HDFKFFADCTVNIDPDADELAEIAITTSDLARYFEVTPRVAMLSYSTFGSAGGGSPQKMR
CCCEEEEEEEEECCCCHHHHHHHEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHH
DAAALVRQRRPDLEVEGEIQVAIATNGDVRVPEFPFSTLKEDANVFVFPNLDSANIAYQL
HHHHHHHHCCCCCCCCCEEEEEEECCCCEECCCCCHHHHHCCCCEEEEECCCCHHHHHHH
LENVGGAEVIGPVLLGMHKPVNCLQMGCSVQSIVNLAAITALRAQGDQFLF
HHCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ASDFTPPQNPPSSPVPKKKIRREDALAYHSSGRRGKIEVVPTKPCATARDLALAYSPGV
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHEEEEECCCC
AEPCLEIEKDPDASYLYTARGNLVAVVSNGTAVLGLGNIGPAAGKPVMEGKGVLFKKFAD
CCHHHHCCCCCCCCEEEEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEEECC
VDVFDINVDALEIDKFCTVVKALEPTFGGINLEDIKAPECFVIEARLKKEMQIPVFHDDQ
CEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEEHHHCCCCCCEEECCC
HGTAIISGAALLNALELAGKKIGDVRVVVSGAGASAIACTKFYLTLGVRRENVVMVDTKG
CCCEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHEEEEEECCCCCCEEEEECCC
VIYRGRTEGMNEWKAEFAADTKARTLADALKGADVLLGCSTKGMVAQEMVRSMAKDPIVF
EEEECCCCCCHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEE
ALANPDPEIDYPEAKAAREDVIMATGRSDFPNQVNNVLGFPYIFRGALDVRAKAITEDMK
EECCCCCCCCCCCHHHHHCCEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
MAAAKALAELAKQDVPDSVSRAYAGEKFRFGRDYIIPKPLDPRVLLWVAPAVAQAAIDGG
HHHHHHHHHHHHHCCCHHHHHHHCCCCEECCCCCCCCCCCCCCEEEEECHHHHHHHHCCC
VARVKLDMDEYRDRLRKMQSRSHQVMGSIFTKAKKKLARIVFPEGHHPKIQQAAEILREE
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
AICEPVLLGPVEAIRRSIADQRLDDLDGVTIIDPMDSPEFARYVARYWELRQRRGITVEE
HHCCCHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHH
ARRRIRTRNYFGAVMLELGEVDGLVTGLTSGYADAVRPSLEVVRTRAGKRAAGVYIVVTK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHCCCCCCCEEEEEEE
HDFKFFADCTVNIDPDADELAEIAITTSDLARYFEVTPRVAMLSYSTFGSAGGGSPQKMR
CCCEEEEEEEEECCCCHHHHHHHEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHH
DAAALVRQRRPDLEVEGEIQVAIATNGDVRVPEFPFSTLKEDANVFVFPNLDSANIAYQL
HHHHHHHHCCCCCCCCCEEEEEEECCCCEECCCCCHHHHHCCCCEEEEECCCCHHHHHHH
LENVGGAEVIGPVLLGMHKPVNCLQMGCSVQSIVNLAAITALRAQGDQFLF
HHCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]