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The map label for this gene is mutM [H]

Identifier: 220919150

GI number: 220919150

Start: 4548182

End: 4549147

Strand: Direct

Name: mutM [H]

Synonym: A2cp1_4070

Alternate gene names: 220919150

Gene position: 4548182-4549147 (Clockwise)

Preceding gene: 220919146

Following gene: 220919151

Centisome position: 90.43

GC content: 76.5

Gene sequence:

>966_bases
GTGCCGGAGCTGCCGGACATCGAGGTGTACGTCGAGGCGCTCGCGGCGCGGGTGCTGGGTCAGCCGCTGGAGCGCATCCG
GCTGGGGAACCCCTTCCTGCTCCGCTCCGCAGACCCGCCGCTCGCGGAGGCGGAGGGGCGGCGCGTCGCCGCGGTGCGCC
GGCAGGGCAAGCGCCTCGTCCTGGCGCTCGACGGCGACCTCCACCTGGCGCTGCACCTCATGATCGCGGGCCGGCTGCAC
TGGAAGGACCCCGGCGCGCGGCTCCCGGGGAAGGCGGGGCTGGCGGCGTTCGACTTCCCCAACGGCACGCTGGTCCTCAC
CGAGGCCGGCACGAAGCGGCGCGCCGCGCTCCACCTGGTGCGCGGCGCCGCGGCGCTCGCCGCGCTGGACCGCGGCGGCA
TCGAGCCGCTCGACGTGGACCTCGCCGCGTTCGCCGCCGCGCTCCGGCGCGAGAACCACACGCTGAAGCGCGCGCTGACG
GATCCCTCGCTCTTCTCCGGCATCGGCAACGCCTACTCGGACGAGATCCTGCACCGGGCCCGCCTGTCGCCGGTCGCGCT
GACGTCGCGGCTCGGCGACGCAGAGGTGGCGCGCCTGTTCGAGGCCACGCGCGAGGTGCTGACCGGCTGGACGGCGCGGC
TCCGCGAGGAGGCGGGGAGCGGCTTCCCCGAGGGCGTCACCGCGTTCCGCGAGGGAATGGCCGTGCACGGACGGCACCGC
CAGCCGTGCCCGGTGTGCGGCACCGCGGTGCAGCGGATCGTGCGCGCGGAGAACGAGGTGAACTACTGCCCGCGCTGCCA
GACCGGCGGGCAGATCCTCTCGGACCGCTCCCTCGCCCGCCTGCTGAAGCACGACTGGCCACGGACGGTGGACGAGCTGG
AGCGCAACCCGGCGCTCGGCCTCCGGCCCGCGCCGGGGCCGGCCGGGCCGCGATCCAGGGGGCCGCCGCGCCGTTCGTCG
CGCTGA

Upstream 100 bases:

>100_bases
TCTAGCAGATTTCGGGGGCGCGGCGGGGCGGCGGTGCCCGGTCGGGCGGGGGGGCGGAGACGGCCTGGCCGCGCGGGCCG
CGCCGGGGCAGGATCCCGGG

Downstream 100 bases:

>100_bases
CGCCCCGCGCCTGCGTCGAGTCCCACGCGCACGGTGCCACGCGCGCGACGCACCCGTGGACCGGAAGGCGACGGCCCGTC
CGTGCGGAAGTGCCTGCAAT

Product: DNA-formamidopyrimidine glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MPELPDIEVYVEALAARVLGQPLERIRLGNPFLLRSADPPLAEAEGRRVAAVRRQGKRLVLALDGDLHLALHLMIAGRLH
WKDPGARLPGKAGLAAFDFPNGTLVLTEAGTKRRAALHLVRGAAALAALDRGGIEPLDVDLAAFAAALRRENHTLKRALT
DPSLFSGIGNAYSDEILHRARLSPVALTSRLGDAEVARLFEATREVLTGWTARLREEAGSGFPEGVTAFREGMAVHGRHR
QPCPVCGTAVQRIVRAENEVNYCPRCQTGGQILSDRSLARLLKHDWPRTVDELERNPALGLRPAPGPAGPRSRGPPRRSS
R

Sequences:

>Translated_321_residues
MPELPDIEVYVEALAARVLGQPLERIRLGNPFLLRSADPPLAEAEGRRVAAVRRQGKRLVLALDGDLHLALHLMIAGRLH
WKDPGARLPGKAGLAAFDFPNGTLVLTEAGTKRRAALHLVRGAAALAALDRGGIEPLDVDLAAFAAALRRENHTLKRALT
DPSLFSGIGNAYSDEILHRARLSPVALTSRLGDAEVARLFEATREVLTGWTARLREEAGSGFPEGVTAFREGMAVHGRHR
QPCPVCGTAVQRIVRAENEVNYCPRCQTGGQILSDRSLARLLKHDWPRTVDELERNPALGLRPAPGPAGPRSRGPPRRSS
R
>Mature_320_residues
PELPDIEVYVEALAARVLGQPLERIRLGNPFLLRSADPPLAEAEGRRVAAVRRQGKRLVLALDGDLHLALHLMIAGRLHW
KDPGARLPGKAGLAAFDFPNGTLVLTEAGTKRRAALHLVRGAAALAALDRGGIEPLDVDLAAFAAALRRENHTLKRALTD
PSLFSGIGNAYSDEILHRARLSPVALTSRLGDAEVARLFEATREVLTGWTARLREEAGSGFPEGVTAFREGMAVHGRHRQ
PCPVCGTAVQRIVRAENEVNYCPRCQTGGQILSDRSLARLLKHDWPRTVDELERNPALGLRPAPGPAGPRSRGPPRRSSR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=275, Percent_Identity=26.5454545454545, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 34830; Mature: 34699

Theoretical pI: Translated: 10.76; Mature: 10.76

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPDIEVYVEALAARVLGQPLERIRLGNPFLLRSADPPLAEAEGRRVAAVRRQGKRLV
CCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECCCCCCHHHCCCHHHHHHHCCCEEE
LALDGDLHLALHLMIAGRLHWKDPGARLPGKAGLAAFDFPNGTLVLTEAGTKRRAALHLV
EEECCCHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHH
RGAAALAALDRGGIEPLDVDLAAFAAALRRENHTLKRALTDPSLFSGIGNAYSDEILHRA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHHH
RLSPVALTSRLGDAEVARLFEATREVLTGWTARLREEAGSGFPEGVTAFREGMAVHGRHR
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHCCCCC
QPCPVCGTAVQRIVRAENEVNYCPRCQTGGQILSDRSLARLLKHDWPRTVDELERNPALG
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCC
LRPAPGPAGPRSRGPPRRSSR
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPDIEVYVEALAARVLGQPLERIRLGNPFLLRSADPPLAEAEGRRVAAVRRQGKRLV
CCCCHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECCCCCCHHHCCCHHHHHHHCCCEEE
LALDGDLHLALHLMIAGRLHWKDPGARLPGKAGLAAFDFPNGTLVLTEAGTKRRAALHLV
EEECCCHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHH
RGAAALAALDRGGIEPLDVDLAAFAAALRRENHTLKRALTDPSLFSGIGNAYSDEILHRA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHHH
RLSPVALTSRLGDAEVARLFEATREVLTGWTARLREEAGSGFPEGVTAFREGMAVHGRHR
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHCCCCC
QPCPVCGTAVQRIVRAENEVNYCPRCQTGGQILSDRSLARLLKHDWPRTVDELERNPALG
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCC
LRPAPGPAGPRSRGPPRRSSR
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA