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The map label for this gene is metC [H]

Identifier: 220918933

GI number: 220918933

Start: 4276404

End: 4277576

Strand: Direct

Name: metC [H]

Synonym: A2cp1_3847

Alternate gene names: 220918933

Gene position: 4276404-4277576 (Clockwise)

Preceding gene: 220918932

Following gene: 220918934

Centisome position: 85.03

GC content: 72.8

Gene sequence:

>1173_bases
ATGGCCGACGCCGAGACGAAGCCCGGGTTCGACACCCTCGCCATCCACGCCGGCCAGGCGCCGGATCCGACCACCGGCGC
GATCATGACGCCGGTGTACCTGTCGTCCACCTACGTGCAGGCCTCGCCCGGCGTGCACAAGGGCTTCGAGTACTCGCGCA
CCCGCAACCCGACGCGCGACGCGCTCCAGGGCTGCCTGGCGGCGCTGGAGGGCGGCCGGCACGCGCTCGCGTTCGCCTCC
GGCCTCGCCGCCACCGACGCGATCCTCCACCTGCTCCAGGCGGGCGACCACGTCCTCGCCTCGGACGACGTGTACGGCGG
CACCTTCCGCATCTTCGACAAGGTGTTCCGCCGCCACGGGCTGGAGTTCTCGCACGTGGACATGAGCGACCCGCGCAACG
TGGAGCGCGGGCTGCGCCCGAACACGCGGCTGGTGTGGATCGAGAGCCCCACCAACCCCATGCTGAAGATCGTGGACCTC
GCCGAGGTGGCGCGGATGGCGCGGGCGCACGGGGCGCGCACGGTGGTGGACAACACCTTCGCCACGCCGTACTTCCAGCG
TCCGCTCGAGCTCGGCATCGACCTCGTCGCCCACTCCACCACCAAGTACCTGAACGGCCACTCCGACGTGATCGGCGGGG
CGCTGGTGACCTCGGACGACGCGCTGCACGAGCGGCTCGCGTTCCTGCAGAACGCGGTGGGCGGGGTGCCCGGGCCGCTC
GACAGCTTCCTGGTGCTGCGCGGGCTGAAGACGCTGCACGTGCGCATGCAGCGCCACGCCGAGAACGCGCTCGCGCTGGC
GCGCTTCCTGGAGGGCCACCCGCAGGTGGAGCGCGTCACCTACCCGGGCCTCGCCTCGCACCCGCAGCACGGGCTCGCGG
CCCGGCAGATGAGGGGCTTCGGCGGCATGCTCACGTTCGTGATCCGCGGCGGCCTGCCGGCGGCGCGCGCCTTCCTCGAG
CACGTGCGGATCTTCGCGTGCGCGGAGTCGCTCGGGGGCGTGGAGAGCCTCATCGAGCACCCGGCCATCATGACCCACGC
GTCGGTGCCGAAGGAGACGCGCGAGGCGCTCGGGATCGCGGACGGCTTCATCCGCGTCTCCGCCGGGATCGAGGCGGTGG
ACGACCTCCGAGCCGACCTCGAGCGCGGCTTCGCCGCCGCGCGCCGCGCGTGA

Upstream 100 bases:

>100_bases
AGGAGGGCGATCGGGTCACCGGCATCGTGACCAAGATCGACCTCATCGAGTTCCTGGCGCAGCGGCTCCGCTAGCCGCCC
CGCCCTCCCACGGAGCGACC

Downstream 100 bases:

>100_bases
CGGCGGCCCCGGTCCGTGCCACGCTCGCGGGCATGAGACCGCTCGCTGCCGCCTGCCTCGCCGCCGTCCTCGCCGTCACC
GCGGCTCCGGCCGCCCGGGC

Product: Cystathionine gamma-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MADAETKPGFDTLAIHAGQAPDPTTGAIMTPVYLSSTYVQASPGVHKGFEYSRTRNPTRDALQGCLAALEGGRHALAFAS
GLAATDAILHLLQAGDHVLASDDVYGGTFRIFDKVFRRHGLEFSHVDMSDPRNVERGLRPNTRLVWIESPTNPMLKIVDL
AEVARMARAHGARTVVDNTFATPYFQRPLELGIDLVAHSTTKYLNGHSDVIGGALVTSDDALHERLAFLQNAVGGVPGPL
DSFLVLRGLKTLHVRMQRHAENALALARFLEGHPQVERVTYPGLASHPQHGLAARQMRGFGGMLTFVIRGGLPAARAFLE
HVRIFACAESLGGVESLIEHPAIMTHASVPKETREALGIADGFIRVSAGIEAVDDLRADLERGFAAARRA

Sequences:

>Translated_390_residues
MADAETKPGFDTLAIHAGQAPDPTTGAIMTPVYLSSTYVQASPGVHKGFEYSRTRNPTRDALQGCLAALEGGRHALAFAS
GLAATDAILHLLQAGDHVLASDDVYGGTFRIFDKVFRRHGLEFSHVDMSDPRNVERGLRPNTRLVWIESPTNPMLKIVDL
AEVARMARAHGARTVVDNTFATPYFQRPLELGIDLVAHSTTKYLNGHSDVIGGALVTSDDALHERLAFLQNAVGGVPGPL
DSFLVLRGLKTLHVRMQRHAENALALARFLEGHPQVERVTYPGLASHPQHGLAARQMRGFGGMLTFVIRGGLPAARAFLE
HVRIFACAESLGGVESLIEHPAIMTHASVPKETREALGIADGFIRVSAGIEAVDDLRADLERGFAAARRA
>Mature_389_residues
ADAETKPGFDTLAIHAGQAPDPTTGAIMTPVYLSSTYVQASPGVHKGFEYSRTRNPTRDALQGCLAALEGGRHALAFASG
LAATDAILHLLQAGDHVLASDDVYGGTFRIFDKVFRRHGLEFSHVDMSDPRNVERGLRPNTRLVWIESPTNPMLKIVDLA
EVARMARAHGARTVVDNTFATPYFQRPLELGIDLVAHSTTKYLNGHSDVIGGALVTSDDALHERLAFLQNAVGGVPGPLD
SFLVLRGLKTLHVRMQRHAENALALARFLEGHPQVERVTYPGLASHPQHGLAARQMRGFGGMLTFVIRGGLPAARAFLEH
VRIFACAESLGGVESLIEHPAIMTHASVPKETREALGIADGFIRVSAGIEAVDDLRADLERGFAAARRA

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=362, Percent_Identity=54.6961325966851, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI299473759, Length=362, Percent_Identity=48.3425414364641, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI25453487, Length=361, Percent_Identity=48.1994459833795, Blast_Score=337, Evalue=1e-92,
Organism=Escherichia coli, GI1790375, Length=379, Percent_Identity=43.7994722955145, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1789383, Length=404, Percent_Identity=30.9405940594059, Blast_Score=171, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=370, Percent_Identity=53.5135135135135, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17538055, Length=370, Percent_Identity=54.8648648648649, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71980708, Length=365, Percent_Identity=38.3561643835616, Blast_Score=255, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6319307, Length=388, Percent_Identity=47.1649484536082, Blast_Score=353, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6321254, Length=398, Percent_Identity=33.9195979899498, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323333, Length=434, Percent_Identity=33.4101382488479, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6321170, Length=334, Percent_Identity=32.3353293413174, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6321904, Length=333, Percent_Identity=31.2312312312312, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI19922554, Length=387, Percent_Identity=49.8708010335917, Blast_Score=411, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42060; Mature: 41929

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAETKPGFDTLAIHAGQAPDPTTGAIMTPVYLSSTYVQASPGVHKGFEYSRTRNPTRD
CCCCCCCCCCCEEEEECCCCCCCCCCCEECHHHHCCEEEECCCCCCCCCCCHHCCCCHHH
ALQGCLAALEGGRHALAFASGLAATDAILHLLQAGDHVLASDDVYGGTFRIFDKVFRRHG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHC
LEFSHVDMSDPRNVERGLRPNTRLVWIESPTNPMLKIVDLAEVARMARAHGARTVVDNTF
CCEEECCCCCCHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEECCCCC
ATPYFQRPLELGIDLVAHSTTKYLNGHSDVIGGALVTSDDALHERLAFLQNAVGGVPGPL
CCHHHHCHHHHCHHHHHHHHHHHHCCCCHHHCCEEECCCHHHHHHHHHHHHHHCCCCCCH
DSFLVLRGLKTLHVRMQRHAENALALARFLEGHPQVERVTYPGLASHPQHGLAARQMRGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHCC
GGMLTFVIRGGLPAARAFLEHVRIFACAESLGGVESLIEHPAIMTHASVPKETREALGIA
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCCCCHHHHHHHHHH
DGFIRVSAGIEAVDDLRADLERGFAAARRA
HHHEEECCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADAETKPGFDTLAIHAGQAPDPTTGAIMTPVYLSSTYVQASPGVHKGFEYSRTRNPTRD
CCCCCCCCCCEEEEECCCCCCCCCCCEECHHHHCCEEEECCCCCCCCCCCHHCCCCHHH
ALQGCLAALEGGRHALAFASGLAATDAILHLLQAGDHVLASDDVYGGTFRIFDKVFRRHG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHC
LEFSHVDMSDPRNVERGLRPNTRLVWIESPTNPMLKIVDLAEVARMARAHGARTVVDNTF
CCEEECCCCCCHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEECCCCC
ATPYFQRPLELGIDLVAHSTTKYLNGHSDVIGGALVTSDDALHERLAFLQNAVGGVPGPL
CCHHHHCHHHHCHHHHHHHHHHHHCCCCHHHCCEEECCCHHHHHHHHHHHHHHCCCCCCH
DSFLVLRGLKTLHVRMQRHAENALALARFLEGHPQVERVTYPGLASHPQHGLAARQMRGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHCC
GGMLTFVIRGGLPAARAFLEHVRIFACAESLGGVESLIEHPAIMTHASVPKETREALGIA
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCCCCHHHHHHHHHH
DGFIRVSAGIEAVDDLRADLERGFAAARRA
HHHEEECCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]