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The map label for this gene is atoC [H]

Identifier: 220918878

GI number: 220918878

Start: 4212300

End: 4213757

Strand: Direct

Name: atoC [H]

Synonym: A2cp1_3792

Alternate gene names: 220918878

Gene position: 4212300-4213757 (Clockwise)

Preceding gene: 220918877

Following gene: 220918879

Centisome position: 83.75

GC content: 76.68

Gene sequence:

>1458_bases
ATGGGCGCGAGCGATGCGGCCGAGCCGTTCGGCGCGGGAAGGTCCTGCCTGGTCGTCGCGGCGGGCGGCGCGCCGGAGAT
CGCGGCGGCGCTGGTGCGGGCGGGCTTCGCCCCCGCGGTGGTCGAGGGCGAGCACGACGCGCTCGCCGCGCTGGAGGGCG
GCGGGTTCGCGGCGGTCTACGTGGAGCAGGCGCTGGGCAGCGCCGCGGTCTCGACGCTCGCCGCCGCCGCCGGGCAGCGG
CTGGGCGGCGCGCCGGTGACGGTGCTCGGGCGCAGCGGCACGGTCCAGGAGGCGGTGGACGCCATGCAGCTCGGCGCCGA
CGACTACCTGCCGCCGCCGTTCCCCGCCGGCGAGCTGCTGCGGCGCCTCGCCCGCGCGCTGGAGCGCCCCGGGCCCGCGC
GCACGGCCGCGCCGGGCCGGCTGCTCGGCCTGGACGGCTCCTCGCCCGCGGTGCGGCGGCTCCACGCCGCCATCGAGAAG
ATCTCGCGCTACAAGAGCAACGTCCTGCTGCTCGGCGAGAGCGGCACCGGCAAGGAGATCGTCGCGCACGCGCTGCACGA
CCGCGGGCCGCGCCGGCAGCACCTGTTCGTCCCGGTGAACTGCGCCACGCTCGGGCGCGACATCCTCGAGAACGAGCTGT
TCGGGCACGAGCGCGGCGCGTTCACCGGCGCGAACGAGCGCAAGCGGGGGCTGTTCGAGCTCGCCGACGGCGGGACGTTC
TTCCTCGACGAGATCGCCGAGATGGACCTCTCCACGCAGGCGAAGCTGCTGCGCGTGCTGGAGCGGAACGAGTTCCGGCG
CGTGGGCGGCACCGGCAAGGTGAAGGTGGACCTCTCCATCGTGGCCGCCACCAACCGCGACCTCGAGCAGGCCATCGCCG
CCGGGCGCTTCCGCCACGACCTGTACTACCGGCTGAAGGTAGTGACGCTGGTGGTCCCGCCCCTGCGCGAGCGGCGCGAG
GACATCCCGGCGCTCGTCCACGCGTTCATCGCCGACTTCAACCGGCGGAGCGGCGGGCAGATCGCCGGGATCGCGCCGGC
GGCCATCCAGCGCCTGGTGGAGCAGGACTGGCCGGGCAACGTCCGCGAGCTGCGCAACGCGGTCGAGGGCGCCTGCGTGC
TCGCGAACGGCGAGGTGGTGAAGCTCGAGGACCTGGAGCTGGCCGGCCGGCCCGCCGGCGAGGTCCCCGCGCCCCGGCGC
CTCGCCGCGCCCCGGCGCACCGCGGCGGCTCCCGCGCCGACCTCGACCGTCGCCGCGCCCGCGCCGGCCGCCGGCGCGGT
GGTCGAGGTGTCGCTCGACGAGACGCTCGCCGAGGCGGAGCGGCGAATCGTGCTCGCGGCCCTCCGCCGCCACGGCACGC
GCGCCCGGACCGCGCGTGCGCTCGGCATCGGGCTCCGCACGCTCTACACCAAGCTCGCGGCCTGGGGCCTCGAGCCCGAG
GATGCCGGATCGGCATGA

Upstream 100 bases:

>100_bases
GCGACGACGGCCGCTGACCGGCCGGTCGCGCCGCGGGCGCTGGCCTGCCGTTCTTGCATCACGTGCCGAATCGGCAGTAG
AAGGGGCGGCAGGAGGCCCC

Downstream 100 bases:

>100_bases
TGCGGCCGGCGCCCACCGACGCCTGCGGATGCGCCAAGCGCCCGGATTCCCGGCGTTCCGGATGAAATGACGCGGTGGCG
CGGTTCCTGCTCTCGGGTGG

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MGASDAAEPFGAGRSCLVVAAGGAPEIAAALVRAGFAPAVVEGEHDALAALEGGGFAAVYVEQALGSAAVSTLAAAAGQR
LGGAPVTVLGRSGTVQEAVDAMQLGADDYLPPPFPAGELLRRLARALERPGPARTAAPGRLLGLDGSSPAVRRLHAAIEK
ISRYKSNVLLLGESGTGKEIVAHALHDRGPRRQHLFVPVNCATLGRDILENELFGHERGAFTGANERKRGLFELADGGTF
FLDEIAEMDLSTQAKLLRVLERNEFRRVGGTGKVKVDLSIVAATNRDLEQAIAAGRFRHDLYYRLKVVTLVVPPLRERRE
DIPALVHAFIADFNRRSGGQIAGIAPAAIQRLVEQDWPGNVRELRNAVEGACVLANGEVVKLEDLELAGRPAGEVPAPRR
LAAPRRTAAAPAPTSTVAAPAPAAGAVVEVSLDETLAEAERRIVLAALRRHGTRARTARALGIGLRTLYTKLAAWGLEPE
DAGSA

Sequences:

>Translated_485_residues
MGASDAAEPFGAGRSCLVVAAGGAPEIAAALVRAGFAPAVVEGEHDALAALEGGGFAAVYVEQALGSAAVSTLAAAAGQR
LGGAPVTVLGRSGTVQEAVDAMQLGADDYLPPPFPAGELLRRLARALERPGPARTAAPGRLLGLDGSSPAVRRLHAAIEK
ISRYKSNVLLLGESGTGKEIVAHALHDRGPRRQHLFVPVNCATLGRDILENELFGHERGAFTGANERKRGLFELADGGTF
FLDEIAEMDLSTQAKLLRVLERNEFRRVGGTGKVKVDLSIVAATNRDLEQAIAAGRFRHDLYYRLKVVTLVVPPLRERRE
DIPALVHAFIADFNRRSGGQIAGIAPAAIQRLVEQDWPGNVRELRNAVEGACVLANGEVVKLEDLELAGRPAGEVPAPRR
LAAPRRTAAAPAPTSTVAAPAPAAGAVVEVSLDETLAEAERRIVLAALRRHGTRARTARALGIGLRTLYTKLAAWGLEPE
DAGSA
>Mature_484_residues
GASDAAEPFGAGRSCLVVAAGGAPEIAAALVRAGFAPAVVEGEHDALAALEGGGFAAVYVEQALGSAAVSTLAAAAGQRL
GGAPVTVLGRSGTVQEAVDAMQLGADDYLPPPFPAGELLRRLARALERPGPARTAAPGRLLGLDGSSPAVRRLHAAIEKI
SRYKSNVLLLGESGTGKEIVAHALHDRGPRRQHLFVPVNCATLGRDILENELFGHERGAFTGANERKRGLFELADGGTFF
LDEIAEMDLSTQAKLLRVLERNEFRRVGGTGKVKVDLSIVAATNRDLEQAIAAGRFRHDLYYRLKVVTLVVPPLRERRED
IPALVHAFIADFNRRSGGQIAGIAPAAIQRLVEQDWPGNVRELRNAVEGACVLANGEVVKLEDLELAGRPAGEVPAPRRL
AAPRRTAAAPAPTSTVAAPAPAAGAVVEVSLDETLAEAERRIVLAALRRHGTRARTARALGIGLRTLYTKLAAWGLEPED
AGSA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=411, Percent_Identity=40.1459854014599, Blast_Score=282, Evalue=4e-77,
Organism=Escherichia coli, GI1790437, Length=396, Percent_Identity=40.6565656565657, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI1790299, Length=411, Percent_Identity=40.632603406326, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1789233, Length=339, Percent_Identity=41.8879056047198, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082117, Length=237, Percent_Identity=46.8354430379747, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789087, Length=237, Percent_Identity=47.2573839662447, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1788905, Length=303, Percent_Identity=40.9240924092409, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI87082152, Length=354, Percent_Identity=38.9830508474576, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1786524, Length=282, Percent_Identity=41.8439716312057, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1787583, Length=356, Percent_Identity=33.9887640449438, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI87081872, Length=289, Percent_Identity=38.0622837370242, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1789828, Length=254, Percent_Identity=37.007874015748, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081858, Length=332, Percent_Identity=29.5180722891566, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50933; Mature: 50802

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGASDAAEPFGAGRSCLVVAAGGAPEIAAALVRAGFAPAVVEGEHDALAALEGGGFAAVY
CCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEECCCCCCEEEECCCCEEEEH
VEQALGSAAVSTLAAAAGQRLGGAPVTVLGRSGTVQEAVDAMQLGADDYLPPPFPAGELL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHH
RRLARALERPGPARTAAPGRLLGLDGSSPAVRRLHAAIEKISRYKSNVLLLGESGTGKEI
HHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHH
VAHALHDRGPRRQHLFVPVNCATLGRDILENELFGHERGAFTGANERKRGLFELADGGTF
HHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEECCCCCH
FLDEIAEMDLSTQAKLLRVLERNEFRRVGGTGKVKVDLSIVAATNRDLEQAIAAGRFRHD
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHH
LYYRLKVVTLVVPPLRERREDIPALVHAFIADFNRRSGGQIAGIAPAAIQRLVEQDWPGN
HHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHCCCCCC
VRELRNAVEGACVLANGEVVKLEDLELAGRPAGEVPAPRRLAAPRRTAAAPAPTSTVAAP
HHHHHHHHCCEEEEECCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCC
APAAGAVVEVSLDETLAEAERRIVLAALRRHGTRARTARALGIGLRTLYTKLAAWGLEPE
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
DAGSA
CCCCC
>Mature Secondary Structure 
GASDAAEPFGAGRSCLVVAAGGAPEIAAALVRAGFAPAVVEGEHDALAALEGGGFAAVY
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEECCCCCCEEEECCCCEEEEH
VEQALGSAAVSTLAAAAGQRLGGAPVTVLGRSGTVQEAVDAMQLGADDYLPPPFPAGELL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHH
RRLARALERPGPARTAAPGRLLGLDGSSPAVRRLHAAIEKISRYKSNVLLLGESGTGKEI
HHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHH
VAHALHDRGPRRQHLFVPVNCATLGRDILENELFGHERGAFTGANERKRGLFELADGGTF
HHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEECCCCCH
FLDEIAEMDLSTQAKLLRVLERNEFRRVGGTGKVKVDLSIVAATNRDLEQAIAAGRFRHD
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHH
LYYRLKVVTLVVPPLRERREDIPALVHAFIADFNRRSGGQIAGIAPAAIQRLVEQDWPGN
HHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHCCCCCC
VRELRNAVEGACVLANGEVVKLEDLELAGRPAGEVPAPRRLAAPRRTAAAPAPTSTVAAP
HHHHHHHHCCEEEEECCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCC
APAAGAVVEVSLDETLAEAERRIVLAALRRHGTRARTARALGIGLRTLYTKLAAWGLEPE
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
DAGSA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]