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The map label for this gene is lon1 [H]

Identifier: 220918588

GI number: 220918588

Start: 3907953

End: 3910391

Strand: Reverse

Name: lon1 [H]

Synonym: A2cp1_3496

Alternate gene names: 220918588

Gene position: 3910391-3907953 (Counterclockwise)

Preceding gene: 220918590

Following gene: 220918584

Centisome position: 77.75

GC content: 66.46

Gene sequence:

>2439_bases
GTGCCCATTTTCTCGCGCAACGACGACGGGAAGAAGGACGGGAAGAAGAGCCGCACGCTGCCGCTCCTCCCGCTCCGCGA
CATCATCGTGTTTCCCCACATGGTGGTGCCGCTGTTCGTCGGCCGTCAGAAGTCGATCGCCGCACTCGAGGAGGCCATGG
CGCACGACAAGGCCATCCTCCTCTGCGCGCAGAAGAAGGCGAAGACGAACGAGCCCGCCGCCGACGACATCTTCGCGGTC
GGGACCGTCGGCTCGATCATCCAGCTGCTCCGCCTGCCCGACGGCACCGTGAAGGTGCTGGTCGAGGGCAAGCAGCGCGC
CCGCGTCCGCCGCTTCCTCGACTCCGACAAGTTCCTGGTGGTCGAGGCGGAGGACATCGAGGAGGAGAGCGAGCGCACCG
TCGAGCTCGAGGCGCTGATGCGCTCCGTGCACTCGACGTTCGAGGCCTACGTCAAGCTCAACAAGCGCATCCCGCCGGAG
ATGCTGACCTCGGTGTCGTCCATCGACGATCCGGCGCGGCTCGCCGACACCATCGTCGCGCACCTCTCGCTCAAGCTGAA
CGACAAGCAGTCGATCCTCGAGACCGAGTCCCCGGCGAAGCGGCTGGAGAAGCTCTACGAGCTGATGCAGGGCGAGATCG
AGATCCTGCAGGTCGAGAAGAAGATCCGGACGCGCGTCAAGAAGCAGATGGAGAAGACGCAGAAGGAGTACTACCTCAAC
GAGCAGATGCAGGCGATCCAGAAGGAGCTCGGCGAGCGCGACGAGTTCAAGAACGAGATCCAGGAGCTCGAGGAGAAGAT
CAAGAACAAGAAGATGTCGAAGGAGGCCACCCTCAAGGCCAAGAAGGAGCTCAAGAAGCTCAAGATGATGAGCCCGATGA
GCGCCGAGGCCACGGTGGTCCGCAACTACATCGACTGGATCCTCTCGCTCCCCTGGTACGACTACACCGAGGACAAGCTC
GAGATCCCCGAGGCCGAGAAGGTCCTCGACGAGGATCACTACGGGTTGAAGAAGCCCAAGGAGCGGATCATCGAGTACCT
CGCGGTCCAGAAGCTGGTGGACCGGATCCGCGGCCCCATCCTCTGCTTCGTGGGCCCGCCGGGCGTGGGCAAGACCTCGC
TGGCGAAGTCGATCGCCCGCTCCATGAACCGCCGCTTCGTGCGCATCAGCCTCGGCGGCGTGCGCGACGAGGCCGAGATC
CGCGGGCACCGGCGCACGTACATCGGCGCGCTGCCGGGCAAGATCATCCAGTCGCTGAAGAAGGCGGGCTCCGGCAACCC
GGTGTTCCTGCTCGACGAGGTGGACAAGATGTCCACCGACTTCCGCGGCGACCCGTCGGCCGCGCTGCTCGAGGTGCTCG
ACCCCGAGCAGAACTTCAACTTCAACGACCACTACCTCGACCTCGACTACGACCTCTCCAAGGTCATGTTCATCTGCACG
GCGAACACCATGGCGGGCATCCCGCTGCCGCTGCAGGACCGCATGGAGGTGATCCGGCTCGCGGGCTACACCGACCTGGA
GAAGCTCTCCATCGCGAAGCGGTACCTGGTCCCGAAGCAGAAGGAGGTCAACGGCCTCGAGCACGTGCCGGTCGAGTTCA
AGCGCAGCGCGATGCGGGCCCTGGTGCACAAGTACACCAAGGAGTCCGGCGTCCGCTCGCTGGAGCGCGAGATCGGCTCG
ATCTGCCGGAAGATCGCGAAGGACGTGCTGAAGACCGGGCAGGTGGACGGCAAGACGTACGTGGTCACCGAGCGGATGGT
GCAGAAGTACCTGGGCCCGCCGCGCTACCGCTACGGCACCGCCGAGGAGCAGGACCAGGTCGGCCTCACCACCGGCCTCG
CCTGGACCGAGCTCGGCGGCGAGCTGCTCACCGTCGAGGCGCAGGTCATGCCCGGCAAGGGCAAGCTCACCATCACCGGC
AAGCTCGGCGAGGTGATGCAGGAGTCCGCGCAGGCCGCCATGAGCTACGTGCGCTCGCGCGCCGAGCTGCTCGGGCTCGA
CAAGCGGTTCCTCGAGAACGTGGACATCCACGTCCACGTGCCCGAGGGCGCCATCCCCAAGGACGGCCCCTCCGCCGGCA
TCACCATGGCCACCACGCTGGTCTCGGCGCTCTGCCGCATCCCCGTCCGCAAGGACGTGGCCATGACCGGCGAGATCACG
CTGCGCGGCCGCGTGCTTCCCATCGGCGGCCTGAAGGAGAAGGTCCTCGCCGCCCACCGCGGCGGGATCAAGAAGGTCCT
GATCCCGAAGGAGAACCAGAAGGACATCCGCGAGATCCCCCGCCGCGTCCGCGAGAAGCTCCAGATCGTGCCCGTGGACC
ACGCCGACGAGGTGCTGCGCGAGGCGCTGCTGCTCGAGCACCCCGAGGAGTTCCTCGCGAAGCCCGGCGGCCCGAAGCCC
GAGGCCTCCTCCGCCGGCGGCGCCGCCGCGCAGGCCTAG

Upstream 100 bases:

>100_bases
TGAGTGCGGTCCCGAAGAACGGGGGCGGCCCGGATGTTAAGTGTTAGTCTCTCACCGGCCTCGACGGGCTGCTCCGGGGC
CACCAAGGAGCCTGACCACC

Downstream 100 bases:

>100_bases
CCTCCGCCGCTCCGACGTTCCCGTGGCCGGTCGCGCACCCGCGCGGCCGGCCCTTCTCGTTCATCGCGGCGGGCTCGCGG
CCTACGGGAGATGCCCGCTG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 812; Mature: 811

Protein sequence:

>812_residues
MPIFSRNDDGKKDGKKSRTLPLLPLRDIIVFPHMVVPLFVGRQKSIAALEEAMAHDKAILLCAQKKAKTNEPAADDIFAV
GTVGSIIQLLRLPDGTVKVLVEGKQRARVRRFLDSDKFLVVEAEDIEEESERTVELEALMRSVHSTFEAYVKLNKRIPPE
MLTSVSSIDDPARLADTIVAHLSLKLNDKQSILETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEYYLN
EQMQAIQKELGERDEFKNEIQELEEKIKNKKMSKEATLKAKKELKKLKMMSPMSAEATVVRNYIDWILSLPWYDYTEDKL
EIPEAEKVLDEDHYGLKKPKERIIEYLAVQKLVDRIRGPILCFVGPPGVGKTSLAKSIARSMNRRFVRISLGGVRDEAEI
RGHRRTYIGALPGKIIQSLKKAGSGNPVFLLDEVDKMSTDFRGDPSAALLEVLDPEQNFNFNDHYLDLDYDLSKVMFICT
ANTMAGIPLPLQDRMEVIRLAGYTDLEKLSIAKRYLVPKQKEVNGLEHVPVEFKRSAMRALVHKYTKESGVRSLEREIGS
ICRKIAKDVLKTGQVDGKTYVVTERMVQKYLGPPRYRYGTAEEQDQVGLTTGLAWTELGGELLTVEAQVMPGKGKLTITG
KLGEVMQESAQAAMSYVRSRAELLGLDKRFLENVDIHVHVPEGAIPKDGPSAGITMATTLVSALCRIPVRKDVAMTGEIT
LRGRVLPIGGLKEKVLAAHRGGIKKVLIPKENQKDIREIPRRVREKLQIVPVDHADEVLREALLLEHPEEFLAKPGGPKP
EASSAGGAAAQA

Sequences:

>Translated_812_residues
MPIFSRNDDGKKDGKKSRTLPLLPLRDIIVFPHMVVPLFVGRQKSIAALEEAMAHDKAILLCAQKKAKTNEPAADDIFAV
GTVGSIIQLLRLPDGTVKVLVEGKQRARVRRFLDSDKFLVVEAEDIEEESERTVELEALMRSVHSTFEAYVKLNKRIPPE
MLTSVSSIDDPARLADTIVAHLSLKLNDKQSILETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEYYLN
EQMQAIQKELGERDEFKNEIQELEEKIKNKKMSKEATLKAKKELKKLKMMSPMSAEATVVRNYIDWILSLPWYDYTEDKL
EIPEAEKVLDEDHYGLKKPKERIIEYLAVQKLVDRIRGPILCFVGPPGVGKTSLAKSIARSMNRRFVRISLGGVRDEAEI
RGHRRTYIGALPGKIIQSLKKAGSGNPVFLLDEVDKMSTDFRGDPSAALLEVLDPEQNFNFNDHYLDLDYDLSKVMFICT
ANTMAGIPLPLQDRMEVIRLAGYTDLEKLSIAKRYLVPKQKEVNGLEHVPVEFKRSAMRALVHKYTKESGVRSLEREIGS
ICRKIAKDVLKTGQVDGKTYVVTERMVQKYLGPPRYRYGTAEEQDQVGLTTGLAWTELGGELLTVEAQVMPGKGKLTITG
KLGEVMQESAQAAMSYVRSRAELLGLDKRFLENVDIHVHVPEGAIPKDGPSAGITMATTLVSALCRIPVRKDVAMTGEIT
LRGRVLPIGGLKEKVLAAHRGGIKKVLIPKENQKDIREIPRRVREKLQIVPVDHADEVLREALLLEHPEEFLAKPGGPKP
EASSAGGAAAQA
>Mature_811_residues
PIFSRNDDGKKDGKKSRTLPLLPLRDIIVFPHMVVPLFVGRQKSIAALEEAMAHDKAILLCAQKKAKTNEPAADDIFAVG
TVGSIIQLLRLPDGTVKVLVEGKQRARVRRFLDSDKFLVVEAEDIEEESERTVELEALMRSVHSTFEAYVKLNKRIPPEM
LTSVSSIDDPARLADTIVAHLSLKLNDKQSILETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEYYLNE
QMQAIQKELGERDEFKNEIQELEEKIKNKKMSKEATLKAKKELKKLKMMSPMSAEATVVRNYIDWILSLPWYDYTEDKLE
IPEAEKVLDEDHYGLKKPKERIIEYLAVQKLVDRIRGPILCFVGPPGVGKTSLAKSIARSMNRRFVRISLGGVRDEAEIR
GHRRTYIGALPGKIIQSLKKAGSGNPVFLLDEVDKMSTDFRGDPSAALLEVLDPEQNFNFNDHYLDLDYDLSKVMFICTA
NTMAGIPLPLQDRMEVIRLAGYTDLEKLSIAKRYLVPKQKEVNGLEHVPVEFKRSAMRALVHKYTKESGVRSLEREIGSI
CRKIAKDVLKTGQVDGKTYVVTERMVQKYLGPPRYRYGTAEEQDQVGLTTGLAWTELGGELLTVEAQVMPGKGKLTITGK
LGEVMQESAQAAMSYVRSRAELLGLDKRFLENVDIHVHVPEGAIPKDGPSAGITMATTLVSALCRIPVRKDVAMTGEITL
RGRVLPIGGLKEKVLAAHRGGIKKVLIPKENQKDIREIPRRVREKLQIVPVDHADEVLREALLLEHPEEFLAKPGGPKPE
ASSAGGAAAQA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=780, Percent_Identity=41.025641025641, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI21396489, Length=834, Percent_Identity=36.6906474820144, Blast_Score=538, Evalue=1e-153,
Organism=Escherichia coli, GI1786643, Length=764, Percent_Identity=61.7801047120419, Blast_Score=943, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=701, Percent_Identity=39.8002853067047, Blast_Score=501, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17556486, Length=535, Percent_Identity=42.9906542056075, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6319449, Length=736, Percent_Identity=39.945652173913, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24666867, Length=668, Percent_Identity=41.9161676646707, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=668, Percent_Identity=41.9161676646707, Blast_Score=516, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 91106; Mature: 90975

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIFSRNDDGKKDGKKSRTLPLLPLRDIIVFPHMVVPLFVGRQKSIAALEEAMAHDKAIL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEE
LCAQKKAKTNEPAADDIFAVGTVGSIIQLLRLPDGTVKVLVEGKQRARVRRFLDSDKFLV
EEECHHCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCEEE
VEAEDIEEESERTVELEALMRSVHSTFEAYVKLNKRIPPEMLTSVSSIDDPARLADTIVA
EEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHH
HLSLKLNDKQSILETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEYYLN
HHHEEECCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQMQAIQKELGERDEFKNEIQELEEKIKNKKMSKEATLKAKKELKKLKMMSPMSAEATVV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RNYIDWILSLPWYDYTEDKLEIPEAEKVLDEDHYGLKKPKERIIEYLAVQKLVDRIRGPI
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCE
LCFVGPPGVGKTSLAKSIARSMNRRFVRISLGGVRDEAEIRGHRRTYIGALPGKIIQSLK
EEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCHHHHCCCHHHHHHCCCHHHHHHHH
KAGSGNPVFLLDEVDKMSTDFRGDPSAALLEVLDPEQNFNFNDHYLDLDYDLSKVMFICT
HCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCHHHEEEEEE
ANTMAGIPLPLQDRMEVIRLAGYTDLEKLSIAKRYLVPKQKEVNGLEHVPVEFKRSAMRA
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHH
LVHKYTKESGVRSLEREIGSICRKIAKDVLKTGQVDGKTYVVTERMVQKYLGPPRYRYGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCCCCCC
AEEQDQVGLTTGLAWTELGGELLTVEAQVMPGKGKLTITGKLGEVMQESAQAAMSYVRSR
CCCCCCCCHHHCCHHHHCCCEEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHH
AELLGLDKRFLENVDIHVHVPEGAIPKDGPSAGITMATTLVSALCRIPVRKDVAMTGEIT
HHHHCCCHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECEEE
LRGRVLPIGGLKEKVLAAHRGGIKKVLIPKENQKDIREIPRRVREKLQIVPVDHADEVLR
EEEEEEECCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCEECCCCCHHHHHH
EALLLEHPEEFLAKPGGPKPEASSAGGAAAQA
HHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PIFSRNDDGKKDGKKSRTLPLLPLRDIIVFPHMVVPLFVGRQKSIAALEEAMAHDKAIL
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEE
LCAQKKAKTNEPAADDIFAVGTVGSIIQLLRLPDGTVKVLVEGKQRARVRRFLDSDKFLV
EEECHHCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCEEE
VEAEDIEEESERTVELEALMRSVHSTFEAYVKLNKRIPPEMLTSVSSIDDPARLADTIVA
EEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHH
HLSLKLNDKQSILETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEYYLN
HHHEEECCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQMQAIQKELGERDEFKNEIQELEEKIKNKKMSKEATLKAKKELKKLKMMSPMSAEATVV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RNYIDWILSLPWYDYTEDKLEIPEAEKVLDEDHYGLKKPKERIIEYLAVQKLVDRIRGPI
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCE
LCFVGPPGVGKTSLAKSIARSMNRRFVRISLGGVRDEAEIRGHRRTYIGALPGKIIQSLK
EEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCHHHHCCCHHHHHHCCCHHHHHHHH
KAGSGNPVFLLDEVDKMSTDFRGDPSAALLEVLDPEQNFNFNDHYLDLDYDLSKVMFICT
HCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCHHHEEEEEE
ANTMAGIPLPLQDRMEVIRLAGYTDLEKLSIAKRYLVPKQKEVNGLEHVPVEFKRSAMRA
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHH
LVHKYTKESGVRSLEREIGSICRKIAKDVLKTGQVDGKTYVVTERMVQKYLGPPRYRYGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCCCCCC
AEEQDQVGLTTGLAWTELGGELLTVEAQVMPGKGKLTITGKLGEVMQESAQAAMSYVRSR
CCCCCCCCHHHCCHHHHCCCEEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHH
AELLGLDKRFLENVDIHVHVPEGAIPKDGPSAGITMATTLVSALCRIPVRKDVAMTGEIT
HHHHCCCHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECEEE
LRGRVLPIGGLKEKVLAAHRGGIKKVLIPKENQKDIREIPRRVREKLQIVPVDHADEVLR
EEEEEEECCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCEECCCCCHHHHHH
EALLLEHPEEFLAKPGGPKPEASSAGGAAAQA
HHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8468287 [H]