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The map label for this gene is htpX [H]

Identifier: 220918540

GI number: 220918540

Start: 3837610

End: 3839631

Strand: Direct

Name: htpX [H]

Synonym: A2cp1_3448

Alternate gene names: 220918540

Gene position: 3837610-3839631 (Clockwise)

Preceding gene: 220918539

Following gene: 220918542

Centisome position: 76.3

GC content: 80.86

Gene sequence:

>2022_bases
ATGGCCGCCCAGGCCCCGCCCGCCGGGCGGGTCACGCTGGACTTCTTCGCCGCCCAGCGGAACGCCCGCCGGCGCACCAC
CGTCCTCGTGATCGCGTTCGCGGTGGCGCTCGCCGCCGTCATCGCGGTGGTCTACCTCGCGCTCGCCGTGGCGCTCGGGC
TGGGCGCCGGCGCGGGCGGCGGCGGGTGGGCGGTGGACGGGTCCGGCGCGGTGTACGGCCCGCCGCTCCTCCAGCCCGGC
CTGCTCGCGCTCACCGCGCTCGGCGTCGGCGCGGTCACCGGGGTGGGCGGCGCGTGGCACGCGGCGCGGCTCTCGGCGGG
CGGCGGCGCCGCGGTGGCGGAGCTGCTGGGCGGCACGCCGGTCGACCGCGCCACCCGGGATCCCGCCGAGCGGCGCCTCG
TCAACGTGACGGAGGAGATGGCCCTCGCCGCCGGGATGCCGGTGCCGCGGCTCTACGTGCTCCGCGGCGAGGCCGGCATC
AACGCGTTCGCGGCCGGCCACACGCCCGGTCACAGCGTGGTGGCGGTGACGCGGGGCGCGCTGGAGCGGCTCACCCGCGA
CGAGCTGCAGGGCGTGGTGGCCCACGAGCTGTCGCACGTGCTGAACGCGGACACGCGCATCGACCTGCGGCTCATGGCGG
CGGTGGGCGGGCTCGGGTTCCTGACGCTGCTCGGGCGGCTGCTCCTCGACGTCGACTCCGGGCCGCGCCGCTCGCGCGAT
CGCAACCGCGGCGCCATCGCGCTGGTCGGGCTGGGGCTGCTCGTCGCCGGCGCCATGGGCAGCCTGTGCGGCCGGCTGGT
CCGCTTCGCGGTGGCGCGGCAGCGCGAGTGGCTGGCGGACGCGTCGGCGGTGCAGTTCACGCGCAACCCGGACGGCCTGG
CGGGCGCGCTCCGGAAGATCGCGGCGGAGGGGTCGGCGGTGTCCGGGCCGCACGTCGCCGAGGCGGCGCACCTGTTCTTC
GCGCGGGCCTCGGGCGGCCTCCTCGCCGGCCTGTTCTCCACGCACCCGCCCATCGAGGAGCGCCTCCGCCGGATCGCGCC
GCACCTCGCCGGCGCCCCCCTCTCCCGCGCCACGGCGGCCTCCGCGGAGGCGTCGCCGCCCCGCCCTGCGCCGGCCCCGG
CCGCTGCGCAGGCGCCGGACCGCGCCGGCGAGGCGGGGCTCGCGGGCGGACCGGCGGAGCCGGCGTCGGCGCCGCCCGCG
TCCGCGCTCCTGGCGGACCACCTCCCCCGCGCGGCCGGGCTGCTCTCGGGCCTCCCGCCCGCGCTCGCGGCGGCGGCGCG
CGAGCCGTTCGGCGCGCGCGGCCTCGCCTGCGCGCTGCTCGTGGACGCGGCGGCGCCGGTGCGCGCGGCGCAGCTCGCGT
ACCTCGAGCGGAACGACCGGGCGCTCCGTGCCGAGGTGGAGCGGCTCCTCCCCGCGCTCTCGGGGCTGGATCGCACCGCC
CGCAACGCGCTCCTCGCGCTGGCGCTCCCGGCGCTCGACGCGCTCTCGCCGGCGCAGGGCACCGCGCTCGCCGCCGACCT
CCGCGCGCTCGCCGCCGCGGACCGCGCCGTGTCGCCCTACGAGCTGGCCGTGCTCCGCGCCGTCCTCCGGCGGCTCTCCC
GCGGCGCCGGCGCGCCGCCCCGGGCGCTCCTGCGCACCGTCGAGGAGGCGGGGCCGGAGTGCCTGGAGCTGCTCTCCTGC
CTGGCGTGGACCGGCGGGCGCGACGCGGCCGCGGCGCAGGCCGCGCTCGACGCCGGCGCGCGGGCGCTGGGTGCGCGCGG
GCCGTGGCGGGTCCTCCCGCGCGACCGGCTCGGGCTCGGGCGCCTCGAGACCGCGCTCGACCGGCTCGACGCGGCGTCAC
CCTCAGTGAAGTCCGCGACGCTGGAGGCGTGCTCGGCCGTGGTCCGGGCCGACGGGCGCGTCGGCGCGGACGAGGCCGAG
CTGGTCCGGGCGGTCGCTGCCTCGCTCGGCCTACCCTTTCCGCCCGGGCTGGAGGCGGCCACCGCGCCCGGGGCGGACGC
CCTGGCGCCCCCGCTCAGTTGA

Upstream 100 bases:

>100_bases
GTTCCCCGGCGTGCTGCTCGCCGGCGGCTTCCCGCCCGCCACGTCGTTCGAGCTGCAGGGCGCCGCCGAGCGCGAGCCGG
TGCGGGTGCAGTTCTAGCCG

Downstream 100 bases:

>100_bases
AGAACGCGGGCGGCCGGACCGTCACGCCCTCGATCGGCTGCCGGGCGGCGAACCCCGCGTCCACGGGGTGCCAGTGCGAC
ACCGCCGGCTCCCCGAACTG

Product: peptidase M48 Ste24p

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MAAQAPPAGRVTLDFFAAQRNARRRTTVLVIAFAVALAAVIAVVYLALAVALGLGAGAGGGGWAVDGSGAVYGPPLLQPG
LLALTALGVGAVTGVGGAWHAARLSAGGGAAVAELLGGTPVDRATRDPAERRLVNVTEEMALAAGMPVPRLYVLRGEAGI
NAFAAGHTPGHSVVAVTRGALERLTRDELQGVVAHELSHVLNADTRIDLRLMAAVGGLGFLTLLGRLLLDVDSGPRRSRD
RNRGAIALVGLGLLVAGAMGSLCGRLVRFAVARQREWLADASAVQFTRNPDGLAGALRKIAAEGSAVSGPHVAEAAHLFF
ARASGGLLAGLFSTHPPIEERLRRIAPHLAGAPLSRATAASAEASPPRPAPAPAAAQAPDRAGEAGLAGGPAEPASAPPA
SALLADHLPRAAGLLSGLPPALAAAAREPFGARGLACALLVDAAAPVRAAQLAYLERNDRALRAEVERLLPALSGLDRTA
RNALLALALPALDALSPAQGTALAADLRALAAADRAVSPYELAVLRAVLRRLSRGAGAPPRALLRTVEEAGPECLELLSC
LAWTGGRDAAAAQAALDAGARALGARGPWRVLPRDRLGLGRLETALDRLDAASPSVKSATLEACSAVVRADGRVGADEAE
LVRAVAASLGLPFPPGLEAATAPGADALAPPLS

Sequences:

>Translated_673_residues
MAAQAPPAGRVTLDFFAAQRNARRRTTVLVIAFAVALAAVIAVVYLALAVALGLGAGAGGGGWAVDGSGAVYGPPLLQPG
LLALTALGVGAVTGVGGAWHAARLSAGGGAAVAELLGGTPVDRATRDPAERRLVNVTEEMALAAGMPVPRLYVLRGEAGI
NAFAAGHTPGHSVVAVTRGALERLTRDELQGVVAHELSHVLNADTRIDLRLMAAVGGLGFLTLLGRLLLDVDSGPRRSRD
RNRGAIALVGLGLLVAGAMGSLCGRLVRFAVARQREWLADASAVQFTRNPDGLAGALRKIAAEGSAVSGPHVAEAAHLFF
ARASGGLLAGLFSTHPPIEERLRRIAPHLAGAPLSRATAASAEASPPRPAPAPAAAQAPDRAGEAGLAGGPAEPASAPPA
SALLADHLPRAAGLLSGLPPALAAAAREPFGARGLACALLVDAAAPVRAAQLAYLERNDRALRAEVERLLPALSGLDRTA
RNALLALALPALDALSPAQGTALAADLRALAAADRAVSPYELAVLRAVLRRLSRGAGAPPRALLRTVEEAGPECLELLSC
LAWTGGRDAAAAQAALDAGARALGARGPWRVLPRDRLGLGRLETALDRLDAASPSVKSATLEACSAVVRADGRVGADEAE
LVRAVAASLGLPFPPGLEAATAPGADALAPPLS
>Mature_672_residues
AAQAPPAGRVTLDFFAAQRNARRRTTVLVIAFAVALAAVIAVVYLALAVALGLGAGAGGGGWAVDGSGAVYGPPLLQPGL
LALTALGVGAVTGVGGAWHAARLSAGGGAAVAELLGGTPVDRATRDPAERRLVNVTEEMALAAGMPVPRLYVLRGEAGIN
AFAAGHTPGHSVVAVTRGALERLTRDELQGVVAHELSHVLNADTRIDLRLMAAVGGLGFLTLLGRLLLDVDSGPRRSRDR
NRGAIALVGLGLLVAGAMGSLCGRLVRFAVARQREWLADASAVQFTRNPDGLAGALRKIAAEGSAVSGPHVAEAAHLFFA
RASGGLLAGLFSTHPPIEERLRRIAPHLAGAPLSRATAASAEASPPRPAPAPAAAQAPDRAGEAGLAGGPAEPASAPPAS
ALLADHLPRAAGLLSGLPPALAAAAREPFGARGLACALLVDAAAPVRAAQLAYLERNDRALRAEVERLLPALSGLDRTAR
NALLALALPALDALSPAQGTALAADLRALAAADRAVSPYELAVLRAVLRRLSRGAGAPPRALLRTVEEAGPECLELLSCL
AWTGGRDAAAAQAALDAGARALGARGPWRVLPRDRLGLGRLETALDRLDAASPSVKSATLEACSAVVRADGRVGADEAEL
VRAVAASLGLPFPPGLEAATAPGADALAPPLS

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=296, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 67816; Mature: 67685

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQAPPAGRVTLDFFAAQRNARRRTTVLVIAFAVALAAVIAVVYLALAVALGLGAGAGG
CCCCCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GGWAVDGSGAVYGPPLLQPGLLALTALGVGAVTGVGGAWHAARLSAGGGAAVAELLGGTP
CCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHCCCC
VDRATRDPAERRLVNVTEEMALAAGMPVPRLYVLRGEAGINAFAAGHTPGHSVVAVTRGA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCCCCCEEEHHHHH
LERLTRDELQGVVAHELSHVLNADTRIDLRLMAAVGGLGFLTLLGRLLLDVDSGPRRSRD
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RNRGAIALVGLGLLVAGAMGSLCGRLVRFAVARQREWLADASAVQFTRNPDGLAGALRKI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCHHHHHHHHH
AAEGSAVSGPHVAEAAHLFFARASGGLLAGLFSTHPPIEERLRRIAPHLAGAPLSRATAA
HHCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHC
SAEASPPRPAPAPAAAQAPDRAGEAGLAGGPAEPASAPPASALLADHLPRAAGLLSGLPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHCCCH
ALAAAAREPFGARGLACALLVDAAAPVRAAQLAYLERNDRALRAEVERLLPALSGLDRTA
HHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHH
RNALLALALPALDALSPAQGTALAADLRALAAADRAVSPYELAVLRAVLRRLSRGAGAPP
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCH
RALLRTVEEAGPECLELLSCLAWTGGRDAAAAQAALDAGARALGARGPWRVLPRDRLGLG
HHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
RLETALDRLDAASPSVKSATLEACSAVVRADGRVGADEAELVRAVAASLGLPFPPGLEAA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
TAPGADALAPPLS
CCCCCCCCCCCCC
>Mature Secondary Structure 
AAQAPPAGRVTLDFFAAQRNARRRTTVLVIAFAVALAAVIAVVYLALAVALGLGAGAGG
CCCCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GGWAVDGSGAVYGPPLLQPGLLALTALGVGAVTGVGGAWHAARLSAGGGAAVAELLGGTP
CCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHCCCC
VDRATRDPAERRLVNVTEEMALAAGMPVPRLYVLRGEAGINAFAAGHTPGHSVVAVTRGA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCCCCCEEEHHHHH
LERLTRDELQGVVAHELSHVLNADTRIDLRLMAAVGGLGFLTLLGRLLLDVDSGPRRSRD
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RNRGAIALVGLGLLVAGAMGSLCGRLVRFAVARQREWLADASAVQFTRNPDGLAGALRKI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCHHHHHHHHH
AAEGSAVSGPHVAEAAHLFFARASGGLLAGLFSTHPPIEERLRRIAPHLAGAPLSRATAA
HHCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHC
SAEASPPRPAPAPAAAQAPDRAGEAGLAGGPAEPASAPPASALLADHLPRAAGLLSGLPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHCCCH
ALAAAAREPFGARGLACALLVDAAAPVRAAQLAYLERNDRALRAEVERLLPALSGLDRTA
HHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHH
RNALLALALPALDALSPAQGTALAADLRALAAADRAVSPYELAVLRAVLRRLSRGAGAPP
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCH
RALLRTVEEAGPECLELLSCLAWTGGRDAAAAQAALDAGARALGARGPWRVLPRDRLGLG
HHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
RLETALDRLDAASPSVKSATLEACSAVVRADGRVGADEAELVRAVAASLGLPFPPGLEAA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
TAPGADALAPPLS
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA