Click here to switch to the map view.

The map label for this gene is yahK [H]

Identifier: 220918453

GI number: 220918453

Start: 3736534

End: 3737592

Strand: Direct

Name: yahK [H]

Synonym: A2cp1_3357

Alternate gene names: 220918453

Gene position: 3736534-3737592 (Clockwise)

Preceding gene: 220918449

Following gene: 220918454

Centisome position: 74.29

GC content: 72.05

Gene sequence:

>1059_bases
ATGTTCCACGCCAAGGCGTACGCCGCCACCAGCCCGACGTCCCCGCTCGCAGCCACCACGATCCCGCGCCGCGACCCGAC
CCCGCGCGACGTCCAGATCGAGATCCTCTACTGCGGCATCTGCCACTCCGACCTGCACACCGTGCGCAACGAGTGGAGCA
GCCTCGCGTCCACCGTCTACCCTTGCGTGCCGGGCCACGAGATCGTCGGCCGCGTCGCGAAGGTCGGCGCCGAGGTGACG
CGGTTCGCGCCCGGCGACCTCGTCGGCGTCGGCTGCATGGTGGACTCCGACCGCACCTGCCCCGAGTGCCGGGCCGGCCT
CGAGCAGTTCTGCGCGGGCCAGGTCCTCACCTACGGCGCGCCGGACAGGCACCTCGGCGGCGTGACCTACGGCGGCTACT
CCGGCAGCGTCGTGGTGGACGAGCACTTCGTGCTGCACGTCCCCCCGAACCTCGATCCCGCCGCCGCCGCGCCGCTCCTG
TGCGCCGGCATCACCACCTGGTCGCCGCTGCGGCACTGGGGCGTGAAGGAGGGCAAGAAGGTCGGCGTGGTCGGCCTGGG
CGGGCTCGGCCACATGGGCGTGAAGTTCGCGCGCGCGCTCGGCGCGCACGTGGTCGTGTTCACGACCTCGCCCGGCAAGC
GGGAGGACGCGCTCCGCCTCGGGGCGCACGAGGTGGTCCTCTCCCGCGACGCGAACGAGATGCGCAAGCACGCCGGCAGC
TTCGACTTCATCCTCGACGCGGTCGCCGCCGACCACGACCTCAACGCGTACGTGGCCCTGCTCCGCCGCGACGGCAACCT
GACGCTCGTCGGCGCGCCGGAGAAGCCGCTCCCGGTCGCCGCGTTCGGCCTGCTCCTCGGCCGCCGCAGCATCTCCGGCT
CGCCCATCGGCGGCATCGCCGAGACGCAGGAGATGCTCGACTTCTGCGGCTCGCACGGCATCACCGCCGACGTCGAGGTG
ATCCCGATGCAGCAGGTGAACGAGGCCTACGAGCGGATGCTCCGCTCGGACGTGAAGTACCGCTTCTCGATCGACATGGC
CTCGCTCCAGGCGGGGTGA

Upstream 100 bases:

>100_bases
CATGCGCGATCCGCCCGTTTCGTGGCGCCGCGCGCGCGCGTAGCTTCCTCCCCGCCGCCCGGCTCCCGGTGGAGCCGCGG
CGAGCCCCGGAGGAAGCCAC

Downstream 100 bases:

>100_bases
AGGCCCGCGCCGGCTCCCGCGCGGCGGTAGGATCGCGCCGCCGGGGGCCCGGGCCCGCGGTGAGACGGAGGTCGCGACGA
TGTCCCCGAAGCGCTCCAGG

Product: alcohol dehydrogenase zinc-binding domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MFHAKAYAATSPTSPLAATTIPRRDPTPRDVQIEILYCGICHSDLHTVRNEWSSLASTVYPCVPGHEIVGRVAKVGAEVT
RFAPGDLVGVGCMVDSDRTCPECRAGLEQFCAGQVLTYGAPDRHLGGVTYGGYSGSVVVDEHFVLHVPPNLDPAAAAPLL
CAGITTWSPLRHWGVKEGKKVGVVGLGGLGHMGVKFARALGAHVVVFTTSPGKREDALRLGAHEVVLSRDANEMRKHAGS
FDFILDAVAADHDLNAYVALLRRDGNLTLVGAPEKPLPVAAFGLLLGRRSISGSPIGGIAETQEMLDFCGSHGITADVEV
IPMQQVNEAYERMLRSDVKYRFSIDMASLQAG

Sequences:

>Translated_352_residues
MFHAKAYAATSPTSPLAATTIPRRDPTPRDVQIEILYCGICHSDLHTVRNEWSSLASTVYPCVPGHEIVGRVAKVGAEVT
RFAPGDLVGVGCMVDSDRTCPECRAGLEQFCAGQVLTYGAPDRHLGGVTYGGYSGSVVVDEHFVLHVPPNLDPAAAAPLL
CAGITTWSPLRHWGVKEGKKVGVVGLGGLGHMGVKFARALGAHVVVFTTSPGKREDALRLGAHEVVLSRDANEMRKHAGS
FDFILDAVAADHDLNAYVALLRRDGNLTLVGAPEKPLPVAAFGLLLGRRSISGSPIGGIAETQEMLDFCGSHGITADVEV
IPMQQVNEAYERMLRSDVKYRFSIDMASLQAG
>Mature_352_residues
MFHAKAYAATSPTSPLAATTIPRRDPTPRDVQIEILYCGICHSDLHTVRNEWSSLASTVYPCVPGHEIVGRVAKVGAEVT
RFAPGDLVGVGCMVDSDRTCPECRAGLEQFCAGQVLTYGAPDRHLGGVTYGGYSGSVVVDEHFVLHVPPNLDPAAAAPLL
CAGITTWSPLRHWGVKEGKKVGVVGLGGLGHMGVKFARALGAHVVVFTTSPGKREDALRLGAHEVVLSRDANEMRKHAGS
FDFILDAVAADHDLNAYVALLRRDGNLTLVGAPEKPLPVAAFGLLLGRRSISGSPIGGIAETQEMLDFCGSHGITADVEV
IPMQQVNEAYERMLRSDVKYRFSIDMASLQAG

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=375, Percent_Identity=25.6, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI71565152, Length=369, Percent_Identity=23.3062330623306, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI71743840, Length=380, Percent_Identity=23.6842105263158, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI262073058, Length=380, Percent_Identity=23.6842105263158, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=25.5434782608696, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI156627571, Length=267, Percent_Identity=29.5880149812734, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=61.3832853025937, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI87082401, Length=344, Percent_Identity=35.1744186046512, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081918, Length=313, Percent_Identity=25.8785942492013, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI226510992, Length=323, Percent_Identity=28.4829721362229, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786552, Length=382, Percent_Identity=25.9162303664921, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788075, Length=296, Percent_Identity=25.6756756756757, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=345, Percent_Identity=26.9565217391304, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562584, Length=340, Percent_Identity=27.0588235294118, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562582, Length=351, Percent_Identity=26.2108262108262, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25146526, Length=337, Percent_Identity=27.893175074184, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=339, Percent_Identity=27.7286135693215, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=226, Percent_Identity=30.5309734513274, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=223, Percent_Identity=30.0448430493274, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=331, Percent_Identity=37.4622356495468, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6319949, Length=330, Percent_Identity=36.0606060606061, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6323961, Length=352, Percent_Identity=28.6931818181818, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6323729, Length=338, Percent_Identity=27.5147928994083, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319621, Length=337, Percent_Identity=26.7062314540059, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324486, Length=342, Percent_Identity=27.7777777777778, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=320, Percent_Identity=27.5, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=370, Percent_Identity=26.7567567567568, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17737895, Length=381, Percent_Identity=24.9343832020997, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 37489; Mature: 37489

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHAKAYAATSPTSPLAATTIPRRDPTPRDVQIEILYCGICHSDLHTVRNEWSSLASTVY
CCCCCEECCCCCCCCCEECCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHC
PCVPGHEIVGRVAKVGAEVTRFAPGDLVGVGCMVDSDRTCPECRAGLEQFCAGQVLTYGA
CCCCCHHHHHHHHHHCHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEEECCC
PDRHLGGVTYGGYSGSVVVDEHFVLHVPPNLDPAAAAPLLCAGITTWSPLRHWGVKEGKK
CCCCCCCEEECCCCCCEEEECEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCE
VGVVGLGGLGHMGVKFARALGAHVVVFTTSPGKREDALRLGAHEVVLSRDANEMRKHAGS
EEEEEECCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHCCHHHEEEECCHHHHHHHCCC
FDFILDAVAADHDLNAYVALLRRDGNLTLVGAPEKPLPVAAFGLLLGRRSISGSPIGGIA
HHHHHHHHHCCCCCCEEEEEEEECCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHH
ETQEMLDFCGSHGITADVEVIPMQQVNEAYERMLRSDVKYRFSIDMASLQAG
HHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHCCCEEEEEEHHHCCCC
>Mature Secondary Structure
MFHAKAYAATSPTSPLAATTIPRRDPTPRDVQIEILYCGICHSDLHTVRNEWSSLASTVY
CCCCCEECCCCCCCCCEECCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHC
PCVPGHEIVGRVAKVGAEVTRFAPGDLVGVGCMVDSDRTCPECRAGLEQFCAGQVLTYGA
CCCCCHHHHHHHHHHCHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEEECCC
PDRHLGGVTYGGYSGSVVVDEHFVLHVPPNLDPAAAAPLLCAGITTWSPLRHWGVKEGKK
CCCCCCCEEECCCCCCEEEECEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCE
VGVVGLGGLGHMGVKFARALGAHVVVFTTSPGKREDALRLGAHEVVLSRDANEMRKHAGS
EEEEEECCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHCCHHHEEEECCHHHHHHHCCC
FDFILDAVAADHDLNAYVALLRRDGNLTLVGAPEKPLPVAAFGLLLGRRSISGSPIGGIA
HHHHHHHHHCCCCCCEEEEEEEECCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHH
ETQEMLDFCGSHGITADVEVIPMQQVNEAYERMLRSDVKYRFSIDMASLQAG
HHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHCCCEEEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]