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The map label for this gene is kynA [H]

Identifier: 220918452

GI number: 220918452

Start: 3735489

End: 3736286

Strand: Reverse

Name: kynA [H]

Synonym: A2cp1_3356

Alternate gene names: 220918452

Gene position: 3736286-3735489 (Counterclockwise)

Preceding gene: 220918455

Following gene: 220918451

Centisome position: 74.29

GC content: 73.31

Gene sequence:

>798_bases
ATGACCGATCCCTCGGCCCACTCGGCGGCCCTGACCTACGGCTCGTACCTCGCGCTCGACGAGCTCCTCTCGGCGCAGCG
GCCGCGCTCCGAGGAGCACGACGAGCTGCTGTTCATCGTGGTGCACCAGGTCTACGAGCTCTGGTTCAAGCAGGTGGTCC
ACGAGCTGGCCCACCTGCAGGAGCGGCTGCACCGGGGCGAGGGCGGCCACGCGCTCGCGACGCTGAAGCGCGTCCTCACC
ATCCTGAAGACCGTCGTGTCCCAGGTGGACGTCATCGAGACGATGACGCCGCGCCAGTTCACCGCGTTCCGCAGCCGCCT
GGAGGCGGCGAGCGGGTTCCAGTCGGCGCAGTTCCGGGTGCTGGAGGCGATGCTCGGGCGCCGGGACGAGCGGATGCTCG
CACCCTATCCGCCGGGCGGTCCGGGGCACGCGCCGATCGCGGCGGCGATGGCGGCGCCGTCGCTGTTCGACTCGCTCCTG
CGCTACCTCGCGACCCAGGGCTTCGCGCCGCCGCCGGTCCCCGAGGCGCGCGCGGCGGGCTGGCGCCAGCCGTCCGAGGC
GGTGCAGCGCGTGCTGCTGGACGTGTACCGCGCCGACGGCGAGGCGGCCCTGGTGTGCGAGCGCTTCGTGGACCTCGACG
AGGGCGTGCAGGAGTGGCGCTACCGGCACGTGAAGATGGTCGAGCGGACCATCGGCGACAAGCCGGGCACGGGCGGCTCG
GCGGGCGCGCAGTACCTGCGCACGACGCTGTTCACCCCGGCGTTCCCCGACCTGTGGGCGGTGCGGGGCGCGCTGTGA

Upstream 100 bases:

>100_bases
ACGGGCGCCGGCACGTCGGGCTGGGCGGCGCCGCGTCCCCGACGGAGCGCGGCGGGGCGGACCGCCCCGGCCCGTGTTAG
GCATCCCCGCCGGAGGACGC

Downstream 100 bases:

>100_bases
ACCCGCTCGCGCGCCACTACACGCGGTTCCGGGTGGCGGAGCGGCTGCTGCTCACGGGCCACTCGCACCAGGCCTGGCCG
GACGTCGCGCGGGAGGGAGT

Product: tryptophan 23-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTDPSAHSAALTYGSYLALDELLSAQRPRSEEHDELLFIVVHQVYELWFKQVVHELAHLQERLHRGEGGHALATLKRVLT
ILKTVVSQVDVIETMTPRQFTAFRSRLEAASGFQSAQFRVLEAMLGRRDERMLAPYPPGGPGHAPIAAAMAAPSLFDSLL
RYLATQGFAPPPVPEARAAGWRQPSEAVQRVLLDVYRADGEAALVCERFVDLDEGVQEWRYRHVKMVERTIGDKPGTGGS
AGAQYLRTTLFTPAFPDLWAVRGAL

Sequences:

>Translated_265_residues
MTDPSAHSAALTYGSYLALDELLSAQRPRSEEHDELLFIVVHQVYELWFKQVVHELAHLQERLHRGEGGHALATLKRVLT
ILKTVVSQVDVIETMTPRQFTAFRSRLEAASGFQSAQFRVLEAMLGRRDERMLAPYPPGGPGHAPIAAAMAAPSLFDSLL
RYLATQGFAPPPVPEARAAGWRQPSEAVQRVLLDVYRADGEAALVCERFVDLDEGVQEWRYRHVKMVERTIGDKPGTGGS
AGAQYLRTTLFTPAFPDLWAVRGAL
>Mature_264_residues
TDPSAHSAALTYGSYLALDELLSAQRPRSEEHDELLFIVVHQVYELWFKQVVHELAHLQERLHRGEGGHALATLKRVLTI
LKTVVSQVDVIETMTPRQFTAFRSRLEAASGFQSAQFRVLEAMLGRRDERMLAPYPPGGPGHAPIAAAMAAPSLFDSLLR
YLATQGFAPPPVPEARAAGWRQPSEAVQRVLLDVYRADGEAALVCERFVDLDEGVQEWRYRHVKMVERTIGDKPGTGGSA
GAQYLRTTLFTPAFPDLWAVRGAL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=142, Percent_Identity=44.3661971830986, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17552370, Length=130, Percent_Identity=43.8461538461538, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32564651, Length=130, Percent_Identity=43.8461538461538, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17530891, Length=205, Percent_Identity=37.5609756097561, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 29400; Mature: 29269

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPSAHSAALTYGSYLALDELLSAQRPRSEEHDELLFIVVHQVYELWFKQVVHELAHLQ
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLHRGEGGHALATLKRVLTILKTVVSQVDVIETMTPRQFTAFRSRLEAASGFQSAQFRV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHH
LEAMLGRRDERMLAPYPPGGPGHAPIAAAMAAPSLFDSLLRYLATQGFAPPPVPEARAAG
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCC
WRQPSEAVQRVLLDVYRADGEAALVCERFVDLDEGVQEWRYRHVKMVERTIGDKPGTGGS
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AGAQYLRTTLFTPAFPDLWAVRGAL
HHHHHHHHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure 
TDPSAHSAALTYGSYLALDELLSAQRPRSEEHDELLFIVVHQVYELWFKQVVHELAHLQ
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLHRGEGGHALATLKRVLTILKTVVSQVDVIETMTPRQFTAFRSRLEAASGFQSAQFRV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHH
LEAMLGRRDERMLAPYPPGGPGHAPIAAAMAAPSLFDSLLRYLATQGFAPPPVPEARAAG
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCC
WRQPSEAVQRVLLDVYRADGEAALVCERFVDLDEGVQEWRYRHVKMVERTIGDKPGTGGS
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AGAQYLRTTLFTPAFPDLWAVRGAL
HHHHHHHHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA