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The map label for this gene is argG [H]

Identifier: 220918374

GI number: 220918374

Start: 3647284

End: 3648636

Strand: Reverse

Name: argG [H]

Synonym: A2cp1_3278

Alternate gene names: 220918374

Gene position: 3648636-3647284 (Counterclockwise)

Preceding gene: 220918380

Following gene: 220918373

Centisome position: 72.55

GC content: 70.36

Gene sequence:

>1353_bases
ATGAGCCGGATCTACAAGTCGCTTCCTCCGAAGGGCACCGCCATCGGCATCGCGTTCAGCGGCGGCCTGGACACGCGCTG
CGCGGTGGCCTGGATGTCCGAGCAGGGCATGGCGGTCCACGCCTACACCGCGGACCTCGCCCAGCCCGACGAGGCGAACC
CGGCCGACATCCCGCCCATCGCGCTCCAGCACGGCGCGGCGAAGGCGCGGCTGGTGGACTGCCGCGAGGCGATGGTGCGC
GAGGGCATCGCCGCCATCCAGTGCGGCGCGTTCCACCTGTCCTCCGGCGGCAAGAAGTACTTCAACACCACGCCGCTCGG
CCGCGCGGTCACCGGCACCGCCATCGTGCGCGCCATGCGCGAGGACGGCGTGCACGTCTTCGGCGACGGCTCCACGCACA
AGGGCAACGACATCCAGCGGTTCTACCGGTACGGCATCCTGGTGGACCCGCAGCTCAAGATCTACAAGCCCTGGCTCGAC
CAGGCCTTCGTGACCGCGTTCGGCGGCCGCAAGGAGATGAGCGAGTACCTGGAGCGCCGGGAGCTGCCCTACAAGATGGG
CAAGGAGAAGGCCTACTCCACCGACGCGAACGTGCTCGGCGCCACGCACGAGGCGAAGGACCTCGAGCGCCTCGACTCGA
GCATGCGGATCGTCGAGCCGATCATGGGCGTGGCGCACTGGAAGCCCGAGGTCCAGATCGCGCCCGAGGAGATCGAGATC
ACCTGGGAGCAGGGTCAGCCGGTCGAGCTGAACGGGAAGCGCTTCCCCTCGCCGTACGAGCTGTTCCTCGAGGCGAACCG
CATCGGCGGGCGCCACGGCCTGGGGATGAGCGACCAGATCGAGAACCGGGTCATCGACGCGAAGAGCCGGGGCATCTACG
AGGCCCCCGGCATGGCGCTCCTGCACCTCGGCTACGAGCGGCTGCTCTCCGCCATCCACAACGAGAACACGCTCGACCTG
TACTTCACGCTGGGCCGCCGCCTGGGCCGCCTGCTCTACGAGGGCAAGTGGTTCGACCCCGAGGCGCTCATGCTGCGCGA
CGGGCTCACCCGCTGGGTCGCGCCCGCCGTCACCGGCAGCGTGCGCGTCGAGCTGCGCCGGGGCGACGACTGGACCGTCC
TCTCGACCCGCGCCGAGTACATGAGCTACGCGCCGGAGAAGCTGTCGATGGAGCGCGTGGCCGATCCCGCGTTCACGCCG
GAGGACCGCATCGGCGCGCTGGAGCTGCAGAACCTGAGCGTGGGCGACAACCGCGACCTGCTGCTGCACCACCTCGACGC
CGTCCGGAAGCTGGGCGCCGCGACCCGCGGCCCCGGCCTCGGGGCGCTGCTCGGCTCCGGCGAGGACGAGTGA

Upstream 100 bases:

>100_bases
CCCGCTCCGGCGCTCCCGCCGCCGCGACGGGAGGAGATCGGTCCGGGTGCGCTCACGCCCGCTGGAACACGGCCCGGAAT
TCTGCTACTTGGCCCGTCCC

Downstream 100 bases:

>100_bases
TCGCCCGGCGCGGCCCCGCGGCCGCGCCGGATCTGCTCCCTGCTCCCACATCGACGCCCCGGCGTCCCCTGCGACGGGAG
CGCGAGCCGGGTTAGGACTG

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSRIYKSLPPKGTAIGIAFSGGLDTRCAVAWMSEQGMAVHAYTADLAQPDEANPADIPPIALQHGAAKARLVDCREAMVR
EGIAAIQCGAFHLSSGGKKYFNTTPLGRAVTGTAIVRAMREDGVHVFGDGSTHKGNDIQRFYRYGILVDPQLKIYKPWLD
QAFVTAFGGRKEMSEYLERRELPYKMGKEKAYSTDANVLGATHEAKDLERLDSSMRIVEPIMGVAHWKPEVQIAPEEIEI
TWEQGQPVELNGKRFPSPYELFLEANRIGGRHGLGMSDQIENRVIDAKSRGIYEAPGMALLHLGYERLLSAIHNENTLDL
YFTLGRRLGRLLYEGKWFDPEALMLRDGLTRWVAPAVTGSVRVELRRGDDWTVLSTRAEYMSYAPEKLSMERVADPAFTP
EDRIGALELQNLSVGDNRDLLLHHLDAVRKLGAATRGPGLGALLGSGEDE

Sequences:

>Translated_450_residues
MSRIYKSLPPKGTAIGIAFSGGLDTRCAVAWMSEQGMAVHAYTADLAQPDEANPADIPPIALQHGAAKARLVDCREAMVR
EGIAAIQCGAFHLSSGGKKYFNTTPLGRAVTGTAIVRAMREDGVHVFGDGSTHKGNDIQRFYRYGILVDPQLKIYKPWLD
QAFVTAFGGRKEMSEYLERRELPYKMGKEKAYSTDANVLGATHEAKDLERLDSSMRIVEPIMGVAHWKPEVQIAPEEIEI
TWEQGQPVELNGKRFPSPYELFLEANRIGGRHGLGMSDQIENRVIDAKSRGIYEAPGMALLHLGYERLLSAIHNENTLDL
YFTLGRRLGRLLYEGKWFDPEALMLRDGLTRWVAPAVTGSVRVELRRGDDWTVLSTRAEYMSYAPEKLSMERVADPAFTP
EDRIGALELQNLSVGDNRDLLLHHLDAVRKLGAATRGPGLGALLGSGEDE
>Mature_449_residues
SRIYKSLPPKGTAIGIAFSGGLDTRCAVAWMSEQGMAVHAYTADLAQPDEANPADIPPIALQHGAAKARLVDCREAMVRE
GIAAIQCGAFHLSSGGKKYFNTTPLGRAVTGTAIVRAMREDGVHVFGDGSTHKGNDIQRFYRYGILVDPQLKIYKPWLDQ
AFVTAFGGRKEMSEYLERRELPYKMGKEKAYSTDANVLGATHEAKDLERLDSSMRIVEPIMGVAHWKPEVQIAPEEIEIT
WEQGQPVELNGKRFPSPYELFLEANRIGGRHGLGMSDQIENRVIDAKSRGIYEAPGMALLHLGYERLLSAIHNENTLDLY
FTLGRRLGRLLYEGKWFDPEALMLRDGLTRWVAPAVTGSVRVELRRGDDWTVLSTRAEYMSYAPEKLSMERVADPAFTPE
DRIGALELQNLSVGDNRDLLLHHLDAVRKLGAATRGPGLGALLGSGEDE

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=419, Percent_Identity=29.1169451073986, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI16950633, Length=419, Percent_Identity=29.1169451073986, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1789563, Length=422, Percent_Identity=61.8483412322275, Blast_Score=554, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6324514, Length=419, Percent_Identity=29.8329355608592, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI21358151, Length=370, Percent_Identity=30.2702702702703, Blast_Score=161, Evalue=7e-40,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 49805; Mature: 49674

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIYKSLPPKGTAIGIAFSGGLDTRCAVAWMSEQGMAVHAYTADLAQPDEANPADIPPI
CCCCHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCH
ALQHGAAKARLVDCREAMVREGIAAIQCGAFHLSSGGKKYFNTTPLGRAVTGTAIVRAMR
HHHCCCCHHHHHHHHHHHHHCCHHEEEECCEEECCCCCEECCCCCCCCHHHHHHHHHHHH
EDGVHVFGDGSTHKGNDIQRFYRYGILVDPQLKIYKPWLDQAFVTAFGGRKEMSEYLERR
HCCCEEEECCCCCCCHHHHHHHHCCCEECCCCEEECCHHHHHHHHHCCCHHHHHHHHHHH
ELPYKMGKEKAYSTDANVLGATHEAKDLERLDSSMRIVEPIMGVAHWKPEVQIAPEEIEI
CCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEE
TWEQGQPVELNGKRFPSPYELFLEANRIGGRHGLGMSDQIENRVIDAKSRGIYEAPGMAL
EECCCCCEEECCCCCCCHHHEEEEHHHCCCCCCCCCCHHHHHHEECCCCCCCCCCCCHHH
LHLGYERLLSAIHNENTLDLYFTLGRRLGRLLYEGKWFDPEALMLRDGLTRWVAPAVTGS
HHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCE
VRVELRRGDDWTVLSTRAEYMSYAPEKLSMERVADPAFTPEDRIGALELQNLSVGDNRDL
EEEEEEECCCEEEEEHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCHH
LLHHLDAVRKLGAATRGPGLGALLGSGEDE
HHHHHHHHHHHCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
SRIYKSLPPKGTAIGIAFSGGLDTRCAVAWMSEQGMAVHAYTADLAQPDEANPADIPPI
CCCHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCH
ALQHGAAKARLVDCREAMVREGIAAIQCGAFHLSSGGKKYFNTTPLGRAVTGTAIVRAMR
HHHCCCCHHHHHHHHHHHHHCCHHEEEECCEEECCCCCEECCCCCCCCHHHHHHHHHHHH
EDGVHVFGDGSTHKGNDIQRFYRYGILVDPQLKIYKPWLDQAFVTAFGGRKEMSEYLERR
HCCCEEEECCCCCCCHHHHHHHHCCCEECCCCEEECCHHHHHHHHHCCCHHHHHHHHHHH
ELPYKMGKEKAYSTDANVLGATHEAKDLERLDSSMRIVEPIMGVAHWKPEVQIAPEEIEI
CCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEE
TWEQGQPVELNGKRFPSPYELFLEANRIGGRHGLGMSDQIENRVIDAKSRGIYEAPGMAL
EECCCCCEEECCCCCCCHHHEEEEHHHCCCCCCCCCCHHHHHHEECCCCCCCCCCCCHHH
LHLGYERLLSAIHNENTLDLYFTLGRRLGRLLYEGKWFDPEALMLRDGLTRWVAPAVTGS
HHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCE
VRVELRRGDDWTVLSTRAEYMSYAPEKLSMERVADPAFTPEDRIGALELQNLSVGDNRDL
EEEEEEECCCEEEEEHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCHH
LLHHLDAVRKLGAATRGPGLGALLGSGEDE
HHHHHHHHHHHCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA