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The map label for this gene is iolS [H]

Identifier: 220918331

GI number: 220918331

Start: 3594712

End: 3595698

Strand: Reverse

Name: iolS [H]

Synonym: A2cp1_3235

Alternate gene names: 220918331

Gene position: 3595698-3594712 (Counterclockwise)

Preceding gene: 220918332

Following gene: 220918329

Centisome position: 71.49

GC content: 72.54

Gene sequence:

>987_bases
ATGGAGCAGCGCACGCTGGGGACGCAGGGGCTCACGGTCTCGGCCGTCGGGCTGGGCTGCATGGGCATGAGCGACTTCTA
CGGCGGCGCCGACGAGCGCGAGTCGGTCGCGACCATCCACCGCGCCATCGAGCTCGGCGTCACCTTCCTCGACACGGCCG
ACATGTACGGTCCGTTCAAGAACGAGGAGCTGGTCGGGCGGGCCGTGCGCGATCGGCGCGACCGGGTGGTGCTCGCCACC
AAGTTCGGGAACGAGCGCCGCGCCGACGGCACCTTCGTCGGCATCAACGGGCGACCCGAGTACGTGCGCGCCGCCTGCGA
CGCGTCGCTGCGGCGGCTCGGGGTGGACCACGTGGACCTCTACTACCAGCACCGGGTGGACGCGACCGTGCCCATCGAGG
ACACCGTCGGCGCGATGGCCGACCTGGTGAAGGCGGGCAAGGTCCGCTACCTCGGCCTCTCCGAGGCCGCGCCCGGCACG
ATCCGCCGCGCGCACGTGGTGCACCCGATCACCGCGCTCCAGACCGAGTACTCGCTGTGGAGCCGGGATCCCGAGGACGC
GCTGCTGCCCACCCTGCGCGAGCTCGGCATCGGCTTCGTCCCGTACAGCCCGCTCGGCCGCGGCTTCCTCACCGGCCGGT
TCCGCTCGCCCGACGATCTCCCCGAGGGCGACTTCCGGCGGACCTCGCCGCGCTTCCAGGGCGAGAACTTCCAGCGGAAC
CTCGACCTGGTGGACCGCATCCGCGACATGGCGAGCGCGAAGGGCGTCTCGGCCTCGCAGCTCGCGCTGGCCTGGGTCCT
CGGCAAGGGAGACGACATCGCGCCCATCCCCGGCACGACCACGCGCCGGCACCTGGAGGAGAACGTGGCCGCGGCGTCGA
TCCGCCTCACTCCCGAGGATCTCGCCGCCATCGACCAGGTGGCGCCGAAGGGCGCGGCCGCCGGCGATCGCTACCCGCCG
TCGGGGATGGTGCGGGTCGACCTCTAG

Upstream 100 bases:

>100_bases
CCGGGCGTCCGCGCGATCGCGCAGGGATGACGCGGCGGAGCGCGGCGCGGGCGGTTATGAGTCGCCCCGCCGCGCCCTCC
GGCGCGCCGGAGGCGATCAC

Downstream 100 bases:

>100_bases
CCGCGCCCGGTCACGGCGCGGGAGCCTCCGCGCCGGCCCCGAGGCCCATCTCCGCGGCCAGCTCGGCCAGGCGCGTCGCC
AGCGCCGGCCCGCGCGCCTC

Product: aldo/keto reductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MEQRTLGTQGLTVSAVGLGCMGMSDFYGGADERESVATIHRAIELGVTFLDTADMYGPFKNEELVGRAVRDRRDRVVLAT
KFGNERRADGTFVGINGRPEYVRAACDASLRRLGVDHVDLYYQHRVDATVPIEDTVGAMADLVKAGKVRYLGLSEAAPGT
IRRAHVVHPITALQTEYSLWSRDPEDALLPTLRELGIGFVPYSPLGRGFLTGRFRSPDDLPEGDFRRTSPRFQGENFQRN
LDLVDRIRDMASAKGVSASQLALAWVLGKGDDIAPIPGTTTRRHLEENVAAASIRLTPEDLAAIDQVAPKGAAAGDRYPP
SGMVRVDL

Sequences:

>Translated_328_residues
MEQRTLGTQGLTVSAVGLGCMGMSDFYGGADERESVATIHRAIELGVTFLDTADMYGPFKNEELVGRAVRDRRDRVVLAT
KFGNERRADGTFVGINGRPEYVRAACDASLRRLGVDHVDLYYQHRVDATVPIEDTVGAMADLVKAGKVRYLGLSEAAPGT
IRRAHVVHPITALQTEYSLWSRDPEDALLPTLRELGIGFVPYSPLGRGFLTGRFRSPDDLPEGDFRRTSPRFQGENFQRN
LDLVDRIRDMASAKGVSASQLALAWVLGKGDDIAPIPGTTTRRHLEENVAAASIRLTPEDLAAIDQVAPKGAAAGDRYPP
SGMVRVDL
>Mature_328_residues
MEQRTLGTQGLTVSAVGLGCMGMSDFYGGADERESVATIHRAIELGVTFLDTADMYGPFKNEELVGRAVRDRRDRVVLAT
KFGNERRADGTFVGINGRPEYVRAACDASLRRLGVDHVDLYYQHRVDATVPIEDTVGAMADLVKAGKVRYLGLSEAAPGT
IRRAHVVHPITALQTEYSLWSRDPEDALLPTLRELGIGFVPYSPLGRGFLTGRFRSPDDLPEGDFRRTSPRFQGENFQRN
LDLVDRIRDMASAKGVSASQLALAWVLGKGDDIAPIPGTTTRRHLEENVAAASIRLTPEDLAAIDQVAPKGAAAGDRYPP
SGMVRVDL

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436966, Length=328, Percent_Identity=28.6585365853659, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI27436964, Length=328, Percent_Identity=28.6585365853659, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI27436962, Length=328, Percent_Identity=28.6585365853659, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI27436969, Length=325, Percent_Identity=26.7692307692308, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI27436971, Length=321, Percent_Identity=28.0373831775701, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4504825, Length=322, Percent_Identity=26.7080745341615, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI223718702, Length=290, Percent_Identity=30.6896551724138, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI41327764, Length=275, Percent_Identity=31.2727272727273, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI41152114, Length=294, Percent_Identity=28.9115646258503, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI87081735, Length=327, Percent_Identity=35.474006116208, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1789375, Length=326, Percent_Identity=33.1288343558282, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788070, Length=323, Percent_Identity=31.5789473684211, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1787674, Length=314, Percent_Identity=29.6178343949045, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1788081, Length=322, Percent_Identity=29.5031055900621, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789199, Length=349, Percent_Identity=29.2263610315186, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994888, Length=318, Percent_Identity=25.7861635220126, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325384, Length=332, Percent_Identity=28.3132530120482, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323998, Length=328, Percent_Identity=28.3536585365854, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6325169, Length=342, Percent_Identity=26.6081871345029, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319958, Length=300, Percent_Identity=26.6666666666667, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322615, Length=262, Percent_Identity=29.0076335877863, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319951, Length=328, Percent_Identity=26.5243902439024, Blast_Score=106, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24640980, Length=323, Percent_Identity=25.3869969040248, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45549126, Length=323, Percent_Identity=25.3869969040248, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646155, Length=311, Percent_Identity=26.6881028938907, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45553081, Length=321, Percent_Identity=27.1028037383178, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24646159, Length=161, Percent_Identity=33.5403726708075, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281366140, Length=287, Percent_Identity=26.8292682926829, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35764; Mature: 35764

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQRTLGTQGLTVSAVGLGCMGMSDFYGGADERESVATIHRAIELGVTFLDTADMYGPFK
CCCCCCCCCCCEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCEEECHHHCCCCC
NEELVGRAVRDRRDRVVLATKFGNERRADGTFVGINGRPEYVRAACDASLRRLGVDHVDL
CHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHH
YYQHRVDATVPIEDTVGAMADLVKAGKVRYLGLSEAAPGTIRRAHVVHPITALQTEYSLW
EEHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHH
SRDPEDALLPTLRELGIGFVPYSPLGRGFLTGRFRSPDDLPEGDFRRTSPRFQGENFQRN
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCC
LDLVDRIRDMASAKGVSASQLALAWVLGKGDDIAPIPGTTTRRHLEENVAAASIRLTPED
HHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHEEEEEECHHH
LAAIDQVAPKGAAAGDRYPPSGMVRVDL
HHHHHHHCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MEQRTLGTQGLTVSAVGLGCMGMSDFYGGADERESVATIHRAIELGVTFLDTADMYGPFK
CCCCCCCCCCCEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCEEECHHHCCCCC
NEELVGRAVRDRRDRVVLATKFGNERRADGTFVGINGRPEYVRAACDASLRRLGVDHVDL
CHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHH
YYQHRVDATVPIEDTVGAMADLVKAGKVRYLGLSEAAPGTIRRAHVVHPITALQTEYSLW
EEHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHH
SRDPEDALLPTLRELGIGFVPYSPLGRGFLTGRFRSPDDLPEGDFRRTSPRFQGENFQRN
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCC
LDLVDRIRDMASAKGVSASQLALAWVLGKGDDIAPIPGTTTRRHLEENVAAASIRLTPED
HHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHEEEEEECHHH
LAAIDQVAPKGAAAGDRYPPSGMVRVDL
HHHHHHHCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]