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The map label for this gene is hutU [H]

Identifier: 220917547

GI number: 220917547

Start: 2705127

End: 2706767

Strand: Direct

Name: hutU [H]

Synonym: A2cp1_2447

Alternate gene names: 220917547

Gene position: 2705127-2706767 (Clockwise)

Preceding gene: 220917540

Following gene: 220917548

Centisome position: 53.79

GC content: 74.77

Gene sequence:

>1641_bases
ATGGACGCGATCCGCGCACCGCGAGGGAGCGCCCTCTCCTGCCGAGGCTGGGTGCAGGAGGCGGCGCTCCGCATGCTGAT
GAACAACCTCGATCCGGACGTGGCCGAGCGGCCCGAGGACCTGGTGGTCTACGGCGGCACCGGCAAGGCGGCCCGCGACT
GGGAGAGCTACCGCCGCATCGTCGCGGCGCTGAAGGCGCTCGGCGACGACGAGACGCTGCTCGTGCAGAGCGGCAAGCCG
GTGGGCGTGCTCGGCACGCACCCCGACGCGCCGCGCGTGCTCATCGCGAACTCGAACCTGGTCCCGCGCTTCGCCACCTG
GGAGCACTTCTGGGACCTCGAGGCGCGCGGGCTCATGATGTACGGGCAGATGACGGCGGGCTCCTGGATCTACATCGGCA
GCCAGGGGATCCTGCAGGGCACCTACGAGACGTTCGCGCAGGCCGGCCGCACGCACTTCGGCACCGACGACCTCGGCGGC
CGCCTGGTGCTGTCCGGCGGCCTCGGCGGCATGGGCGGCGCGCAGCCGCTCGCGGCCACGCTGCTCGGCGCGGCGTTCCT
CGGCGTGGACGTGGACCCGGCCCGCATCGAGAAGCGGCTCGCGACCGGCTACCTCGACGCGCGCGCCGCCGACCTGGACG
ACGCGCTCGCCCGGCTCGAGGCTGCGCGCCGCGACCGGCGCCCGCTGTCGGTGGGCCTGGTCGGCAACGCCGCCACCGTG
TACGCCGAGCTGGCCCGCCGCGGCGTCGCGCCCGACCTCGTCACCGACCAGACCTCCGCCCACGATCCGCTGAACGGCTA
CGTCCCCGCCGACGTCCCGCTCGCGGACCTCCCCGCGCTCCGCGCCCGCGACCCCGAGGGCGTGGTGCGGCGCGCGAAGG
AGTCGATGGCCCGGCAGGTCGAGGCGATGCTGGCCATGCGCCGCCTGGGCAGCCACGTGTTCGACTACGGCAACAACCTG
CGCGCCGGGGCGCGGGAGGCGGGCCTCGCCGACGCGTTCGCCTACCCCGGGTTCGTCCCGGCCTACATCCGGCCCATGTT
CTGCGAGGGCAAGGGCCCGTTCCGCTGGGTGGCGCTGTCCGGCGACCCGGCCGACATCGCGCGCACCGACCGCGCCGTGA
TGGAGCTGTTCCCGGAGAACGCCGGCCTGCGCCGCTGGCTCGACCTCGCCGCCCGCAAGGTCCGGTTCCAGGGGCTGCCC
GCGCGCATCTGCTGGCTCGGCTACGGCGAGCGCGATCGCGCCGGGCTGGCGTTCAACGAGCTGGTGCGGCGGGGCGAGGT
GAAGGCGCCCATCGTCATCGGCCGCGACCACCTCGACTGCGGCTCGGTGGCCTCGCCGAACCGCGAGACCGAGGCCATGA
AGGACGGCTCCGACGCGGTGGCCGACTGGCCCATCCTGAACGCGCTCGTCAACGCGGTGAACGGGGCGTCCTGGGTCAGC
TTCCACCACGGCGGCGGGGTGGGCATCGGCTGGAGCCTCCACGCCGGCCAGGTGATCGTGGCGGACGGGACGGATGCGGC
GGCGCGCCGCGTCGCCCGGGTGCTGCGCAGCGACCCGGCCATGGGGGTGCTCCGTCACGCGGACGCGGGCTATCCGGAGG
CCGAGCGCGTCGCGCGGGAACGGGGTATCAAGCTCCCGTGA

Upstream 100 bases:

>100_bases
AGCGCGCGGAGTCTAGCAGCGCGCGCCCGCGGCGGGCCCCGTTTTTCGCGGTGCGGCCGGCGCGGCCCCGGGCCAGGCTC
TCGCGCCGGAGGTGGCTCCC

Downstream 100 bases:

>100_bases
GCCGCCCCACCGCGACCCTGGTCCTCCGCAACGCCGTCGTCGCCACCTGCGACCGCAGCCCCTCCGACGCCGGCCTGCTC
CCCGGGGCCGCGGTGGCCGT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MDAIRAPRGSALSCRGWVQEAALRMLMNNLDPDVAERPEDLVVYGGTGKAARDWESYRRIVAALKALGDDETLLVQSGKP
VGVLGTHPDAPRVLIANSNLVPRFATWEHFWDLEARGLMMYGQMTAGSWIYIGSQGILQGTYETFAQAGRTHFGTDDLGG
RLVLSGGLGGMGGAQPLAATLLGAAFLGVDVDPARIEKRLATGYLDARAADLDDALARLEAARRDRRPLSVGLVGNAATV
YAELARRGVAPDLVTDQTSAHDPLNGYVPADVPLADLPALRARDPEGVVRRAKESMARQVEAMLAMRRLGSHVFDYGNNL
RAGAREAGLADAFAYPGFVPAYIRPMFCEGKGPFRWVALSGDPADIARTDRAVMELFPENAGLRRWLDLAARKVRFQGLP
ARICWLGYGERDRAGLAFNELVRRGEVKAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALVNAVNGASWVS
FHHGGGVGIGWSLHAGQVIVADGTDAAARRVARVLRSDPAMGVLRHADAGYPEAERVARERGIKLP

Sequences:

>Translated_546_residues
MDAIRAPRGSALSCRGWVQEAALRMLMNNLDPDVAERPEDLVVYGGTGKAARDWESYRRIVAALKALGDDETLLVQSGKP
VGVLGTHPDAPRVLIANSNLVPRFATWEHFWDLEARGLMMYGQMTAGSWIYIGSQGILQGTYETFAQAGRTHFGTDDLGG
RLVLSGGLGGMGGAQPLAATLLGAAFLGVDVDPARIEKRLATGYLDARAADLDDALARLEAARRDRRPLSVGLVGNAATV
YAELARRGVAPDLVTDQTSAHDPLNGYVPADVPLADLPALRARDPEGVVRRAKESMARQVEAMLAMRRLGSHVFDYGNNL
RAGAREAGLADAFAYPGFVPAYIRPMFCEGKGPFRWVALSGDPADIARTDRAVMELFPENAGLRRWLDLAARKVRFQGLP
ARICWLGYGERDRAGLAFNELVRRGEVKAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALVNAVNGASWVS
FHHGGGVGIGWSLHAGQVIVADGTDAAARRVARVLRSDPAMGVLRHADAGYPEAERVARERGIKLP
>Mature_546_residues
MDAIRAPRGSALSCRGWVQEAALRMLMNNLDPDVAERPEDLVVYGGTGKAARDWESYRRIVAALKALGDDETLLVQSGKP
VGVLGTHPDAPRVLIANSNLVPRFATWEHFWDLEARGLMMYGQMTAGSWIYIGSQGILQGTYETFAQAGRTHFGTDDLGG
RLVLSGGLGGMGGAQPLAATLLGAAFLGVDVDPARIEKRLATGYLDARAADLDDALARLEAARRDRRPLSVGLVGNAATV
YAELARRGVAPDLVTDQTSAHDPLNGYVPADVPLADLPALRARDPEGVVRRAKESMARQVEAMLAMRRLGSHVFDYGNNL
RAGAREAGLADAFAYPGFVPAYIRPMFCEGKGPFRWVALSGDPADIARTDRAVMELFPENAGLRRWLDLAARKVRFQGLP
ARICWLGYGERDRAGLAFNELVRRGEVKAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALVNAVNGASWVS
FHHGGGVGIGWSLHAGQVIVADGTDAAARRVARVLRSDPAMGVLRHADAGYPEAERVARERGIKLP

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=552, Percent_Identity=36.231884057971, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI260306182, Length=206, Percent_Identity=40.2912621359223, Blast_Score=169, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71997891, Length=555, Percent_Identity=35.3153153153153, Blast_Score=327, Evalue=1e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 58704; Mature: 58704

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAIRAPRGSALSCRGWVQEAALRMLMNNLDPDVAERPEDLVVYGGTGKAARDWESYRRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCCHHHHHHHHHH
VAALKALGDDETLLVQSGKPVGVLGTHPDAPRVLIANSNLVPRFATWEHFWDLEARGLMM
HHHHHHCCCCCEEEEECCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEE
YGQMTAGSWIYIGSQGILQGTYETFAQAGRTHFGTDDLGGRLVLSGGLGGMGGAQPLAAT
EEEECCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHH
LLGAAFLGVDVDPARIEKRLATGYLDARAADLDDALARLEAARRDRRPLSVGLVGNAATV
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCHHHH
YAELARRGVAPDLVTDQTSAHDPLNGYVPADVPLADLPALRARDPEGVVRRAKESMARQV
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHCCCHHHHHHHHHHHHHHHH
EAMLAMRRLGSHVFDYGNNLRAGAREAGLADAFAYPGFVPAYIRPMFCEGKGPFRWVALS
HHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHCCCCCHHHHCEEEECCCCCEEEEEEC
GDPADIARTDRAVMELFPENAGLRRWLDLAARKVRFQGLPARICWLGYGERDRAGLAFNE
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
LVRRGEVKAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALVNAVNGASWVS
HHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEE
FHHGGGVGIGWSLHAGQVIVADGTDAAARRVARVLRSDPAMGVLRHADAGYPEAERVARE
EECCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHH
RGIKLP
CCCCCC
>Mature Secondary Structure
MDAIRAPRGSALSCRGWVQEAALRMLMNNLDPDVAERPEDLVVYGGTGKAARDWESYRRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCCHHHHHHHHHH
VAALKALGDDETLLVQSGKPVGVLGTHPDAPRVLIANSNLVPRFATWEHFWDLEARGLMM
HHHHHHCCCCCEEEEECCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEE
YGQMTAGSWIYIGSQGILQGTYETFAQAGRTHFGTDDLGGRLVLSGGLGGMGGAQPLAAT
EEEECCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHH
LLGAAFLGVDVDPARIEKRLATGYLDARAADLDDALARLEAARRDRRPLSVGLVGNAATV
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCHHHH
YAELARRGVAPDLVTDQTSAHDPLNGYVPADVPLADLPALRARDPEGVVRRAKESMARQV
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHCCCHHHHHHHHHHHHHHHH
EAMLAMRRLGSHVFDYGNNLRAGAREAGLADAFAYPGFVPAYIRPMFCEGKGPFRWVALS
HHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHCCCCCHHHHCEEEECCCCCEEEEEEC
GDPADIARTDRAVMELFPENAGLRRWLDLAARKVRFQGLPARICWLGYGERDRAGLAFNE
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
LVRRGEVKAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALVNAVNGASWVS
HHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEE
FHHGGGVGIGWSLHAGQVIVADGTDAAARRVARVLRSDPAMGVLRHADAGYPEAERVARE
EECCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHH
RGIKLP
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA