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The map label for this gene is rnd [H]

Identifier: 220917449

GI number: 220917449

Start: 2604155

End: 2605021

Strand: Reverse

Name: rnd [H]

Synonym: A2cp1_2349

Alternate gene names: 220917449

Gene position: 2605021-2604155 (Counterclockwise)

Preceding gene: 220917450

Following gene: 220917447

Centisome position: 51.8

GC content: 74.97

Gene sequence:

>867_bases
ATGTCCGCCGCTCCGCGCCCCAGCCCCGTCTTCGTCTCCGATCCCGACGCGCTCTCCCGGCTGCTCGACGCGCTGGCGGG
CGAGCGCGTGCTCGCGCTCGACACCGAGTCCAACAGCTTCCACGTCTACCGCGAGCGGGTGTGCCTGCTGCAGCTCTCCA
CGCGGGCGCAGGACTTCGTGGTGGACCCCATCTCGGTGGACGTCCGCCCGCTCGGGGAGATCCTGTGCGACGGGCGCGAG
GTGGTGCTGCACGGCGCGGACTACGACGTCCGCTGCCTGCACCGCGAGTACGGCTGGCGCATCCCCCGCCTGTTCGACAC
GATGATCGCGGCGCGGCGGCTGGGGCGGCCCGGCCTCGGCCTCTCGGCGCTGGTGGAGGCGCACTTCGGCGTGCGGCTCT
CGAAGGCGTTCCAGCGATCCGACTGGGGCCGGCGGCCGCTCACCCCCGATCAGCTCGCCTACGCCTCGCTCGACACGCAC
TTCCTGCTGCCGCTGTTCGACCTGCTCACCGGCGAGCTGGCCACCCGCGGCGCGCTCGAGGAGGCGTGGAAGGAGTCGCA
GCGCATCGCCTCGGTCGTGGCGCGCGAGCGCGTGTTCGACCCGGAGGGCTGGCGGCGCATCAAGGGGTCCCGCGAGCTCG
ACGCGCCCGGCAAGGCGGTGCTGCGCGCGCTGTGGATCGCCCGCGAGGACCGGGCCCGCGCGTCGGACCGGCCGCCGTTC
AAGGTGCTGGGCGAGCCGGCGATGCTCGAGATCGCGCGCCGGCGCCCGGCCACGCGCGAGGCGCTCGCCGCCATCCCGGG
CGTCACGCCGTCGGTGCTCGGGCGCATGGGGGAGACGATCGCCGCCGCCCTGAAGGCGGCCGGGTAG

Upstream 100 bases:

>100_bases
TGGCGGCCGATGCTGCCTGAGCCCCGGGGGCGACGTCGCCGCGGATTCCGGGGCGAATCGCGAGCCGCGCGGCGCGGTCT
CCTCTAGAATGCCGCGTCCG

Downstream 100 bases:

>100_bases
GTCGGTCGCCTAGAACCCGACGCCGGGGGCCGGCGCCGCCACCGGCCGCGCGGGGTCGATGGGCGCCGCCGGGCCGCCGG
AGAGCCGGCGGTAGACGTCC

Product: 3'-5' exonuclease

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSAAPRPSPVFVSDPDALSRLLDALAGERVLALDTESNSFHVYRERVCLLQLSTRAQDFVVDPISVDVRPLGEILCDGRE
VVLHGADYDVRCLHREYGWRIPRLFDTMIAARRLGRPGLGLSALVEAHFGVRLSKAFQRSDWGRRPLTPDQLAYASLDTH
FLLPLFDLLTGELATRGALEEAWKESQRIASVVARERVFDPEGWRRIKGSRELDAPGKAVLRALWIAREDRARASDRPPF
KVLGEPAMLEIARRRPATREALAAIPGVTPSVLGRMGETIAAALKAAG

Sequences:

>Translated_288_residues
MSAAPRPSPVFVSDPDALSRLLDALAGERVLALDTESNSFHVYRERVCLLQLSTRAQDFVVDPISVDVRPLGEILCDGRE
VVLHGADYDVRCLHREYGWRIPRLFDTMIAARRLGRPGLGLSALVEAHFGVRLSKAFQRSDWGRRPLTPDQLAYASLDTH
FLLPLFDLLTGELATRGALEEAWKESQRIASVVARERVFDPEGWRRIKGSRELDAPGKAVLRALWIAREDRARASDRPPF
KVLGEPAMLEIARRRPATREALAAIPGVTPSVLGRMGETIAAALKAAG
>Mature_287_residues
SAAPRPSPVFVSDPDALSRLLDALAGERVLALDTESNSFHVYRERVCLLQLSTRAQDFVVDPISVDVRPLGEILCDGREV
VLHGADYDVRCLHREYGWRIPRLFDTMIAARRLGRPGLGLSALVEAHFGVRLSKAFQRSDWGRRPLTPDQLAYASLDTHF
LLPLFDLLTGELATRGALEEAWKESQRIASVVARERVFDPEGWRRIKGSRELDAPGKAVLRALWIAREDRARASDRPPFK
VLGEPAMLEIARRRPATREALAAIPGVTPSVLGRMGETIAAALKAAG

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=273, Percent_Identity=30.7692307692308, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI50301240, Length=273, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1788105, Length=281, Percent_Identity=31.3167259786477, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17531757, Length=260, Percent_Identity=33.0769230769231, Blast_Score=121, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324574, Length=211, Percent_Identity=33.175355450237, Blast_Score=116, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161078302, Length=278, Percent_Identity=28.4172661870504, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 31888; Mature: 31757

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAPRPSPVFVSDPDALSRLLDALAGERVLALDTESNSFHVYRERVCLLQLSTRAQDFV
CCCCCCCCCEEECCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHEE
VDPISVDVRPLGEILCDGREVVLHGADYDVRCLHREYGWRIPRLFDTMIAARRLGRPGLG
ECCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
LSALVEAHFGVRLSKAFQRSDWGRRPLTPDQLAYASLDTHFLLPLFDLLTGELATRGALE
HHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
EAWKESQRIASVVARERVFDPEGWRRIKGSRELDAPGKAVLRALWIAREDRARASDRPPF
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCH
KVLGEPAMLEIARRRPATREALAAIPGVTPSVLGRMGETIAAALKAAG
HCCCCHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAAPRPSPVFVSDPDALSRLLDALAGERVLALDTESNSFHVYRERVCLLQLSTRAQDFV
CCCCCCCCEEECCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHEE
VDPISVDVRPLGEILCDGREVVLHGADYDVRCLHREYGWRIPRLFDTMIAARRLGRPGLG
ECCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
LSALVEAHFGVRLSKAFQRSDWGRRPLTPDQLAYASLDTHFLLPLFDLLTGELATRGALE
HHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
EAWKESQRIASVVARERVFDPEGWRRIKGSRELDAPGKAVLRALWIAREDRARASDRPPF
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCH
KVLGEPAMLEIARRRPATREALAAIPGVTPSVLGRMGETIAAALKAAG
HCCCCHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]