Click here to switch to the map view.

The map label for this gene is actR [H]

Identifier: 220917443

GI number: 220917443

Start: 2597430

End: 2597987

Strand: Reverse

Name: actR [H]

Synonym: A2cp1_2343

Alternate gene names: 220917443

Gene position: 2597987-2597430 (Counterclockwise)

Preceding gene: 220917444

Following gene: 220917442

Centisome position: 51.66

GC content: 72.94

Gene sequence:

>558_bases
ATGAACACGATGACGCCCGAAGTGACCCGCGAGTCGTTGCCGAGCATCCTGCTGGTGGACGACGACGAGGTGCTGCGCGA
GCGGCTCGCCACCGCCATCCGCGCCCGCGGGTACGAGGTCCGGACCGCCGGCTCCGCCGAGGAGGCGATGCGCGAGGCGA
CCCGCGACTCGCCGGAGATGGCGGTGCTCGACCTGCGCATGCCCGGCGGCTCGGGCCTGGAGATCCTGCGCGAGCTGCGC
CGCCAGGATCCCTCCACCCGCGTGCTCATGCTCACCGGCTACGGGAGCATCGCGACGGCGGTCGAGGCGGTGCGCGAGGG
CGCGGTGGGCTACCTGCCCAAGCCCGCCGACGCGGACGAGATCCTGGCCGCGCTGAACGGCACCAACACCGCCAAGGAGA
AGGGCATCGAGACGCCCTCGCTCGCCCGGGCGGAGTGGGAGCACATCCAGCGCGTGCTCACCGACTGCGGCGGCAACATC
TCCGAGGCGGCGCGGCGGCTCGGCATCCACCGCCGCTCGCTGCAGCGGAAGCTGCACAAGTACCCGCCGGCGAGGTAG

Upstream 100 bases:

>100_bases
AGCAGCTCGGCGGCGAGTTCAACATCACCTCCACCCCGGGGGACGGGACGGAGGCGCGTTTCGAGCTGCCGGTGTCGACC
GCCGGCGAGAGGAGCAGTCC

Downstream 100 bases:

>100_bases
CGCCCCGCCCCGCCGACGCCGGCCCACCGCGCGCCCTCCCGTCAGGGCGGGGGCGCGCGGCGAACCCTTTTCCCCGCGGC
GGGGTCGAACTCCGTGTCAG

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MNTMTPEVTRESLPSILLVDDDEVLRERLATAIRARGYEVRTAGSAEEAMREATRDSPEMAVLDLRMPGGSGLEILRELR
RQDPSTRVLMLTGYGSIATAVEAVREGAVGYLPKPADADEILAALNGTNTAKEKGIETPSLARAEWEHIQRVLTDCGGNI
SEAARRLGIHRRSLQRKLHKYPPAR

Sequences:

>Translated_185_residues
MNTMTPEVTRESLPSILLVDDDEVLRERLATAIRARGYEVRTAGSAEEAMREATRDSPEMAVLDLRMPGGSGLEILRELR
RQDPSTRVLMLTGYGSIATAVEAVREGAVGYLPKPADADEILAALNGTNTAKEKGIETPSLARAEWEHIQRVLTDCGGNI
SEAARRLGIHRRSLQRKLHKYPPAR
>Mature_185_residues
MNTMTPEVTRESLPSILLVDDDEVLRERLATAIRARGYEVRTAGSAEEAMREATRDSPEMAVLDLRMPGGSGLEILRELR
RQDPSTRVLMLTGYGSIATAVEAVREGAVGYLPKPADADEILAALNGTNTAKEKGIETPSLARAEWEHIQRVLTDCGGNI
SEAARRLGIHRRSLQRKLHKYPPAR

Specific function: Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two- component sensor may be involved in pH sensing and/or response [H]

COG id: COG4567

COG function: function code TK; Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=139, Percent_Identity=32.3741007194245, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1790437, Length=133, Percent_Identity=34.5864661654135, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1789809, Length=109, Percent_Identity=39.4495412844037, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1788905, Length=111, Percent_Identity=36.036036036036, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1786911, Length=113, Percent_Identity=31.858407079646, Blast_Score=60, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 20357; Mature: 20357

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMTPEVTRESLPSILLVDDDEVLRERLATAIRARGYEVRTAGSAEEAMREATRDSPEM
CCCCCCHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCE
AVLDLRMPGGSGLEILRELRRQDPSTRVLMLTGYGSIATAVEAVREGAVGYLPKPADADE
EEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHH
ILAALNGTNTAKEKGIETPSLARAEWEHIQRVLTDCGGNISEAARRLGIHRRSLQRKLHK
HHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YPPAR
CCCCC
>Mature Secondary Structure
MNTMTPEVTRESLPSILLVDDDEVLRERLATAIRARGYEVRTAGSAEEAMREATRDSPEM
CCCCCCHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCE
AVLDLRMPGGSGLEILRELRRQDPSTRVLMLTGYGSIATAVEAVREGAVGYLPKPADADE
EEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHH
ILAALNGTNTAKEKGIETPSLARAEWEHIQRVLTDCGGNISEAARRLGIHRRSLQRKLHK
HHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YPPAR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]