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The map label for this gene is ndk

Identifier: 220917419

GI number: 220917419

Start: 2570737

End: 2571180

Strand: Reverse

Name: ndk

Synonym: A2cp1_2319

Alternate gene names: 220917419

Gene position: 2571180-2570737 (Counterclockwise)

Preceding gene: 220917420

Following gene: 220917418

Centisome position: 51.12

GC content: 64.41

Gene sequence:

>444_bases
ATGGCGATCGAGCGCACGCTGTCCATCATCAAGCCCGACGGCGTCGAGAAGGGCATCATCGGGAAGATCATCGGCCGCTT
CGAGGAGAAGGGCCTGAAGCCGGTGGCCATCCGGCTGACGCAGCTGTCGAAGGCGGAGGCCGAGGGCTTCTACGCGGTGC
ACAAGGCCCGGCCGTTCTTCGGCGATCTGGTGAAGTTCATGACCAGCGGCCCGGTGGTCCTGATGGTCCTCGAGGGCGAG
AACGCGGTCGCCCGGAACCGCGAGATCATGGGCGCCACCGACCCGAAGAAGGCCGACGCGGGCACGATCCGCAAGGACTT
CGCGACCGACATCGAGAAGAACACCGTCCACGGCTCGGACAGCGTGGAGAACGCGAAGATCGAGGTCTCGTACTTCTTCC
CCGAGGTGCAGGTCCACGCCTACGAGTGGAAGAAGCTCGCTTAA

Upstream 100 bases:

>100_bases
CCCGAGGATCCAGGGACGCTCGCGCCCCCGTGCTCACGGTGAGCCGGGGGCGCGGCTTTCCCGCAACCACCCGGAACACC
GGACGAACGGAGAGCATCAC

Downstream 100 bases:

>100_bases
CCGACCGATCTCCTTGCACTCCTGGGGGCGTTCCCCCGCTCGGCCGGGCGCGCCGCGCCCGGTTCGGGCTACAATGCACG
AACCCGTCCCGCCCCAGGGA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 147; Mature: 146

Protein sequence:

>147_residues
MAIERTLSIIKPDGVEKGIIGKIIGRFEEKGLKPVAIRLTQLSKAEAEGFYAVHKARPFFGDLVKFMTSGPVVLMVLEGE
NAVARNREIMGATDPKKADAGTIRKDFATDIEKNTVHGSDSVENAKIEVSYFFPEVQVHAYEWKKLA

Sequences:

>Translated_147_residues
MAIERTLSIIKPDGVEKGIIGKIIGRFEEKGLKPVAIRLTQLSKAEAEGFYAVHKARPFFGDLVKFMTSGPVVLMVLEGE
NAVARNREIMGATDPKKADAGTIRKDFATDIEKNTVHGSDSVENAKIEVSYFFPEVQVHAYEWKKLA
>Mature_146_residues
AIERTLSIIKPDGVEKGIIGKIIGRFEEKGLKPVAIRLTQLSKAEAEGFYAVHKARPFFGDLVKFMTSGPVVLMVLEGEN
AVARNREIMGATDPKKADAGTIRKDFATDIEKNTVHGSDSVENAKIEVSYFFPEVQVHAYEWKKLA

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=141, Percent_Identity=46.8085106382979, Blast_Score=137, Evalue=3e-33,
Organism=Homo sapiens, GI66392227, Length=146, Percent_Identity=46.5753424657534, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392205, Length=146, Percent_Identity=46.5753424657534, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI4505409, Length=146, Percent_Identity=46.5753424657534, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392192, Length=146, Percent_Identity=46.5753424657534, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392203, Length=146, Percent_Identity=46.5753424657534, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI4557797, Length=134, Percent_Identity=48.5074626865672, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI38045913, Length=134, Percent_Identity=48.5074626865672, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=42.3076923076923, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI37574614, Length=134, Percent_Identity=35.0746268656716, Blast_Score=91, Evalue=2e-19,
Organism=Homo sapiens, GI7019465, Length=134, Percent_Identity=35.0746268656716, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI5031951, Length=139, Percent_Identity=34.5323741007194, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4505413, Length=140, Percent_Identity=35, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=33.8129496402878, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=31.1594202898551, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1788866, Length=138, Percent_Identity=55.7971014492754, Blast_Score=162, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17506807, Length=138, Percent_Identity=45.6521739130435, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322783, Length=139, Percent_Identity=43.8848920863309, Blast_Score=130, Evalue=7e-32,
Organism=Drosophila melanogaster, GI45549037, Length=138, Percent_Identity=49.2753623188406, Blast_Score=142, Evalue=8e-35,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=30.8823529411765, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_ANAD2 (B8JAD8)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002492723.1
- ProteinModelPortal:   B8JAD8
- SMR:   B8JAD8
- GeneID:   7297573
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2319
- HOGENOM:   HBG445152
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16265; Mature: 16134

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTLSIIKPDGVEKGIIGKIIGRFEEKGLKPVAIRLTQLSKAEAEGFYAVHKARPFF
CCCCHHHEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCEEEEECCCCHH
GDLVKFMTSGPVVLMVLEGENAVARNREIMGATDPKKADAGTIRKDFATDIEKNTVHGSD
HHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
SVENAKIEVSYFFPEVQVHAYEWKKLA
CCCCCEEEEEEECCCEEEEEECCEECC
>Mature Secondary Structure 
AIERTLSIIKPDGVEKGIIGKIIGRFEEKGLKPVAIRLTQLSKAEAEGFYAVHKARPFF
CCCHHHEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCEEEEECCCCHH
GDLVKFMTSGPVVLMVLEGENAVARNREIMGATDPKKADAGTIRKDFATDIEKNTVHGSD
HHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
SVENAKIEVSYFFPEVQVHAYEWKKLA
CCCCCEEEEEEECCCEEEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA