Click here to switch to the map view.

The map label for this gene is ribBA [H]

Identifier: 220917383

GI number: 220917383

Start: 2534456

End: 2535130

Strand: Reverse

Name: ribBA [H]

Synonym: A2cp1_2283

Alternate gene names: 220917383

Gene position: 2535130-2534456 (Counterclockwise)

Preceding gene: 220917386

Following gene: 220917378

Centisome position: 50.41

GC content: 73.48

Gene sequence:

>675_bases
ATGAGCAACCTGGTGGCGGTCGCCGGCCGCAAGGGGCGCGGGGCCCACGAGGCGAGCGCCGCGACCATCGACCTGTATGC
GGAGGCCCCGCTGCCGACGGAGCGCGGCCTGTTCCGCGCGGTGGTGTTCCGGGAGCGCCGCACCGGCGTCGAGCACGTGG
CCATGGTGATGGGCGACGTGGCCGGCGAGTCCGTCGCGGTGCGCGTCCACTCCGAGTGCCTCACCAGCGAGGTGCTCGGC
TCGCTGAAGTGCGACTGCCGCGCGCAGCTCGACCGCGCGCTCGACCTCATCGCGGCCCGCGGCCGCGGCGCGCTCCTGTA
CCTGCGCCAGGAAGGCCGCGGCATCGGGCTCGGCAACAAGATCCGCGCCTACGCGCTTCAGGCCCAGGGGCACGACACCT
ACGAGGCGAACCGGCTGCTCGGGTTCCCCGACGACCTGCGGCGCTACGACGTCGCCGCCGAGATGCTTCGCCTGCTGGGC
GTGCGCTCGGTGGAGCTCATCACGAACAACCCGCAGAAGCTCTCCGGGCTGGCCGAGGCCGGCGTCCCGGTGCGGGGGCG
GATCCAGCTGCCCTCCCCGGCCAACCCGTTCAACGTCGAGTACCTGCGGGTGAAGCGCGAGCGGACCGGGCACCTCATCC
AGACCGACGACGACGGCACCGCGCGCACCGCCTGA

Upstream 100 bases:

>100_bases
ATTTCGGGAGAGCGTTCGGCTTGACCGGGGTCGCCGTCGGCCGTTATGTGCAGCCCGCTGGCGCACCGCTTCGCGGGCGC
GACCCTGAGGAGCATCCGAG

Downstream 100 bases:

>100_bases
CCGCCCGCGGCGCGGCGCGCCTAACCGCGCGCCGGCGCCCCGCCGTCCTTCAGGAGCTCCCGCGCGATCACGAGGCGCTG
GATCTCGCTCGTGCCCTCGT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSNLVAVAGRKGRGAHEASAATIDLYAEAPLPTERGLFRAVVFRERRTGVEHVAMVMGDVAGESVAVRVHSECLTSEVLG
SLKCDCRAQLDRALDLIAARGRGALLYLRQEGRGIGLGNKIRAYALQAQGHDTYEANRLLGFPDDLRRYDVAAEMLRLLG
VRSVELITNNPQKLSGLAEAGVPVRGRIQLPSPANPFNVEYLRVKRERTGHLIQTDDDGTARTA

Sequences:

>Translated_224_residues
MSNLVAVAGRKGRGAHEASAATIDLYAEAPLPTERGLFRAVVFRERRTGVEHVAMVMGDVAGESVAVRVHSECLTSEVLG
SLKCDCRAQLDRALDLIAARGRGALLYLRQEGRGIGLGNKIRAYALQAQGHDTYEANRLLGFPDDLRRYDVAAEMLRLLG
VRSVELITNNPQKLSGLAEAGVPVRGRIQLPSPANPFNVEYLRVKRERTGHLIQTDDDGTARTA
>Mature_223_residues
SNLVAVAGRKGRGAHEASAATIDLYAEAPLPTERGLFRAVVFRERRTGVEHVAMVMGDVAGESVAVRVHSECLTSEVLGS
LKCDCRAQLDRALDLIAARGRGALLYLRQEGRGIGLGNKIRAYALQAQGHDTYEANRLLGFPDDLRRYDVAAEMLRLLGV
RSVELITNNPQKLSGLAEAGVPVRGRIQLPSPANPFNVEYLRVKRERTGHLIQTDDDGTARTA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=189, Percent_Identity=55.5555555555556, Blast_Score=196, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6319438, Length=174, Percent_Identity=40.2298850574713, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 24369; Mature: 24238

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLVAVAGRKGRGAHEASAATIDLYAEAPLPTERGLFRAVVFRERRTGVEHVAMVMGDV
CCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHC
AGESVAVRVHSECLTSEVLGSLKCDCRAQLDRALDLIAARGRGALLYLRQEGRGIGLGNK
CCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
IRAYALQAQGHDTYEANRLLGFPDDLRRYDVAAEMLRLLGVRSVELITNNPQKLSGLAEA
EEEEEEECCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHC
GVPVRGRIQLPSPANPFNVEYLRVKRERTGHLIQTDDDGTARTA
CCCCEEEEECCCCCCCCCEEEEEEEHHCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
SNLVAVAGRKGRGAHEASAATIDLYAEAPLPTERGLFRAVVFRERRTGVEHVAMVMGDV
CCEEEECCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHC
AGESVAVRVHSECLTSEVLGSLKCDCRAQLDRALDLIAARGRGALLYLRQEGRGIGLGNK
CCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
IRAYALQAQGHDTYEANRLLGFPDDLRRYDVAAEMLRLLGVRSVELITNNPQKLSGLAEA
EEEEEEECCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHC
GVPVRGRIQLPSPANPFNVEYLRVKRERTGHLIQTDDDGTARTA
CCCCEEEEECCCCCCCCCEEEEEEEHHCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA