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The map label for this gene is mmgB [H]

Identifier: 220917379

GI number: 220917379

Start: 2530314

End: 2531171

Strand: Direct

Name: mmgB [H]

Synonym: A2cp1_2279

Alternate gene names: 220917379

Gene position: 2530314-2531171 (Clockwise)

Preceding gene: 220917377

Following gene: 220917380

Centisome position: 50.31

GC content: 72.14

Gene sequence:

>858_bases
ATGGGCAGCGGGATCGAGCGGCTGGCGGTGGTGGGCGCGGGGCAGATGGGCTCGGGCATCGCGCAGGTGGCGGCCCAGGC
CGGGCTCTCGGTGCAGGTGGCGGACGCCACGCCCGAGCTGGCGCGGCGCGCGGTGGAGCGGCTCGGCGCGGCGCTCGCGA
AGGGGGTGGAGAAGGGGAAGCTGGCGGCGGCGGAGCGGGAGGCGGTGCTGGGCCGGATCCGTGCGGTGGACCGGATCGAG
GACTGCGCGGGCGCCGACCTCGCCATCGAGGCGGTGGTGGAGCAGGAGGCGGTGAAGGCCGACCTGTTCCGCCGGCTCGA
CGCGGTGCTCGCGCCGGGCGCCATCCTCGCGTCCAACACCAGCTCGATCTCGATCACCAAGCTCGCCGCCGGGACCCGCC
GGCCGGACCGGTTCGTGGGGATGCACTTCATGAACCCGCCGCCGGTGATGCAGCTCATCGAGGTCATCCGCGGACTGCAG
ACCTCCGACGAGACCTACCAGGCGGTGATGGCGCTCGCGAAGCGCTTCGGGAAGACCACCGTCACCTCCAAGGACTCGCC
CGGCTTCATCGTGAACCGGATCCTCATCCCGCTGCTGAACGAGGCCTGCTTCGCGCTGCAGGAGGGCCTCGCCTCGCCGG
AGGACATCGACACCGCGGTGAAGCTCGGCCTCAACCACCCGATGGGCCCGCTCACGCTGGCCGACTTCATCGGGCTCGAC
ACCTGCCTGTTCATCGCCGAGGTGCTCCACCGCGAGCTGGGCGACGACAAGTACCGGCCCGCGCCGCTGCTGCGGAGCTA
CGTGGCGGCGGGCTGGAACGGCCGCAAGAGCGGGCGCGGCTTCTACACCTACGGCTAG

Upstream 100 bases:

>100_bases
CGCCGGATCGTCACACGCTCGAACGTTCGCTGACAAGCCCGGCATGGTCGCGCCGCGACGGCGCACGGCCGCAGGGCCAC
ACCCGAGCGACGGAGGGAGC

Downstream 100 bases:

>100_bases
CGCGAGGACGCCATGGCCTACGAGAACGTGCTCTGGGAGGTCGCCGACGGGATCGGCACCCTCACCGTGAACCGCCCGAA
GCAGCTCAACGCGCTCGACC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MGSGIERLAVVGAGQMGSGIAQVAAQAGLSVQVADATPELARRAVERLGAALAKGVEKGKLAAAEREAVLGRIRAVDRIE
DCAGADLAIEAVVEQEAVKADLFRRLDAVLAPGAILASNTSSISITKLAAGTRRPDRFVGMHFMNPPPVMQLIEVIRGLQ
TSDETYQAVMALAKRFGKTTVTSKDSPGFIVNRILIPLLNEACFALQEGLASPEDIDTAVKLGLNHPMGPLTLADFIGLD
TCLFIAEVLHRELGDDKYRPAPLLRSYVAAGWNGRKSGRGFYTYG

Sequences:

>Translated_285_residues
MGSGIERLAVVGAGQMGSGIAQVAAQAGLSVQVADATPELARRAVERLGAALAKGVEKGKLAAAEREAVLGRIRAVDRIE
DCAGADLAIEAVVEQEAVKADLFRRLDAVLAPGAILASNTSSISITKLAAGTRRPDRFVGMHFMNPPPVMQLIEVIRGLQ
TSDETYQAVMALAKRFGKTTVTSKDSPGFIVNRILIPLLNEACFALQEGLASPEDIDTAVKLGLNHPMGPLTLADFIGLD
TCLFIAEVLHRELGDDKYRPAPLLRSYVAAGWNGRKSGRGFYTYG
>Mature_284_residues
GSGIERLAVVGAGQMGSGIAQVAAQAGLSVQVADATPELARRAVERLGAALAKGVEKGKLAAAEREAVLGRIRAVDRIED
CAGADLAIEAVVEQEAVKADLFRRLDAVLAPGAILASNTSSISITKLAAGTRRPDRFVGMHFMNPPPVMQLIEVIRGLQT
SDETYQAVMALAKRFGKTTVTSKDSPGFIVNRILIPLLNEACFALQEGLASPEDIDTAVKLGLNHPMGPLTLADFIGLDT
CLFIAEVLHRELGDDKYRPAPLLRSYVAAGWNGRKSGRGFYTYG

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=43.4027777777778, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=41.8300653594771, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI20127408, Length=281, Percent_Identity=35.5871886120996, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=31.8493150684932, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=31.8493150684932, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI115430219, Length=223, Percent_Identity=28.6995515695067, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1787661, Length=285, Percent_Identity=41.4035087719298, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1788682, Length=263, Percent_Identity=38.0228136882129, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=33.8345864661654, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=42.9065743944637, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=42.5087108013937, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=37.6306620209059, Blast_Score=192, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17508953, Length=290, Percent_Identity=36.8965517241379, Blast_Score=174, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25144276, Length=290, Percent_Identity=36.8965517241379, Blast_Score=174, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17508951, Length=290, Percent_Identity=36.8965517241379, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=35.8156028368794, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=29.2253521126761, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=26.0714285714286, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=37.9432624113475, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=37.9432624113475, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=37.9432624113475, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI45549573, Length=244, Percent_Identity=30.327868852459, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI20129993, Length=225, Percent_Identity=28, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30224; Mature: 30093

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSGIERLAVVGAGQMGSGIAQVAAQAGLSVQVADATPELARRAVERLGAALAKGVEKGK
CCCCHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LAAAEREAVLGRIRAVDRIEDCAGADLAIEAVVEQEAVKADLFRRLDAVLAPGAILASNT
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCC
SSISITKLAAGTRRPDRFVGMHFMNPPPVMQLIEVIRGLQTSDETYQAVMALAKRFGKTT
CCEEEEHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
VTSKDSPGFIVNRILIPLLNEACFALQEGLASPEDIDTAVKLGLNHPMGPLTLADFIGLD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
TCLFIAEVLHRELGDDKYRPAPLLRSYVAAGWNGRKSGRGFYTYG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GSGIERLAVVGAGQMGSGIAQVAAQAGLSVQVADATPELARRAVERLGAALAKGVEKGK
CCCHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LAAAEREAVLGRIRAVDRIEDCAGADLAIEAVVEQEAVKADLFRRLDAVLAPGAILASNT
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCC
SSISITKLAAGTRRPDRFVGMHFMNPPPVMQLIEVIRGLQTSDETYQAVMALAKRFGKTT
CCEEEEHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
VTSKDSPGFIVNRILIPLLNEACFALQEGLASPEDIDTAVKLGLNHPMGPLTLADFIGLD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
TCLFIAEVLHRELGDDKYRPAPLLRSYVAAGWNGRKSGRGFYTYG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]