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The map label for this gene is barA [C]

Identifier: 220917378

GI number: 220917378

Start: 2527986

End: 2530175

Strand: Reverse

Name: barA [C]

Synonym: A2cp1_2278

Alternate gene names: 220917378

Gene position: 2530175-2527986 (Counterclockwise)

Preceding gene: 220917383

Following gene: 220917370

Centisome position: 50.31

GC content: 78.86

Gene sequence:

>2190_bases
ATGCTCAGGATCCACCGGGAGATCGCGCGGGATGCGGCTCGGGCCGCCGGGGTTCCCCTGGCCCAGCTCGTGGCCGTGGT
GCCCGGTGAGGCCGCGCCGGCGGTCACGCTGGCGGTCGAGGGACCTGCCCTCTCCTCGCGCACCCTCAGGGGGCGGATCG
CCACCCTCCTCGACGGTGCGCCGGGCCACCTGCCCGCGGGGCCGCTGCTGGCCGCGCCGCGGGTGTTCCGGCTGACCGCG
CCGTGCGAGTCGGCGCTGGCCGTCGCGCTCTGGCCGGACCACGTGCAGCCGCCGGCCGCGACCTCGGTGTTCTTCCGCCT
CCAGGCCGGCCCCGGCGAGGCGGTGCTCCTGCGGATGGTGGCCGCCGGGCGGCTCGACGCGGGCGAGCTGCGCGCGCTCG
ACGCGGTGGCGCGCCTGGCGGCGGGCCGGCTCGCGGGCGAGAGCTACCGCCGCGAGGCGGCCGGGCGCCGTGCCGCGTAC
CGCGTCTACCAGGAGGCCGCCGGCGAGCCGATCCTGGTGCTCGACGCCGGGACCGGGCGGCTGCTCGAGGCGAACCAGCG
CCTGTCGCAGCTCACCGGCTGGGGGCGCCAGGAGCTGCGCCGCCTCACGCTGGGGCGGCTCGTGGAGCATCCGGCGCTCG
ACGCGGGGGCGCTGCTGGAGGCGCTCTCGGGGACCGCGACGGCCTCGGTGGACGACGCCCGCCTGCGGCGCCGGCGCGGC
GAGCCGGTGCCGGTGGCGCTCACCAGCGCCCGGATCGAGCTGGACGGCCGTCCGGTGCTCCACCTCATCGCCCGCGACGT
GAGCCGCGAGCGGCGCGCGCTCGCCGAGCAGCGGGAGGCGCGCGAGCTGCTCGCGGCGCTGCACCTCGCGGGCGCGCACC
TCAGCGTCGAGACCGACGAGGAGGCGGTGTACGGCGTGCTGGCGCGCGAGCTGGCGCGGCTCGGCTACCACTGCGGTGTC
CTCGCCCCCGCGCCGGACGGCCCGCCCGCCTTCACGTGGCGGTTCCTGTCCTTCCCGCCGTCGCTCCGGCGCGCGCTCGA
TCACGCGCTCGGGACCCCGCTGGCGGCGGTCCGCGTCGATCCCATGGAGGCGCCGCTGCTCCGGCGCTGCCTGGCGGAGC
GCCGGACCGTGCACACCGACCGGCCGCGCCGCGCCGCCGCCGGGCTCCTCGGCGCGGCGTCGCCGCTCGACCTCCGGCGG
CTGGCGCGGCTCGTCGCCATCCGGCGGGTGATCCTGGCCCCGCTCCTGCGCGAGGGGCGGGCCGCCGCGGCGCTGGTGGT
GGCGGCGCCGCGGGTCCGGCGCAGCGATCCGGAGGCCATCGACGCGTTCGCGCTGCAGGCCTCGATCGCGCTCGACAAGG
CGCGGCTGGTGGGCGCGCTGCGGGACGAGCGCGCCCGGCTGGAGAGCGAGGTCGAGCGGCGCACCGCGGAGCTGCGCCGC
GCGGTGACGGCCCTCGAGGCGGCGGACCGGCGCAAGGACAACTTCCTCGCCAACGTCTCGCACGAGCTGCGCACGCCGCT
CGTGACGGTGCTCGGCTACGCCGACCTGCTGCTGGCCGACAAGCTGGGCCCGCTCGCGCCCCGGCAGCGCACCGCGCTGC
AAGTGGTGGCGAGCAGCGGCCGGCGGCTGCGCGCCTTCATCGAGGAGCTGCTGGAGCTGTCGCGCCACGAGCTGGCGCGG
CCCGCCGAGCCGTTCGCGCCGTTCCCGCTCGCGGACGTGATCACGCAGGCGGTGGTGGCGCTCGCGCCGCGCTTCGCCGA
GCGCGGGCTCCGGGTCCGGGCGCGGGTGGCGCGCGGCACGCCCCCGGCCCAGGGCCAGCGCGAGCGCGTGCTGCAGGTGA
TCGTCAACCTGCTCGGGAACGCCGAGCGCTACGCGCCGGCGGGCTCGGCCATCCACCTCGCCGCCGCGGCGGTCGGGGAT
CGGGTGGCGGTCTCGGTCACCGACCGGGGGCCCGGCATCCCGGTGGAGCACCAGGCGCTGATCTTCGAGCGGCTGTACCA
GGTCCGGGACGACGCCCCGCGCCGCGAGGGCGGCGCGCTGGGGATCGGCCTCTCCATCGCGAAGGGGATCGTGGAGGCCC
ACGGCGGCGAGATCGGCGTCCGCTCGCGCGTGGGCTGGGGCACGCGGTTCCGCTTCACCCTCCCCGCCGCCGCGACCGCG
CCCGGCGGGCGCGAGGCCGACGCCTCGTAG

Upstream 100 bases:

>100_bases
GCCGTCGCGGCGCGACCATGCCGGGCTTGTCAGCGAACGTTCGAGCGTGTGACGATCCGGCGCCGAGCGCGAGATCCCAA
CCGGGGTGCGCGCCGCTTTC

Downstream 100 bases:

>100_bases
CGTCGCCGTCCGTTCGAGGAAAAAAAACGGCGCCCGCGCGCTCCCTGGAACGCGCGGGCGCCGGGCTGCGGCGCAGGGGG
GAAGGCGCCGCCGCCTGAGC

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 729; Mature: 729

Protein sequence:

>729_residues
MLRIHREIARDAARAAGVPLAQLVAVVPGEAAPAVTLAVEGPALSSRTLRGRIATLLDGAPGHLPAGPLLAAPRVFRLTA
PCESALAVALWPDHVQPPAATSVFFRLQAGPGEAVLLRMVAAGRLDAGELRALDAVARLAAGRLAGESYRREAAGRRAAY
RVYQEAAGEPILVLDAGTGRLLEANQRLSQLTGWGRQELRRLTLGRLVEHPALDAGALLEALSGTATASVDDARLRRRRG
EPVPVALTSARIELDGRPVLHLIARDVSRERRALAEQREARELLAALHLAGAHLSVETDEEAVYGVLARELARLGYHCGV
LAPAPDGPPAFTWRFLSFPPSLRRALDHALGTPLAAVRVDPMEAPLLRRCLAERRTVHTDRPRRAAAGLLGAASPLDLRR
LARLVAIRRVILAPLLREGRAAAALVVAAPRVRRSDPEAIDAFALQASIALDKARLVGALRDERARLESEVERRTAELRR
AVTALEAADRRKDNFLANVSHELRTPLVTVLGYADLLLADKLGPLAPRQRTALQVVASSGRRLRAFIEELLELSRHELAR
PAEPFAPFPLADVITQAVVALAPRFAERGLRVRARVARGTPPAQGQRERVLQVIVNLLGNAERYAPAGSAIHLAAAAVGD
RVAVSVTDRGPGIPVEHQALIFERLYQVRDDAPRREGGALGIGLSIAKGIVEAHGGEIGVRSRVGWGTRFRFTLPAAATA
PGGREADAS

Sequences:

>Translated_729_residues
MLRIHREIARDAARAAGVPLAQLVAVVPGEAAPAVTLAVEGPALSSRTLRGRIATLLDGAPGHLPAGPLLAAPRVFRLTA
PCESALAVALWPDHVQPPAATSVFFRLQAGPGEAVLLRMVAAGRLDAGELRALDAVARLAAGRLAGESYRREAAGRRAAY
RVYQEAAGEPILVLDAGTGRLLEANQRLSQLTGWGRQELRRLTLGRLVEHPALDAGALLEALSGTATASVDDARLRRRRG
EPVPVALTSARIELDGRPVLHLIARDVSRERRALAEQREARELLAALHLAGAHLSVETDEEAVYGVLARELARLGYHCGV
LAPAPDGPPAFTWRFLSFPPSLRRALDHALGTPLAAVRVDPMEAPLLRRCLAERRTVHTDRPRRAAAGLLGAASPLDLRR
LARLVAIRRVILAPLLREGRAAAALVVAAPRVRRSDPEAIDAFALQASIALDKARLVGALRDERARLESEVERRTAELRR
AVTALEAADRRKDNFLANVSHELRTPLVTVLGYADLLLADKLGPLAPRQRTALQVVASSGRRLRAFIEELLELSRHELAR
PAEPFAPFPLADVITQAVVALAPRFAERGLRVRARVARGTPPAQGQRERVLQVIVNLLGNAERYAPAGSAIHLAAAAVGD
RVAVSVTDRGPGIPVEHQALIFERLYQVRDDAPRREGGALGIGLSIAKGIVEAHGGEIGVRSRVGWGTRFRFTLPAAATA
PGGREADAS
>Mature_729_residues
MLRIHREIARDAARAAGVPLAQLVAVVPGEAAPAVTLAVEGPALSSRTLRGRIATLLDGAPGHLPAGPLLAAPRVFRLTA
PCESALAVALWPDHVQPPAATSVFFRLQAGPGEAVLLRMVAAGRLDAGELRALDAVARLAAGRLAGESYRREAAGRRAAY
RVYQEAAGEPILVLDAGTGRLLEANQRLSQLTGWGRQELRRLTLGRLVEHPALDAGALLEALSGTATASVDDARLRRRRG
EPVPVALTSARIELDGRPVLHLIARDVSRERRALAEQREARELLAALHLAGAHLSVETDEEAVYGVLARELARLGYHCGV
LAPAPDGPPAFTWRFLSFPPSLRRALDHALGTPLAAVRVDPMEAPLLRRCLAERRTVHTDRPRRAAAGLLGAASPLDLRR
LARLVAIRRVILAPLLREGRAAAALVVAAPRVRRSDPEAIDAFALQASIALDKARLVGALRDERARLESEVERRTAELRR
AVTALEAADRRKDNFLANVSHELRTPLVTVLGYADLLLADKLGPLAPRQRTALQVVASSGRRLRAFIEELLELSRHELAR
PAEPFAPFPLADVITQAVVALAPRFAERGLRVRARVARGTPPAQGQRERVLQVIVNLLGNAERYAPAGSAIHLAAAAVGD
RVAVSVTDRGPGIPVEHQALIFERLYQVRDDAPRREGGALGIGLSIAKGIVEAHGGEIGVRSRVGWGTRFRFTLPAAATA
PGGREADAS

Specific function: Member Of The Two-Component Regulatory System Uvry/Bara Involved In The Regulation Of Carbon Metabolism Via The Csra/Csrb Regulatory System. Phosphorylates Uvry, Probably Via A Four-Step Phosphorelay. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=261, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI87081816, Length=279, Percent_Identity=36.2007168458781, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI145693157, Length=312, Percent_Identity=30.4487179487179, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=32.6271186440678, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=29.8701298701299, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI48994928, Length=256, Percent_Identity=30.078125, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87082128, Length=242, Percent_Identity=28.9256198347107, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786783, Length=251, Percent_Identity=29.4820717131474, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1786912, Length=313, Percent_Identity=29.073482428115, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=29.4642857142857, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788549, Length=304, Percent_Identity=25.9868421052632, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=312, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1790346, Length=240, Percent_Identity=27.5, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1790551, Length=240, Percent_Identity=29.5833333333333, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78054; Mature: 78054

Theoretical pI: Translated: 11.49; Mature: 11.49

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIHREIARDAARAAGVPLAQLVAVVPGEAAPAVTLAVEGPALSSRTLRGRIATLLDGA
CCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
PGHLPAGPLLAAPRVFRLTAPCESALAVALWPDHVQPPAATSVFFRLQAGPGEAVLLRMV
CCCCCCCCHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHH
AAGRLDAGELRALDAVARLAAGRLAGESYRREAAGRRAAYRVYQEAAGEPILVLDAGTGR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
LLEANQRLSQLTGWGRQELRRLTLGRLVEHPALDAGALLEALSGTATASVDDARLRRRRG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCC
EPVPVALTSARIELDGRPVLHLIARDVSRERRALAEQREARELLAALHLAGAHLSVETDE
CCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCH
EAVYGVLARELARLGYHCGVLAPAPDGPPAFTWRFLSFPPSLRRALDHALGTPLAAVRVD
HHHHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEC
PMEAPLLRRCLAERRTVHTDRPRRAAAGLLGAASPLDLRRLARLVAIRRVILAPLLREGR
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AAAALVVAAPRVRRSDPEAIDAFALQASIALDKARLVGALRDERARLESEVERRTAELRR
HHEEHEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVTALEAADRRKDNFLANVSHELRTPLVTVLGYADLLLADKLGPLAPRQRTALQVVASSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
RRLRAFIEELLELSRHELARPAEPFAPFPLADVITQAVVALAPRFAERGLRVRARVARGT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCC
PPAQGQRERVLQVIVNLLGNAERYAPAGSAIHLAAAAVGDRVAVSVTDRGPGIPVEHQAL
CCCCCHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHH
IFERLYQVRDDAPRREGGALGIGLSIAKGIVEAHGGEIGVRSRVGWGTRFRFTLPAAATA
HHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHCCCCEECCCCCCCCCEEEEECCCCCCC
PGGREADAS
CCCCCCCCC
>Mature Secondary Structure
MLRIHREIARDAARAAGVPLAQLVAVVPGEAAPAVTLAVEGPALSSRTLRGRIATLLDGA
CCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
PGHLPAGPLLAAPRVFRLTAPCESALAVALWPDHVQPPAATSVFFRLQAGPGEAVLLRMV
CCCCCCCCHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHH
AAGRLDAGELRALDAVARLAAGRLAGESYRREAAGRRAAYRVYQEAAGEPILVLDAGTGR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
LLEANQRLSQLTGWGRQELRRLTLGRLVEHPALDAGALLEALSGTATASVDDARLRRRRG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCC
EPVPVALTSARIELDGRPVLHLIARDVSRERRALAEQREARELLAALHLAGAHLSVETDE
CCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCH
EAVYGVLARELARLGYHCGVLAPAPDGPPAFTWRFLSFPPSLRRALDHALGTPLAAVRVD
HHHHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEC
PMEAPLLRRCLAERRTVHTDRPRRAAAGLLGAASPLDLRRLARLVAIRRVILAPLLREGR
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AAAALVVAAPRVRRSDPEAIDAFALQASIALDKARLVGALRDERARLESEVERRTAELRR
HHEEHEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVTALEAADRRKDNFLANVSHELRTPLVTVLGYADLLLADKLGPLAPRQRTALQVVASSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
RRLRAFIEELLELSRHELARPAEPFAPFPLADVITQAVVALAPRFAERGLRVRARVARGT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCC
PPAQGQRERVLQVIVNLLGNAERYAPAGSAIHLAAAAVGDRVAVSVTDRGPGIPVEHQAL
CCCCCHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHH
IFERLYQVRDDAPRREGGALGIGLSIAKGIVEAHGGEIGVRSRVGWGTRFRFTLPAAATA
HHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHCCCCEECCCCCCCCCEEEEECCCCCCC
PGGREADAS
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 7756693 [H]