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The map label for this gene is rtcA [H]

Identifier: 220917369

GI number: 220917369

Start: 2520187

End: 2521302

Strand: Direct

Name: rtcA [H]

Synonym: A2cp1_2269

Alternate gene names: 220917369

Gene position: 2520187-2521302 (Clockwise)

Preceding gene: 220917364

Following gene: 220917371

Centisome position: 50.11

GC content: 77.69

Gene sequence:

>1116_bases
ATGCCGGCGGATCTCCCCATCGTGCTGGACGGCAGCGCCGGCGAGGGCGGCGGCCAGATCCTGCGCACCGCGCTCGCGCT
GTCGGCGGTCACCGGGCGGCCGTTCACCATCGAGCGCATCCGCGAGCACCGGCTCAAGCCGGGGCTGCGCCCGCAGCACC
GCGAGGCGGCGCGCGCCACCGCCCGGATCGTGGAGGCGGAGCTCGCGGGCGACGAGGTCGGCTCGAGCGCGCTCGAGTTC
CGGCCGCGCCACGCGCCGCGCGCGGGCGACTGGGCCTTCGACATCGGGACCGCCGGCTCGACGCCGCTCCTGTTCCAGAC
GGTGTGCTGGCCGCTGGCGCTGGCCGGCGCACCCTCCACGCTCACCCTGCGCGGCGGGACGCACCAGGACCACGCGCCCA
CGTTCCACTACCTGGCGCTGGTGTGGGCGCCGGCGGTGGCGCGGCTCGGGTTCCGGTTCGGGCTGGAGCTGCAGGCGGCC
GGGTTCTACCCCGAGGGCGGCGGCGAGATGACCGCCCGCATCGAGCCGGCGCACCCGATGCCGCCGCTCGACGTGCGCCA
CCGCGGCACGCTGCAGGACGTCGAGGTGGTGTCGATGGTGGGCGGGCTCGGCTTCGAGATCGCCGAGCGGCAGGCGGCGC
GCGCGCTGCGCGGCCTGCGCGACGCGGGCATCCCCGCGGAGGCCGAGCGGGTGCCGGTGCCCTCGCGCGCCTCGCGGGGC
GGGCACGTGCTCCTGGTCTCCACGTTCGAGCGGACCCGCACCGGGCACGGCGCGGTCAGCGCGCGCGAGCGGTCGCCGGA
GGAGGTCGCGGACCTGGCGGTGGAGGGGCTGCGCGACCACCTCCGCGGCGGCGCCGCGGTCGACCTGCACCTCGGCGATC
AGCTGCTCCTGCCGGCCGCGCTGGCCGCGGCCGGGATCCTGCCCGCCGCCCCCGGCGTCGTGCCGGTGACGCGCTACAGC
GTGGCCACGATCACGCGGCACCTCACCACCAACGCCGAGGTGATCCGCCGGTTCCTCGACGTGGAGATCGCGGTGGACGG
CGGCGAGGGTCAGGAGGGCGAGGTGCGGGTCCAGCCGCCCGGCGCCCGGGGCGACGTGGTGCCGATCGGACGCTGA

Upstream 100 bases:

>100_bases
CGGCGATCACCCGCGCCTTGTAGCACGCCCCGGGGAGGGGGCGGCCGGCCCAGCCCACGCACCGCTTAACGCCGCGGCGT
CGCCGGACTACATTGCGCCG

Downstream 100 bases:

>100_bases
GCGGCTACAGCCAGCGCTTCCGCCGGAACACCCCGTACATCGCGACCGGCATCACCACCATCGACAGGAGCACCAGCGGC
ACCGCGAGGCGCGGTGGCAG

Product: RNA 3'-phosphate cyclase

Products: NA

Alternate protein names: RNA cyclase; RNA-3'-phosphate cyclase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MPADLPIVLDGSAGEGGGQILRTALALSAVTGRPFTIERIREHRLKPGLRPQHREAARATARIVEAELAGDEVGSSALEF
RPRHAPRAGDWAFDIGTAGSTPLLFQTVCWPLALAGAPSTLTLRGGTHQDHAPTFHYLALVWAPAVARLGFRFGLELQAA
GFYPEGGGEMTARIEPAHPMPPLDVRHRGTLQDVEVVSMVGGLGFEIAERQAARALRGLRDAGIPAEAERVPVPSRASRG
GHVLLVSTFERTRTGHGAVSARERSPEEVADLAVEGLRDHLRGGAAVDLHLGDQLLLPAALAAAGILPAAPGVVPVTRYS
VATITRHLTTNAEVIRRFLDVEIAVDGGEGQEGEVRVQPPGARGDVVPIGR

Sequences:

>Translated_371_residues
MPADLPIVLDGSAGEGGGQILRTALALSAVTGRPFTIERIREHRLKPGLRPQHREAARATARIVEAELAGDEVGSSALEF
RPRHAPRAGDWAFDIGTAGSTPLLFQTVCWPLALAGAPSTLTLRGGTHQDHAPTFHYLALVWAPAVARLGFRFGLELQAA
GFYPEGGGEMTARIEPAHPMPPLDVRHRGTLQDVEVVSMVGGLGFEIAERQAARALRGLRDAGIPAEAERVPVPSRASRG
GHVLLVSTFERTRTGHGAVSARERSPEEVADLAVEGLRDHLRGGAAVDLHLGDQLLLPAALAAAGILPAAPGVVPVTRYS
VATITRHLTTNAEVIRRFLDVEIAVDGGEGQEGEVRVQPPGARGDVVPIGR
>Mature_370_residues
PADLPIVLDGSAGEGGGQILRTALALSAVTGRPFTIERIREHRLKPGLRPQHREAARATARIVEAELAGDEVGSSALEFR
PRHAPRAGDWAFDIGTAGSTPLLFQTVCWPLALAGAPSTLTLRGGTHQDHAPTFHYLALVWAPAVARLGFRFGLELQAAG
FYPEGGGEMTARIEPAHPMPPLDVRHRGTLQDVEVVSMVGGLGFEIAERQAARALRGLRDAGIPAEAERVPVPSRASRGG
HVLLVSTFERTRTGHGAVSARERSPEEVADLAVEGLRDHLRGGAAVDLHLGDQLLLPAALAAAGILPAAPGVVPVTRYSV
ATITRHLTTNAEVIRRFLDVEIAVDGGEGQEGEVRVQPPGARGDVVPIGR

Specific function: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A;

COG id: COG0430

COG function: function code A; RNA 3'-terminal phosphate cyclase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4506589, Length=353, Percent_Identity=31.728045325779, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI195927044, Length=366, Percent_Identity=30.6010928961749, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI48994937, Length=344, Percent_Identity=36.9186046511628, Blast_Score=175, Evalue=5e-45,
Organism=Drosophila melanogaster, GI18543269, Length=309, Percent_Identity=30.0970873786408, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013791
- InterPro:   IPR000228
- InterPro:   IPR013796
- InterPro:   IPR020723
- InterPro:   IPR017770
- InterPro:   IPR013792 [H]

Pfam domain/function: PF01137 RTC; PF05189 RTC_insert [H]

EC number: =6.5.1.4 [H]

Molecular weight: Translated: 39205; Mature: 39074

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPADLPIVLDGSAGEGGGQILRTALALSAVTGRPFTIERIREHRLKPGLRPQHREAARAT
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCHHHHHHHH
ARIVEAELAGDEVGSSALEFRPRHAPRAGDWAFDIGTAGSTPLLFQTVCWPLALAGAPST
HHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCE
LTLRGGTHQDHAPTFHYLALVWAPAVARLGFRFGLELQAAGFYPEGGGEMTARIEPAHPM
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCEEEEECCCCCC
PPLDVRHRGTLQDVEVVSMVGGLGFEIAERQAARALRGLRDAGIPAEAERVPVPSRASRG
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GHVLLVSTFERTRTGHGAVSARERSPEEVADLAVEGLRDHLRGGAAVDLHLGDQLLLPAA
CEEEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LAAAGILPAAPGVVPVTRYSVATITRHLTTNAEVIRRFLDVEIAVDGGEGQEGEVRVQPP
HHHHCCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHCEEEEEECCCCCCCEEEEECC
GARGDVVPIGR
CCCCCEEECCC
>Mature Secondary Structure 
PADLPIVLDGSAGEGGGQILRTALALSAVTGRPFTIERIREHRLKPGLRPQHREAARAT
CCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCHHHHHHHH
ARIVEAELAGDEVGSSALEFRPRHAPRAGDWAFDIGTAGSTPLLFQTVCWPLALAGAPST
HHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCE
LTLRGGTHQDHAPTFHYLALVWAPAVARLGFRFGLELQAAGFYPEGGGEMTARIEPAHPM
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCEEEEECCCCCC
PPLDVRHRGTLQDVEVVSMVGGLGFEIAERQAARALRGLRDAGIPAEAERVPVPSRASRG
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GHVLLVSTFERTRTGHGAVSARERSPEEVADLAVEGLRDHLRGGAAVDLHLGDQLLLPAA
CEEEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LAAAGILPAAPGVVPVTRYSVATITRHLTTNAEVIRRFLDVEIAVDGGEGQEGEVRVQPP
HHHHCCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHCEEEEEECCCCCCCEEEEECC
GARGDVVPIGR
CCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA