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The map label for this gene is map [C]

Identifier: 220917289

GI number: 220917289

Start: 2427769

End: 2428566

Strand: Reverse

Name: map [C]

Synonym: A2cp1_2188

Alternate gene names: 220917289

Gene position: 2428566-2427769 (Counterclockwise)

Preceding gene: 220917293

Following gene: 220917288

Centisome position: 48.29

GC content: 74.44

Gene sequence:

>798_bases
ATGGCAATCCCATTGCTGGGCGAGCAGGCGATCGAGCGGACGCGGCATGCGGGCAGGGCCGCGGCGGCGACGCTGGCGCA
CGTGGCCGAGCGGCTCGCGGCGGGCGTCTCCACGGCCGACATCGACGCCTGGGTGCGCGAGGACACCGCGCGGCGGGGCG
GCCATCCGAGCCAGCTCGGCTTCCACGGCTTTCCTGCGGCGGTCTGCACGAGCCGGAACGACGTCGTCTGCCACGGCGTC
CCGCGCGCCGAGGAGCGGCTGCGCCCCGGCGACATCGTGAACGTGGACGTGACCACGCGCCTCGACGGCTTCCACGGGGA
CACCTCGGCGACGTTCTGCATCGGCGAGGTCTCCGCGGAGGCGCGGCACGTCGTCGAGGTCGCCCGCCGCTGCCGCGAGG
CCGGGGTGGCGGTCGTGCGCCACGGCGTCCGGCTCGGCGACGTGGGCGCGGCCATCGAGGAGGTCGCGCGCGCCGGCGGC
TGCAGCGTGGTGCGCGAGTACGGCGGTCACGGCATCGGCAAGGCGATGCACGGCCCGCCGCTCGTGATGCACGTCGGCCC
GAGGGGACAGGGCGTGAAGCTGAAGGCCGGGATGGCCATCACCGTCGAGCCGATGGTGAACCTCGGCCGACCGGAGGTGA
AGCTGCTCGCCGACGGGTGGACGGTGGTCACGGCGGACGGGAGCCTCTCGGCGCAGTTCGAGCACACGGTGGTAGTGACG
CGCGACGGGTGCGAGGTGATGACCGGATGCGCCGGACGTGCAGCTCTGGCGCCCGCCGCGTCCGGGCTGAGCGCTTGA

Upstream 100 bases:

>100_bases
GTGCGTGTCAGGTCCCGGAGGACCACGGCCCTCGGCGGAAGCACGGGCCGATGCCGAGACGGCATTGGACCCCTCCGGCG
GCTCGCGGGACCTTGCCGGC

Downstream 100 bases:

>100_bases
CCGAGCGTCATCCCGCCGCCGCCGTTCGGGCCACCCCTCACGACCGCGCCCTCGCCTCGTTCGCGGCACCGCGGCCCGCG
CGCACCGCGCGAGACTGGCG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MAIPLLGEQAIERTRHAGRAAAATLAHVAERLAAGVSTADIDAWVREDTARRGGHPSQLGFHGFPAAVCTSRNDVVCHGV
PRAEERLRPGDIVNVDVTTRLDGFHGDTSATFCIGEVSAEARHVVEVARRCREAGVAVVRHGVRLGDVGAAIEEVARAGG
CSVVREYGGHGIGKAMHGPPLVMHVGPRGQGVKLKAGMAITVEPMVNLGRPEVKLLADGWTVVTADGSLSAQFEHTVVVT
RDGCEVMTGCAGRAALAPAASGLSA

Sequences:

>Translated_265_residues
MAIPLLGEQAIERTRHAGRAAAATLAHVAERLAAGVSTADIDAWVREDTARRGGHPSQLGFHGFPAAVCTSRNDVVCHGV
PRAEERLRPGDIVNVDVTTRLDGFHGDTSATFCIGEVSAEARHVVEVARRCREAGVAVVRHGVRLGDVGAAIEEVARAGG
CSVVREYGGHGIGKAMHGPPLVMHVGPRGQGVKLKAGMAITVEPMVNLGRPEVKLLADGWTVVTADGSLSAQFEHTVVVT
RDGCEVMTGCAGRAALAPAASGLSA
>Mature_264_residues
AIPLLGEQAIERTRHAGRAAAATLAHVAERLAAGVSTADIDAWVREDTARRGGHPSQLGFHGFPAAVCTSRNDVVCHGVP
RAEERLRPGDIVNVDVTTRLDGFHGDTSATFCIGEVSAEARHVVEVARRCREAGVAVVRHGVRLGDVGAAIEEVARAGGC
SVVREYGGHGIGKAMHGPPLVMHVGPRGQGVKLKAGMAITVEPMVNLGRPEVKLLADGWTVVTADGSLSAQFEHTVVVTR
DGCEVMTGCAGRAALAPAASGLSA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=253, Percent_Identity=39.5256916996047, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI164420681, Length=246, Percent_Identity=42.2764227642276, Blast_Score=191, Evalue=5e-49,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=44.9799196787149, Blast_Score=225, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=40.4858299595142, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=39.5161290322581, Blast_Score=196, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24583427, Length=238, Percent_Identity=37.8151260504202, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=38.2113821138211, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27462; Mature: 27330

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPLLGEQAIERTRHAGRAAAATLAHVAERLAAGVSTADIDAWVREDTARRGGHPSQLG
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
FHGFPAAVCTSRNDVVCHGVPRAEERLRPGDIVNVDVTTRLDGFHGDTSATFCIGEVSAE
CCCCCHHHCCCCCCEEEECCCCHHHHCCCCCEEEEEEEEEECCCCCCCCCEEEEECCCHH
ARHVVEVARRCREAGVAVVRHGVRLGDVGAAIEEVARAGGCSVVREYGGHGIGKAMHGPP
HHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCE
LVMHVGPRGQGVKLKAGMAITVEPMVNLGRPEVKLLADGWTVVTADGSLSAQFEHTVVVT
EEEEECCCCCCEEEECCEEEEECHHHCCCCCCEEEEECCEEEEEECCCCEEEEEEEEEEE
RDGCEVMTGCAGRAALAPAASGLSA
ECCCHHHHCCCCCHHHCCCCCCCCC
>Mature Secondary Structure 
AIPLLGEQAIERTRHAGRAAAATLAHVAERLAAGVSTADIDAWVREDTARRGGHPSQLG
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
FHGFPAAVCTSRNDVVCHGVPRAEERLRPGDIVNVDVTTRLDGFHGDTSATFCIGEVSAE
CCCCCHHHCCCCCCEEEECCCCHHHHCCCCCEEEEEEEEEECCCCCCCCCEEEEECCCHH
ARHVVEVARRCREAGVAVVRHGVRLGDVGAAIEEVARAGGCSVVREYGGHGIGKAMHGPP
HHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCE
LVMHVGPRGQGVKLKAGMAITVEPMVNLGRPEVKLLADGWTVVTADGSLSAQFEHTVVVT
EEEEECCCCCCEEEECCEEEEECHHHCCCCCCEEEEECCEEEEEECCCCEEEEEEEEEEE
RDGCEVMTGCAGRAALAPAASGLSA
ECCCHHHHCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]