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The map label for this gene is atoC [H]

Identifier: 220917277

GI number: 220917277

Start: 2417549

End: 2418985

Strand: Direct

Name: atoC [H]

Synonym: A2cp1_2176

Alternate gene names: 220917277

Gene position: 2417549-2418985 (Clockwise)

Preceding gene: 220917276

Following gene: 220917278

Centisome position: 48.07

GC content: 73.76

Gene sequence:

>1437_bases
GTGAGCGAGATCGCGTACCCGCCGTTCGCCGTGCTGCTCGTGGACGACGAGCCGGGCTGGCTGCGGACCATGTCGCTCAG
CCTGGAGCGCTCGCTGGGCGTCACGAACCTGCTCACCTGCCAGGATCCTCGGGAGGTCATGGGCCTGCTCGGGCGGCACG
AGGTGGGGCTGGTGCTGCTCGACCTCACCATGCCGCACCTGCCGGGCGAGGAGCTGCTCCGGCGGATCGTCGAGGCCCAC
CCCGAGGTCTCGGTCATCGTGGTGAGCGGGCTCAACCAGCTCGAGACCGCGGTGCGCTGCATGCAGGCGGGCGCGTTCGA
CTACTTCGTGAAGACCAGCGAGGAGGACCGGATCGTCAAGGGCGTCGGGCGCGCCGTCCGCATGCAGGAGCTGCAGCGCG
AGAACCGCGAGATCCGCCGGCGGTTCCTCGACGACCAGCTCGAGCACCCGGAGGCGTTCGACCGGATCGTCACGGCCGAC
GCGCGCATGCACGCGGTCTTCCGCTACGTCGAGGCGGTGAGCCGCAGCCGGCAGCCGGTGCTGGTCACCGGCGAGAGCGG
CACCGGCAAGGAGCTCATCGCGCGCGCGGTGCACCAGGTGTCGGGCCGCGCCGGCGAGCTGGTGCCGGTGAACGTGGCCG
GCCTCGACGACACCGTGTTCGCCGACACGCTGTTCGGGCACGTGCGCGGCGCCTTCACCGGCGCGAACGAGGCGCGCAGC
GGGATGGTGGAGCGCGCGGCCGAGGGCACGCTGTTCCTCGACGAGATCGGCGATCTCAGCCCGGCGTCGCAGGTGAAGCT
GCTGCGGCTGCTGCAGGAGGGCGAGTACTACCCGCTCGGCGCCGATCGGCCGCGGTGGATGCGCGCGCGGGTGGTGGTCG
CCACCCACCACGACCTCGCCGCCCGCCAGGCGGCGGGCACGTTCCGCCCCGACCTGTACTACCGCCTTCGCGCCCACCAC
GTGCACCTGCCGCCGCTCCGGGAGCGCCGGGGCGACATCCCGCTGCTGCTCGAGCACTTCCTCGACGAGGCGGCCCGCGA
GCTCGGCAAGAAGAAGCCCACCCCGCCGAAGCAGCTCGCCGGGCTGCTCGCGAGCTACGCGTTCCCGGGCAACGTGCGCG
AGCTGCGCGCCATGGTGCTCGACGCGGTGGGCGCGCACCAGGGGCGGGTGCTGTCGATGGAGGCGTTCCGGCGCGCCATC
GGCGAGGCCGAGGTGGCGCACGAGGCCGACCGGCGGGGCGAGGCGCCCGCCAGCCCGTTCGCGGCGCTGGAGCGCATCCC
GACGCTGGACGAGGCCGACGAGCTGCTGGTGCAGGAGGCGCTCCGGCGCGCCGACGGGAACCAGTCGCTCGCGGCGCGCC
TGCTCGGCATCACGCCCTCGGCGCTCTCGAAGCGCCTCAAGGCGCGGCGCGAGGCCGAGGGCCAGCGCGAAGGGTAG

Upstream 100 bases:

>100_bases
GCATCGTGAAGGAGCACGGCGGCACGCTCGAGTTCGAGTCGGCGCCGGGGCAGGGCACCGCGGCGCGAGTGGTCCTGCCC
GTCGCCCGCGAGGAGGCCGC

Downstream 100 bases:

>100_bases
GGAGATCCCTCAACCCTGTGAGATCCGTCACGGCGGGCCAACCCCGCCGGATTCCTCGGGGTGCGCCCGCCGCGCGGCGC
GCGCGTTTCCTCCGCTCAAC

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MSEIAYPPFAVLLVDDEPGWLRTMSLSLERSLGVTNLLTCQDPREVMGLLGRHEVGLVLLDLTMPHLPGEELLRRIVEAH
PEVSVIVVSGLNQLETAVRCMQAGAFDYFVKTSEEDRIVKGVGRAVRMQELQRENREIRRRFLDDQLEHPEAFDRIVTAD
ARMHAVFRYVEAVSRSRQPVLVTGESGTGKELIARAVHQVSGRAGELVPVNVAGLDDTVFADTLFGHVRGAFTGANEARS
GMVERAAEGTLFLDEIGDLSPASQVKLLRLLQEGEYYPLGADRPRWMRARVVVATHHDLAARQAAGTFRPDLYYRLRAHH
VHLPPLRERRGDIPLLLEHFLDEAARELGKKKPTPPKQLAGLLASYAFPGNVRELRAMVLDAVGAHQGRVLSMEAFRRAI
GEAEVAHEADRRGEAPASPFAALERIPTLDEADELLVQEALRRADGNQSLAARLLGITPSALSKRLKARREAEGQREG

Sequences:

>Translated_478_residues
MSEIAYPPFAVLLVDDEPGWLRTMSLSLERSLGVTNLLTCQDPREVMGLLGRHEVGLVLLDLTMPHLPGEELLRRIVEAH
PEVSVIVVSGLNQLETAVRCMQAGAFDYFVKTSEEDRIVKGVGRAVRMQELQRENREIRRRFLDDQLEHPEAFDRIVTAD
ARMHAVFRYVEAVSRSRQPVLVTGESGTGKELIARAVHQVSGRAGELVPVNVAGLDDTVFADTLFGHVRGAFTGANEARS
GMVERAAEGTLFLDEIGDLSPASQVKLLRLLQEGEYYPLGADRPRWMRARVVVATHHDLAARQAAGTFRPDLYYRLRAHH
VHLPPLRERRGDIPLLLEHFLDEAARELGKKKPTPPKQLAGLLASYAFPGNVRELRAMVLDAVGAHQGRVLSMEAFRRAI
GEAEVAHEADRRGEAPASPFAALERIPTLDEADELLVQEALRRADGNQSLAARLLGITPSALSKRLKARREAEGQREG
>Mature_477_residues
SEIAYPPFAVLLVDDEPGWLRTMSLSLERSLGVTNLLTCQDPREVMGLLGRHEVGLVLLDLTMPHLPGEELLRRIVEAHP
EVSVIVVSGLNQLETAVRCMQAGAFDYFVKTSEEDRIVKGVGRAVRMQELQRENREIRRRFLDDQLEHPEAFDRIVTADA
RMHAVFRYVEAVSRSRQPVLVTGESGTGKELIARAVHQVSGRAGELVPVNVAGLDDTVFADTLFGHVRGAFTGANEARSG
MVERAAEGTLFLDEIGDLSPASQVKLLRLLQEGEYYPLGADRPRWMRARVVVATHHDLAARQAAGTFRPDLYYRLRAHHV
HLPPLRERRGDIPLLLEHFLDEAARELGKKKPTPPKQLAGLLASYAFPGNVRELRAMVLDAVGAHQGRVLSMEAFRRAIG
EAEVAHEADRRGEAPASPFAALERIPTLDEADELLVQEALRRADGNQSLAARLLGITPSALSKRLKARREAEGQREG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=458, Percent_Identity=34.2794759825328, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1790299, Length=477, Percent_Identity=38.1551362683438, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI1790437, Length=459, Percent_Identity=34.640522875817, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI1789087, Length=415, Percent_Identity=34.9397590361446, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1788905, Length=467, Percent_Identity=33.4047109207709, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI87082117, Length=286, Percent_Identity=41.6083916083916, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1789233, Length=308, Percent_Identity=35.3896103896104, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI87082152, Length=304, Percent_Identity=41.1184210526316, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87081872, Length=299, Percent_Identity=38.1270903010033, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1787583, Length=238, Percent_Identity=38.2352941176471, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786524, Length=330, Percent_Identity=35.7575757575758, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789828, Length=249, Percent_Identity=36.9477911646586, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI87081858, Length=257, Percent_Identity=31.9066147859922, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52983; Mature: 52852

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIAYPPFAVLLVDDEPGWLRTMSLSLERSLGVTNLLTCQDPREVMGLLGRHEVGLVLL
CCCCCCCCEEEEEEECCCCCEEHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCEEEE
DLTMPHLPGEELLRRIVEAHPEVSVIVVSGLNQLETAVRCMQAGAFDYFVKTSEEDRIVK
EECCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCHHEEEECCCCHHHHH
GVGRAVRMQELQRENREIRRRFLDDQLEHPEAFDRIVTADARMHAVFRYVEAVSRSRQPV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LVTGESGTGKELIARAVHQVSGRAGELVPVNVAGLDDTVFADTLFGHVRGAFTGANEARS
EEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHH
GMVERAAEGTLFLDEIGDLSPASQVKLLRLLQEGEYYPLGADRPRWMRARVVVATHHDLA
HHHHHHHCCCEEHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECHHHH
ARQAAGTFRPDLYYRLRAHHVHLPPLRERRGDIPLLLEHFLDEAARELGKKKPTPPKQLA
HHHHCCCCCCCHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
GLLASYAFPGNVRELRAMVLDAVGAHQGRVLSMEAFRRAIGEAEVAHEADRRGEAPASPF
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHH
AALERIPTLDEADELLVQEALRRADGNQSLAARLLGITPSALSKRLKARREAEGQREG
HHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEIAYPPFAVLLVDDEPGWLRTMSLSLERSLGVTNLLTCQDPREVMGLLGRHEVGLVLL
CCCCCCCEEEEEEECCCCCEEHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCEEEE
DLTMPHLPGEELLRRIVEAHPEVSVIVVSGLNQLETAVRCMQAGAFDYFVKTSEEDRIVK
EECCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCHHEEEECCCCHHHHH
GVGRAVRMQELQRENREIRRRFLDDQLEHPEAFDRIVTADARMHAVFRYVEAVSRSRQPV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LVTGESGTGKELIARAVHQVSGRAGELVPVNVAGLDDTVFADTLFGHVRGAFTGANEARS
EEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHH
GMVERAAEGTLFLDEIGDLSPASQVKLLRLLQEGEYYPLGADRPRWMRARVVVATHHDLA
HHHHHHHCCCEEHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECHHHH
ARQAAGTFRPDLYYRLRAHHVHLPPLRERRGDIPLLLEHFLDEAARELGKKKPTPPKQLA
HHHHCCCCCCCHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
GLLASYAFPGNVRELRAMVLDAVGAHQGRVLSMEAFRRAIGEAEVAHEADRRGEAPASPF
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHH
AALERIPTLDEADELLVQEALRRADGNQSLAARLLGITPSALSKRLKARREAEGQREG
HHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]