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The map label for this gene is uvrY [H]

Identifier: 220917273

GI number: 220917273

Start: 2413385

End: 2414017

Strand: Direct

Name: uvrY [H]

Synonym: A2cp1_2172

Alternate gene names: 220917273

Gene position: 2413385-2414017 (Clockwise)

Preceding gene: 220917272

Following gene: 220917274

Centisome position: 47.99

GC content: 72.83

Gene sequence:

>633_bases
ATGCTGCGCATCCTGCTGGCTGACGATCACGCGATGTTCCGGTCCGGGCTCCGGCGCATCCTCGAGGCCGAGTTCCCGGG
CGCGTCGGTGGGCGAGGCGGCCACCATCGGCGAGCTCGAGGCGCGGCTCGGGGCGCAGCCGTGCGACGTGCTCGTGCTCG
ACATCTCCATGGCCGGGCAGAACAGCCTGAACGCGCTCCCCGGGCTGAAGGAGCGCCACCCGCGGCTCCCGGTGGTGGTG
CTGAGCATGTACGGCGACCGCCCGTTCGTGATCCAGGCGCTGCGCGCCGGCGCGTCCGCCTACCTCACCAAGGAGCGCGC
GCCGGAGGAGCTGATCCGCGCCATCCGCAGCGTGCTCGCCGGCCGGCGCTACGTCGGCGACGAGCTCGCCGAGCAGCTGG
CCGACCACCTGGCCGGCGGCGGCACCGGGAGCCCGCACGAGCGCCTCTCGCCGCGCGAGCTGGAGATCTTCCTGCAGCTC
GCGGCGGCGCGCTCGGTGTCCGAGATCGCCGAACGGCTGCAGCTCAGCGTGAAGACCGTCAGCACCTATCGCAGCCGCAT
CCTCGAGAAGATGGCCCTGCGCTCGAACGCCGAGCTGATGCAGTACGCGGTGCGCCACGGGCTGGCCGGGTAG

Upstream 100 bases:

>100_bases
CGCGCCCTGCTCGTGGACGGCACGTTCGAGATCTCCGGGACGCCGGGCGGCGGGACGACCGTCGTGGTAACGATCCCTCG
GACGAGGACGGGCGCGACCG

Downstream 100 bases:

>100_bases
CGCGAGCCCGGACGGGCGTCGGACGGACGCCGACACCGGGCCACCCCGCGTCCTACGCGCGCGTCGGACGCCGGCCGATG
CACGCGGCGCCGCGCCGTCG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MLRILLADDHAMFRSGLRRILEAEFPGASVGEAATIGELEARLGAQPCDVLVLDISMAGQNSLNALPGLKERHPRLPVVV
LSMYGDRPFVIQALRAGASAYLTKERAPEELIRAIRSVLAGRRYVGDELAEQLADHLAGGGTGSPHERLSPRELEIFLQL
AAARSVSEIAERLQLSVKTVSTYRSRILEKMALRSNAELMQYAVRHGLAG

Sequences:

>Translated_210_residues
MLRILLADDHAMFRSGLRRILEAEFPGASVGEAATIGELEARLGAQPCDVLVLDISMAGQNSLNALPGLKERHPRLPVVV
LSMYGDRPFVIQALRAGASAYLTKERAPEELIRAIRSVLAGRRYVGDELAEQLADHLAGGGTGSPHERLSPRELEIFLQL
AAARSVSEIAERLQLSVKTVSTYRSRILEKMALRSNAELMQYAVRHGLAG
>Mature_210_residues
MLRILLADDHAMFRSGLRRILEAEFPGASVGEAATIGELEARLGAQPCDVLVLDISMAGQNSLNALPGLKERHPRLPVVV
LSMYGDRPFVIQALRAGASAYLTKERAPEELIRAIRSVLAGRRYVGDELAEQLADHLAGGGTGSPHERLSPRELEIFLQL
AAARSVSEIAERLQLSVKTVSTYRSRILEKMALRSNAELMQYAVRHGLAG

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=212, Percent_Identity=37.2641509433962, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1788521, Length=198, Percent_Identity=30.3030303030303, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790102, Length=199, Percent_Identity=33.6683417085427, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=26.9607843137255, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786747, Length=204, Percent_Identity=26.9607843137255, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788712, Length=206, Percent_Identity=24.2718446601942, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=32.2404371584699, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22891; Mature: 22891

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRILLADDHAMFRSGLRRILEAEFPGASVGEAATIGELEARLGAQPCDVLVLDISMAGQ
CEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCC
NSLNALPGLKERHPRLPVVVLSMYGDRPFVIQALRAGASAYLTKERAPEELIRAIRSVLA
CCCCCCCCCHHHCCCCCEEEEEECCCCHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHH
GRRYVGDELAEQLADHLAGGGTGSPHERLSPRELEIFLQLAAARSVSEIAERLQLSVKTV
CCHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STYRSRILEKMALRSNAELMQYAVRHGLAG
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MLRILLADDHAMFRSGLRRILEAEFPGASVGEAATIGELEARLGAQPCDVLVLDISMAGQ
CEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCC
NSLNALPGLKERHPRLPVVVLSMYGDRPFVIQALRAGASAYLTKERAPEELIRAIRSVLA
CCCCCCCCCHHHCCCCCEEEEEECCCCHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHH
GRRYVGDELAEQLADHLAGGGTGSPHERLSPRELEIFLQLAAARSVSEIAERLQLSVKTV
CCHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STYRSRILEKMALRSNAELMQYAVRHGLAG
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]