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The map label for this gene is hutH

Identifier: 220917218

GI number: 220917218

Start: 2363594

End: 2365120

Strand: Reverse

Name: hutH

Synonym: A2cp1_2116

Alternate gene names: 220917218

Gene position: 2365120-2363594 (Counterclockwise)

Preceding gene: 220917223

Following gene: 220917213

Centisome position: 47.03

GC content: 76.75

Gene sequence:

>1527_bases
ATGGAAACCCTCCTCCTCGACGGCGAGACCCTCACGCTGGAGCAGGTCCGTGCGGTCGCGACCGGGGCCGCCCGCGCCGC
GCTCGCCCCCGCGGCCCGCGAGCGCGTGCGGCGTTCCCGCGCGCTGGTGGACGCCCGGCTCGAGGACGGCGAGGCGCACT
ACGGCATCAACACCGGCTTCGGGACGCTCGCCGAGGTCCGCATCCCGCGGGCCGACCTCGAGCGGCTGCAGCGCAACCTG
GTGCTCTCGCACGCCGCCGGCGTGGGCGCGCCGCTGCCCCTCCCGGAGGCGCGCGCGCTGGTGCTGCTGCGCGCCAACGT
GCTCGCGAAGGGCGTCTCCGGGATCCGCGAGCACACGCTGGACCTGCTGCTCGCCATGCTGGAGCGCGGCGTGGTGCCGG
TGGTGCCGGAGCGCGGGTCGGTGGGCGCGTCGGGCGACCTCGCCCCGCTCGCGCACCTGGCGCTGGTGCTGATCGGCGAC
GGCGAGGCGTTCCTCGCGCCGCCCGGCGCGGCGGGCCGGCCCGAGCGGCTCCCCGGCGGCGAGGCGCTGCGGCGCGCCGG
GCTCGAGCCGGTCGTGCTGCAGCCGAAGGAGGGGCTGGCGCTGGTGAACGGCACCCAGGCCATGGCCGCGGTCGGCACGC
TCGCGCTGCTCCGCGCGGAGCGGCTGGCGGCGCTCGCCGATCTCGCCGGCGCCATGACGCTGGAGGGCCTGCTCGGCTCG
CACCGGCCGTTCGCGCCGGAGATCCAGGCCGCCCGCGGGCAGCCCGGCCAGATCGCCGCGGCGGCGCACCTGCGCGCGCT
GCTGGCCGGCTCCGAGCTGAACGCCTCGCACCAGGGCCCGGGCTGCCACAAGGTGCAGGACCCCTACTCGCTCCGCTGCA
TGCCGCAGGTGCACGGCGCCGCGCGCGACGGCATCGACTTCTGCCGCGGCGTGCTGGCGCGCGAGGTGAACGCCGCCACG
GACAACCCGCTGGTCTTCCCGGACACCGGGGAGATCGTCTCGGGCGGCAACTTCCACGGCCAGCCGGTGGCGCTCGCGCT
CGACGTGCTCGCGGTGGCCGCCTCGCACCTCGCCGCGATCTCGGAGCGCCGCGTGGAGCAGCTCGTGAACCCGTCGCTGT
CCGGGCTCCCGCCGTTCCTGGCGCCCCAGCACGGGCTGAACTCGGGGTTCATGATCGCGCAGGTGACCAGCGCGGCGCTC
GTCTCGGAGAACAAGGTGCTCTGCCACCCGGCCTCGGTGGACTCGATCCCGTCCTCCGCCGGCCGCGAGGACCACGTGTC
GATGGGCATGACCGCGGCGCTCAAGGCGCGCCAGGTGGTGGAGAACGTCCGCACCTGCCTCGCCATCGAGCTGCTGGTCG
CGGCCCAGGCGCTCGATCTCCGCGCCCCGCTCCGGCCCGCGCAGCGCGTGGCCGAGGCGCACGCGCGCCTGCGCGAGCGC
GTCCCGCACCTGTCCGAGGACCGCGCGCTGCACCGCGACATCGAGGCGGTGTCGCGGCTCGTGGACGAGGGCGCGCTGGA
GCCGTGA

Upstream 100 bases:

>100_bases
GGACCGCACACCACGGCGGGTGCCCCGGCCGGAAGCGACGGCGGCCGACGCCGGGACGGTGTAGGAAGGCGCCGCCGGTC
CATCCCAGCACGGAGCGCCC

Downstream 100 bases:

>100_bases
GCCTGGCCCGGGCCGCTGCCCGCACGGGCGGCGGCGCCGGCAGCCTCCCTACGCCACCGCCTGCGTCGGCGGGTTCAGGC
AGAGCGCCCGGTTCAGCGCG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
METLLLDGETLTLEQVRAVATGAARAALAPAARERVRRSRALVDARLEDGEAHYGINTGFGTLAEVRIPRADLERLQRNL
VLSHAAGVGAPLPLPEARALVLLRANVLAKGVSGIREHTLDLLLAMLERGVVPVVPERGSVGASGDLAPLAHLALVLIGD
GEAFLAPPGAAGRPERLPGGEALRRAGLEPVVLQPKEGLALVNGTQAMAAVGTLALLRAERLAALADLAGAMTLEGLLGS
HRPFAPEIQAARGQPGQIAAAAHLRALLAGSELNASHQGPGCHKVQDPYSLRCMPQVHGAARDGIDFCRGVLAREVNAAT
DNPLVFPDTGEIVSGGNFHGQPVALALDVLAVAASHLAAISERRVEQLVNPSLSGLPPFLAPQHGLNSGFMIAQVTSAAL
VSENKVLCHPASVDSIPSSAGREDHVSMGMTAALKARQVVENVRTCLAIELLVAAQALDLRAPLRPAQRVAEAHARLRER
VPHLSEDRALHRDIEAVSRLVDEGALEP

Sequences:

>Translated_508_residues
METLLLDGETLTLEQVRAVATGAARAALAPAARERVRRSRALVDARLEDGEAHYGINTGFGTLAEVRIPRADLERLQRNL
VLSHAAGVGAPLPLPEARALVLLRANVLAKGVSGIREHTLDLLLAMLERGVVPVVPERGSVGASGDLAPLAHLALVLIGD
GEAFLAPPGAAGRPERLPGGEALRRAGLEPVVLQPKEGLALVNGTQAMAAVGTLALLRAERLAALADLAGAMTLEGLLGS
HRPFAPEIQAARGQPGQIAAAAHLRALLAGSELNASHQGPGCHKVQDPYSLRCMPQVHGAARDGIDFCRGVLAREVNAAT
DNPLVFPDTGEIVSGGNFHGQPVALALDVLAVAASHLAAISERRVEQLVNPSLSGLPPFLAPQHGLNSGFMIAQVTSAAL
VSENKVLCHPASVDSIPSSAGREDHVSMGMTAALKARQVVENVRTCLAIELLVAAQALDLRAPLRPAQRVAEAHARLRER
VPHLSEDRALHRDIEAVSRLVDEGALEP
>Mature_508_residues
METLLLDGETLTLEQVRAVATGAARAALAPAARERVRRSRALVDARLEDGEAHYGINTGFGTLAEVRIPRADLERLQRNL
VLSHAAGVGAPLPLPEARALVLLRANVLAKGVSGIREHTLDLLLAMLERGVVPVVPERGSVGASGDLAPLAHLALVLIGD
GEAFLAPPGAAGRPERLPGGEALRRAGLEPVVLQPKEGLALVNGTQAMAAVGTLALLRAERLAALADLAGAMTLEGLLGS
HRPFAPEIQAARGQPGQIAAAAHLRALLAGSELNASHQGPGCHKVQDPYSLRCMPQVHGAARDGIDFCRGVLAREVNAAT
DNPLVFPDTGEIVSGGNFHGQPVALALDVLAVAASHLAAISERRVEQLVNPSLSGLPPFLAPQHGLNSGFMIAQVTSAAL
VSENKVLCHPASVDSIPSSAGREDHVSMGMTAALKARQVVENVRTCLAIELLVAAQALDLRAPLRPAQRVAEAHARLRER
VPHLSEDRALHRDIEAVSRLVDEGALEP

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=502, Percent_Identity=49.003984063745, Blast_Score=450, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17567831, Length=509, Percent_Identity=45.9724950884086, Blast_Score=405, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_ANAD2 (B8J950)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002492522.1
- ProteinModelPortal:   B8J950
- SMR:   B8J950
- GeneID:   7296009
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2116
- HOGENOM:   HBG510887
- ProtClustDB:   PRK09367
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 53112; Mature: 53112

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLLLDGETLTLEQVRAVATGAARAALAPAARERVRRSRALVDARLEDGEAHYGINTGF
CCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GTLAEVRIPRADLERLQRNLVLSHAAGVGAPLPLPEARALVLLRANVLAKGVSGIREHTL
CCHHHEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DLLLAMLERGVVPVVPERGSVGASGDLAPLAHLALVLIGDGEAFLAPPGAAGRPERLPGG
HHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHEEEEEEECCCEEECCCCCCCCCCCCCCH
EALRRAGLEPVVLQPKEGLALVNGTQAMAAVGTLALLRAERLAALADLAGAMTLEGLLGS
HHHHHCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HRPFAPEIQAARGQPGQIAAAAHLRALLAGSELNASHQGPGCHKVQDPYSLRCMPQVHGA
CCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHCCC
ARDGIDFCRGVLAREVNAATDNPLVFPDTGEIVSGGNFHGQPVALALDVLAVAASHLAAI
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHH
SERRVEQLVNPSLSGLPPFLAPQHGLNSGFMIAQVTSAALVSENKVLCHPASVDSIPSSA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCEEECCCCCCCCCCCC
GREDHVSMGMTAALKARQVVENVRTCLAIELLVAAQALDLRAPLRPAQRVAEAHARLRER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VPHLSEDRALHRDIEAVSRLVDEGALEP
CCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
METLLLDGETLTLEQVRAVATGAARAALAPAARERVRRSRALVDARLEDGEAHYGINTGF
CCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GTLAEVRIPRADLERLQRNLVLSHAAGVGAPLPLPEARALVLLRANVLAKGVSGIREHTL
CCHHHEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DLLLAMLERGVVPVVPERGSVGASGDLAPLAHLALVLIGDGEAFLAPPGAAGRPERLPGG
HHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHEEEEEEECCCEEECCCCCCCCCCCCCCH
EALRRAGLEPVVLQPKEGLALVNGTQAMAAVGTLALLRAERLAALADLAGAMTLEGLLGS
HHHHHCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HRPFAPEIQAARGQPGQIAAAAHLRALLAGSELNASHQGPGCHKVQDPYSLRCMPQVHGA
CCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHCCC
ARDGIDFCRGVLAREVNAATDNPLVFPDTGEIVSGGNFHGQPVALALDVLAVAASHLAAI
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHH
SERRVEQLVNPSLSGLPPFLAPQHGLNSGFMIAQVTSAALVSENKVLCHPASVDSIPSSA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCEEECCCCCCCCCCCC
GREDHVSMGMTAALKARQVVENVRTCLAIELLVAAQALDLRAPLRPAQRVAEAHARLRER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VPHLSEDRALHRDIEAVSRLVDEGALEP
CCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA