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The map label for this gene is gyaR [H]

Identifier: 220917190

GI number: 220917190

Start: 2327702

End: 2328640

Strand: Direct

Name: gyaR [H]

Synonym: A2cp1_2087

Alternate gene names: 220917190

Gene position: 2327702-2328640 (Clockwise)

Preceding gene: 220917189

Following gene: 220917191

Centisome position: 46.28

GC content: 77.64

Gene sequence:

>939_bases
GTGAGGCCCGCGCTCGTCCTGGCCCGGCCGCTGCCGCTCGCCGACCTCGGCGCGCTCGCCGGCCGGTTCGAGCTCCGCGG
CGGCGAGGTCGCGCTGTCCCGGGCCGAGCTCGGCGTGGCGGTGCGCGAGGCCGAGGTGCTGGTGGTCACCTACCTCGACC
GCGTGGACGCCGCGCTCCTCGAGGGCGCACCGCGGCTCCGCCACGTCGCGTCGTACGGCATCGGCGTGAACCACCTCGAC
CTCGGCGCCTGCCGCGCCCGCGGGCTGTGCGTCACCAACACGCCGGACGTGGTGACCGCCGCCACCGCCGATCACGCCTG
GGCGCTCCTGCTCGCGGCCGCGCGCCGCGTCGCCGAGGGCGATCGGGTGATCCGCGCCGGCGGGTGGACCGGCGTCGATC
CCGCCTGGATGCTCGGCACCGAGGTCAGCGGCAAGACGCTCGGCCTGGTGGGGTTCGGGCGCATCGGACGGGCGGTGGCG
CAGCGGGCCGCCGGCTTCGGCATGCGCGTCCTCTACGCCGCGCCGCGCGACGCCGCGGTCCCGGGCGCGCGACGGGTGGA
CCTCGACGCGCTGCTCACCGCGTCCGACCTCGTCAGCCTGCACGTGCCGCTCACGCCCGCCACCGACGGCCTGATGGACC
GGGCGCGCCTGGCGCGCATGAAGCCCGGCGCCATCCTGGTGAACACCGCGCGCGGGCAGGTGGTGGACGACGCGGCGCTG
GCCGAGGCGCTGGCCTCGGGCCGGCTCGCCGCCGCCGGCCTCGACGTCTTCCGCGACGAGCCGAGGATCCCCGAGGCGTT
CCTGCGCCTCCCGAACGTCGTGCTGACGCCGCACCTCGGCTCGGGCACGCGCGAAACGCGCGCCGCGATGACGCGGATGG
TGATCGACGAGGTCCTGCGGGTGGCCGCGGGCGACGCGCCCCGTCACCCGGTGCCGTAG

Upstream 100 bases:

>100_bases
TCGGCAAGTGGCTGGGCGAGGAGTACCGGATCCCCGGCCCGCGCGCCGGTGACGGCGCCGACGCGCCGGCGCGGCCCGAG
GAGCGCGAGGACGACGAGCC

Downstream 100 bases:

>100_bases
CGCGCGACCCGCGCGCCCGCGGGTCGCCGGCATGGTATGAGGGGCAGCCATGCCGGACGCCGCAGCCAGCCCACCGCGCG
CCAGGAGCCACCGCGCGGCG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MRPALVLARPLPLADLGALAGRFELRGGEVALSRAELGVAVREAEVLVVTYLDRVDAALLEGAPRLRHVASYGIGVNHLD
LGACRARGLCVTNTPDVVTAATADHAWALLLAAARRVAEGDRVIRAGGWTGVDPAWMLGTEVSGKTLGLVGFGRIGRAVA
QRAAGFGMRVLYAAPRDAAVPGARRVDLDALLTASDLVSLHVPLTPATDGLMDRARLARMKPGAILVNTARGQVVDDAAL
AEALASGRLAAAGLDVFRDEPRIPEAFLRLPNVVLTPHLGSGTRETRAAMTRMVIDEVLRVAAGDAPRHPVP

Sequences:

>Translated_312_residues
MRPALVLARPLPLADLGALAGRFELRGGEVALSRAELGVAVREAEVLVVTYLDRVDAALLEGAPRLRHVASYGIGVNHLD
LGACRARGLCVTNTPDVVTAATADHAWALLLAAARRVAEGDRVIRAGGWTGVDPAWMLGTEVSGKTLGLVGFGRIGRAVA
QRAAGFGMRVLYAAPRDAAVPGARRVDLDALLTASDLVSLHVPLTPATDGLMDRARLARMKPGAILVNTARGQVVDDAAL
AEALASGRLAAAGLDVFRDEPRIPEAFLRLPNVVLTPHLGSGTRETRAAMTRMVIDEVLRVAAGDAPRHPVP
>Mature_312_residues
MRPALVLARPLPLADLGALAGRFELRGGEVALSRAELGVAVREAEVLVVTYLDRVDAALLEGAPRLRHVASYGIGVNHLD
LGACRARGLCVTNTPDVVTAATADHAWALLLAAARRVAEGDRVIRAGGWTGVDPAWMLGTEVSGKTLGLVGFGRIGRAVA
QRAAGFGMRVLYAAPRDAAVPGARRVDLDALLTASDLVSLHVPLTPATDGLMDRARLARMKPGAILVNTARGQVVDDAAL
AEALASGRLAAAGLDVFRDEPRIPEAFLRLPNVVLTPHLGSGTRETRAAMTRMVIDEVLRVAAGDAPRHPVP

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=272, Percent_Identity=38.9705882352941, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI23308577, Length=261, Percent_Identity=35.632183908046, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI145580578, Length=262, Percent_Identity=33.587786259542, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI4557499, Length=262, Percent_Identity=33.587786259542, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI61743967, Length=261, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4557497, Length=261, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI145580575, Length=262, Percent_Identity=33.587786259542, Blast_Score=118, Evalue=6e-27,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=40.625, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1789279, Length=290, Percent_Identity=32.4137931034483, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787645, Length=258, Percent_Identity=30.2325581395349, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1788660, Length=264, Percent_Identity=28.030303030303, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87081824, Length=149, Percent_Identity=35.5704697986577, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=277, Percent_Identity=31.0469314079422, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=294, Percent_Identity=27.2108843537415, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=239, Percent_Identity=36.8200836820084, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320925, Length=291, Percent_Identity=32.9896907216495, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322116, Length=304, Percent_Identity=31.9078947368421, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6321253, Length=195, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=247, Percent_Identity=29.1497975708502, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=31.0344827586207, Blast_Score=82, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=152, Percent_Identity=30.9210526315789, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571528, Length=279, Percent_Identity=43.010752688172, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI28574284, Length=284, Percent_Identity=37.3239436619718, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24585514, Length=284, Percent_Identity=37.3239436619718, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI28574282, Length=284, Percent_Identity=37.3239436619718, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI45552429, Length=284, Percent_Identity=37.3239436619718, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI45551003, Length=284, Percent_Identity=37.3239436619718, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI28574286, Length=287, Percent_Identity=37.2822299651568, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI19921140, Length=282, Percent_Identity=32.2695035460993, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=36.6795366795367, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=36.6795366795367, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=36.6795366795367, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=36.6795366795367, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=36.6795366795367, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24585516, Length=279, Percent_Identity=30.8243727598566, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32692; Mature: 32692

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPALVLARPLPLADLGALAGRFELRGGEVALSRAELGVAVREAEVLVVTYLDRVDAALL
CCCCEEEECCCCHHHHHHHHCEEEECCCEEEEEHHHHCEEEECCCEEEEEEHHHHHHHHH
EGAPRLRHVASYGIGVNHLDLGACRARGLCVTNTPDVVTAATADHAWALLLAAARRVAEG
CCCHHHHHHHHHCCCCCCCCCHHHHHCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHCC
DRVIRAGGWTGVDPAWMLGTEVSGKTLGLVGFGRIGRAVAQRAAGFGMRVLYAAPRDAAV
CCEEEECCCCCCCCHHEECCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCC
PGARRVDLDALLTASDLVSLHVPLTPATDGLMDRARLARMKPGAILVNTARGQVVDDAAL
CCCCEECHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHH
AEALASGRLAAAGLDVFRDEPRIPEAFLRLPNVVLTPHLGSGTRETRAAMTRMVIDEVLR
HHHHHCCCHHHHHHHHHCCCCCCCHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
VAAGDAPRHPVP
HHCCCCCCCCCC
>Mature Secondary Structure
MRPALVLARPLPLADLGALAGRFELRGGEVALSRAELGVAVREAEVLVVTYLDRVDAALL
CCCCEEEECCCCHHHHHHHHCEEEECCCEEEEEHHHHCEEEECCCEEEEEEHHHHHHHHH
EGAPRLRHVASYGIGVNHLDLGACRARGLCVTNTPDVVTAATADHAWALLLAAARRVAEG
CCCHHHHHHHHHCCCCCCCCCHHHHHCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHCC
DRVIRAGGWTGVDPAWMLGTEVSGKTLGLVGFGRIGRAVAQRAAGFGMRVLYAAPRDAAV
CCEEEECCCCCCCCHHEECCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCC
PGARRVDLDALLTASDLVSLHVPLTPATDGLMDRARLARMKPGAILVNTARGQVVDDAAL
CCCCEECHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHH
AEALASGRLAAAGLDVFRDEPRIPEAFLRLPNVVLTPHLGSGTRETRAAMTRMVIDEVLR
HHHHHCCCHHHHHHHHHCCCCCCCHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
VAAGDAPRHPVP
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA