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The map label for this gene is msrA [H]

Identifier: 220917175

GI number: 220917175

Start: 2313165

End: 2313806

Strand: Direct

Name: msrA [H]

Synonym: A2cp1_2072

Alternate gene names: 220917175

Gene position: 2313165-2313806 (Clockwise)

Preceding gene: 220917173

Following gene: 220917176

Centisome position: 45.99

GC content: 73.68

Gene sequence:

>642_bases
ATGTTCGCGACCAAGACCACGCTGCCGGCGGCCGGCGAGGCGCTCCCCGGGCGCGCCGAGCCGATGCCGGTTCCCGAGCG
CCACTTCGTGAACGGGGACCGGATCGTCCCTCCGTTCCCCGCCGGCCTGGAGCTCGCCGACTTCGGCCTCGGCTGCTTCT
GGGGCGCCGAGCGCGTCTTCTGGAAGCTGCCGGGCGTGTACGCGACCGCGGTCGGCTACGCGGGCGGCGAGACGCCCAAC
CCGACCTACCGCGAGGTCTGCACCGGCCGCACCGGCCACGCCGAGGTGGTCCGCGTGGTGTTCGACCCGGCCAGGATCAC
CTACGCCGACCTGCTGAAGGTGTTCTGGGAATCGCACGACCCGACCCAGGGCATGCGGCAGGGGAACGACGTGGGGACGC
AGTACCGGTCCGCCATCCACGTGCACGGGGAGGCGCAGCGCCGGCTGGCGGACGCGTCGCGCGAGGCGTACCAGGCCGCG
CTCGCGCCGCGCGGGGGCGGGGCGATCACCACCGAGATCCGCGCCGCGCCGCCCTTCTACTACGCCGAGGAGTATCACCA
GCAGTACCTGGCCAAGAACCCCGAGGGCTACTGCGGGATCGGCGGCACCGGGGTGAGCTGCCCCGGCTTCGCGGCGCGCT
GA

Upstream 100 bases:

>100_bases
GCGGGCGTACTTGACGCTGTGTCCCGGCGGCGCGGAAGCGTCACATGGGGTGCCCTCGGGCGGGTGGCGCCAGGCGCGCC
GTGCCCGTTAGATCCCGCGC

Downstream 100 bases:

>100_bases
CGCGCGGCCGGTCCGGTCCGGCGCCGCGCAGTTGATCCAGGGCAGGCGGCGCGAAAGCTTTGCGCCGCGCGGCCGCGTGC
CGTGGTGGCGGGGCTGTCGG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MFATKTTLPAAGEALPGRAEPMPVPERHFVNGDRIVPPFPAGLELADFGLGCFWGAERVFWKLPGVYATAVGYAGGETPN
PTYREVCTGRTGHAEVVRVVFDPARITYADLLKVFWESHDPTQGMRQGNDVGTQYRSAIHVHGEAQRRLADASREAYQAA
LAPRGGGAITTEIRAAPPFYYAEEYHQQYLAKNPEGYCGIGGTGVSCPGFAAR

Sequences:

>Translated_213_residues
MFATKTTLPAAGEALPGRAEPMPVPERHFVNGDRIVPPFPAGLELADFGLGCFWGAERVFWKLPGVYATAVGYAGGETPN
PTYREVCTGRTGHAEVVRVVFDPARITYADLLKVFWESHDPTQGMRQGNDVGTQYRSAIHVHGEAQRRLADASREAYQAA
LAPRGGGAITTEIRAAPPFYYAEEYHQQYLAKNPEGYCGIGGTGVSCPGFAAR
>Mature_213_residues
MFATKTTLPAAGEALPGRAEPMPVPERHFVNGDRIVPPFPAGLELADFGLGCFWGAERVFWKLPGVYATAVGYAGGETPN
PTYREVCTGRTGHAEVVRVVFDPARITYADLLKVFWESHDPTQGMRQGNDVGTQYRSAIHVHGEAQRRLADASREAYQAA
LAPRGGGAITTEIRAAPPFYYAEEYHQQYLAKNPEGYCGIGGTGVSCPGFAAR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=208, Percent_Identity=62.0192307692308, Blast_Score=279, Evalue=1e-75,
Organism=Homo sapiens, GI208609995, Length=182, Percent_Identity=65.3846153846154, Blast_Score=262, Evalue=1e-70,
Organism=Homo sapiens, GI208609993, Length=208, Percent_Identity=48.0769230769231, Blast_Score=194, Evalue=6e-50,
Organism=Escherichia coli, GI1790665, Length=191, Percent_Identity=61.7801047120419, Blast_Score=233, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=40.2684563758389, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=40.3614457831325, Blast_Score=119, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=42.3611111111111, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=41.4285714285714, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=40.9722222222222, Blast_Score=100, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23047; Mature: 23047

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFATKTTLPAAGEALPGRAEPMPVPERHFVNGDRIVPPFPAGLELADFGLGCFWGAERVF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEECCCCCCCCCHHHCCCHHHHHHHHHH
WKLPGVYATAVGYAGGETPNPTYREVCTGRTGHAEVVRVVFDPARITYADLLKVFWESHD
HCCCCHHHHHHCCCCCCCCCCHHHHHHCCCCCHHHEEEEEECCCHHHHHHHHHHHHCCCC
PTQGMRQGNDVGTQYRSAIHVHGEAQRRLADASREAYQAALAPRGGGAITTEIRAAPPFY
CHHHHHCCCHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCH
YAEEYHQQYLAKNPEGYCGIGGTGVSCPGFAAR
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFATKTTLPAAGEALPGRAEPMPVPERHFVNGDRIVPPFPAGLELADFGLGCFWGAERVF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEECCCCCCCCCHHHCCCHHHHHHHHHH
WKLPGVYATAVGYAGGETPNPTYREVCTGRTGHAEVVRVVFDPARITYADLLKVFWESHD
HCCCCHHHHHHCCCCCCCCCCHHHHHHCCCCCHHHEEEEEECCCHHHHHHHHHHHHCCCC
PTQGMRQGNDVGTQYRSAIHVHGEAQRRLADASREAYQAALAPRGGGAITTEIRAAPPFY
CHHHHHCCCHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCH
YAEEYHQQYLAKNPEGYCGIGGTGVSCPGFAAR
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA