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The map label for this gene is speA [H]

Identifier: 220917171

GI number: 220917171

Start: 2309973

End: 2311937

Strand: Direct

Name: speA [H]

Synonym: A2cp1_2068

Alternate gene names: 220917171

Gene position: 2309973-2311937 (Clockwise)

Preceding gene: 220917166

Following gene: 220917172

Centisome position: 45.93

GC content: 67.38

Gene sequence:

>1965_bases
ATGAGCATCCCCGAGCAGCGGAGCGACGCGACGACGGCGATGGCGGCCGCGGACTGGTCCATCGAGCGCGCGGCGCAGTA
CTACAACGTGAGCGGCTGGGGCGCCGGCTTCTTCTCGATCAACGAGAAGGGGCACGTCGCCGTCCACCCCATGGGCCAGC
CGGGCCCGACCATCGACCTGATGGACGTGGTCGAGGACATCCGCGAGCGCAACATCGGCTTCCCGTGCGTGGTCCGGTTC
CAGGACGTGCTGCGCGCCCGGGTGAAGCAGATCAACGAGGCGTTCGGGAAGGCCGTCGCCGAGATGGGCTACGGCGCGAG
CTACTTCGGCGTCTACCCGATCAAGGTGAACCAGATGCGCGAGGTCGTCGACGAGATCGTCGACGCCGGCGCGCCGTACC
ACTACGGCCTCGAGGCGGGCTCGAAGGGCGAGCTGCTGGTGGTGCTCGGGATGAACGCCGACCCCGACGCGCTCACCATC
TGCAACGGCTACAAGGACGAGGAGTACCTGCGGCTGGCGCTGCTCGGGCGCAAGCTCGGCCGCAAGGTCATCGTGGTGAT
CGAGAAGCTCTCCGAGCTGCCGCAGCTGCTGCGGCTCGGCGAGGAGATGGGCGTGGACCCGATGATCGGGCTCCGCTCGA
AGCTCACCACCCGCGGCACCGGGAAGTGGGAGGGCTCCTCCGGCGACTTCGCCAAGTTCGGCCTCACCGTGCCCGAGCTG
ATCCAGGCGGTCCGGATCCTGAAGGAGGCCGGCAAGGAGCACTGCGCGAAGCTCCTCCACTTCCACGTCGGCTCGCAGCT
CACCGAGATCCGGGTGGTGAAGGACGCGGTGAACGAGGGCGCCCGCGTCTACGCCAAGCTGCGCAAGATGGGGCTGCCCA
TCGAGTACTTCGACGTGGGCGGCGGCCTGGGCGTGGACTACGTGGGCACCCGCACCAACGACTTCACCTCGTCGGTGAAC
TACTCGATGGACGAGTACGTCGGCGACGTCGTCTACAACGTGCAGCGCGTCTGCATGAACGAGGGCGTGCCCGAGCCGCA
CATCGTCTCGGAGTCGGGGCGCGCGGTGACCGCGCACCACTCCTGCATCATCATCCCGGTGTTCGGGCACATCGAGATCG
GCTCGGTCGAGGAGATCGCCAAGGCCTCCGAGCCGGAGCCGAACGAGGCCAAGGTGGTCCGCGAGATGCGCGAGATCGTC
TCCTCGCTCACCCCGCGCAACCGCGCCGAGACCTACCACGACGCCGCCGCCAAGAAGGAGGAGGCGCTCCAGATGTTCAA
GCTCGGCATCCTCGGGCTGGAGGAGCGCGCGGTGGTGGAGAGCCTGTTCTGGAAGCTGGTGCGCGGCATCGCCGACATGA
ACCGCGGCAAGAAGCGCCCGCCGCGCGAGACCAAGGACCTGGGCGACAAGATCGCCGATCAGTACATGGCGAACTTCTCG
CTCTTCCAGAGCGCGCCGGATCACTGGGCGTTCGACCAGCTCTTCCCCATCGTCCCGCTGCACCGCATGGGCGAGGCGCC
CACCCGCGACACGACCATCGTCGACATCACCTGCGACTCGGACGGGAAGATCGACCGCTTCATCGAGGGGGAGGGGGTGG
ACGAGACGCTCTCGCTCCACGCGCTCCGCCCCGGCGAGCCGTACTACCTCGGCATGTTCATGACCGGCGCCTACCAGGAC
ATCATGGGCGACATGCACAACCTGTTCGGCCGGGTGAACGAGATCCACGTGTTCGTGGACGACGAGGACCCCGAGGACTT
CTACATCGAGGAGGTCATCCCGGGGGACACCATCGAGAAGGTGCTCTCGCGCGTGCAGTACGAGCCCGCCGACCTGTTCC
GCCGCGTCAAGGCCGCGCTCGACCAGAAGGTGAAGGAGGGCGCCATCCGGCCGAAGGAGGGCGTGAGCCTCCAGGACTTC
TACGAGGCGGTGATGAAGGGCTACACGTACCTGGGCGGCGTGTAG

Upstream 100 bases:

>100_bases
CGCGGGGTCACCGGGGATCGTTCCTTAGCGGACGGCGCCCGCGAAGTCGACGGGCGCGGCGCTTCATTTCTCGGCCGCGG
TGTCGTAGATCAGCGGCGAC

Downstream 100 bases:

>100_bases
CGCTTGCGCCCGCGCGCCCGCGGCGCCATGGATCCGGCGTGGCGCGGCGCAGGCAGGGCGAGAGCCACGAAGGGTTCGTG
GAGCGCCTCATCCGCGAGGC

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MSIPEQRSDATTAMAAADWSIERAAQYYNVSGWGAGFFSINEKGHVAVHPMGQPGPTIDLMDVVEDIRERNIGFPCVVRF
QDVLRARVKQINEAFGKAVAEMGYGASYFGVYPIKVNQMREVVDEIVDAGAPYHYGLEAGSKGELLVVLGMNADPDALTI
CNGYKDEEYLRLALLGRKLGRKVIVVIEKLSELPQLLRLGEEMGVDPMIGLRSKLTTRGTGKWEGSSGDFAKFGLTVPEL
IQAVRILKEAGKEHCAKLLHFHVGSQLTEIRVVKDAVNEGARVYAKLRKMGLPIEYFDVGGGLGVDYVGTRTNDFTSSVN
YSMDEYVGDVVYNVQRVCMNEGVPEPHIVSESGRAVTAHHSCIIIPVFGHIEIGSVEEIAKASEPEPNEAKVVREMREIV
SSLTPRNRAETYHDAAAKKEEALQMFKLGILGLEERAVVESLFWKLVRGIADMNRGKKRPPRETKDLGDKIADQYMANFS
LFQSAPDHWAFDQLFPIVPLHRMGEAPTRDTTIVDITCDSDGKIDRFIEGEGVDETLSLHALRPGEPYYLGMFMTGAYQD
IMGDMHNLFGRVNEIHVFVDDEDPEDFYIEEVIPGDTIEKVLSRVQYEPADLFRRVKAALDQKVKEGAIRPKEGVSLQDF
YEAVMKGYTYLGGV

Sequences:

>Translated_654_residues
MSIPEQRSDATTAMAAADWSIERAAQYYNVSGWGAGFFSINEKGHVAVHPMGQPGPTIDLMDVVEDIRERNIGFPCVVRF
QDVLRARVKQINEAFGKAVAEMGYGASYFGVYPIKVNQMREVVDEIVDAGAPYHYGLEAGSKGELLVVLGMNADPDALTI
CNGYKDEEYLRLALLGRKLGRKVIVVIEKLSELPQLLRLGEEMGVDPMIGLRSKLTTRGTGKWEGSSGDFAKFGLTVPEL
IQAVRILKEAGKEHCAKLLHFHVGSQLTEIRVVKDAVNEGARVYAKLRKMGLPIEYFDVGGGLGVDYVGTRTNDFTSSVN
YSMDEYVGDVVYNVQRVCMNEGVPEPHIVSESGRAVTAHHSCIIIPVFGHIEIGSVEEIAKASEPEPNEAKVVREMREIV
SSLTPRNRAETYHDAAAKKEEALQMFKLGILGLEERAVVESLFWKLVRGIADMNRGKKRPPRETKDLGDKIADQYMANFS
LFQSAPDHWAFDQLFPIVPLHRMGEAPTRDTTIVDITCDSDGKIDRFIEGEGVDETLSLHALRPGEPYYLGMFMTGAYQD
IMGDMHNLFGRVNEIHVFVDDEDPEDFYIEEVIPGDTIEKVLSRVQYEPADLFRRVKAALDQKVKEGAIRPKEGVSLQDF
YEAVMKGYTYLGGV
>Mature_653_residues
SIPEQRSDATTAMAAADWSIERAAQYYNVSGWGAGFFSINEKGHVAVHPMGQPGPTIDLMDVVEDIRERNIGFPCVVRFQ
DVLRARVKQINEAFGKAVAEMGYGASYFGVYPIKVNQMREVVDEIVDAGAPYHYGLEAGSKGELLVVLGMNADPDALTIC
NGYKDEEYLRLALLGRKLGRKVIVVIEKLSELPQLLRLGEEMGVDPMIGLRSKLTTRGTGKWEGSSGDFAKFGLTVPELI
QAVRILKEAGKEHCAKLLHFHVGSQLTEIRVVKDAVNEGARVYAKLRKMGLPIEYFDVGGGLGVDYVGTRTNDFTSSVNY
SMDEYVGDVVYNVQRVCMNEGVPEPHIVSESGRAVTAHHSCIIIPVFGHIEIGSVEEIAKASEPEPNEAKVVREMREIVS
SLTPRNRAETYHDAAAKKEEALQMFKLGILGLEERAVVESLFWKLVRGIADMNRGKKRPPRETKDLGDKIADQYMANFSL
FQSAPDHWAFDQLFPIVPLHRMGEAPTRDTTIVDITCDSDGKIDRFIEGEGVDETLSLHALRPGEPYYLGMFMTGAYQDI
MGDMHNLFGRVNEIHVFVDDEDPEDFYIEEVIPGDTIEKVLSRVQYEPADLFRRVKAALDQKVKEGAIRPKEGVSLQDFY
EAVMKGYTYLGGV

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=653, Percent_Identity=38.43797856049, Blast_Score=468, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 72743; Mature: 72612

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPEQRSDATTAMAAADWSIERAAQYYNVSGWGAGFFSINEKGHVAVHPMGQPGPTIDL
CCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCCCCCCHH
MDVVEDIRERNIGFPCVVRFQDVLRARVKQINEAFGKAVAEMGYGASYFGVYPIKVNQMR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHH
EVVDEIVDAGAPYHYGLEAGSKGELLVVLGMNADPDALTICNGYKDEEYLRLALLGRKLG
HHHHHHHHCCCCEEECCCCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHC
RKVIVVIEKLSELPQLLRLGEEMGVDPMIGLRSKLTTRGTGKWEGSSGDFAKFGLTVPEL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHH
IQAVRILKEAGKEHCAKLLHFHVGSQLTEIRVVKDAVNEGARVYAKLRKMGLPIEYFDVG
HHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECC
GGLGVDYVGTRTNDFTSSVNYSMDEYVGDVVYNVQRVCMNEGVPEPHIVSESGRAVTAHH
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEECC
SCIIIPVFGHIEIGSVEEIAKASEPEPNEAKVVREMREIVSSLTPRNRAETYHDAAAKKE
CEEEEEEECCEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EALQMFKLGILGLEERAVVESLFWKLVRGIADMNRGKKRPPRETKDLGDKIADQYMANFS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LFQSAPDHWAFDQLFPIVPLHRMGEAPTRDTTIVDITCDSDGKIDRFIEGEGVDETLSLH
HHHCCCCCCCHHHHHCCCCHHHCCCCCCCCCEEEEEEECCCCCEEHEECCCCCCCCEEEE
ALRPGEPYYLGMFMTGAYQDIMGDMHNLFGRVNEIHVFVDDEDPEDFYIEEVIPGDTIEK
EECCCCCEEEEEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEHHHCCCCHHHHH
VLSRVQYEPADLFRRVKAALDQKVKEGAIRPKEGVSLQDFYEAVMKGYTYLGGV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHCCC
>Mature Secondary Structure 
SIPEQRSDATTAMAAADWSIERAAQYYNVSGWGAGFFSINEKGHVAVHPMGQPGPTIDL
CCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCCCCCCHH
MDVVEDIRERNIGFPCVVRFQDVLRARVKQINEAFGKAVAEMGYGASYFGVYPIKVNQMR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHH
EVVDEIVDAGAPYHYGLEAGSKGELLVVLGMNADPDALTICNGYKDEEYLRLALLGRKLG
HHHHHHHHCCCCEEECCCCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHC
RKVIVVIEKLSELPQLLRLGEEMGVDPMIGLRSKLTTRGTGKWEGSSGDFAKFGLTVPEL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHH
IQAVRILKEAGKEHCAKLLHFHVGSQLTEIRVVKDAVNEGARVYAKLRKMGLPIEYFDVG
HHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECC
GGLGVDYVGTRTNDFTSSVNYSMDEYVGDVVYNVQRVCMNEGVPEPHIVSESGRAVTAHH
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEECC
SCIIIPVFGHIEIGSVEEIAKASEPEPNEAKVVREMREIVSSLTPRNRAETYHDAAAKKE
CEEEEEEECCEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EALQMFKLGILGLEERAVVESLFWKLVRGIADMNRGKKRPPRETKDLGDKIADQYMANFS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LFQSAPDHWAFDQLFPIVPLHRMGEAPTRDTTIVDITCDSDGKIDRFIEGEGVDETLSLH
HHHCCCCCCCHHHHHCCCCHHHCCCCCCCCCEEEEEEECCCCCEEHEECCCCCCCCEEEE
ALRPGEPYYLGMFMTGAYQDIMGDMHNLFGRVNEIHVFVDDEDPEDFYIEEVIPGDTIEK
EECCCCCEEEEEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEHHHCCCCHHHHH
VLSRVQYEPADLFRRVKAALDQKVKEGAIRPKEGVSLQDFYEAVMKGYTYLGGV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]