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The map label for this gene is yfhQ [H]

Identifier: 220917116

GI number: 220917116

Start: 2266786

End: 2267991

Strand: Direct

Name: yfhQ [H]

Synonym: A2cp1_2013

Alternate gene names: 220917116

Gene position: 2266786-2267991 (Clockwise)

Preceding gene: 220917115

Following gene: 220917117

Centisome position: 45.07

GC content: 80.85

Gene sequence:

>1206_bases
TTGACGGTGCGCCGCGCCCCCGCCTACCCTCCGCCCGTGCCCGCTCCCCACGCGCCCGCCCGCCTCGCCGCGCTCCGCCG
CCGCCTGCTGGCGTGGTGGGACGCCGGCCACCGGCCGCTGCCGTGGCGCCAGCCGCAGCGCGGCGCGGACCCGTACCGCG
TCTGGCTCGCGGAGGTGATGCTGCAGCAGACGCAGGTGGTGACGGCCACGCCGTACTGGCTGCGCTTCGTGGAGCGCTGG
CCCACGCTCGAGGCGCTCGCGGCCGCGCGCGACGAGGACGTGCTCGCCGCCTGGAGCGGCCTCGGCTACTACGCCCGCTG
CCGCAACCTGCTCGCCGCCGCGCGCGAGGCGCTGCGCCGCCACGGCGGCCTGCCGTCCGGCTACGACGCGCTGCGCGCGC
TGCCCGGGTTCGGGCCGTACACCGCCGGTGCAGTGGCCTCGATCGCGTTCGCCGCGCCCGTGCCGGCGGTGGACGGCAAC
GTCACGCGCGTGCTGTCGCGGCTGTTCCTGGTCGAGGGCGATCCCGCCGCGCGCGCCGCCCGCGCGCGCGTGGCCGCGCT
CGCCGCGGCGCTGGTGGACCGCGAGCGGCCGGGCGACCTCAACCAGGCGCTCATGGAGCTGGGCGCGACGGTGTGTCGGC
CGAGCCCGGACTGCGCGCGCTGCCCGGTGGCGGCGCGGTGCGCGGCGCGGGCCGCCGGCCGCGCGGCGGAGCTCCCGCCG
CCGCGGCGTCGCCCGGACAAGGTGCGCCTCGTCCTCGCCTGCGCCGTGGTGGTGCGCGAGGGGAGGGTGGCGCTGGTGCG
CCGGCCCGCGGGCGGGCTGTTCGCCGGCCTGGCGGCGTTCCCCGCCGCGGAGGTCGGGCCGGGCGCCGAGGCCGGCGCCG
CGCTGGAGCGCGAGGCCCGCGAGCGCCACGGCCTGCGGCTGCGCGCCGGCGAGGAGCTGGGCCGGGTCGAGCGGGTGCTC
ACGCATCGCCTGCTCGAGCTCCGCGCGCTCCGCTGCTCCCTCGCACGGCCGCCGCCGGAGGAGGGGATCCGCTGGATCCC
TGCGGACGAGCTGGACGGCGCCGGCCTCCCCGCGGCCATGCGGGCGCTGGCCGGGGTGGTCTGCGACGTGCTCGGGCAGG
CGCCGCCGCCGTCCGGGGGAGCCCGCGACCGGGGGCGCGCGCGGGCCCGCGCGAATTCGCTCGCACCCCCGCGCGATTTC
GTGTAG

Upstream 100 bases:

>100_bases
GCCGTCGTGCGTCCGGGCCCGCGCTGACCTCGCGTCAGCCCGCGAACCGGGGCGCGCGAAGCCACGCGGCGCGGAGGGCC
GGCGGGGAGGCCCGGGGAGT

Downstream 100 bases:

>100_bases
AAGCGCGGCCTTCCGGGCGTCATCCGGGAGGTTGCAGCGCGCGTCAAGACCCGAGTTCGGGAACCGCTTGACACGTGTGG
GCTCCTCCGTATAATTCGCC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTVRRAPAYPPPVPAPHAPARLAALRRRLLAWWDAGHRPLPWRQPQRGADPYRVWLAEVMLQQTQVVTATPYWLRFVERW
PTLEALAAARDEDVLAAWSGLGYYARCRNLLAAAREALRRHGGLPSGYDALRALPGFGPYTAGAVASIAFAAPVPAVDGN
VTRVLSRLFLVEGDPAARAARARVAALAAALVDRERPGDLNQALMELGATVCRPSPDCARCPVAARCAARAAGRAAELPP
PRRRPDKVRLVLACAVVVREGRVALVRRPAGGLFAGLAAFPAAEVGPGAEAGAALEREARERHGLRLRAGEELGRVERVL
THRLLELRALRCSLARPPPEEGIRWIPADELDGAGLPAAMRALAGVVCDVLGQAPPPSGGARDRGRARARANSLAPPRDF
V

Sequences:

>Translated_401_residues
MTVRRAPAYPPPVPAPHAPARLAALRRRLLAWWDAGHRPLPWRQPQRGADPYRVWLAEVMLQQTQVVTATPYWLRFVERW
PTLEALAAARDEDVLAAWSGLGYYARCRNLLAAAREALRRHGGLPSGYDALRALPGFGPYTAGAVASIAFAAPVPAVDGN
VTRVLSRLFLVEGDPAARAARARVAALAAALVDRERPGDLNQALMELGATVCRPSPDCARCPVAARCAARAAGRAAELPP
PRRRPDKVRLVLACAVVVREGRVALVRRPAGGLFAGLAAFPAAEVGPGAEAGAALEREARERHGLRLRAGEELGRVERVL
THRLLELRALRCSLARPPPEEGIRWIPADELDGAGLPAAMRALAGVVCDVLGQAPPPSGGARDRGRARARANSLAPPRDF
V
>Mature_400_residues
TVRRAPAYPPPVPAPHAPARLAALRRRLLAWWDAGHRPLPWRQPQRGADPYRVWLAEVMLQQTQVVTATPYWLRFVERWP
TLEALAAARDEDVLAAWSGLGYYARCRNLLAAAREALRRHGGLPSGYDALRALPGFGPYTAGAVASIAFAAPVPAVDGNV
TRVLSRLFLVEGDPAARAARARVAALAAALVDRERPGDLNQALMELGATVCRPSPDCARCPVAARCAARAAGRAAELPPP
RRRPDKVRLVLACAVVVREGRVALVRRPAGGLFAGLAAFPAAEVGPGAEAGAALEREARERHGLRLRAGEELGRVERVLT
HRLLELRALRCSLARPPPEEGIRWIPADELDGAGLPAAMRALAGVVCDVLGQAPPPSGGARDRGRARARANSLAPPRDFV

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=427, Percent_Identity=35.8313817330211, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI190358497, Length=427, Percent_Identity=35.8313817330211, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI115298654, Length=427, Percent_Identity=35.8313817330211, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI115298652, Length=427, Percent_Identity=35.8313817330211, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI6912520, Length=427, Percent_Identity=35.8313817330211, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI115298648, Length=427, Percent_Identity=35.8313817330211, Blast_Score=201, Evalue=7e-52,
Organism=Escherichia coli, GI1789331, Length=260, Percent_Identity=41.1538461538462, Blast_Score=187, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 42971; Mature: 42840

Theoretical pI: Translated: 11.43; Mature: 11.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRRAPAYPPPVPAPHAPARLAALRRRLLAWWDAGHRPLPWRQPQRGADPYRVWLAEVM
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
LQQTQVVTATPYWLRFVERWPTLEALAAARDEDVLAAWSGLGYYARCRNLLAAAREALRR
HHHHHHEECCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
HGGLPSGYDALRALPGFGPYTAGAVASIAFAAPVPAVDGNVTRVLSRLFLVEGDPAARAA
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHH
RARVAALAAALVDRERPGDLNQALMELGATVCRPSPDCARCPVAARCAARAAGRAAELPP
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCCCCCC
PRRRPDKVRLVLACAVVVREGRVALVRRPAGGLFAGLAAFPAAEVGPGAEAGAALEREAR
CCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ERHGLRLRAGEELGRVERVLTHRLLELRALRCSLARPPPEEGIRWIPADELDGAGLPAAM
HHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEECCCCCCCCCCCHHHH
RALAGVVCDVLGQAPPPSGGARDRGRARARANSLAPPRDFV
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TVRRAPAYPPPVPAPHAPARLAALRRRLLAWWDAGHRPLPWRQPQRGADPYRVWLAEVM
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
LQQTQVVTATPYWLRFVERWPTLEALAAARDEDVLAAWSGLGYYARCRNLLAAAREALRR
HHHHHHEECCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
HGGLPSGYDALRALPGFGPYTAGAVASIAFAAPVPAVDGNVTRVLSRLFLVEGDPAARAA
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHH
RARVAALAAALVDRERPGDLNQALMELGATVCRPSPDCARCPVAARCAARAAGRAAELPP
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCCCCCC
PRRRPDKVRLVLACAVVVREGRVALVRRPAGGLFAGLAAFPAAEVGPGAEAGAALEREAR
CCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ERHGLRLRAGEELGRVERVLTHRLLELRALRCSLARPPPEEGIRWIPADELDGAGLPAAM
HHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEECCCCCCCCCCCHHHH
RALAGVVCDVLGQAPPPSGGARDRGRARARANSLAPPRDFV
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]