Click here to switch to the map view.

The map label for this gene is galE [C]

Identifier: 220917113

GI number: 220917113

Start: 2263916

End: 2264848

Strand: Direct

Name: galE [C]

Synonym: A2cp1_2010

Alternate gene names: 220917113

Gene position: 2263916-2264848 (Clockwise)

Preceding gene: 220917112

Following gene: 220917115

Centisome position: 45.01

GC content: 75.56

Gene sequence:

>933_bases
ATGGGCAAGCGCATCCTCATCACCGGCGGGGCCGGGTTCATCGGCTCCACCATCGCAGACCTGTTCGTGCAGGCGGGCTG
GGACGTCGCGGTCCTCGACGATCTCTCCAGCGGCAAGCGCGAGAACGTGCCGCAGGGCGCGCGCTTCTACCCGGTGGACG
TGCGCAGCGCCGCCGCGGCCGAGGCGGTCCGCAAGGAGCGGCCGCAGGTGATCTGCCACCACGCCGCGCAGATCGACGTG
CGGCGCTCCATGGCGGACCCGCGCTTCGACGCCGACGTCAACGTGGGCGGCCTGCTCAACCTCATGCAGGCAGCGGCCGC
GGCGGGCTCGGTGGAGCACGTCCTGTTCGCCTCCTCCGGCGGCGCCACCTACGGCGACACGGCGGTGATCCCCACGCCCG
AGACGCACCCGCAGGCGCCGGTCTCGCACTACGGGGCGGCGAAGGCCGCGAGCGAGCTGTACCTGGGCGTCTACCGGGCG
GCCCTGGGCATCCCGGTGGCGGCGCTGCGCTACGCGAACGTGTACGGGCCGCGCCAGGACCCGCACGGCGAGGCGGGCGT
GGTGGCGATCTTCTGCGGGCGGCTGCTCGAGGGACGTCCCTGCACCGTGTACGGCGACGGCGGCCAGACCCGCGACTACG
TGTTCGTGGGCGACGTGGCGCGCGCGAACCTGCTCGCGGCGGAGCGGCGCCACGACGGGCCGCTCAACGTCGGCACCGGC
GTGGAGACCGACGTGAACGCGCTCTACGCGCACCTGGCGCGCGCCGCCGGCGTGGATCGCCCCGCGGAGCACGCGCCGGC
GCGGCCGGGCGAGCAGCGCCGGTCGTGCATCGACCCGTCGCTCGCCGCGCGGGCGATCGGCTGGCGGCCCGAGGTGCCGC
TGGCGGACGGCCTGGCCCGCACGCTGGAGTGGTTCCGGGCGCCCCGCGGATGA

Upstream 100 bases:

>100_bases
GGCTCGGCTGGGCGCCGCGGATCGGGTTCGAGGAAGGGATGCGCCGGACCATCGACTGGTTCCGCGCGCACGTCTGACCG
GCGAGGGCGGGGGACACACC

Downstream 100 bases:

>100_bases
GCGGCTAGCGCGGCTCGCCGGGGCCGGCCGCCTCTGCGGCCGCGGGCTCCGGGGCCGCCGCCGCGGCCGCGGGCACCGGC
TCCGCCCGCGGCACCGCCGC

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MGKRILITGGAGFIGSTIADLFVQAGWDVAVLDDLSSGKRENVPQGARFYPVDVRSAAAAEAVRKERPQVICHHAAQIDV
RRSMADPRFDADVNVGGLLNLMQAAAAAGSVEHVLFASSGGATYGDTAVIPTPETHPQAPVSHYGAAKAASELYLGVYRA
ALGIPVAALRYANVYGPRQDPHGEAGVVAIFCGRLLEGRPCTVYGDGGQTRDYVFVGDVARANLLAAERRHDGPLNVGTG
VETDVNALYAHLARAAGVDRPAEHAPARPGEQRRSCIDPSLAARAIGWRPEVPLADGLARTLEWFRAPRG

Sequences:

>Translated_310_residues
MGKRILITGGAGFIGSTIADLFVQAGWDVAVLDDLSSGKRENVPQGARFYPVDVRSAAAAEAVRKERPQVICHHAAQIDV
RRSMADPRFDADVNVGGLLNLMQAAAAAGSVEHVLFASSGGATYGDTAVIPTPETHPQAPVSHYGAAKAASELYLGVYRA
ALGIPVAALRYANVYGPRQDPHGEAGVVAIFCGRLLEGRPCTVYGDGGQTRDYVFVGDVARANLLAAERRHDGPLNVGTG
VETDVNALYAHLARAAGVDRPAEHAPARPGEQRRSCIDPSLAARAIGWRPEVPLADGLARTLEWFRAPRG
>Mature_309_residues
GKRILITGGAGFIGSTIADLFVQAGWDVAVLDDLSSGKRENVPQGARFYPVDVRSAAAAEAVRKERPQVICHHAAQIDVR
RSMADPRFDADVNVGGLLNLMQAAAAAGSVEHVLFASSGGATYGDTAVIPTPETHPQAPVSHYGAAKAASELYLGVYRAA
LGIPVAALRYANVYGPRQDPHGEAGVVAIFCGRLLEGRPCTVYGDGGQTRDYVFVGDVARANLLAAERRHDGPLNVGTGV
ETDVNALYAHLARAAGVDRPAEHAPARPGEQRRSCIDPSLAARAIGWRPEVPLADGLARTLEWFRAPRG

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=323, Percent_Identity=29.1021671826625, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI42516563, Length=310, Percent_Identity=29.3548387096774, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI56237023, Length=337, Percent_Identity=26.4094955489614, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI56118217, Length=337, Percent_Identity=26.4094955489614, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI189083684, Length=337, Percent_Identity=26.4094955489614, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI48994969, Length=339, Percent_Identity=30.3834808259587, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=30.952380952381, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1788353, Length=336, Percent_Identity=29.7619047619048, Blast_Score=114, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17539532, Length=315, Percent_Identity=29.5238095238095, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71982035, Length=349, Percent_Identity=30.3724928366762, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71982038, Length=351, Percent_Identity=30.1994301994302, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17568069, Length=325, Percent_Identity=26.1538461538462, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI115532424, Length=326, Percent_Identity=25.4601226993865, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=28.7390029325513, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356223, Length=310, Percent_Identity=30.3225806451613, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19923002, Length=336, Percent_Identity=27.0833333333333, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 32716; Mature: 32585

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKRILITGGAGFIGSTIADLFVQAGWDVAVLDDLSSGKRENVPQGARFYPVDVRSAAAA
CCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECHHHHHHH
EAVRKERPQVICHHAAQIDVRRSMADPRFDADVNVGGLLNLMQAAAAAGSVEHVLFASSG
HHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCC
GATYGDTAVIPTPETHPQAPVSHYGAAKAASELYLGVYRAALGIPVAALRYANVYGPRQD
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
PHGEAGVVAIFCGRLLEGRPCTVYGDGGQTRDYVFVGDVARANLLAAERRHDGPLNVGTG
CCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCC
VETDVNALYAHLARAAGVDRPAEHAPARPGEQRRSCIDPSLAARAIGWRPEVPLADGLAR
CCHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHCCHHHHHHHCCCCCCCCHHHHHHH
TLEWFRAPRG
HHHHHHCCCC
>Mature Secondary Structure 
GKRILITGGAGFIGSTIADLFVQAGWDVAVLDDLSSGKRENVPQGARFYPVDVRSAAAA
CCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECHHHHHHH
EAVRKERPQVICHHAAQIDVRRSMADPRFDADVNVGGLLNLMQAAAAAGSVEHVLFASSG
HHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCC
GATYGDTAVIPTPETHPQAPVSHYGAAKAASELYLGVYRAALGIPVAALRYANVYGPRQD
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
PHGEAGVVAIFCGRLLEGRPCTVYGDGGQTRDYVFVGDVARANLLAAERRHDGPLNVGTG
CCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCC
VETDVNALYAHLARAAGVDRPAEHAPARPGEQRRSCIDPSLAARAIGWRPEVPLADGLAR
CCHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHCCHHHHHHHCCCCCCCCHHHHHHH
TLEWFRAPRG
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]