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The map label for this gene is hemB [H]

Identifier: 220916609

GI number: 220916609

Start: 1683551

End: 1684576

Strand: Direct

Name: hemB [H]

Synonym: A2cp1_1503

Alternate gene names: 220916609

Gene position: 1683551-1684576 (Clockwise)

Preceding gene: 220916608

Following gene: 220916610

Centisome position: 33.47

GC content: 71.64

Gene sequence:

>1026_bases
ATGCCTTTCCCCCAGCACCGCCCCCGCCGCATGCGCCGCACCGAGGCCCTCCGGAGCCTGGTGCGCGAGACCACCCTCGC
CCCGCAGCACCTGGTGTGGCCGCTCTTCGTGCTCCCCGGCACGAAGGTGCGGAACCCGGTGAAGAGCATGCCGGGCGTGT
TCCAGCTCTCCGTGGACGAGCTGGTCGCCGAGGTGCAGCAGGGCTTCGAGGCGGGCGTCCGCTCGGTGATCCTGTTCGGC
ATCCCCGAGCACAAGGACCCGCAGGGCACCGAGGCGTACGCCGACGACGGGATCGTCCCGCAGGCCATCCGGGCGCTGAA
GGAGCGGGTGCCCGGCATGGTGGTGATGACCGACGTGTGCATGTGCGAGTACACGGATCACGGCCACTGCGGCATCCTCA
AGGCGTCGAAGGCCGGTGGCCCGGGCAACGAGCTGCAGGTCGACAACGACCTCACGCTCCCGCTCCTCGCCAAGGAGGCG
CTCGCCCACGCCCGCGCCGGCGCCGACATCGTGGCGCCCTCGGACATGATGGACGGGCGCGTGGCGGCGATCCGCGCCGA
GCTGGACGGCGCCGGCTACCAGGACGTGCCCATCCTGTCGTACGCGGCGAAGTTCGCGGGCGCGTTCTACGGCCCGTTCC
GCGACGCCGCGGAGAGCGCGCCGGTGGAGGGCCCGGGCATCCCCAAGGACCGCAAGGGCTACCAGATGGATCCCGCCAAC
TGGCGCGAGGCGCTCCGCGAGGTGGAGCTCGACGTCGCCGAGGGCGCGGACATGATCATGGTGAAGCCGGCCGTGCCGTA
CCTCGACATCGTGCGCCAGGTGCGCGACCGCTTCGACCTGCCCACCGCCGCGTACCACGTGTCCGGCGAGTACGCGATGA
TCAAGGCCGCCGCCGAGCGCGGCTGGATCGACGAGGACCGGGTGGTGCTCGAGACGCTGCTCTGCTGCCGGCGCGCCGGC
GCGGACCTCGTGCTCACCTACTACGCGAAGCACGCCGCCCAGCTCCTCTCCGGGAAGAAGCGTTGA

Upstream 100 bases:

>100_bases
CGTCGCCCTGACCCCGCCCGCCGGGCGGCGGGCCGGGGCGCGGGCCCCCGGGGCACTCGGCCGCCTTTCCCGGCGGCCCC
GACTGCGCTAGAAAACGCCC

Downstream 100 bases:

>100_bases
CCGTGCTCCGGCCCGCGCCCCAGCCCGCCGCGTACAAGGTCGTCGAGGTCTCGCCGGTGTCCGACGAGACGCTCGAGCGC
GCCCTGAACGAGCGGACGGG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MPFPQHRPRRMRRTEALRSLVRETTLAPQHLVWPLFVLPGTKVRNPVKSMPGVFQLSVDELVAEVQQGFEAGVRSVILFG
IPEHKDPQGTEAYADDGIVPQAIRALKERVPGMVVMTDVCMCEYTDHGHCGILKASKAGGPGNELQVDNDLTLPLLAKEA
LAHARAGADIVAPSDMMDGRVAAIRAELDGAGYQDVPILSYAAKFAGAFYGPFRDAAESAPVEGPGIPKDRKGYQMDPAN
WREALREVELDVAEGADMIMVKPAVPYLDIVRQVRDRFDLPTAAYHVSGEYAMIKAAAERGWIDEDRVVLETLLCCRRAG
ADLVLTYYAKHAAQLLSGKKR

Sequences:

>Translated_341_residues
MPFPQHRPRRMRRTEALRSLVRETTLAPQHLVWPLFVLPGTKVRNPVKSMPGVFQLSVDELVAEVQQGFEAGVRSVILFG
IPEHKDPQGTEAYADDGIVPQAIRALKERVPGMVVMTDVCMCEYTDHGHCGILKASKAGGPGNELQVDNDLTLPLLAKEA
LAHARAGADIVAPSDMMDGRVAAIRAELDGAGYQDVPILSYAAKFAGAFYGPFRDAAESAPVEGPGIPKDRKGYQMDPAN
WREALREVELDVAEGADMIMVKPAVPYLDIVRQVRDRFDLPTAAYHVSGEYAMIKAAAERGWIDEDRVVLETLLCCRRAG
ADLVLTYYAKHAAQLLSGKKR
>Mature_340_residues
PFPQHRPRRMRRTEALRSLVRETTLAPQHLVWPLFVLPGTKVRNPVKSMPGVFQLSVDELVAEVQQGFEAGVRSVILFGI
PEHKDPQGTEAYADDGIVPQAIRALKERVPGMVVMTDVCMCEYTDHGHCGILKASKAGGPGNELQVDNDLTLPLLAKEAL
AHARAGADIVAPSDMMDGRVAAIRAELDGAGYQDVPILSYAAKFAGAFYGPFRDAAESAPVEGPGIPKDRKGYQMDPANW
REALREVELDVAEGADMIMVKPAVPYLDIVRQVRDRFDLPTAAYHVSGEYAMIKAAAERGWIDEDRVVLETLLCCRRAGA
DLVLTYYAKHAAQLLSGKKR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=317, Percent_Identity=45.4258675078864, Blast_Score=256, Evalue=2e-68,
Organism=Escherichia coli, GI87081728, Length=329, Percent_Identity=51.063829787234, Blast_Score=319, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6321398, Length=318, Percent_Identity=43.3962264150943, Blast_Score=233, Evalue=4e-62,
Organism=Drosophila melanogaster, GI21358291, Length=306, Percent_Identity=42.156862745098, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37384; Mature: 37253

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFPQHRPRRMRRTEALRSLVRETTLAPQHLVWPLFVLPGTKVRNPVKSMPGVFQLSVDE
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHCCHHHHCCCEEEECHHH
LVAEVQQGFEAGVRSVILFGIPEHKDPQGTEAYADDGIVPQAIRALKERVPGMVVMTDVC
HHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHCCCCCCHHHHHHHHHHCCCEEEEEHHH
MCEYTDHGHCGILKASKAGGPGNELQVDNDLTLPLLAKEALAHARAGADIVAPSDMMDGR
HHCCCCCCCEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHCCCC
VAAIRAELDGAGYQDVPILSYAAKFAGAFYGPFRDAAESAPVEGPGIPKDRKGYQMDPAN
EEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
WREALREVELDVAEGADMIMVKPAVPYLDIVRQVRDRFDLPTAAYHVSGEYAMIKAAAER
HHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCHHEEEHHHHC
GWIDEDRVVLETLLCCRRAGADLVLTYYAKHAAQLLSGKKR
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PFPQHRPRRMRRTEALRSLVRETTLAPQHLVWPLFVLPGTKVRNPVKSMPGVFQLSVDE
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHCCHHHHCCCEEEECHHH
LVAEVQQGFEAGVRSVILFGIPEHKDPQGTEAYADDGIVPQAIRALKERVPGMVVMTDVC
HHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHCCCCCCHHHHHHHHHHCCCEEEEEHHH
MCEYTDHGHCGILKASKAGGPGNELQVDNDLTLPLLAKEALAHARAGADIVAPSDMMDGR
HHCCCCCCCEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHCCCC
VAAIRAELDGAGYQDVPILSYAAKFAGAFYGPFRDAAESAPVEGPGIPKDRKGYQMDPAN
EEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
WREALREVELDVAEGADMIMVKPAVPYLDIVRQVRDRFDLPTAAYHVSGEYAMIKAAAER
HHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCHHEEEHHHHC
GWIDEDRVVLETLLCCRRAGADLVLTYYAKHAAQLLSGKKR
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]