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The map label for this gene is hemD [H]

Identifier: 220916567

GI number: 220916567

Start: 1634877

End: 1635671

Strand: Direct

Name: hemD [H]

Synonym: A2cp1_1461

Alternate gene names: 220916567

Gene position: 1634877-1635671 (Clockwise)

Preceding gene: 220916566

Following gene: 220916568

Centisome position: 32.51

GC content: 80.75

Gene sequence:

>795_bases
GTGCCTGCCGCGCCCGCGCGGCCGCTGGCCGGCCGCACCGTGGTGGTGACCCGGGGCAAGGGCTCCGAGGGCAAGGACGC
GCTCGCGGCCCGGCTCGAGGCGCTGGGCGCGGAGGTGCGCGCGCTCCCCTCGATCGCGTTCGCTCCGCCCGCCGATCCCG
CGCCGCTCGACGCCGCGCTCCGCGCGCTCGACCGCTTCGACTGGGCGGTGTTCACCAGCGCGAACGCGGTGGACCGGACG
GTGGAGCGGCTGCGCGCGCTCGGCCTCGATCCGGCCGCCCTGGGCCGGCTCCGCCTCGCCGCCGTCGGGCCCGCCACCGC
CGAGCGGCTGGCGGCGGCGGTGCGCGCGCCGGACGTGGTGCCGGTCGAGGCGAAGGGAGACGTGCTCGCCCGCACCCTGG
GCGACCACATCCGCGGCCGGCGGGTGCTGTTCCCGCGCCCGGCCGAGGGCCGGCCCGAGACCGTGGCCGGGCTCCTCGCC
GCCGGGGCCGAGCTGACCGCGGTCGAGGCGTACCGGACGGTCCCCGCGCCCGCCGAGGCGCTGGCGCACCTGGCGGGCTG
GCTCGCGGCCGGTGAGGTCGCGGCGGTCGCGTTCGCGTCCCCCTCGGCGGTGGCGGCCGTGCTGGCGGCGCTCGGGGACC
GGTCGGCCCTCCTCCGAGGGGTGCTGATCGCGGCGATCGGGCCCACCACTGCGGACACGCTGCGCGAGGCGGGGCTCCCG
GTGGGCGCCGTCCCGGCGCACTACACCGGCCGAGACCTCGCGGAGGCCATCGCCGAGCGGCTCGGCCCCGGGTAG

Upstream 100 bases:

>100_bases
GGCCGACGAGCTGCTCTCGCGCGGCGCCGACCAGATCCTGCGCGAGACCGAGGGCAAGGCGCCCGGGCTCGCCGCGCCGA
AGCGCGGGTAGGGGGACGCG

Downstream 100 bases:

>100_bases
ATTCGGTCGGGGGTGCCGCGTCGATGACCGTCGAGCTCGAGGCCGCCGAGGGGCTGGTGCGAGTCCGGGTGCCGCTGGAC
CGGGCGCCCGGGGAGCCCGG

Product: Uroporphyrinogen III synthase HEM4

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MPAAPARPLAGRTVVVTRGKGSEGKDALAARLEALGAEVRALPSIAFAPPADPAPLDAALRALDRFDWAVFTSANAVDRT
VERLRALGLDPAALGRLRLAAVGPATAERLAAAVRAPDVVPVEAKGDVLARTLGDHIRGRRVLFPRPAEGRPETVAGLLA
AGAELTAVEAYRTVPAPAEALAHLAGWLAAGEVAAVAFASPSAVAAVLAALGDRSALLRGVLIAAIGPTTADTLREAGLP
VGAVPAHYTGRDLAEAIAERLGPG

Sequences:

>Translated_264_residues
MPAAPARPLAGRTVVVTRGKGSEGKDALAARLEALGAEVRALPSIAFAPPADPAPLDAALRALDRFDWAVFTSANAVDRT
VERLRALGLDPAALGRLRLAAVGPATAERLAAAVRAPDVVPVEAKGDVLARTLGDHIRGRRVLFPRPAEGRPETVAGLLA
AGAELTAVEAYRTVPAPAEALAHLAGWLAAGEVAAVAFASPSAVAAVLAALGDRSALLRGVLIAAIGPTTADTLREAGLP
VGAVPAHYTGRDLAEAIAERLGPG
>Mature_263_residues
PAAPARPLAGRTVVVTRGKGSEGKDALAARLEALGAEVRALPSIAFAPPADPAPLDAALRALDRFDWAVFTSANAVDRTV
ERLRALGLDPAALGRLRLAAVGPATAERLAAAVRAPDVVPVEAKGDVLARTLGDHIRGRRVLFPRPAEGRPETVAGLLAA
GAELTAVEAYRTVPAPAEALAHLAGWLAAGEVAAVAFASPSAVAAVLAALGDRSALLRGVLIAAIGPTTADTLREAGLPV
GAVPAHYTGRDLAEAIAERLGPG

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 26701; Mature: 26570

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAPARPLAGRTVVVTRGKGSEGKDALAARLEALGAEVRALPSIAFAPPADPAPLDAAL
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
RALDRFDWAVFTSANAVDRTVERLRALGLDPAALGRLRLAAVGPATAERLAAAVRAPDVV
HHHHHHHHHEECCCHHHHHHHHHHHHCCCCHHHHHHEHEEECCCHHHHHHHHHHCCCCEE
PVEAKGDVLARTLGDHIRGRRVLFPRPAEGRPETVAGLLAAGAELTAVEAYRTVPAPAEA
EECCCCHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHH
LAHLAGWLAAGEVAAVAFASPSAVAAVLAALGDRSALLRGVLIAAIGPTTADTLREAGLP
HHHHHHHHHHHHHHHEEECCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCCC
VGAVPAHYTGRDLAEAIAERLGPG
CCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
PAAPARPLAGRTVVVTRGKGSEGKDALAARLEALGAEVRALPSIAFAPPADPAPLDAAL
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
RALDRFDWAVFTSANAVDRTVERLRALGLDPAALGRLRLAAVGPATAERLAAAVRAPDVV
HHHHHHHHHEECCCHHHHHHHHHHHHCCCCHHHHHHEHEEECCCHHHHHHHHHHCCCCEE
PVEAKGDVLARTLGDHIRGRRVLFPRPAEGRPETVAGLLAAGAELTAVEAYRTVPAPAEA
EECCCCHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHH
LAHLAGWLAAGEVAAVAFASPSAVAAVLAALGDRSALLRGVLIAAIGPTTADTLREAGLP
HHHHHHHHHHHHHHHEEECCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCCC
VGAVPAHYTGRDLAEAIAERLGPG
CCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]