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The map label for this gene is nuoD2 [H]

Identifier: 220916488

GI number: 220916488

Start: 1545769

End: 1547064

Strand: Direct

Name: nuoD2 [H]

Synonym: A2cp1_1382

Alternate gene names: 220916488

Gene position: 1545769-1547064 (Clockwise)

Preceding gene: 220916487

Following gene: 220916489

Centisome position: 30.74

GC content: 68.52

Gene sequence:

>1296_bases
ATGAGCGAGGCGAAGGGAGTCGGAGGCATCGATCCGCGGGCGACGCCGGGCAGCGCCGGCGCCGGCGAGCGGCCGCCGAT
GGGGACGCTGTCCCCCCGGGCGGGCGAGGGCGAGCTGTACGCGCCCATGCCGTCGAAGCACATGGTGATCAACCTCGGCC
CCTCGCACCCGGCCATGCACGGCGTGACCCGCGCCGTGGTGGAGCTGAACGGCGAGATCATCGAGGGGATGAAGCTGGAC
ATCGGCTTCCTCCATCGCGGCTTCGAGAAGAGCTGCGAGAACGTGACCTGGGGCCAGGTGTTCCCGTACACCGACCGGCT
CAACTACGTCAGCTCGATCATGAACAACGTGGGGTTCGCGCTGGCGGTCGAGAAGCTCGCCAAGCTCGAGATCCCCGAGC
GCGCCCGGTACCTGCGCGTCATCACCAGCGAGATCCACCGCATCTGCGACCACCTCACGCTGGTGGGCGCCATGGCGATG
GAGCTCGGCGCGATGACCGTGTTCCTGTACGGCATCGAGGCCCGCGACCTGCTGTGGGACCGCCTCGCCGAGCTGTGCGG
CGCGCGGCTCACCTCGAACTACGCGCGCATCGGCGGCGTGGCGCGCGACATGCCGGAGGGCTGGCAGGAGAAGACGCTGA
AGGTGCTGGACCGCGTCGTCGCCATCCGCGAGGAGATCGGCCAGCTCCTCAACCGCAACCGCATCTTCATCGACCGCTGC
CTCAACACCGGCAAGGTGTCGCGCGAGGACGCGCTGGAGCTGGGCTTCACCGGCCCGTGCCTGCGCGCGTCCGGCGAGCC
CTACGACGTGCGCAAGGCGGCGCCGTACCTGGTCTACGACCGGCTCGACTTCGACATCCCGGTCGGCTCGAACGGCGACA
ACTTCGACCGCTACCTCATGCGCATGGAGGAGATGCGGCAGTCGGACAAGATCATCCGCCAGTGCTTCGAGCAGATGGCG
CCCGGCGAGATCATCGTCCAGGACTTCCGCTACGCGCTGCCGCCCAAGCCGCTCGTGTACGGCACCATCGAGGGCGTGAT
GGCGCACTTCAAGCTGGTGATGGAGGGGATCAAGGTCCCCGCCGGCGAGGTCTACAGCTACACCGAGGCCGCCAACGGCG
AGCTCGGGTTCTACGTCGTCTCCGACGGCGGCGGCCGCCCGTACAAGCTCGGCCTGCGAGCGCCGGGCTGGCCGATGCTG
GCGGCCCTGCCGGTGATGACCAAGGGTTCGCTGCTGTCCGACCTCATCCCCACCTTCGACAGCATCAACATGATCGGCGG
CGAGGTGGAGCAGTAG

Upstream 100 bases:

>100_bases
CCGCGTCGCGCGACTAGCCGTTTCTTTCCACGCCGCCGGGCCGCGCCGAGCGCGCTGCGGCGGGCGCCCCTCCGGAAGGA
CCGGGCGCGCGGAGGACGAG

Downstream 100 bases:

>100_bases
CCTCGCCCGGGAACCAGGAGCCTCCGATGGCCGAAGAGAAGAAGCCCGACGCCGCGCCGCCCAAGCCGCCCGGCCCCCCG
GCCCCGCCGCCGCCGAAGAA

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 2; NDH-1 subunit D 2 [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSEAKGVGGIDPRATPGSAGAGERPPMGTLSPRAGEGELYAPMPSKHMVINLGPSHPAMHGVTRAVVELNGEIIEGMKLD
IGFLHRGFEKSCENVTWGQVFPYTDRLNYVSSIMNNVGFALAVEKLAKLEIPERARYLRVITSEIHRICDHLTLVGAMAM
ELGAMTVFLYGIEARDLLWDRLAELCGARLTSNYARIGGVARDMPEGWQEKTLKVLDRVVAIREEIGQLLNRNRIFIDRC
LNTGKVSREDALELGFTGPCLRASGEPYDVRKAAPYLVYDRLDFDIPVGSNGDNFDRYLMRMEEMRQSDKIIRQCFEQMA
PGEIIVQDFRYALPPKPLVYGTIEGVMAHFKLVMEGIKVPAGEVYSYTEAANGELGFYVVSDGGGRPYKLGLRAPGWPML
AALPVMTKGSLLSDLIPTFDSINMIGGEVEQ

Sequences:

>Translated_431_residues
MSEAKGVGGIDPRATPGSAGAGERPPMGTLSPRAGEGELYAPMPSKHMVINLGPSHPAMHGVTRAVVELNGEIIEGMKLD
IGFLHRGFEKSCENVTWGQVFPYTDRLNYVSSIMNNVGFALAVEKLAKLEIPERARYLRVITSEIHRICDHLTLVGAMAM
ELGAMTVFLYGIEARDLLWDRLAELCGARLTSNYARIGGVARDMPEGWQEKTLKVLDRVVAIREEIGQLLNRNRIFIDRC
LNTGKVSREDALELGFTGPCLRASGEPYDVRKAAPYLVYDRLDFDIPVGSNGDNFDRYLMRMEEMRQSDKIIRQCFEQMA
PGEIIVQDFRYALPPKPLVYGTIEGVMAHFKLVMEGIKVPAGEVYSYTEAANGELGFYVVSDGGGRPYKLGLRAPGWPML
AALPVMTKGSLLSDLIPTFDSINMIGGEVEQ
>Mature_430_residues
SEAKGVGGIDPRATPGSAGAGERPPMGTLSPRAGEGELYAPMPSKHMVINLGPSHPAMHGVTRAVVELNGEIIEGMKLDI
GFLHRGFEKSCENVTWGQVFPYTDRLNYVSSIMNNVGFALAVEKLAKLEIPERARYLRVITSEIHRICDHLTLVGAMAME
LGAMTVFLYGIEARDLLWDRLAELCGARLTSNYARIGGVARDMPEGWQEKTLKVLDRVVAIREEIGQLLNRNRIFIDRCL
NTGKVSREDALELGFTGPCLRASGEPYDVRKAAPYLVYDRLDFDIPVGSNGDNFDRYLMRMEEMRQSDKIIRQCFEQMAP
GEIIVQDFRYALPPKPLVYGTIEGVMAHFKLVMEGIKVPAGEVYSYTEAANGELGFYVVSDGGGRPYKLGLRAPGWPMLA
ALPVMTKGSLLSDLIPTFDSINMIGGEVEQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=386, Percent_Identity=43.5233160621762, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI260898743, Length=371, Percent_Identity=44.4743935309973, Blast_Score=325, Evalue=4e-89,
Organism=Escherichia coli, GI145693162, Length=385, Percent_Identity=36.8831168831169, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1789076, Length=371, Percent_Identity=22.1024258760108, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788832, Length=302, Percent_Identity=24.5033112582781, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555284, Length=386, Percent_Identity=41.1917098445596, Blast_Score=320, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17568379, Length=389, Percent_Identity=41.9023136246787, Blast_Score=318, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24638644, Length=386, Percent_Identity=41.1917098445596, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=40.7310704960835, Blast_Score=320, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47566; Mature: 47434

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAKGVGGIDPRATPGSAGAGERPPMGTLSPRAGEGELYAPMPSKHMVINLGPSHPAMH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEEECCCCCHHH
GVTRAVVELNGEIIEGMKLDIGFLHRGFEKSCENVTWGQVFPYTDRLNYVSSIMNNVGFA
HHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LAVEKLAKLEIPERARYLRVITSEIHRICDHLTLVGAMAMELGAMTVFLYGIEARDLLWD
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHH
RLAELCGARLTSNYARIGGVARDMPEGWQEKTLKVLDRVVAIREEIGQLLNRNRIFIDRC
HHHHHHHHHHHCCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
LNTGKVSREDALELGFTGPCLRASGEPYDVRKAAPYLVYDRLDFDIPVGSNGDNFDRYLM
CCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHCCCEEEEECCCEECCCCCCCCHHHHHHH
RMEEMRQSDKIIRQCFEQMAPGEIIVQDFRYALPPKPLVYGTIEGVMAHFKLVMEGIKVP
HHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCC
AGEVYSYTEAANGELGFYVVSDGGGRPYKLGLRAPGWPMLAALPVMTKGSLLSDLIPTFD
CCHHEEHHHCCCCCEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
SINMIGGEVEQ
HHHHCCCCCCC
>Mature Secondary Structure 
SEAKGVGGIDPRATPGSAGAGERPPMGTLSPRAGEGELYAPMPSKHMVINLGPSHPAMH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEEECCCCCHHH
GVTRAVVELNGEIIEGMKLDIGFLHRGFEKSCENVTWGQVFPYTDRLNYVSSIMNNVGFA
HHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LAVEKLAKLEIPERARYLRVITSEIHRICDHLTLVGAMAMELGAMTVFLYGIEARDLLWD
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHH
RLAELCGARLTSNYARIGGVARDMPEGWQEKTLKVLDRVVAIREEIGQLLNRNRIFIDRC
HHHHHHHHHHHCCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
LNTGKVSREDALELGFTGPCLRASGEPYDVRKAAPYLVYDRLDFDIPVGSNGDNFDRYLM
CCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHCCCEEEEECCCEECCCCCCCCHHHHHHH
RMEEMRQSDKIIRQCFEQMAPGEIIVQDFRYALPPKPLVYGTIEGVMAHFKLVMEGIKVP
HHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCC
AGEVYSYTEAANGELGFYVVSDGGGRPYKLGLRAPGWPMLAALPVMTKGSLLSDLIPTFD
CCHHEEHHHCCCCCEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
SINMIGGEVEQ
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA