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The map label for this gene is fumC [H]

Identifier: 220916452

GI number: 220916452

Start: 1505218

End: 1506645

Strand: Direct

Name: fumC [H]

Synonym: A2cp1_1346

Alternate gene names: 220916452

Gene position: 1505218-1506645 (Clockwise)

Preceding gene: 220916450

Following gene: 220916453

Centisome position: 29.93

GC content: 76.19

Gene sequence:

>1428_bases
ATGGCCAGACAGCCCCGCGCCCGCGCCGCACGCGGCGCCCGCACCCGGATCGAGCGCGACACGATGGGCGAGATGACCGT
CCCGGCGACGGCCCTCTACGGCGCCCAGACCGCCCGGGCCGTCGAGAACTTTCCCATCTCGGGCCTGCGCGCCCATCCGG
CGTTCGTCGACGCCACCGTCCGCATCAAGCTCGCCGCCGCGCGCACCAACGCCGGCCTAGGCCTGCTGCCGCGGCGGAAG
GCGCGCGCCATCGAGCAGGTGGCCCGCGAGGTCCTGGCCGGCCGCCACCGCGACCAGTTCGTGGTGGACGTGTACCAGGC
GGGGGCCGGCACGTCGCACAACATGAACGTGAACGAGGTGCTCGCGAACCGCGCCGCCGAGCTGCTCGGCGGGCGGCGCG
GCGACCGCGCACTGGTGGACCCGAACGACGACGTCAACATGGCGCAGTCCACCAACGACGTGGTGCCCACCGCCATCCGG
CTCGCCGCGCTCGAGCTCGCGCCGGAGGTGATCGCGGCGCTCTCGGCGCTCGCCGGCACCTTCGACGCGAAGGCGCGCGC
CTGGGACGGCGTGGTGAAGTCCGGGCGGACGCACCTCATGGACGCGACGCCCATCCGGCTCGGGCAGGAGGTGTCGGGGT
GGGCCGCGGCGCTGGGCGCGGCGGCGGGCCGGGTGCGCGACGCGCTGCCGGAGCTGTCGGTCCTGGGCCTCGGCGGCACC
GCGGTGGGCACCGGCCTGAACGCGGATGCGCGCTACCGCGCGCGGGTGGTGCGGGAGCTGGAGCGGCTCACCGGCGTGCC
GCTCACGCCGGCACCGAACCCGTTCTACGCGATGCAGTCACTGGCGCCGTTCGTGGCGCTGTCGGGGGCGCTCCGCACCG
CGGCGCTGGAGCTGCTCCGCATCGGCGGCGACGTGCGCCTGCTCGGGAGCGGCCCGAACACCGGGCTGGGCGAGCTGCGC
CTGCCGCCGGTGCAGCCCGGGTCGTCGATCATGCCGGGCAAGGTGAACCCGTCCATGGCGGAGATGCTGGCCATGGTCTC
GTACCAGGTGGTCGCCCTCGACGGCGCGGTGGCGTGGGCCGCGAGCGGCGGCCAGCTCGAGCTGAACGTGATGATGCCGC
TGGTGGCGTTCGACCTGTGCCACGCGCTCGACATCCTGGCCCGCGCGGTGCGCGCGTTCGACGCGCGCTGCGCGCGCGGG
CTCGAGGCGGACCGGGAGCGCGCCCGGCACTACGCCGAGCGCACCGTGAGCCTCGCCACCGCGCTGGCGCCACGGCTCGG
CTACGCCGGCGCGGCGGAGATCGTGAAGGCCTCGGTGGCCACCGGCCGGTCCATCGTCGACCTCGCGATCGAGAAGGGCG
GCCTCACCCCGGCGCAGGCGCGCCGCGCCCTGGACGCCGCCCGCCTCACCCGGCCCGGCCGCGGCTAG

Upstream 100 bases:

>100_bases
CGGGCCCGGGGCCGGCACGGGCCCGGCGAGCCGCCCGCCGGCACGATTCCGGAGCAGGCGAGCCGCCGCACACGTAGACT
CGCCTCGGAGGCGACCTCAC

Downstream 100 bases:

>100_bases
TCCCTGGTATCCTCCCGGCGTGCGCACCCGCCTCGGCGAGCTCCTCCTGCGCGCCGGCGCGTGCACGCCGGCGGCGATCC
GCGACGCGCTCGAGAACCAG

Product: aspartate ammonia-lyase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MARQPRARAARGARTRIERDTMGEMTVPATALYGAQTARAVENFPISGLRAHPAFVDATVRIKLAAARTNAGLGLLPRRK
ARAIEQVAREVLAGRHRDQFVVDVYQAGAGTSHNMNVNEVLANRAAELLGGRRGDRALVDPNDDVNMAQSTNDVVPTAIR
LAALELAPEVIAALSALAGTFDAKARAWDGVVKSGRTHLMDATPIRLGQEVSGWAAALGAAAGRVRDALPELSVLGLGGT
AVGTGLNADARYRARVVRELERLTGVPLTPAPNPFYAMQSLAPFVALSGALRTAALELLRIGGDVRLLGSGPNTGLGELR
LPPVQPGSSIMPGKVNPSMAEMLAMVSYQVVALDGAVAWAASGGQLELNVMMPLVAFDLCHALDILARAVRAFDARCARG
LEADRERARHYAERTVSLATALAPRLGYAGAAEIVKASVATGRSIVDLAIEKGGLTPAQARRALDAARLTRPGRG

Sequences:

>Translated_475_residues
MARQPRARAARGARTRIERDTMGEMTVPATALYGAQTARAVENFPISGLRAHPAFVDATVRIKLAAARTNAGLGLLPRRK
ARAIEQVAREVLAGRHRDQFVVDVYQAGAGTSHNMNVNEVLANRAAELLGGRRGDRALVDPNDDVNMAQSTNDVVPTAIR
LAALELAPEVIAALSALAGTFDAKARAWDGVVKSGRTHLMDATPIRLGQEVSGWAAALGAAAGRVRDALPELSVLGLGGT
AVGTGLNADARYRARVVRELERLTGVPLTPAPNPFYAMQSLAPFVALSGALRTAALELLRIGGDVRLLGSGPNTGLGELR
LPPVQPGSSIMPGKVNPSMAEMLAMVSYQVVALDGAVAWAASGGQLELNVMMPLVAFDLCHALDILARAVRAFDARCARG
LEADRERARHYAERTVSLATALAPRLGYAGAAEIVKASVATGRSIVDLAIEKGGLTPAQARRALDAARLTRPGRG
>Mature_474_residues
ARQPRARAARGARTRIERDTMGEMTVPATALYGAQTARAVENFPISGLRAHPAFVDATVRIKLAAARTNAGLGLLPRRKA
RAIEQVAREVLAGRHRDQFVVDVYQAGAGTSHNMNVNEVLANRAAELLGGRRGDRALVDPNDDVNMAQSTNDVVPTAIRL
AALELAPEVIAALSALAGTFDAKARAWDGVVKSGRTHLMDATPIRLGQEVSGWAAALGAAAGRVRDALPELSVLGLGGTA
VGTGLNADARYRARVVRELERLTGVPLTPAPNPFYAMQSLAPFVALSGALRTAALELLRIGGDVRLLGSGPNTGLGELRL
PPVQPGSSIMPGKVNPSMAEMLAMVSYQVVALDGAVAWAASGGQLELNVMMPLVAFDLCHALDILARAVRAFDARCARGL
EADRERARHYAERTVSLATALAPRLGYAGAAEIVKASVATGRSIVDLAIEKGGLTPAQARRALDAARLTRPGRG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG1027

COG function: function code E; Aspartate ammonia-lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=456, Percent_Identity=43.421052631579, Blast_Score=355, Evalue=4e-98,
Organism=Escherichia coli, GI1787896, Length=445, Percent_Identity=46.2921348314607, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI87082375, Length=460, Percent_Identity=39.3478260869565, Blast_Score=322, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17553882, Length=450, Percent_Identity=42.8888888888889, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI32565146, Length=314, Percent_Identity=40.7643312101911, Blast_Score=241, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6324993, Length=447, Percent_Identity=41.3870246085011, Blast_Score=350, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24640179, Length=448, Percent_Identity=43.75, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640177, Length=448, Percent_Identity=43.75, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24662684, Length=450, Percent_Identity=41.1111111111111, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=39.8268398268398, Blast_Score=337, Evalue=8e-93,
Organism=Drosophila melanogaster, GI24583245, Length=444, Percent_Identity=38.0630630630631, Blast_Score=325, Evalue=4e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49864; Mature: 49733

Theoretical pI: Translated: 10.88; Mature: 10.88

Prosite motif: PS00163 FUMARATE_LYASES ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARQPRARAARGARTRIERDTMGEMTVPATALYGAQTARAVENFPISGLRAHPAFVDATV
CCCCCHHHHHHHHHHHHCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
RIKLAAARTNAGLGLLPRRKARAIEQVAREVLAGRHRDQFVVDVYQAGAGTSHNMNVNEV
EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCCCCCCCCCHHHH
LANRAAELLGGRRGDRALVDPNDDVNMAQSTNDVVPTAIRLAALELAPEVIAALSALAGT
HHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
FDAKARAWDGVVKSGRTHLMDATPIRLGQEVSGWAAALGAAAGRVRDALPELSVLGLGGT
CCHHHHHHHHHHHCCCCEECCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
AVGTGLNADARYRARVVRELERLTGVPLTPAPNPFYAMQSLAPFVALSGALRTAALELLR
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGDVRLLGSGPNTGLGELRLPPVQPGSSIMPGKVNPSMAEMLAMVSYQVVALDGAVAWA
CCCCEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCEEEE
ASGGQLELNVMMPLVAFDLCHALDILARAVRAFDARCARGLEADRERARHYAERTVSLAT
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ALAPRLGYAGAAEIVKASVATGRSIVDLAIEKGGLTPAQARRALDAARLTRPGRG
HHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ARQPRARAARGARTRIERDTMGEMTVPATALYGAQTARAVENFPISGLRAHPAFVDATV
CCCCHHHHHHHHHHHHCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
RIKLAAARTNAGLGLLPRRKARAIEQVAREVLAGRHRDQFVVDVYQAGAGTSHNMNVNEV
EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCCCCCCCCCHHHH
LANRAAELLGGRRGDRALVDPNDDVNMAQSTNDVVPTAIRLAALELAPEVIAALSALAGT
HHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
FDAKARAWDGVVKSGRTHLMDATPIRLGQEVSGWAAALGAAAGRVRDALPELSVLGLGGT
CCHHHHHHHHHHHCCCCEECCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
AVGTGLNADARYRARVVRELERLTGVPLTPAPNPFYAMQSLAPFVALSGALRTAALELLR
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGDVRLLGSGPNTGLGELRLPPVQPGSSIMPGKVNPSMAEMLAMVSYQVVALDGAVAWA
CCCCEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCEEEE
ASGGQLELNVMMPLVAFDLCHALDILARAVRAFDARCARGLEADRERARHYAERTVSLAT
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ALAPRLGYAGAAEIVKASVATGRSIVDLAIEKGGLTPAQARRALDAARLTRPGRG
HHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]