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The map label for this gene is dut

Identifier: 220916342

GI number: 220916342

Start: 1387761

End: 1388204

Strand: Direct

Name: dut

Synonym: A2cp1_1236

Alternate gene names: 220916342

Gene position: 1387761-1388204 (Clockwise)

Preceding gene: 220916341

Following gene: 220916343

Centisome position: 27.59

GC content: 77.48

Gene sequence:

>444_bases
ATGCCCGTGACCGTCCGAGTCCGCCGCGTCGGCCATCGCGGCCCCCCGCTCGATCTCCCCCGCTACGAGTCCGCCGGCGC
CGCAGGCCTCGACCTGCGCGCCGACGAGCCGTTCACGCTCGCCCCGGGCGAGCGGCGGGTGGTCCCGACCGGCCTCGCGC
TGGAGCTGCCGCCCGGCCACGAGGGCCAGGTGCGGCCGCGCTCCGGCCTGGCCGCGCGCCACGGCGTCGGCATGGTGAAC
GCGCCGGGCACCATCGACGCGGACTACCGCGGCGAGGTGGGGGTCATCCTGGTGAACCACGGGCAGGCGCCGGTGGCGTT
CGCCCGCGGCGATCGCATCGCCCAGCTCGTGATCGCGCCCGTGGTCCGGGCCGAGCTCGAGCTGGTGGACGCGCTGAGCG
ACAGCGACCGAGGCGCCGGCGGCTTCGGCTCGACCGGCCAGTAG

Upstream 100 bases:

>100_bases
CGCAAGGAGGCCCTCGCCGACAGCGCCAAGAAGTCCGAGGGCACCGAGCCGCCGAAGGGCGAGCCGGCCAAGTAGGCCGC
GAGGGGCCGCGAGGACGCCG

Downstream 100 bases:

>100_bases
CCTCACGGAGGACGCCATGATCCCGCGCTACACCCGGCCCGACATGGGCCGCATCTGGACTTCCGAGCACCGCTTCCGCA
TCTGGCTCGACGTGGAGCTG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 147; Mature: 146

Protein sequence:

>147_residues
MPVTVRVRRVGHRGPPLDLPRYESAGAAGLDLRADEPFTLAPGERRVVPTGLALELPPGHEGQVRPRSGLAARHGVGMVN
APGTIDADYRGEVGVILVNHGQAPVAFARGDRIAQLVIAPVVRAELELVDALSDSDRGAGGFGSTGQ

Sequences:

>Translated_147_residues
MPVTVRVRRVGHRGPPLDLPRYESAGAAGLDLRADEPFTLAPGERRVVPTGLALELPPGHEGQVRPRSGLAARHGVGMVN
APGTIDADYRGEVGVILVNHGQAPVAFARGDRIAQLVIAPVVRAELELVDALSDSDRGAGGFGSTGQ
>Mature_146_residues
PVTVRVRRVGHRGPPLDLPRYESAGAAGLDLRADEPFTLAPGERRVVPTGLALELPPGHEGQVRPRSGLAARHGVGMVNA
PGTIDADYRGEVGVILVNHGQAPVAFARGDRIAQLVIAPVVRAELELVDALSDSDRGAGGFGSTGQ

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI70906444, Length=124, Percent_Identity=49.1935483870968, Blast_Score=116, Evalue=5e-27,
Organism=Homo sapiens, GI4503423, Length=124, Percent_Identity=49.1935483870968, Blast_Score=116, Evalue=8e-27,
Organism=Homo sapiens, GI70906441, Length=128, Percent_Identity=48.4375, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI1790071, Length=142, Percent_Identity=44.3661971830986, Blast_Score=115, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71988561, Length=129, Percent_Identity=47.2868217054264, Blast_Score=108, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6319729, Length=143, Percent_Identity=40.5594405594406, Blast_Score=108, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24583610, Length=123, Percent_Identity=41.4634146341463, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19921126, Length=123, Percent_Identity=41.4634146341463, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_ANAD2 (B8JFZ2)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002491646.1
- ProteinModelPortal:   B8JFZ2
- SMR:   B8JFZ2
- GeneID:   7299102
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_1236
- HOGENOM:   HBG436079
- ProtClustDB:   PRK00601
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 15309; Mature: 15177

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: BINDING 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTVRVRRVGHRGPPLDLPRYESAGAAGLDLRADEPFTLAPGERRVVPTGLALELPPGH
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCEEECCCCCEEECCCEEEECCCCC
EGQVRPRSGLAARHGVGMVNAPGTIDADYRGEVGVILVNHGQAPVAFARGDRIAQLVIAP
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCEEEECCCHHHHHHHHH
VVRAELELVDALSDSDRGAGGFGSTGQ
HHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVTVRVRRVGHRGPPLDLPRYESAGAAGLDLRADEPFTLAPGERRVVPTGLALELPPGH
CEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCEEECCCCCEEECCCEEEECCCCC
EGQVRPRSGLAARHGVGMVNAPGTIDADYRGEVGVILVNHGQAPVAFARGDRIAQLVIAP
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCEEEECCCHHHHHHHHH
VVRAELELVDALSDSDRGAGGFGSTGQ
HHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA