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The map label for this gene is galE [C]

Identifier: 220916295

GI number: 220916295

Start: 1331586

End: 1332704

Strand: Direct

Name: galE [C]

Synonym: A2cp1_1188

Alternate gene names: 220916295

Gene position: 1331586-1332704 (Clockwise)

Preceding gene: 220916289

Following gene: 220916296

Centisome position: 26.48

GC content: 74.89

Gene sequence:

>1119_bases
ATGAACGGACGGAGGATCCTCATCACCGGCGGTGCCGGCTTCATCGGGTCACACCTCGCCGACCACCTGCTCGCGCACGG
CCACGCGGTGCGCGCGCTGGACGTCCTCTCACCCCAGGTGCACGGCCCGGGCGCGGCGCGCCCCGCCTACCTCGCCCGGG
AGGTGGAGCTCCAGGTCGGCGACGTGCGCGACCCCGAGGCGGTGCGGCGCGCGCTCCGGGGGGTGGACGCGGTCGTGCAC
CTCGCCGCGGCCGTCGGGGTCGGCCAGAGCATGTACGAGGTGGAGCGCTACGTCGGCGTGAACGATCTCGGGACGGCCAC
CCTGCTCCAGGCGCTCATCGAGCGCCCGGTGGAGCGGCTGGTGGTGGCGTCGTCGATGAGCCTGTACGGCGAGGGGCTGT
ACCGTGACGCGCGGGGCCGGTCCGTCACCGCGGAGCGGACCCGCGCGCAGCTCCTCGCCCGGCGCTGGGAGCCGGACGGG
GAGGACGGCGCGCCGCTCGAGCCGGTCGCGACGCCCGAGACGAAACCGCCGGCGCTCGCGTCGATCTACGCGCTCTCGAA
GTACGACCAGGAGCGGATGAGCCTGCTGGTCGGCGAGGCGTACGGCATCGCCACGGTGGCGCTGCGCTTCTTCAACGTGT
ACGGCACGCGCCAGGCGCTCTCCAACCCGTACACCGGCGTCCTGGCCATCTTCGCGGCGCGCTACCTCAACGGCCGGCCC
CCGCTCGTCAACGAGGACGGCCTGCAGCGCCGCGACTTCGTGTCGGTGCGCGACGTGGCCGAGGCCTGCCGCCTGGCGCT
GACGGTGCCGGGCGCGTCCGGGCAGGTGCTGAACGTCGGCAGCGGCCGGAGCTTCACGGTGCTCGAGGTCGCCGAGCGGC
TGGCCGTGGCGGTCGGCCGCGAGGAGCTGCGGCCCGAGGTGACGCAGCGTTACCGCGTGGGCGACATCCGCCACTGCTTC
GCCGACATCTCGCGGGCGCGCGCCGTGCTCGGCTACGCGCCGGCGGTGGCGTTCGACGACGGGCTGGCGGAGCTGGCGGG
CTGGCTGGAGGGCCAGATCGCGCACGACCGGGTGGGAGAGGCGAGCGCGGAGCTGGCCGCGCGGGGGCTGTCGCTGTGA

Upstream 100 bases:

>100_bases
CACGTTGCCCGGCCACGCACCTGTCCGCACGTTTCGCGAGGAGGGCCGCCCTTCACGCCCGGGGGACGGAGCGGGGGGCG
GGCCCAGGGACGGCGAACGC

Downstream 100 bases:

>100_bases
TCGCCGAGCGCGTGCTGGTGGTGGGCGGGGCGGGGTTCATCGGCGCGAACCTCGCGCACCGGCTGCTCTCGTCGGGGACG
CGGGTGCGGCTCCTCGACAG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNGRRILITGGAGFIGSHLADHLLAHGHAVRALDVLSPQVHGPGAARPAYLAREVELQVGDVRDPEAVRRALRGVDAVVH
LAAAVGVGQSMYEVERYVGVNDLGTATLLQALIERPVERLVVASSMSLYGEGLYRDARGRSVTAERTRAQLLARRWEPDG
EDGAPLEPVATPETKPPALASIYALSKYDQERMSLLVGEAYGIATVALRFFNVYGTRQALSNPYTGVLAIFAARYLNGRP
PLVNEDGLQRRDFVSVRDVAEACRLALTVPGASGQVLNVGSGRSFTVLEVAERLAVAVGREELRPEVTQRYRVGDIRHCF
ADISRARAVLGYAPAVAFDDGLAELAGWLEGQIAHDRVGEASAELAARGLSL

Sequences:

>Translated_372_residues
MNGRRILITGGAGFIGSHLADHLLAHGHAVRALDVLSPQVHGPGAARPAYLAREVELQVGDVRDPEAVRRALRGVDAVVH
LAAAVGVGQSMYEVERYVGVNDLGTATLLQALIERPVERLVVASSMSLYGEGLYRDARGRSVTAERTRAQLLARRWEPDG
EDGAPLEPVATPETKPPALASIYALSKYDQERMSLLVGEAYGIATVALRFFNVYGTRQALSNPYTGVLAIFAARYLNGRP
PLVNEDGLQRRDFVSVRDVAEACRLALTVPGASGQVLNVGSGRSFTVLEVAERLAVAVGREELRPEVTQRYRVGDIRHCF
ADISRARAVLGYAPAVAFDDGLAELAGWLEGQIAHDRVGEASAELAARGLSL
>Mature_372_residues
MNGRRILITGGAGFIGSHLADHLLAHGHAVRALDVLSPQVHGPGAARPAYLAREVELQVGDVRDPEAVRRALRGVDAVVH
LAAAVGVGQSMYEVERYVGVNDLGTATLLQALIERPVERLVVASSMSLYGEGLYRDARGRSVTAERTRAQLLARRWEPDG
EDGAPLEPVATPETKPPALASIYALSKYDQERMSLLVGEAYGIATVALRFFNVYGTRQALSNPYTGVLAIFAARYLNGRP
PLVNEDGLQRRDFVSVRDVAEACRLALTVPGASGQVLNVGSGRSFTVLEVAERLAVAVGREELRPEVTQRYRVGDIRHCF
ADISRARAVLGYAPAVAFDDGLAELAGWLEGQIAHDRVGEASAELAARGLSL

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=370, Percent_Identity=27.8378378378378, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI56118217, Length=370, Percent_Identity=27.8378378378378, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI189083684, Length=370, Percent_Identity=27.8378378378378, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI239745448, Length=376, Percent_Identity=25, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI310132178, Length=379, Percent_Identity=25.065963060686, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI310113012, Length=379, Percent_Identity=25.065963060686, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786974, Length=378, Percent_Identity=25.9259259259259, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319493, Length=375, Percent_Identity=25.3333333333333, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21356223, Length=367, Percent_Identity=26.158038147139, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI19923002, Length=370, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 39947; Mature: 39947

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGRRILITGGAGFIGSHLADHLLAHGHAVRALDVLSPQVHGPGAARPAYLAREVELQVG
CCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHEEEEC
DVRDPEAVRRALRGVDAVVHLAAAVGVGQSMYEVERYVGVNDLGTATLLQALIERPVERL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VVASSMSLYGEGLYRDARGRSVTAERTRAQLLARRWEPDGEDGAPLEPVATPETKPPALA
HHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
SIYALSKYDQERMSLLVGEAYGIATVALRFFNVYGTRQALSNPYTGVLAIFAARYLNGRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
PLVNEDGLQRRDFVSVRDVAEACRLALTVPGASGQVLNVGSGRSFTVLEVAERLAVAVGR
CCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCEEECCCCCCCHHHHHHHHHHHHHCH
EELRPEVTQRYRVGDIRHCFADISRARAVLGYAPAVAFDDGLAELAGWLEGQIAHDRVGE
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCH
ASAELAARGLSL
HHHHHHHHCCCC
>Mature Secondary Structure
MNGRRILITGGAGFIGSHLADHLLAHGHAVRALDVLSPQVHGPGAARPAYLAREVELQVG
CCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHEEEEC
DVRDPEAVRRALRGVDAVVHLAAAVGVGQSMYEVERYVGVNDLGTATLLQALIERPVERL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VVASSMSLYGEGLYRDARGRSVTAERTRAQLLARRWEPDGEDGAPLEPVATPETKPPALA
HHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
SIYALSKYDQERMSLLVGEAYGIATVALRFFNVYGTRQALSNPYTGVLAIFAARYLNGRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
PLVNEDGLQRRDFVSVRDVAEACRLALTVPGASGQVLNVGSGRSFTVLEVAERLAVAVGR
CCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCEEECCCCCCCHHHHHHHHHHHHHCH
EELRPEVTQRYRVGDIRHCFADISRARAVLGYAPAVAFDDGLAELAGWLEGQIAHDRVGE
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCH
ASAELAARGLSL
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]