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The map label for this gene is xapR [H]

Identifier: 220916205

GI number: 220916205

Start: 1222700

End: 1223605

Strand: Reverse

Name: xapR [H]

Synonym: A2cp1_1094

Alternate gene names: 220916205

Gene position: 1223605-1222700 (Counterclockwise)

Preceding gene: 220916208

Following gene: 220916197

Centisome position: 24.33

GC content: 77.04

Gene sequence:

>906_bases
ATGGACCTCCGCGAGCTGCGCGCGTTCCTGGTGGTTGCCGCGGAGCTGAGCTTCCGCCGCGCCGCGGAGCGGCTGCACAT
GAGCCAGCCGCCGCTGAGCCGCCTCATCGCGGGGCTCGAGCGCGACCTCCGCGTGCGCCTCCTGGACCGCAGCACGCGGT
CCGTCTCGCTCACGGCGGCGGGCGCGCTCCTCTTCCGCGAGGGGCCGGCGGTCCTGGAGCGCGCGGAGGCGCTGGAGTCC
CGGGTGCGCGAGCGCGGGCGACGCTCCGGGCAGCCGCTGCGGATCGGGCTGTCGACCGCGGGCTTCGCGACCTGGGTGCC
GGAGCGGATCGCGCGCTTCGAGGCGCAAGGCGAGGGCCGCGGGGTCGAGCTCACCTCGAACGTCCCGGACCGCCTGCTCC
GCGACCTGCAGCTCGGTCGTCTCGACGCGGTCTGCGCGGAGATGGCCGACGAGGAGGCGCCGGGCCTCGAGCGCTGGGTG
GTCGCCGAGGACGCTATCGGCGTGCTGCTGCCGGCCACGCACCGGCTCGCGCGGCGCCGTGCGCTGCGCCTGCGCGACCT
CGAGGGCGAGACCTTCGTGGTCCACCCGCGCCACGAGCACGCCCACCTGTACGAGAGCCAGCAGCGGGCGCTCCGCGCCG
CGGGCATCCGCTACCGGATCGTCACGAAGCGGCCGGACGAGAGCTGCCCGATCCTGGTCGCGCGGGGCAAGGGGCTCCTG
CTGGCGGCGCCCTCGTTCGTGCGGACGCGGGCGTCGAACACGCGCTTCCTCCCGCTGCGGGAGCCCGCGCTCACGCACCG
CGTGGCGCTGCTGTGGCGGGGCGAGCGCGCGAGCCCGGAGCTCACCGCGCTGCTGGACTCCCTGCGACGGGGCGCGCCGC
GCCGGGGCGTCGCCCGGTCCCGGTGA

Upstream 100 bases:

>100_bases
CGGGGCCGGCGCGGTGCGACGCAGTCATGCCCGGGCGGCAGCCGTCGGTGCTTTGCGATTCGCGTTGCCCGATTGATACC
TGGCCGGTATCACCCACGGC

Downstream 100 bases:

>100_bases
CGGCGACCGCCGCGATCGCGCCTGCGAGATGGGCGAGCGGGACCGCGACGATGCCCGGCGGCGCGCCGACGAGGAGCATC
CGCCCGGTGGAGAGCTCCCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MDLRELRAFLVVAAELSFRRAAERLHMSQPPLSRLIAGLERDLRVRLLDRSTRSVSLTAAGALLFREGPAVLERAEALES
RVRERGRRSGQPLRIGLSTAGFATWVPERIARFEAQGEGRGVELTSNVPDRLLRDLQLGRLDAVCAEMADEEAPGLERWV
VAEDAIGVLLPATHRLARRRALRLRDLEGETFVVHPRHEHAHLYESQQRALRAAGIRYRIVTKRPDESCPILVARGKGLL
LAAPSFVRTRASNTRFLPLREPALTHRVALLWRGERASPELTALLDSLRRGAPRRGVARSR

Sequences:

>Translated_301_residues
MDLRELRAFLVVAAELSFRRAAERLHMSQPPLSRLIAGLERDLRVRLLDRSTRSVSLTAAGALLFREGPAVLERAEALES
RVRERGRRSGQPLRIGLSTAGFATWVPERIARFEAQGEGRGVELTSNVPDRLLRDLQLGRLDAVCAEMADEEAPGLERWV
VAEDAIGVLLPATHRLARRRALRLRDLEGETFVVHPRHEHAHLYESQQRALRAAGIRYRIVTKRPDESCPILVARGKGLL
LAAPSFVRTRASNTRFLPLREPALTHRVALLWRGERASPELTALLDSLRRGAPRRGVARSR
>Mature_301_residues
MDLRELRAFLVVAAELSFRRAAERLHMSQPPLSRLIAGLERDLRVRLLDRSTRSVSLTAAGALLFREGPAVLERAEALES
RVRERGRRSGQPLRIGLSTAGFATWVPERIARFEAQGEGRGVELTSNVPDRLLRDLQLGRLDAVCAEMADEEAPGLERWV
VAEDAIGVLLPATHRLARRRALRLRDLEGETFVVHPRHEHAHLYESQQRALRAAGIRYRIVTKRPDESCPILVARGKGLL
LAAPSFVRTRASNTRFLPLREPALTHRVALLWRGERASPELTALLDSLRRGAPRRGVARSR

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=295, Percent_Identity=32.5423728813559, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787879, Length=284, Percent_Identity=29.9295774647887, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1788887, Length=193, Percent_Identity=34.1968911917098, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790399, Length=194, Percent_Identity=30.4123711340206, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787601, Length=143, Percent_Identity=32.1678321678322, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI145693105, Length=150, Percent_Identity=29.3333333333333, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI157672245, Length=297, Percent_Identity=26.5993265993266, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33780; Mature: 33780

Theoretical pI: Translated: 11.89; Mature: 11.89

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRELRAFLVVAAELSFRRAAERLHMSQPPLSRLIAGLERDLRVRLLDRSTRSVSLTAA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHEEEEECCCCCEEEEEEH
GALLFREGPAVLERAEALESRVRERGRRSGQPLRIGLSTAGFATWVPERIARFEAQGEGR
HHHEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCC
GVELTSNVPDRLLRDLQLGRLDAVCAEMADEEAPGLERWVVAEDAIGVLLPATHRLARRR
CEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHEHHHHHHHHHHH
ALRLRDLEGETFVVHPRHEHAHLYESQQRALRAAGIRYRIVTKRPDESCPILVARGKGLL
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCCEEE
LAAPSFVRTRASNTRFLPLREPALTHRVALLWRGERASPELTALLDSLRRGAPRRGVARS
EECCHHHHHCCCCCEEEECCCCHHHHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCC
R
C
>Mature Secondary Structure
MDLRELRAFLVVAAELSFRRAAERLHMSQPPLSRLIAGLERDLRVRLLDRSTRSVSLTAA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHEEEEECCCCCEEEEEEH
GALLFREGPAVLERAEALESRVRERGRRSGQPLRIGLSTAGFATWVPERIARFEAQGEGR
HHHEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCC
GVELTSNVPDRLLRDLQLGRLDAVCAEMADEEAPGLERWVVAEDAIGVLLPATHRLARRR
CEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHEHHHHHHHHHHH
ALRLRDLEGETFVVHPRHEHAHLYESQQRALRAAGIRYRIVTKRPDESCPILVARGKGLL
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCCEEE
LAAPSFVRTRASNTRFLPLREPALTHRVALLWRGERASPELTALLDSLRRGAPRRGVARS
EECCHHHHHCCCCCEEEECCCCHHHHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]