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The map label for this gene is ubiE [H]

Identifier: 220916202

GI number: 220916202

Start: 1220445

End: 1221008

Strand: Direct

Name: ubiE [H]

Synonym: A2cp1_1091

Alternate gene names: 220916202

Gene position: 1220445-1221008 (Clockwise)

Preceding gene: 220916201

Following gene: 220916203

Centisome position: 24.27

GC content: 75.0

Gene sequence:

>564_bases
ATGCGCGTGCTCGGTGGCCCGCTCCCGCGGATGCTCGAGCTCGTCGCGCAGGAGGTCCGCGGGGCGGGCGAGGTGCTCGA
GGTCGCGGCGGGCACGGGCCTCGTGACCACCGCGATCGCGCCCGTCGTGGGCAGCGTCGTCGCGACCGACTACGCCGGCG
CGATGGTCCGGCTGCTCCGCGGCCGCGTCCAGGCCGACGGGCTCGGGAACGTGGAGTGCATCGAGCGCGACGTGTACGCG
CTCGGCATGCCGCCCCGATCGTTCGACGCCGTCGTCTGCGCGAACGTGCTCCACCTGCTCCCGGAGCTCGAGGCCGCGCT
GCGTGCGCTCCGTGCGGTGCTCCGGCCCGGTGGAACGCTCGTCGCGCCGACGTACGCGCACGACGAGACGCGGACCTCGA
GGCTCGTCTCGCGCGTCCTCGGGGCGACCGGGTTTCCCGGTGCGCGCAGGTTCACGGCGGCGTCGCTTTCGGCGGCCATC
TCGGCGGCCGGGTTCGAGGTGCGGCGTACCGAGATGATCCCCGGGCTCATCCCCGTCGCGTTCGTCGCCGCCACCGCGCC
CTGA

Upstream 100 bases:

>100_bases
TGCTCGGGTCGTGATCGGGTAGATTGGCCGCGTGAGCGACACGGATACAGCAAGCGGAAGGCGCTACTGGGAGCGCCACG
CGGCGAGGTACGACCGCTCG

Downstream 100 bases:

>100_bases
GGCGACGCGACGGCCGCGACTCGCCGAGTGCGTCGAGAGAGCGAATGCCGAGGAGGGGCAGGCGCCGCCGAGCTCCAGGG
GTGGCGCGAGGATGATCGCC

Product: type 11 methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MRVLGGPLPRMLELVAQEVRGAGEVLEVAAGTGLVTTAIAPVVGSVVATDYAGAMVRLLRGRVQADGLGNVECIERDVYA
LGMPPRSFDAVVCANVLHLLPELEAALRALRAVLRPGGTLVAPTYAHDETRTSRLVSRVLGATGFPGARRFTAASLSAAI
SAAGFEVRRTEMIPGLIPVAFVAATAP

Sequences:

>Translated_187_residues
MRVLGGPLPRMLELVAQEVRGAGEVLEVAAGTGLVTTAIAPVVGSVVATDYAGAMVRLLRGRVQADGLGNVECIERDVYA
LGMPPRSFDAVVCANVLHLLPELEAALRALRAVLRPGGTLVAPTYAHDETRTSRLVSRVLGATGFPGARRFTAASLSAAI
SAAGFEVRRTEMIPGLIPVAFVAATAP
>Mature_187_residues
MRVLGGPLPRMLELVAQEVRGAGEVLEVAAGTGLVTTAIAPVVGSVVATDYAGAMVRLLRGRVQADGLGNVECIERDVYA
LGMPPRSFDAVVCANVLHLLPELEAALRALRAVLRPGGTLVAPTYAHDETRTSRLVSRVLGATGFPGARRFTAASLSAAI
SAAGFEVRRTEMIPGLIPVAFVAATAP

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 19382; Mature: 19382

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLGGPLPRMLELVAQEVRGAGEVLEVAAGTGLVTTAIAPVVGSVVATDYAGAMVRLLR
CCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRVQADGLGNVECIERDVYALGMPPRSFDAVVCANVLHLLPELEAALRALRAVLRPGGTL
HHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VAPTYAHDETRTSRLVSRVLGATGFPGARRFTAASLSAAISAAGFEVRRTEMIPGLIPVA
ECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHH
FVAATAP
HHHHCCC
>Mature Secondary Structure
MRVLGGPLPRMLELVAQEVRGAGEVLEVAAGTGLVTTAIAPVVGSVVATDYAGAMVRLLR
CCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRVQADGLGNVECIERDVYALGMPPRSFDAVVCANVLHLLPELEAALRALRAVLRPGGTL
HHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VAPTYAHDETRTSRLVSRVLGATGFPGARRFTAASLSAAISAAGFEVRRTEMIPGLIPVA
ECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHH
FVAATAP
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA