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The map label for this gene is ada [H]

Identifier: 220916142

GI number: 220916142

Start: 1151142

End: 1152683

Strand: Reverse

Name: ada [H]

Synonym: A2cp1_1029

Alternate gene names: 220916142

Gene position: 1152683-1151142 (Counterclockwise)

Preceding gene: 220916143

Following gene: 220916141

Centisome position: 22.92

GC content: 81.19

Gene sequence:

>1542_bases
ATGATGCCGCGCATGCCCCGCCCCGCCCCGCCGCCCGCGATCCCCGGCCTCGACGCCGGCGCCTGCTGGCGCGCCCACGT
CGCCCGCGACGCGCGGTTCGACGGCCGCTTCTTCACCGCGGTGCTCTCCACCGGGATCTTCTGCCGCCCGATCTGCCGGG
CGCGCACGCCGCGCCGGGAGCACTGCGCGTTCTACCCGAGCGCCGCCGCCGCGCAGGCGGCCGGTTTCCGGCCGTGCCTG
CGCTGCCGGCCGGAGCTCGCGCCCGGCGTGGCCGGCTGGCGGGGCACCGCGAACACGGTGGCGCGCGCGCTCGCGCTCAT
CTCGGCGGGCGCCTGGGGCGAGCGCGACGACGTGGAGGCGCTCGCCGAGCGCGTCGGCGTCGGCGGCCGGCAGCTCCGCC
GCCTGTTCGCCCGGCACGTGGGCGCGCCGCCGGTCCGGATCGCGCAGGCGCAGCGCGTGCTGCTGGCCCGGCGGCTGCTC
GCCGACACCACCCTGCCGCTCGCCGACGTGGCCTCCGCGGCGGGCTTCGGGAGCGTGCGTCGCTTCAACGAGGCGGTGCG
GCGCACGTTCCGGCGTCCGCCGGGCGCGCTGCGGCGCGGCGCGTCCGCCCCGCCGCCGGACGGCGCGATCGCGATCGCGC
TGCCGCACACCGCGCCGTACGACTGGCCGGCGCTGCTCGGGTTCCTGGGCGCGCGCGCGATCCCGGGCGTCGAGCAGGTG
TCGGACGGCGCGTACCGCCGCACCGTGGCGCTCGACGGCGCCGCGGGCACGGTCGAGGTCCGGCCCGATCCGCGGGGCCG
CGGCCTGGTCGCGACGTTGCGGCTGCCGGGGGTGGCGGCGATCGCGCCCGCGGTGGAGCGCCTGCGGCGGCTGCTCGACC
TCGACGCGGACGCCCGGGCGATCGGCGCGCACCTCTCGGGCGATCCGCTGCTCGCGCCGCTCGTCGCGGCGCGGCCCGGG
CTGCGCGTGCCGGGCGCGTGGGAGCCGTTCGAGCTGGTGGTGCGCGCGGTGCTCGGGCAGCAGGTGAGCGTCGCCGCGGC
CCGCACGCTGGCGGGCCGCCTCGCGGCGCGGCTCGGCGCCCCGGTGGACTCCGGCGACCCCGCGCTGTCGCGGCTGTTCC
CCGGCCCGGAGGCGCTCGCCGGCGCCGACCTGGAGGGGCTCGGGCTGACCCGCGCCCGCGCCGCCACGCTCGCCGCGATC
GGCGCCGCGGTGCGAGACGACCCGTCCCTGCTCGCGCCGGGCGGCGAGCTGGAGGACGCGGTGGCGCGCCTCGACGCGCT
GCCCGGCATCGGGCGCTGGACCGCGCAGTACGTGGCGATGCGGGCGCTGCACCAGCCGGACGCGTTCCCGGAGGGCGACC
TCGGCCTGCTCGCCGCGCTCGGCGGCCTGCGCGGCCGCGGGCGGGCGGCGCCCGGGGAGCTGCTGCGACGCGCCGAGCGC
TGGCGCCCGTGGCGGGCGTACGCGGCGCTGCACCTGTGGACGAGCCTGCGGCCCCGCGCACGCGCGGCGCCCGGCGCACG
GAAGAAGGGGAGGCGGTCATGA

Upstream 100 bases:

>100_bases
GGTTCGACGGCGAGCGCGTCGACGGCTGACGCGCCCGGCGACGGGACGGGCCGCGGCATCGAGGTCCGAAAACGGCGAGC
GCCGCGGCCGGACCGCGGCC

Downstream 100 bases:

>100_bases
CGCTCGAGCACGTGGTGGTGGAGTCGCCCATCGGCCCGGTGCACCTCGTCTCGGACGGGCGCGCGCTCTGCGCGCTCGAC
CTGGGGGACACGCCGCTGCT

Product: AraC family transcriptional regulator

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MMPRMPRPAPPPAIPGLDAGACWRAHVARDARFDGRFFTAVLSTGIFCRPICRARTPRREHCAFYPSAAAAQAAGFRPCL
RCRPELAPGVAGWRGTANTVARALALISAGAWGERDDVEALAERVGVGGRQLRRLFARHVGAPPVRIAQAQRVLLARRLL
ADTTLPLADVASAAGFGSVRRFNEAVRRTFRRPPGALRRGASAPPPDGAIAIALPHTAPYDWPALLGFLGARAIPGVEQV
SDGAYRRTVALDGAAGTVEVRPDPRGRGLVATLRLPGVAAIAPAVERLRRLLDLDADARAIGAHLSGDPLLAPLVAARPG
LRVPGAWEPFELVVRAVLGQQVSVAAARTLAGRLAARLGAPVDSGDPALSRLFPGPEALAGADLEGLGLTRARAATLAAI
GAAVRDDPSLLAPGGELEDAVARLDALPGIGRWTAQYVAMRALHQPDAFPEGDLGLLAALGGLRGRGRAAPGELLRRAER
WRPWRAYAALHLWTSLRPRARAAPGARKKGRRS

Sequences:

>Translated_513_residues
MMPRMPRPAPPPAIPGLDAGACWRAHVARDARFDGRFFTAVLSTGIFCRPICRARTPRREHCAFYPSAAAAQAAGFRPCL
RCRPELAPGVAGWRGTANTVARALALISAGAWGERDDVEALAERVGVGGRQLRRLFARHVGAPPVRIAQAQRVLLARRLL
ADTTLPLADVASAAGFGSVRRFNEAVRRTFRRPPGALRRGASAPPPDGAIAIALPHTAPYDWPALLGFLGARAIPGVEQV
SDGAYRRTVALDGAAGTVEVRPDPRGRGLVATLRLPGVAAIAPAVERLRRLLDLDADARAIGAHLSGDPLLAPLVAARPG
LRVPGAWEPFELVVRAVLGQQVSVAAARTLAGRLAARLGAPVDSGDPALSRLFPGPEALAGADLEGLGLTRARAATLAAI
GAAVRDDPSLLAPGGELEDAVARLDALPGIGRWTAQYVAMRALHQPDAFPEGDLGLLAALGGLRGRGRAAPGELLRRAER
WRPWRAYAALHLWTSLRPRARAAPGARKKGRRS
>Mature_513_residues
MMPRMPRPAPPPAIPGLDAGACWRAHVARDARFDGRFFTAVLSTGIFCRPICRARTPRREHCAFYPSAAAAQAAGFRPCL
RCRPELAPGVAGWRGTANTVARALALISAGAWGERDDVEALAERVGVGGRQLRRLFARHVGAPPVRIAQAQRVLLARRLL
ADTTLPLADVASAAGFGSVRRFNEAVRRTFRRPPGALRRGASAPPPDGAIAIALPHTAPYDWPALLGFLGARAIPGVEQV
SDGAYRRTVALDGAAGTVEVRPDPRGRGLVATLRLPGVAAIAPAVERLRRLLDLDADARAIGAHLSGDPLLAPLVAARPG
LRVPGAWEPFELVVRAVLGQQVSVAAARTLAGRLAARLGAPVDSGDPALSRLFPGPEALAGADLEGLGLTRARAATLAAI
GAAVRDDPSLLAPGGELEDAVARLDALPGIGRWTAQYVAMRALHQPDAFPEGDLGLLAALGGLRGRGRAAPGELLRRAER
WRPWRAYAALHLWTSLRPRARAAPGARKKGRRS

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=280, Percent_Identity=37.5, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788542, Length=140, Percent_Identity=42.1428571428571, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 54096; Mature: 54096

Theoretical pI: Translated: 12.00; Mature: 12.00

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPRMPRPAPPPAIPGLDAGACWRAHVARDARFDGRFFTAVLSTGIFCRPICRARTPRRE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHCCCCCHH
HCAFYPSAAAAQAAGFRPCLRCRPELAPGVAGWRGTANTVARALALISAGAWGERDDVEA
HCCCCCCHHHHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
LAERVGVGGRQLRRLFARHVGAPPVRIAQAQRVLLARRLLADTTLPLADVASAAGFGSVR
HHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHH
RFNEAVRRTFRRPPGALRRGASAPPPDGAIAIALPHTAPYDWPALLGFLGARAIPGVEQV
HHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHH
SDGAYRRTVALDGAAGTVEVRPDPRGRGLVATLRLPGVAAIAPAVERLRRLLDLDADARA
CCCCCEEEEEECCCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHH
IGAHLSGDPLLAPLVAARPGLRVPGAWEPFELVVRAVLGQQVSVAAARTLAGRLAARLGA
HCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
PVDSGDPALSRLFPGPEALAGADLEGLGLTRARAATLAAIGAAVRDDPSLLAPGGELEDA
CCCCCCHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
VARLDALPGIGRWTAQYVAMRALHQPDAFPEGDLGLLAALGGLRGRGRAAPGELLRRAER
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHH
WRPWRAYAALHLWTSLRPRARAAPGARKKGRRS
CCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MMPRMPRPAPPPAIPGLDAGACWRAHVARDARFDGRFFTAVLSTGIFCRPICRARTPRRE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHCCCCCHH
HCAFYPSAAAAQAAGFRPCLRCRPELAPGVAGWRGTANTVARALALISAGAWGERDDVEA
HCCCCCCHHHHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
LAERVGVGGRQLRRLFARHVGAPPVRIAQAQRVLLARRLLADTTLPLADVASAAGFGSVR
HHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHH
RFNEAVRRTFRRPPGALRRGASAPPPDGAIAIALPHTAPYDWPALLGFLGARAIPGVEQV
HHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHH
SDGAYRRTVALDGAAGTVEVRPDPRGRGLVATLRLPGVAAIAPAVERLRRLLDLDADARA
CCCCCEEEEEECCCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHH
IGAHLSGDPLLAPLVAARPGLRVPGAWEPFELVVRAVLGQQVSVAAARTLAGRLAARLGA
HCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
PVDSGDPALSRLFPGPEALAGADLEGLGLTRARAATLAAIGAAVRDDPSLLAPGGELEDA
CCCCCCHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
VARLDALPGIGRWTAQYVAMRALHQPDAFPEGDLGLLAALGGLRGRGRAAPGELLRRAER
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHH
WRPWRAYAALHLWTSLRPRARAAPGARKKGRRS
CCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]