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The map label for this gene is srrB [H]

Identifier: 220915920

GI number: 220915920

Start: 905838

End: 907601

Strand: Direct

Name: srrB [H]

Synonym: A2cp1_0806

Alternate gene names: 220915920

Gene position: 905838-907601 (Clockwise)

Preceding gene: 220915911

Following gene: 220915921

Centisome position: 18.01

GC content: 79.08

Gene sequence:

>1764_bases
ATGGATCGTCGGGAGTCACCGCAGGCGGCCGCGCCGGAGGCGTGGGAGTCCGAGCGCGCCGCCCGCCAGACCGCGGAGGC
GGCGGCGGCGCGGATCGCGCGCCTGCAGGCCGCGACCGCGGCCCTGTCCGGCGCGCGCACGCCCGACGAGGTGGCCGAGG
TGGCGCTGCGGGAGGGCATCGCGGCGCTCGGCGGAGCCCACGGCTTCCTGCTCGTGCCGGGGCGGGGTGGACTGCTGGAC
GTGCTCCGGTCCGCCGGCGTGCCGGACCCGGTGGCGCACGCCGCGGGCAGGCTCGACCACACGCCGGCCACCGACGCGTG
GCGGAGCGGGGAGCCGGTCCTGGTGACGAGCGACGCCGAGCTCGCCGCGCGCTACCCGGTGGTCGCCGAGCTGCGCCGGC
AGGTGGGCGTGCTCGGTGGCCTCGCCGCGCTGCCGCTCCGGGTCCGCGACCGCGTCATCGGCGTCCTCGCGGTCTCGTTC
CAGGGCGACCAGGCGTTCGCGCCGGAGGCGCGCGCCTTCGCCGAGGCGCTCGCCGCCCAGGCGGCGCAGGCGCTCGACCG
GGCCCGGCTGCTGATCGCGGAGCGGGTGGCGCGCGCCGCGGCGGTGGCGGCGCAGCAGCGGCTCGCGTTCCTGGATGCGC
TCGCGGCGCTGCTCGCGGATCGGCTCGACGAGGCGGAGCTGCTGGACGGCGTGGTCCGGACCGCCGTGCCGACGATGTGC
GAGTTCGCGGCGGTGCTGCTCCCGGACGCCGGGGGCGCGCTCGTGCCGGTGGCGCAGGCCGACGCGGCCGGGCTGGGACC
GCGCGCGCTGGCGCTCGTCGCGGAGCGGCAGGCCGGGCTCGAGGCGGTGGTGTCCGGCGGTGCGCCGCTCGTGGTCGGGC
CACGCGAGGGGGACTCCCGGCCGATGACGGTGGCGGCGGCGGGCCTGTCGGTGCAGGGCCGGAGCCTGGGCGCGCTCGTC
GCGGCGAGCGCCGATCCCTCCCGCTGCCGCGGCCCCGCCGACCTGGCGCTGCTCGCCGACGTGGCGCGGCGCACGGCGCT
GGCGCTCGCGCACGCGCGCCTGTTCCGGGAGGTGCAGCGCGGCGCCGAGGCGCGCGAGGAGTTCCTGCACGTCGCCTCGC
ACGAGCTGCGCGGCCCGCTCGGCAACCTGCGCCTGGCGGTGGACCTGCTGGCGCGCGACGTGCGCGCCGAGCGGGGCAGC
GCGCTCGACGGCCGCCTGCGCAAGGTGGCGCGACAGGCCGAGCGGCTGGCGCGCCTGTCCGACCTGCTCCTCGACGTCTC
GCGCATCTCGGCGGGCCGCATCCAGCTCCAGCCCGAGCCGGCCGACCTCGCCCAGCTCGCGCGCGACGCGGTGGCGCGCG
CGGGCGACGAGGCGGAGGAGGCGGACTGTCCGCTCGTGCTGGACGCGCCGGCGCCGGTGCCGTGCACGGTCGACGTCCAG
CGCCTGGACCAGGTGATCACGAACCTGCTCTCGAACGCCATGAAGTACGGGCGGGGCGGCGAGGTGCGGGTGGCGGTGCG
GGCCGACGAGGGGCGGGCCGTGCTGGAGATCGCCGACCAGGGGATCGGCATCGCGCCCGAGCACCAGGCCCGCATCTTCG
AGCGCTTCGAGCGCGCCGCCCCGGCCCGGCAGTACCCGGGGCTCGGGCTCGGGCTCTGGATCGTGCGCAAGCTGGTGGAC
GCGCACGGCGGGACGGTGCGCCTGGACAGCGCCCCGTCCCGGGGCGCCACCTTCACGGTCGAGCTGCCCCTCGACCGCGG
CTGA

Upstream 100 bases:

>100_bases
ACCCGTTTGGCGCATCCGCACCGGGCTCCATGTCGCCTTGTGGTCCTCGGAAGGGTGGTGTCGAATGCGGCGACTGGGTG
CTCGTCGGGGGACCGCACCA

Downstream 100 bases:

>100_bases
CGGCCCCGCCGCCGGCAGGAGGAGGCCGCGTGCCGCTCGCCATCGACTCGACCGCGTTCGCCGCCGGGGCCGAGATCCCC
GCGCGCCACACCTGCGAGGG

Product: GAF sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MDRRESPQAAAPEAWESERAARQTAEAAAARIARLQAATAALSGARTPDEVAEVALREGIAALGGAHGFLLVPGRGGLLD
VLRSAGVPDPVAHAAGRLDHTPATDAWRSGEPVLVTSDAELAARYPVVAELRRQVGVLGGLAALPLRVRDRVIGVLAVSF
QGDQAFAPEARAFAEALAAQAAQALDRARLLIAERVARAAAVAAQQRLAFLDALAALLADRLDEAELLDGVVRTAVPTMC
EFAAVLLPDAGGALVPVAQADAAGLGPRALALVAERQAGLEAVVSGGAPLVVGPREGDSRPMTVAAAGLSVQGRSLGALV
AASADPSRCRGPADLALLADVARRTALALAHARLFREVQRGAEAREEFLHVASHELRGPLGNLRLAVDLLARDVRAERGS
ALDGRLRKVARQAERLARLSDLLLDVSRISAGRIQLQPEPADLAQLARDAVARAGDEAEEADCPLVLDAPAPVPCTVDVQ
RLDQVITNLLSNAMKYGRGGEVRVAVRADEGRAVLEIADQGIGIAPEHQARIFERFERAAPARQYPGLGLGLWIVRKLVD
AHGGTVRLDSAPSRGATFTVELPLDRG

Sequences:

>Translated_587_residues
MDRRESPQAAAPEAWESERAARQTAEAAAARIARLQAATAALSGARTPDEVAEVALREGIAALGGAHGFLLVPGRGGLLD
VLRSAGVPDPVAHAAGRLDHTPATDAWRSGEPVLVTSDAELAARYPVVAELRRQVGVLGGLAALPLRVRDRVIGVLAVSF
QGDQAFAPEARAFAEALAAQAAQALDRARLLIAERVARAAAVAAQQRLAFLDALAALLADRLDEAELLDGVVRTAVPTMC
EFAAVLLPDAGGALVPVAQADAAGLGPRALALVAERQAGLEAVVSGGAPLVVGPREGDSRPMTVAAAGLSVQGRSLGALV
AASADPSRCRGPADLALLADVARRTALALAHARLFREVQRGAEAREEFLHVASHELRGPLGNLRLAVDLLARDVRAERGS
ALDGRLRKVARQAERLARLSDLLLDVSRISAGRIQLQPEPADLAQLARDAVARAGDEAEEADCPLVLDAPAPVPCTVDVQ
RLDQVITNLLSNAMKYGRGGEVRVAVRADEGRAVLEIADQGIGIAPEHQARIFERFERAAPARQYPGLGLGLWIVRKLVD
AHGGTVRLDSAPSRGATFTVELPLDRG
>Mature_587_residues
MDRRESPQAAAPEAWESERAARQTAEAAAARIARLQAATAALSGARTPDEVAEVALREGIAALGGAHGFLLVPGRGGLLD
VLRSAGVPDPVAHAAGRLDHTPATDAWRSGEPVLVTSDAELAARYPVVAELRRQVGVLGGLAALPLRVRDRVIGVLAVSF
QGDQAFAPEARAFAEALAAQAAQALDRARLLIAERVARAAAVAAQQRLAFLDALAALLADRLDEAELLDGVVRTAVPTMC
EFAAVLLPDAGGALVPVAQADAAGLGPRALALVAERQAGLEAVVSGGAPLVVGPREGDSRPMTVAAAGLSVQGRSLGALV
AASADPSRCRGPADLALLADVARRTALALAHARLFREVQRGAEAREEFLHVASHELRGPLGNLRLAVDLLARDVRAERGS
ALDGRLRKVARQAERLARLSDLLLDVSRISAGRIQLQPEPADLAQLARDAVARAGDEAEEADCPLVLDAPAPVPCTVDVQ
RLDQVITNLLSNAMKYGRGGEVRVAVRADEGRAVLEIADQGIGIAPEHQARIFERFERAAPARQYPGLGLGLWIVRKLVD
AHGGTVRLDSAPSRGATFTVELPLDRG

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=33.0508474576271, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788713, Length=238, Percent_Identity=31.0924369747899, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI145693157, Length=262, Percent_Identity=28.2442748091603, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=29.3103448275862, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786912, Length=349, Percent_Identity=28.9398280802292, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87081816, Length=258, Percent_Identity=31.7829457364341, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=29.7959183673469, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=29.5652173913043, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789808, Length=228, Percent_Identity=27.1929824561404, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.1479820627803, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786783, Length=250, Percent_Identity=30.8, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=28.3720930232558, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787894, Length=230, Percent_Identity=30, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=314, Percent_Identity=28.9808917197452, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=27.8260869565217, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61312; Mature: 61312

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRRESPQAAAPEAWESERAARQTAEAAAARIARLQAATAALSGARTPDEVAEVALREGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
AALGGAHGFLLVPGRGGLLDVLRSAGVPDPVAHAAGRLDHTPATDAWRSGEPVLVTSDAE
HHHCCCCCEEEECCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEECCHH
LAARYPVVAELRRQVGVLGGLAALPLRVRDRVIGVLAVSFQGDQAFAPEARAFAEALAAQ
HHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHH
AAQALDRARLLIAERVARAAAVAAQQRLAFLDALAALLADRLDEAELLDGVVRTAVPTMC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EFAAVLLPDAGGALVPVAQADAAGLGPRALALVAERQAGLEAVVSGGAPLVVGPREGDSR
HHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCHHHHHCCCCCEEECCCCCCCC
PMTVAAAGLSVQGRSLGALVAASADPSRCRGPADLALLADVARRTALALAHARLFREVQR
CEEEEEECCEECCCCCCEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAEAREEFLHVASHELRGPLGNLRLAVDLLARDVRAERGSALDGRLRKVARQAERLARLS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
DLLLDVSRISAGRIQLQPEPADLAQLARDAVARAGDEAEEADCPLVLDAPAPVPCTVDVQ
HHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHCCCCEEECCCCCCCCCCCHH
RLDQVITNLLSNAMKYGRGGEVRVAVRADEGRAVLEIADQGIGIAPEHQARIFERFERAA
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHCC
PARQYPGLGLGLWIVRKLVDAHGGTVRLDSAPSRGATFTVELPLDRG
CCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MDRRESPQAAAPEAWESERAARQTAEAAAARIARLQAATAALSGARTPDEVAEVALREGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
AALGGAHGFLLVPGRGGLLDVLRSAGVPDPVAHAAGRLDHTPATDAWRSGEPVLVTSDAE
HHHCCCCCEEEECCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEECCHH
LAARYPVVAELRRQVGVLGGLAALPLRVRDRVIGVLAVSFQGDQAFAPEARAFAEALAAQ
HHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHH
AAQALDRARLLIAERVARAAAVAAQQRLAFLDALAALLADRLDEAELLDGVVRTAVPTMC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EFAAVLLPDAGGALVPVAQADAAGLGPRALALVAERQAGLEAVVSGGAPLVVGPREGDSR
HHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCHHHHHCCCCCEEECCCCCCCC
PMTVAAAGLSVQGRSLGALVAASADPSRCRGPADLALLADVARRTALALAHARLFREVQR
CEEEEEECCEECCCCCCEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAEAREEFLHVASHELRGPLGNLRLAVDLLARDVRAERGSALDGRLRKVARQAERLARLS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
DLLLDVSRISAGRIQLQPEPADLAQLARDAVARAGDEAEEADCPLVLDAPAPVPCTVDVQ
HHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHCCCCEEECCCCCCCCCCCHH
RLDQVITNLLSNAMKYGRGGEVRVAVRADEGRAVLEIADQGIGIAPEHQARIFERFERAA
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHCC
PARQYPGLGLGLWIVRKLVDAHGGTVRLDSAPSRGATFTVELPLDRG
CCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA